Effects of Tandospirone on Cardiac Autonomic Nervous System in Patients with Anxiety and Depression after Intracoronary Stent Implantation_West China Medical Journal

Authors：

 XIONGLu , LUOCai-dong , WUYi , LIUYun-bing , WENYu

Cardiovascular Department of Mianyang Central Hospital, Mianyang, Sichuan 421000, P. R. China;

Corresponding author：

Keywords：

Tandospirone; Anxiety and depression; Intracoronary stent implantation; Heart rate variability; QT dispersion

DOI：

10.7507/1002-0179.20140268

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Objective To investigate the effects of a new anti-anxiety-depression drug tandospirone on heart rate variability (HRV) and QT-dispersion in patients with anxiety and depression after intracoronary stent implantation. Methods Eighty-six anxious and depressive patients after intracoronary stent implantation during May 2011 and May 2013 were treated by tandospirone for 6 weeks. We evaluated the changes of HRV and QT dispersion before and after anti-anxiety-depression treatment. Results After six weeks of treatment, the HRV was increased obviously (P<0.05) and the QT dispersion was decreased significantly (P<0.01). Conclusion The new anti-anxiety-depression drug tandospirone is effective on cardiac autonomic nervous system in patients with anxiety and depression after intracoronary stent implantation. And the drug is secure with a low rate of adverse reactions.

Citation： XIONGLu, LUOCai-dong, WUYi, LIUYun-bing, WENYu. Effects of Tandospirone on Cardiac Autonomic Nervous System in Patients with Anxiety and Depression after Intracoronary Stent Implantation. West China Medical Journal, 2014, 29(5): 883-885. doi: 10.7507/1002-0179.20140268 Copy

1.	朱性霞, 武惠敏, 许志亮, 等. 接受冠状动脉支架置入治疗的心理状态分析[J]. 中国组织工程研究与临床康复, 2009, 13(30):5955-5958.
2.	常宗霞, 闫艳, 刘云. 冠状动脉支架置入术后患者生活质量及其影响因素的调查[J]. 中华现代护理杂志, 2010, 16(13):1500-1503.
3.	Lederbogen F, Strohle A. Stess, mental disorders and coronary heart disease[J]. Nervenarzt, 2012, 83(11):1448-1457.
4.	Summers KM, Martin KE, Watson K. Impact and clinical management of depression in patients with coronary artery disease[J]. Pharmacotherapy, 2010, 30(3):304-322.
5.	李晓红, 张巍, 赵明, 等. 冠心病合并不同程度抑郁患者心率变异性分析[J].中国心血管杂志, 2011, 16(6):425-427.
6.	Wahab A, Zaheer MS, Rabbani MU, et al. A study of heart rate variability and QT dispersion in patients of acute ST elevation myocardial infarction[J]. Indian Heart J, 2009, 61(3):261-264.
7.	张惠琪, 张进鹏, 李自成, 等. 冠心病患者QT离散度与冠脉病变的关系及其干预治疗[J]. 暨南大学学报·自然科学与医学版, 2011, 32(4):426-429.
8.	Pivatelli FC, Dos Santos MA, Fernandes GB, et al. Sensitivity, specificity and predictive values of linear and nonlinear indices of heart rate variability in stable angina patients[J]. Int Arch Med, 2012, 5(1):31.
9.	Roest AM, Martens EJ, de Jonge P, et al. Anxiety and risk of incident coronary heart disease:a meta analysis[J]. J Am Coll Cardiol, 2010, 56(1):38-46.
10.	Serrano CV Jr, Setani KT, Sakamato E, et al. Association between depression and development of coronary artery disease. Pathophysiologic and diagnostic implication[J]. Vasc Health Risk Manag, 2011, 7(3):159-164.
11.	韩健, 杨靖宇, 高志刚. 冠心病患者心率变异性分析[J]. 局解手术学杂志, 2012, 21(2):154-156.
12.	Blumenthal JA, Sherwood A, Babyak MA, et al. Exercise and pharmacological treatment of depressive symptoms in patients with coronary heart disease:results from the UPBEAT (Understan-ding the Prognostic Benefits of Exercise and Antidepressant Therapy)study[J]. J Am Coll Cardiol, 2012, 60(12):1053-1063.

1. 朱性霞, 武惠敏, 许志亮, 等. 接受冠状动脉支架置入治疗的心理状态分析[J]. 中国组织工程研究与临床康复, 2009, 13(30):5955-5958.
2. 常宗霞, 闫艳, 刘云. 冠状动脉支架置入术后患者生活质量及其影响因素的调查[J]. 中华现代护理杂志, 2010, 16(13):1500-1503.
3. Lederbogen F, Strohle A. Stess, mental disorders and coronary heart disease[J]. Nervenarzt, 2012, 83(11):1448-1457.
4. Summers KM, Martin KE, Watson K. Impact and clinical management of depression in patients with coronary artery disease[J]. Pharmacotherapy, 2010, 30(3):304-322.
5. 李晓红, 张巍, 赵明, 等. 冠心病合并不同程度抑郁患者心率变异性分析[J].中国心血管杂志, 2011, 16(6):425-427.
6. Wahab A, Zaheer MS, Rabbani MU, et al. A study of heart rate variability and QT dispersion in patients of acute ST elevation myocardial infarction[J]. Indian Heart J, 2009, 61(3):261-264.
7. 张惠琪, 张进鹏, 李自成, 等. 冠心病患者QT离散度与冠脉病变的关系及其干预治疗[J]. 暨南大学学报·自然科学与医学版, 2011, 32(4):426-429.
8. Pivatelli FC, Dos Santos MA, Fernandes GB, et al. Sensitivity, specificity and predictive values of linear and nonlinear indices of heart rate variability in stable angina patients[J]. Int Arch Med, 2012, 5(1):31.
9. Roest AM, Martens EJ, de Jonge P, et al. Anxiety and risk of incident coronary heart disease:a meta analysis[J]. J Am Coll Cardiol, 2010, 56(1):38-46.
10. Serrano CV Jr, Setani KT, Sakamato E, et al. Association between depression and development of coronary artery disease. Pathophysiologic and diagnostic implication[J]. Vasc Health Risk Manag, 2011, 7(3):159-164.
11. 韩健, 杨靖宇, 高志刚. 冠心病患者心率变异性分析[J]. 局解手术学杂志, 2012, 21(2):154-156.
12. Blumenthal JA, Sherwood A, Babyak MA, et al. Exercise and pharmacological treatment of depressive symptoms in patients with coronary heart disease:results from the UPBEAT (Understan-ding the Prognostic Benefits of Exercise and Antidepressant Therapy)study[J]. J Am Coll Cardiol, 2012, 60(12):1053-1063.

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Effects of Tandospirone on Cardiac Autonomic Nervous System in Patients with Anxiety and Depression after Intracoronary Stent Implantation

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