轮状病毒腹泻研究进展_West China Medical Journal

Authors：

 黄敏 ,  黄英

四川大学华西基础医学与法医学院病理生理学教研室（成都，610041）;

Corresponding author：

黄英, Email: huangying68@163.com

Keywords：

轮状病毒; 腹泻; 被动免疫

DOI：

10.7507/1002-0179.20140237

Video：

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轮状病毒是婴幼儿腹泻最重要的病原体，同样也是造成发展中国家婴幼儿腹泻死亡的主要原因，轮状病毒腹泻已成为一项重要的公共卫生问题，其防治问题引起人们的高度重视。现就轮状病毒的结构、发病机制、临床表现及防治轮状病毒腹泻的研究现状及进展作一综述。

Citation： 黄敏, 黄英. 轮状病毒腹泻研究进展. West China Medical Journal, 2014, 29(4): 780-782. doi: 10.7507/1002-0179.20140237 Copy

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3.	Khatib PK, Khan ZH. Prevalence of rotavirus diarrhoea among childrens in Akola[J]. Int J Pharm Res Allied Sci, 2013, 2(1):65-69.
4.	Parashar UD, Alexander JP, Glass RI, et al. Prevention of rotavirus gastroenteritis among infants and children. Recommendations of the Advisory Committee on Immunization Practices (ACIP)[J]. MMWR Recomm Rep, 2006, 55(RR/12):1-13.
5.	王蓓, 方肇寅, 高倩, 等. 中国轮状病毒腹泻的经济原理浅析[C]//第二届国际轮状病毒疫苗研讨会. 北京:中国疾病预防控制中心, 2005:36-40.
6.	Dennehy PH. Rotavirus vaccines:an overview[J]. Clin Microbiol Rev, 2008, 21(1):198-208.
7.	Chen Y, Wen Y, Liu X, et al. Full genomic analysis of human rotavirus strain TB-Chen isolated in China[J]. Virology, 2008, 375(2):361-373.
8.	Dennehy PH. Rotavirus vaccines:an update[J]. Vaccine, 2007, 25(16):3137-3141.
9.	Lee SY, Hong JH, Lee SW, et al. Comparisons of latex agglutination, immunochromatography and enzyme immunoassay methods for the detection of rotavirus antigen[J]. Korean J Lab Med, 2007, 27(6):437-441.
10.	Díaz Y, Peña F, Aristimuño OC, et al. Dissecting the Ca²⁺ entry pathways induced by rotavirus infection and NSP4-EGFP expression in Cos-7 cells[J]. Virus Res, 2012, 167(2):285-296.
11.	Lorrot M, Vasseur M. How do the rotavirus NSP4 and bacterial enterotoxins Lead differently to diarrhea?[J]. Virol J, 2007, 4(1):31.
12.	聂青和. 感染性腹泻的发病机制研究进展及治疗指导[J]. 中华实验和临床感染病杂志:电子版, 2007, 1(3):181-184.
13.	Petri WA, Miller M, Binder HJ, et al. Enteric infections, diarrhea, and their impact on function and development[J]. J Clin Invest, 2008, 118(4):1277-1290.
14.	Ball JM, Mitchell DM, Gibbons TF, et al. Rotavirus NSP4:a multifunctional viral enterotoxin[J]. Viral Immunol, 2005, 18(1):27-40.
15.	Zambrano JL, Sorondo O, Alcala A, et al. Rotavirus infection of cells in culture induces activation of RhoA and changes in the actin and tubulin cytoskeleton[J]. PLoS One, 2012, 7(10):e47612.
16.	Kordasti S, Sjövall H, Lundgren O, et al. Serotonin and vasoactive intestinal peptide antagonists attenuate rotavirus diarrhoea[J]. Gut, 2004, 53(7):952-957.
17.	Lundgren O, Svensson L. The enteric nervous system and infectious diarrhea[M]//Desselberger U, Gray J. Viral gastroenteritis. Amsterdam:Elsevier Science BV, 2003:51-68.
18.	Parsa-Nahad M, Samarbaf-Zadeh A, Makvandi M, et al. Determination of rotavirus, sapovirus and norovirus coinfection among children suffering from gastroenteritis[J]. Iran J Virol, 2011, 5(4):29-31.
19.	Orenstein EW, Fang ZY, Xu J, et al. The epidemiology and burden of rotavirus in China:a review of the literature from 1983 to 2005[J]. Vaccine, 2007, 25(3):406-413.
20.	Yang XL, Matthijnssens J, Sun H, et al. Temporal changes of rotavirus strain distribution in a city in the northwest of China, 1996-2005[J]. Int J Infect Dis, 2008, 12(6):e11-e17.
21.	Dennehy PH. Rotavirus infection:an update on management and prevention[J]. Adv Pediatr, 2012, 59(1):47-74.
22.	Patel MM, Clark AD, Glass RI, et al. Broadening the age restriction for initiating rotavirus vaccination in regions with high rotavirus mortality:benefits of mortality reduction versus risk of fatal intussusception[J]. Vaccine, 2009, 27(22):2916-2922.
23.	Nakagomi O, Cunliffe NA. Rotavirus vaccines:entering a new stage of deployment[J]. Curr Opin Infect Dis, 2007, 20(5):501-507.
24.	Dennehy PH. Rotavirus infection:an update on management and prevention[J]. Adv Pediatr, 2012, 59(1):47-74.
25.	Dumoulin M, Last AM, Desmyter A, et al. A camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme[J]. Nature, 2003, 424(6950):783-788.
26.	Pant N, Hultberg A, Zhao Y, et al. Lactobacilli expressing variable domain of llama heavy-chain antibody fragments (lactobodies) confer protection against rotavirus-induced diarrhea[J]. J Infect Dis, 2006, 194(11):1580-1588.
27.	Martín MC, Pant N, Ladero V, et al. Integrative expression system for delivery of antibody fragments by lactobacilli[J]. Appl Environ Microbiol, 2011, 77(6):2174-2179.

1. Black RE, Cousens S, Johnson HL, et al. Global, regional, and National causes of child mortality in 2008:a systematic analysis[J]. Lancet, 2010, 375(9730):1969-1987.
2. Fischer Walker CL, Black RE. Rotavirus vaccine and diarrhea mortality:quantifying regional variation in effect size[J]. BMC Public Health, 2011, 11(Suppl 3):S16.
3. Khatib PK, Khan ZH. Prevalence of rotavirus diarrhoea among childrens in Akola[J]. Int J Pharm Res Allied Sci, 2013, 2(1):65-69.
4. Parashar UD, Alexander JP, Glass RI, et al. Prevention of rotavirus gastroenteritis among infants and children. Recommendations of the Advisory Committee on Immunization Practices (ACIP)[J]. MMWR Recomm Rep, 2006, 55(RR/12):1-13.
5. 王蓓, 方肇寅, 高倩, 等. 中国轮状病毒腹泻的经济原理浅析[C]//第二届国际轮状病毒疫苗研讨会. 北京:中国疾病预防控制中心, 2005:36-40.
6. Dennehy PH. Rotavirus vaccines:an overview[J]. Clin Microbiol Rev, 2008, 21(1):198-208.
7. Chen Y, Wen Y, Liu X, et al. Full genomic analysis of human rotavirus strain TB-Chen isolated in China[J]. Virology, 2008, 375(2):361-373.
8. Dennehy PH. Rotavirus vaccines:an update[J]. Vaccine, 2007, 25(16):3137-3141.
9. Lee SY, Hong JH, Lee SW, et al. Comparisons of latex agglutination, immunochromatography and enzyme immunoassay methods for the detection of rotavirus antigen[J]. Korean J Lab Med, 2007, 27(6):437-441.
10. Díaz Y, Peña F, Aristimuño OC, et al. Dissecting the Ca²⁺ entry pathways induced by rotavirus infection and NSP4-EGFP expression in Cos-7 cells[J]. Virus Res, 2012, 167(2):285-296.
11. Lorrot M, Vasseur M. How do the rotavirus NSP4 and bacterial enterotoxins Lead differently to diarrhea?[J]. Virol J, 2007, 4(1):31.
12. 聂青和. 感染性腹泻的发病机制研究进展及治疗指导[J]. 中华实验和临床感染病杂志:电子版, 2007, 1(3):181-184.
13. Petri WA, Miller M, Binder HJ, et al. Enteric infections, diarrhea, and their impact on function and development[J]. J Clin Invest, 2008, 118(4):1277-1290.
14. Ball JM, Mitchell DM, Gibbons TF, et al. Rotavirus NSP4:a multifunctional viral enterotoxin[J]. Viral Immunol, 2005, 18(1):27-40.
15. Zambrano JL, Sorondo O, Alcala A, et al. Rotavirus infection of cells in culture induces activation of RhoA and changes in the actin and tubulin cytoskeleton[J]. PLoS One, 2012, 7(10):e47612.
16. Kordasti S, Sjövall H, Lundgren O, et al. Serotonin and vasoactive intestinal peptide antagonists attenuate rotavirus diarrhoea[J]. Gut, 2004, 53(7):952-957.
17. Lundgren O, Svensson L. The enteric nervous system and infectious diarrhea[M]//Desselberger U, Gray J. Viral gastroenteritis. Amsterdam:Elsevier Science BV, 2003:51-68.
18. Parsa-Nahad M, Samarbaf-Zadeh A, Makvandi M, et al. Determination of rotavirus, sapovirus and norovirus coinfection among children suffering from gastroenteritis[J]. Iran J Virol, 2011, 5(4):29-31.
19. Orenstein EW, Fang ZY, Xu J, et al. The epidemiology and burden of rotavirus in China:a review of the literature from 1983 to 2005[J]. Vaccine, 2007, 25(3):406-413.
20. Yang XL, Matthijnssens J, Sun H, et al. Temporal changes of rotavirus strain distribution in a city in the northwest of China, 1996-2005[J]. Int J Infect Dis, 2008, 12(6):e11-e17.
21. Dennehy PH. Rotavirus infection:an update on management and prevention[J]. Adv Pediatr, 2012, 59(1):47-74.
22. Patel MM, Clark AD, Glass RI, et al. Broadening the age restriction for initiating rotavirus vaccination in regions with high rotavirus mortality:benefits of mortality reduction versus risk of fatal intussusception[J]. Vaccine, 2009, 27(22):2916-2922.
23. Nakagomi O, Cunliffe NA. Rotavirus vaccines:entering a new stage of deployment[J]. Curr Opin Infect Dis, 2007, 20(5):501-507.
24. Dennehy PH. Rotavirus infection:an update on management and prevention[J]. Adv Pediatr, 2012, 59(1):47-74.
25. Dumoulin M, Last AM, Desmyter A, et al. A camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme[J]. Nature, 2003, 424(6950):783-788.
26. Pant N, Hultberg A, Zhao Y, et al. Lactobacilli expressing variable domain of llama heavy-chain antibody fragments (lactobodies) confer protection against rotavirus-induced diarrhea[J]. J Infect Dis, 2006, 194(11):1580-1588.
27. Martín MC, Pant N, Ladero V, et al. Integrative expression system for delivery of antibody fragments by lactobacilli[J]. Appl Environ Microbiol, 2011, 77(6):2174-2179.

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轮状病毒腹泻研究进展

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