盐酸氨基葡萄糖与双醋瑞因治疗骨关节炎的临床对照研究_West China Medical Journal

Authors：

 陈洁 , 兰由玉 , 刘伟 , 赵蕾 , 李发菊 ,  何成松

泸州医学院附属医院风湿免疫科（四川泸州, 646000）;

Corresponding author：

何成松, Email: hcs980878@163.com

Keywords：

盐酸氨基葡萄糖; 双醋瑞因; 骨关节炎

DOI：

10.7507/1002-0179.20140339

Video：

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目的比较盐酸氨基葡萄糖与双醋瑞因治疗骨关节炎（OA）的疗效及安全性。方法选取2011年1月－2012年3月120例OA患者，随机分为盐酸氨基葡萄糖组（A组）、双醋瑞因组（B组）和盐酸氨基葡萄糖联合双醋瑞因组（C组），治疗12 周后观察治疗前后临床疗效和安全性。结果 3组患者治疗后较治疗前在20 m步行痛、关节触痛、采用西方安大略和麦克马斯特大学骨关节炎指数评分（WOMAC）的骨关节炎指数和健康状况均有明显改善（P＜0.05）；3组停药1 个月后上述指标与治疗结束时相比差异无统计学意义（P＞0.05）；C组患者改善率优于A、B组（P＜0.05）；3组患者不良反应发生率差异无统计学意义（P＞0.05），均未出现严重不良反应。结论盐酸氨基葡萄糖与双醋瑞因单用治疗OA疗效和安全性相当，联合应用可取得比单用更好的疗效。

Citation： 陈洁, 兰由玉, 刘伟, 赵蕾, 李发菊, 何成松. 盐酸氨基葡萄糖与双醋瑞因治疗骨关节炎的临床对照研究. West China Medical Journal, 2014, 29(6): 1111-1114. doi: 10.7507/1002-0179.20140339 Copy

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2.	Altman RD. Criteria for the classification of osteoarthritis[J]. J Rheumatol, 1991, 27(Suppl 65): 10-12.
3.	Kellgren JH, Lawrence JS. Radiological assessment of osteo-arthrosis[J]. Ann Rheum Dis, 1957, 16(4): 494-502.
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5.	Ware JE, Sherbourne CD. The MOS 36-item short-form health survey (SF-36): I. Conceptual framework and item selection[J]. Med Care, 1992, 30(6): 473-483.
6.	Williamson A, Hoggart B. Pain: a review of three commonly used pain rating scales[J]. J Clin Nurs, 2005, 14(7): 798-804.
7.	Loeser RF, Goldring SR, Scanzello CR, et al. Osteoarthritis: a disease of the joint as an organ[J]. Arthritis Rheum, 2012, 64(6): 1697-1707.
8.	Van Den Berg WB. Osteoarthritis year 2010 in review: pathomechanisms[J]. Osteoarthritis Cartilage, 2011, 19(4): 338-341.
9.	Mahendira D, Towheed TE. Systematic review of non-surgical therapies for osteoarthritis of the hand: an update[J]. Osteoarthritis Cartilage, 2009, 17(10): 1263-1268.
10.	Lee YH, Woo JH, Choi SJ, et al. Effect of glucosamine or chondroitin sulfate on the osteoarthritis progression: a Meta-analysis[J]. Rheumatol Int, 2010, 30(3): 357-363.
11.	Nakamura H, Shibakawa A, Tanaka M, et al. Effects of glucosamine hydrochloride on the production of prostaglandin E2, nitric oxide and metalloproteases by chondrocytes and synoviocytes in osteoarthritis[J]. Clin Exp Rheumatol, 2004, 22(3): 293-299.
12.	Domagala F, Martin G, Bogdanowicz P, et al. Inhibition of interleukin-1beta-induced activation of MEK/ERK pathway and DNA binding of NF-kappaB and AP-1: potential mechanism for Diacerein effects in osteoarthritis[J]. Biorheology, 2006, 43(3/4): 577-587.
13.	Martel-Pelletier J, Pelletier JP. Effects of diacerein at the molecular level in the osteoarthritis disease process[J]. Ther Adv Musculoskelet Dis, 2010, 2(2): 95-104.
14.	Bennell KL, Hunter DJ, Hinman RS. Management of osteoarthritis of the knee[J]. BMJ, 2012(345): e4934.
15.	刘源, 石桂秀. 骨关节炎的药物治疗进展[J]. 华西医学, 2012, 27(12): 1761-1763.
16.	李敏, 梁翼, 余文景, 等. 盐酸氨基葡萄糖联合双醋瑞因在伴骨髓水肿的膝骨关节炎的疗效评估[J]. 华西医学, 2012, 27(12): 1764-1767.
17.	苏江, 张晶, 吴侗, 等. 盐酸氨基葡萄糖治疗膝骨关节炎的随机对照研究[J]. 华西医学, 2012, 27(12): 1776-1779.

1. 中华医学会风湿病学分会. 骨关节炎诊断及治疗指南[J]. 中华风湿病学杂志, 2010, 14(6): 416-419.
2. Altman RD. Criteria for the classification of osteoarthritis[J]. J Rheumatol, 1991, 27(Suppl 65): 10-12.
3. Kellgren JH, Lawrence JS. Radiological assessment of osteo-arthrosis[J]. Ann Rheum Dis, 1957, 16(4): 494-502.
4. Mcconnell S, Kolopack P, Davis AM. The western Ontario and McMaster universities osteoarthritis index (WOMAC): a review of its utility and measurement properties[J]. Arthritis Rheum, 2001, 45(5): 453-461.
5. Ware JE, Sherbourne CD. The MOS 36-item short-form health survey (SF-36): I. Conceptual framework and item selection[J]. Med Care, 1992, 30(6): 473-483.
6. Williamson A, Hoggart B. Pain: a review of three commonly used pain rating scales[J]. J Clin Nurs, 2005, 14(7): 798-804.
7. Loeser RF, Goldring SR, Scanzello CR, et al. Osteoarthritis: a disease of the joint as an organ[J]. Arthritis Rheum, 2012, 64(6): 1697-1707.
8. Van Den Berg WB. Osteoarthritis year 2010 in review: pathomechanisms[J]. Osteoarthritis Cartilage, 2011, 19(4): 338-341.
9. Mahendira D, Towheed TE. Systematic review of non-surgical therapies for osteoarthritis of the hand: an update[J]. Osteoarthritis Cartilage, 2009, 17(10): 1263-1268.
10. Lee YH, Woo JH, Choi SJ, et al. Effect of glucosamine or chondroitin sulfate on the osteoarthritis progression: a Meta-analysis[J]. Rheumatol Int, 2010, 30(3): 357-363.
11. Nakamura H, Shibakawa A, Tanaka M, et al. Effects of glucosamine hydrochloride on the production of prostaglandin E2, nitric oxide and metalloproteases by chondrocytes and synoviocytes in osteoarthritis[J]. Clin Exp Rheumatol, 2004, 22(3): 293-299.
12. Domagala F, Martin G, Bogdanowicz P, et al. Inhibition of interleukin-1beta-induced activation of MEK/ERK pathway and DNA binding of NF-kappaB and AP-1: potential mechanism for Diacerein effects in osteoarthritis[J]. Biorheology, 2006, 43(3/4): 577-587.
13. Martel-Pelletier J, Pelletier JP. Effects of diacerein at the molecular level in the osteoarthritis disease process[J]. Ther Adv Musculoskelet Dis, 2010, 2(2): 95-104.
14. Bennell KL, Hunter DJ, Hinman RS. Management of osteoarthritis of the knee[J]. BMJ, 2012(345): e4934.
15. 刘源, 石桂秀. 骨关节炎的药物治疗进展[J]. 华西医学, 2012, 27(12): 1761-1763.
16. 李敏, 梁翼, 余文景, 等. 盐酸氨基葡萄糖联合双醋瑞因在伴骨髓水肿的膝骨关节炎的疗效评估[J]. 华西医学, 2012, 27(12): 1764-1767.
17. 苏江, 张晶, 吴侗, 等. 盐酸氨基葡萄糖治疗膝骨关节炎的随机对照研究[J]. 华西医学, 2012, 27(12): 1776-1779.

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West China Medical Journal

盐酸氨基葡萄糖与双醋瑞因治疗骨关节炎的临床对照研究

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