The Effects of Combined Bisoprolol and Candesartan Therapy on Left Ventricular Hypertrophy and Left Heart Function in Elderly Patients with Hypertension_West China Medical Journal

Authors：

 LIUJie

Department of Internal Medicine, the People's Hospital of Dujiangyan, Dujiangyan, Sichuan 611830, P. R. China;

Corresponding author：

Keywords：

Candesartan; Bisoprolol; Hypertension in the elderly; Left ventricular hypertrophy; Heart function

DOI：

10.7507/1002-0179.20140372

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Objective To evaluate the effects of combined bisoprolol and candesartan therapy on left ventricular hypertrophy and left heart function in in elderly patients with hypertension. Methods From July 2011 to August 2012, 117 elderly inpatients or outpatients with hypertension in our hospital were randomly divided into trial group and control group. Patients in the control group received levamlodipine besylate and bisoprolol, and patients in the trial group received candesartan and bisoprolol. Results There was no statistical difference between the two groups at baseline. Three months later, there was no obvious difference of the blood pressure levels between the two groups (P>0.05). The parameters of left ventricular hypertrophy and left heart function were improved at the end of follow-up in both the two groups, but the parameters of the trial group improved better than the control group (P<0.05). Conclusion In the elderly patients with hypertension, the combined bisoprolol and candesartan or levamlodipine besylate and bisoprolol therapy can improve left ventricular hypertrophy and left heart function, and the results are better for the combination of bisoprolol and candesartan.

Citation： LIUJie. The Effects of Combined Bisoprolol and Candesartan Therapy on Left Ventricular Hypertrophy and Left Heart Function in Elderly Patients with Hypertension. West China Medical Journal, 2014, 29(7): 1205-1207. doi: 10.7507/1002-0179.20140372 Copy

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11.	林泽鹏, 孙新华, 彭晓玲, 等. 比索洛尔治疗老年高血压伴心力衰竭的疗效和脉压相关[J]. 中华高血压杂志, 2008, 16(12):1087-1090.
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13.	信思远, 刘晓琴. 苯磺酸左旋氨氯地平和缬纱坦联合治疗原发性高血压的临床观察[J]. 中外医学研究, 2013, 11(10):129.
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1. 马燕妮, 朱启明, 徐李. 比索洛尔对高血压左室肥厚与血压昼夜节律异常的影响[J]. 临床心血管病杂志, 2002, 18(6):266-268.
2. 佘强, 高大中, 殷跃辉, 等. 高血压左室肥厚患者组织纤维化的血清指标观察[J]. 中华心血管病杂志, 1998, 26(3):49-51.
3. 李超, 蒋勇, 韦玉华. 厄贝沙坦联合氢氯噻嗪治疗老年原发性高血压病的临床观察[J]. 柳州医学, 2011, 24(3):135-137.
4. 赵秀丽, 陈捷, 崔艳丽, 等. 中国14省市高血压现状的流行病学研究[J]. 中华医学杂志, 2006, 86(16):1148-1152.
5. 周晓芳, 蔡力, 周鲁, 等. 氯沙坦对高血压患者生存质量影响的研究[J]. 西部医学, 2003, 1(1):23-25.
6. 许慧健, 米红. 坎地沙坦联合卡维地洛治疗高血压并逆转左室肥厚改善心功能的疗效观察[J]. 临床心血管病杂志, 2009, 25(8):615-617.
7. 黄琼艳. 坎地沙坦治疗慢性充血性心力衰竭的临床疗效观察[J]. 现代医药卫生, 2011, 27(9):1336-1337.
8. 何平. 厄贝沙坦联用比索洛尔对42例慢性充血性心力衰竭左室重构和心功能的影响[J]. 重庆医学, 2010, 39(1):93-95.
9. 耿红彬, 刘芳. 缬沙坦对原发性高血压患者左心室肥厚的影响[J]. 中国煤炭工业医学杂志, 2011, 14(4):571-572.
10. 崔维. 比索洛尔对扩张型心肌病心力衰竭的疗效观察[J]. 中国综合临床, 2005, 21(6):488-489.
11. 林泽鹏, 孙新华, 彭晓玲, 等. 比索洛尔治疗老年高血压伴心力衰竭的疗效和脉压相关[J]. 中华高血压杂志, 2008, 16(12):1087-1090.
12. 俞文萍, 罗明, 邓兵, 等. 比索洛尔治疗心力衰竭疗效和β₁受体多态性的相关性研究[J]. 中华心血管病杂志, 2006, 34(9):776-780.
13. 信思远, 刘晓琴. 苯磺酸左旋氨氯地平和缬纱坦联合治疗原发性高血压的临床观察[J]. 中外医学研究, 2013, 11(10):129.
14. 张志民, 陈丽. 坎地沙坦联合美托洛尔治疗慢性心力衰竭临床观察[J]. 中西医结合心脑血管病杂志, 2011, 9(9):1114-1115.

West China Medical Journal

The Effects of Combined Bisoprolol and Candesartan Therapy on Left Ventricular Hypertrophy and Left Heart Function in Elderly Patients with Hypertension

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