慢性阻塞性肺疾病合并抑郁患者与肺性脑病抑郁状态研究分析_West China Medical Journal

Authors：

 沈剑 ,  李艳萍 , 包勇 , 殷俊

成都市第三人民医院/重庆医科大学附属成都第二临床学院呼吸内科（成都，610031）;

Corresponding author：

李艳萍, Email: alyya@163.com

Keywords：

慢性阻塞性肺疾病; 抑郁状态; 呼吸衰竭; 肺性脑病

DOI：

10.7507/1002-0179.20140282

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目的探讨慢性阻塞性肺疾病（COPD）合并抑郁患者与呼吸衰竭、肺性脑病发生的关系。方法随机选取2009年10月－2011年10月住院期间COPD患者共92例，行抑郁自评量表及汉密尔顿抑郁量表测评，记录住院期间血气分析结果。结果汉密尔顿抑郁量表研究计算入选92例患者中合并抑郁患者53例，抑郁发病率57.6%，其中37例（69.8%）为中重度抑郁。COPD抑郁患者合并呼吸衰竭者33例，合并肺性脑病表现24例。呼吸衰竭、肺性脑病的发生率与COPD患者抑郁状态有关，合并抑郁状态的COPD患者发生呼吸衰竭的可能性是单纯COPD患者的2.5倍，发生肺性脑病的可能性是单纯COPD患者的1.7倍。结论 COPD合并抑郁患者较单纯COPD患者易发生呼吸衰竭及肺性脑病，肺性脑病产生的神经精神异常进一步加重抑郁情绪。

Citation： 沈剑, 李艳萍, 包勇, 殷俊. 慢性阻塞性肺疾病合并抑郁患者与肺性脑病抑郁状态研究分析. West China Medical Journal, 2014, 29(5): 931-932. doi: 10.7507/1002-0179.20140282 Copy

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1. Kunik ME, Roundy K, Veazey C, et al. Surprisingly high prevalence of anxiety and depression in chronic breathing disorders[J]. Chest, 2005, 127(4):1205-1211.
2. 晁耀烁, 许志强, 李保顺. 慢性阻塞性肺病并发抑郁障碍相关因素分析[J]. 临床心身疾病杂志, 2006, 12(2):93-95.
3. Maurer J, Rebbapragada V, Borson S, et al. Anxiety and depression in COPD[J]. Chest, 2008, 134(4 Suppl):43s-56s.
4. Yohannes AM, Baldwin RC, Connolly MJ. Depression and anxiety in elderly outpatients with chronic obstructive pulmonary disease:prevalence and validation of the BASDEC screening questionnaire[J]. Int J Geriatr Psychiatry, 2000, 15(12):1090-1096.
5. Kim HF, Kunik ME, Molinari VA, et al. Functional impairment in COPD patients:the impact of anxiety and depression[J]. Psychosomatics, 2001, 41(6):465-471.
6. Sullivan MD, Lacroix AZ, Baum C, et al. Functional status in coronary artery disease:a one-year prospective study of the role of anxiety and depression[J]. Am J Med, 1997, 103(5):348-356.
7. 冯颖, 周兴香, 曹长英. 临床路径在COPD伴抑郁障碍中的应用[J]. 齐齐哈尔医学院学报, 2010, 31(12):1978-1979.
8. Gift AG, McCrone SH. Depression in patients with COPD[J]. Heart Lung, 1993, 22(4):289-297.
9. 晁耀烁, 许志强, 李保顺. 慢性阻塞性肺疾病患者抑郁症患病率及影响因素调查[J]. 中国临床康复, 2005, 9(4):209.
10. Borson S, Mcdonald GJ, Gayle T, et al. Improvement in mood, physical symptoms, and function with nortriptyline for depression in patients with chronic obstructive pulmonary disease[J]. Psychosomatics, 1992, 33(2):190-201.
11. Atlantis E, Fahey P, Cochrane B, et al. Bidirectional associations between clinically relevant depression or anxiety and COPD:a systematic review and meta-analysis[J]. Chest, 2013, 144(3):766-777.
12. 周小燕, 王苑蓉, 黄兆晶. 老年慢性阻塞性肺疾病患者家庭功能与应对方式调查[J]. 华西医学, 2011, 26(4):594-597.

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West China Medical Journal

慢性阻塞性肺疾病合并抑郁患者与肺性脑病抑郁状态研究分析

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