Pulmonary Epithelioid Hemangioendothelioma: A Case Report and the Literatures Review_West China Medical Journal

Authors：

 HUANGYan-hua ,  YANGXiao-dong , ZHANGJuan , HUQiu-fang , LIUZheng-man

Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

YANGXiao-dong, Email: yang_xiaodong@163.com

Keywords：

Lung neoplasm; Epithelioid hemangioendothelioma

DOI：

10.7507/1002-0179.20140328

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To enhance the understanding of pulmonary epithelioid hemangioendothelioma (PEH), and improve the diagnostic rate of the disease. Methods The experience of diagnosis and treatment of a case of PEH in August 2013 was reported in the present study and the related literature was reviewed. The etiology, clinical manifestations, pathological diagnosis, differential diagnosis, therapy and prognosis of this disease were described. Results The etiology of PEH remained unknown. Symptoms of PEH were usually nonspecific and mild. Chest radiograph or computed tomography usually revealed calcification in multiple nodules of half or both lungs. Primitive lumen formed by a single cell was the pathologic feature. Immunohistochemical stains showed that the malignant cells were of endothelial type. Genetic analysis was relatively limited currently. There was no effective treatment for this disease and the prognosis was poor. Conclusion PEH is a low potential malignancy occurring exclusively in young women. Symptoms of PEH are usually nonspecific and variable which can easily lead to misdiagnosis. So, pathological diagnosis should be emphasized.

Citation： HUANGYan-hua, YANGXiao-dong, ZHANGJuan, HUQiu-fang, LIUZheng-man. Pulmonary Epithelioid Hemangioendothelioma: A Case Report and the Literatures Review. West China Medical Journal, 2014, 29(6): 1074-1077. doi: 10.7507/1002-0179.20140328 Copy

1.	Weiss SW, Shak KG, Dail DH, et al. Epithelioid hemangioendothelioma and related lesions[J]. Semin Diagn Pathol, 1986, 3(4): 259-287.
2.	张秀茹, 卢一艳, 郝彦勇, 等. 脾上皮样血管内皮细胞瘤3例临床病理分析[J]. 诊断病理学杂志, 2012, 19(2): 115-117.
3.	郭洁, 杨军, 王晓冰, 等. 心包内上皮样血管内皮细胞瘤超声心动图表现1例[J]. 中国医学影像技术, 2012, 28(2): 351.
4.	丁勇, 钱忠心, 叶树铭, 等. 颅内上皮样血管内皮细胞瘤1例报告[J]. 中华神经外科疾病研究杂志, 2012, 11(1): 78-79.
5.	陈易华, 简燚, 蒋锐, 等. 骨上皮样血管内皮细胞瘤3例临床病理分析[J]. 诊断病理学杂志, 2010, 17(2): 104-106.
6.	贡其星, 范钦和, 谢军, 等. 上皮样血管瘤七例临床病理观察[J]. 中华病理学杂志, 2013, 42(9): 593-598.
7.	Dail DH, Liebow AA, Gmelich JT, et al. Intravascular, bronchiolar, and alveolar tumor of the lung (IVBAT). An analysis of twenty cases of a peculiar sclerosing endothelial tumor[J]. Cancer, 1983, 51(3): 452-464.
8.	Weiss SW, Ehzinger FM. Epithelioid hemangioendothelioma: a distinctive vascular tumor often mistaken for a carcinoma[J]. Cancer, 1982, 50(5): 970-981.
9.	Ohori NP, Yousem SA, Sonmez-Alpan E, et al. Estrogen and progesterone receptors in lymphangioleiomyomatosis, epithelioid hemangioendothelioma, and sclerosing hemangioma of the lung[J]. Am J Clin Pathol, 1991, 96(4): 529-535.
10.	Kitaichi M, Nagai S, Nishimura K, et al. Pulmonary epithelioid haemangioendothelioma in 21 patients, including three with partial spontaneous regression[J]. Eur Respir J, 1998, 12(1): 89-96.
11.	尉连成, 牛子民, 杨小洁. 肺内巨大上皮样血管内皮瘤合并非胰岛细胞性低血糖1例[J]. 中国临床医生, 2005, 33(3): 40.
12.	Vandenheede M, Salem T, Sayago I, et al. Clinical case of the month. Multiple pulmonary nodules. Epithelioid hemangioendothelioma[J]. Rev Med Liege, 1998, 53(8): 454-458.
13.	王兆平, 高志斌, 柳君, 等. 纤维支气管镜标本诊断肺上皮样血管内皮瘤2例[J]. 实用医学杂志, 2009, 25(13): 2205-2206.
14.	管星庆, 宿杰·阿克苏, 许建芳, 等. 肺上皮样血管内皮瘤活体组织病理学检查的诊断意义[J]. 中国临床医学, 2013, 20(3): 309-311.
15.	Ryu HS, Lee SS, Choi HS, et al. A case of pulmonary malignant epithelioid hemangioendothelioma misdiagnosed as adenocarcinoma by fine needle aspiration cytology[J]. Diagn Cytopathol, 2011, 39(11): 801-807.
16.	刘梅, 巴恩平, 赵坡, 等. 上皮样血管肉瘤的临床病理分析[J]. 中华病理学杂志, 2002, 31(5): 407-410.
17.	Kumazawa Y, Maeda K, Ito M, et al. Expression of glucocorticoid receptor and 11beta hydroxysteroid dehydrogenase in a case of pulmonary epithelioid haemangioendothelioma[J]. Mol Pathol, 2002, 55(1): 61-64.
18.	Bharadwaj R, Hejmadi R, Mistry R, et al. Pericardial effusion and raised CA-125 level--unusual manifestations of primary pulmonary epithelioid hemangioendothelioma[J]. Indian J Cancer, 2000, 36(2/4): 194-197.
19.	Yi ES, Auger WR, Friedman PJ, et al. Intravascular bronchioloalveolar tumor of the lung presenting as pulmonary thromboembolic disease and pulmonary hypertension[J]. Arch Pathol Lab Med, 1995, 119(3): 255-260.
20.	Boudousquie AC, Lawce HJ, Sherman R, et al. Complex translocation[7;22] identified in an epithelioid hemangioendothelioma[J]. Cancer Genet Cytogenet, 1996, 92(2): 116-121.
21.	Mendlick MR, Nelson M, Pickering D, et al. Translocation t(1;3)(p36.3;q25) is a nonrandom aberration in epithelioid hemangioendothelioma[J]. Am J Surg Pathol, 2001, 25(5): 684-687.
22.	曹焱, 邹霜梅, 冯林, 等. 肺上皮样血管内皮瘤遗传学分析[J]. 癌变·畸变·突变, 2009, 21(3): 185-188.

1. Weiss SW, Shak KG, Dail DH, et al. Epithelioid hemangioendothelioma and related lesions[J]. Semin Diagn Pathol, 1986, 3(4): 259-287.
2. 张秀茹, 卢一艳, 郝彦勇, 等. 脾上皮样血管内皮细胞瘤3例临床病理分析[J]. 诊断病理学杂志, 2012, 19(2): 115-117.
3. 郭洁, 杨军, 王晓冰, 等. 心包内上皮样血管内皮细胞瘤超声心动图表现1例[J]. 中国医学影像技术, 2012, 28(2): 351.
4. 丁勇, 钱忠心, 叶树铭, 等. 颅内上皮样血管内皮细胞瘤1例报告[J]. 中华神经外科疾病研究杂志, 2012, 11(1): 78-79.
5. 陈易华, 简燚, 蒋锐, 等. 骨上皮样血管内皮细胞瘤3例临床病理分析[J]. 诊断病理学杂志, 2010, 17(2): 104-106.
6. 贡其星, 范钦和, 谢军, 等. 上皮样血管瘤七例临床病理观察[J]. 中华病理学杂志, 2013, 42(9): 593-598.
7. Dail DH, Liebow AA, Gmelich JT, et al. Intravascular, bronchiolar, and alveolar tumor of the lung (IVBAT). An analysis of twenty cases of a peculiar sclerosing endothelial tumor[J]. Cancer, 1983, 51(3): 452-464.
8. Weiss SW, Ehzinger FM. Epithelioid hemangioendothelioma: a distinctive vascular tumor often mistaken for a carcinoma[J]. Cancer, 1982, 50(5): 970-981.
9. Ohori NP, Yousem SA, Sonmez-Alpan E, et al. Estrogen and progesterone receptors in lymphangioleiomyomatosis, epithelioid hemangioendothelioma, and sclerosing hemangioma of the lung[J]. Am J Clin Pathol, 1991, 96(4): 529-535.
10. Kitaichi M, Nagai S, Nishimura K, et al. Pulmonary epithelioid haemangioendothelioma in 21 patients, including three with partial spontaneous regression[J]. Eur Respir J, 1998, 12(1): 89-96.
11. 尉连成, 牛子民, 杨小洁. 肺内巨大上皮样血管内皮瘤合并非胰岛细胞性低血糖1例[J]. 中国临床医生, 2005, 33(3): 40.
12. Vandenheede M, Salem T, Sayago I, et al. Clinical case of the month. Multiple pulmonary nodules. Epithelioid hemangioendothelioma[J]. Rev Med Liege, 1998, 53(8): 454-458.
13. 王兆平, 高志斌, 柳君, 等. 纤维支气管镜标本诊断肺上皮样血管内皮瘤2例[J]. 实用医学杂志, 2009, 25(13): 2205-2206.
14. 管星庆, 宿杰·阿克苏, 许建芳, 等. 肺上皮样血管内皮瘤活体组织病理学检查的诊断意义[J]. 中国临床医学, 2013, 20(3): 309-311.
15. Ryu HS, Lee SS, Choi HS, et al. A case of pulmonary malignant epithelioid hemangioendothelioma misdiagnosed as adenocarcinoma by fine needle aspiration cytology[J]. Diagn Cytopathol, 2011, 39(11): 801-807.
16. 刘梅, 巴恩平, 赵坡, 等. 上皮样血管肉瘤的临床病理分析[J]. 中华病理学杂志, 2002, 31(5): 407-410.
17. Kumazawa Y, Maeda K, Ito M, et al. Expression of glucocorticoid receptor and 11beta hydroxysteroid dehydrogenase in a case of pulmonary epithelioid haemangioendothelioma[J]. Mol Pathol, 2002, 55(1): 61-64.
18. Bharadwaj R, Hejmadi R, Mistry R, et al. Pericardial effusion and raised CA-125 level--unusual manifestations of primary pulmonary epithelioid hemangioendothelioma[J]. Indian J Cancer, 2000, 36(2/4): 194-197.
19. Yi ES, Auger WR, Friedman PJ, et al. Intravascular bronchioloalveolar tumor of the lung presenting as pulmonary thromboembolic disease and pulmonary hypertension[J]. Arch Pathol Lab Med, 1995, 119(3): 255-260.
20. Boudousquie AC, Lawce HJ, Sherman R, et al. Complex translocation[7;22] identified in an epithelioid hemangioendothelioma[J]. Cancer Genet Cytogenet, 1996, 92(2): 116-121.
21. Mendlick MR, Nelson M, Pickering D, et al. Translocation t(1;3)(p36.3;q25) is a nonrandom aberration in epithelioid hemangioendothelioma[J]. Am J Surg Pathol, 2001, 25(5): 684-687.
22. 曹焱, 邹霜梅, 冯林, 等. 肺上皮样血管内皮瘤遗传学分析[J]. 癌变·畸变·突变, 2009, 21(3): 185-188.

West China Medical Journal

Pulmonary Epithelioid Hemangioendothelioma: A Case Report and the Literatures Review

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content