乳腺癌干细胞的研究进展_West China Medical Journal

Authors：

 王荣 ,  羊晓勤 , 吕青

四川大学华西医院甲状腺乳腺外科（成都，610041）;

Corresponding author：

羊晓勤, Email: laurayang1977@hotmail.com

Keywords：

乳腺癌; 乳腺癌干细胞; 分离; 富集; 肿瘤治疗

DOI：

10.7507/1002-0179.20140301

Video：

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乳腺癌是女性最常见的恶性肿瘤，尽管目前治疗手段逐渐多样化、个体化，乳腺癌患者的预后仍没有进一步提高。目前普遍认为造成乳腺癌患者复发转移最后导致死亡的主要原因是肿瘤当中存在一部分具有高致瘤性、对放射化学疗法不敏感的乳腺癌干细胞。随着对乳腺癌干细胞研究的广泛开展，出现了多种对乳腺癌干细胞进行分离和富集的方法，以及乳腺癌干细胞在肿瘤治疗中的应用，现就乳腺癌干细胞的研究进展情况作一综述。

Citation： 王荣, 羊晓勤, 吕青. 乳腺癌干细胞的研究进展. West China Medical Journal, 2014, 29(5): 988-991. doi: 10.7507/1002-0179.20140301 Copy

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1. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013[J]. CA Cancer J Clin, 2013, 63(1):11-30.
2. 石晓君, 张晓佳, 王富生, 等. 1991-2010年中国女性乳腺癌的死亡分布特征[J]. 中华疾病控制杂志, 2012, 16(9):743-747.
3. Reya T, Morrison SJ, Clarke MF, et al. Stem cells, cancer, and cancer stem cells[J]. Nature, 2001, 414(6859):105-111.
4. Kordon EC, Smith GH. An entire functional mammary gland May comprise the progeny from a single cell[J]. Development, 1998, 125(10):1921-1930.
5. Taipale J, Beachy PA. The hedgehog and Wnt signalling pathways in cancer[J]. Nature, 2001, 411(6835):349-354.
6. Reya T, Clevers H. Wnt signalling in stem cells and cancer[J]. Nature, 2005, 434(7035):843-850.
7. Hwang-Verslues WW, Chang KJ, Lee EY, et al. Breast cancer stem cells and tumor suppressor genes[J]. J Formos Med Assoc, 2008, 107(10):751-766.
8. Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell[J]. Nat Med, 1997, 3(7):730-737.
9. Phillips TM, Mcbride WH, Pajonk F. The response of CD24(-/low)/CD44⁺ breast cancer-initiating cells to radiation[J]. J Natl Cancer Inst, 2006, 98(24):1777-1785.
10. Li HZ, Yi TB, Wu ZY. Suspension culture combined with anticancer regimens for screening breast cancer stem cells[J]. Med Hypotheses, 2007, 68(5):988-990.
11. Singh SK, Clarke ID, Hide T, et al. Cancer stem cells in nervous system tumors[J]. Oncogene, 2004, 23(43):7267-7273.
12. Collins AT, Berry PA, Hyde C, et al. Prospective identification of tumorigenic prostate cancer stem cells[J]. Cancer Res, 2005, 65(23):10946-10951.
13. Fang D, Nguyen TK, Leishear K, et al. A tumorigenic subpopulation with stem cell properties in melanomas[J]. Cancer Res, 2005, 65(20):9328-9337.
14. O' brien CA, Pollett A, Gallinger S, et al. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice[J]. Nature, 2007, 445(7123):106-110.
15. Ricci-Vitiani L, Lombardi DG, Pilozzi E, et al. Identification and expansion of human colon-cancer-initiating cells[J]. Nature, 2007, 445(7123):111-115.
16. Matsui W, Huff CA, Wang Q, et al. Characterization of clonogenic multiple myeloma cells[J]. Blood, 2004, 103(6):2332-2336.
17. Li C, Heidt DG, Dalerba P, et al. Identification of pancreatic cancer stem cells[J]. Cancer Res, 2007, 67(3):1030-1037.
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19. Passegué E, Jamieson CH, Ailles LE, et al. Normal and leukemic hematopoiesis:are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?[J]. Proc Natl Acad Sci USA, 2003, 100(Suppl(1):11842-11849.
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26. Dontu G, Abdallah WM, Foley JM, et al. In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells[J]. Genes Dev, 2003, 17(10):1253-1270.
27. Montanaro F, Liadaki K, Schienda J, et al. Demystifying SP cell purification:viability, yield, and phenotype are defined by isolation parameters[J]. Exp Cell Res, 2004, 298(1):144-154.
28. Ucar D, Cogle CR, Zucali JR, et al. Aldehyde dehydrogenase activity as a functional marker for lung cancer[J]. Chem Biol Interact, 2009, 178(1/3):48-55.
29. Gillet JP, Gottesman MM. Mechanisms of multidrug resistance in cancer[J]. Methods Mol Biol, 2010, 596:47-76.
30. Kenney NJ, Smith GH, Lawrence E, et al. Identification of stem cell units in the terminal end bud and duct of the mouse mammary gland[J]. J Biomed Biotechnol, 2001, 1(3):133-143.
31. Dean M, Rzhetsky A, Allikmets R. The human ATP-binding cassette (ABC) transporter superfamily[J]. J Lipid Res, 2001, 11(7):1156-1166.
32. Nishio K, Nakamura T, Koh Y, et al. Drug resistance in lung cancer[J]. Curr Opin Oncol, 1999, 11(2):109.
33. Gossage L, Madhusudan S. Current status of excision repair cross complementing-group 1(ERCC1) in cancer[J]. Cancer Treat Rev, 2007, 33(6):565-577.
34. Li GM. Mechanisms and functions of DNA mismatch repair[J]. Cell Res, 2008, 18(1):85-98.
35. Dean M, Fojo T, Bates S. Tumour stem cells and drug resistance[J]. Nat Rev Cancer, 2005, 5(4):275-284.
36. 王文静. 侧群细胞的研究进展[J]. 国际口腔医学杂志, 2011, 38(6):665-669.
37. Hirsch HA, Iliopoulos D, Tsichlis PN, et al. Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission[J]. Cancer Res, 2009, 69(19):7507-7511.
38. Iliopoulos D, Hirsch HA, Struhl K. Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types[J]. Cancer Res, 2011, 71(9):3196-3201.

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乳腺癌干细胞的研究进展

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