Changes of Erythrocyte Sedimentation Rates, C-reactive Protein, and Serum Amyloid A Proteins after Different Types of Hip Replacement and Their Clinical Significances_West China Medical Journal

Authors：

 HUANGRui-liang ¹ ,  LINWei-wen ¹ , RUANYi ² , XIONGHao ¹ , LIUWei ¹ , XIAXiong-chao ¹ , LINGHua-jun ¹

1. Department of Orthopedics;Gaoming Hospital Affiliated to Guangdong Medical College, Foshan, Guangdong 528500, P. R. China;
2. Department of Orthopedics, Genghe Branch of Gaoming Hospital;Gaoming Hospital Affiliated to Guangdong Medical College, Foshan, Guangdong 528500, P. R. China;

Corresponding author：

LINWei-wen, Email: sixlin666@163.com

Keywords：

Hip replacement surgery; Erythrocyte sedimentation rate; C-reactive protein; Serum amyloid A protein

DOI：

10.7507/1002-0179.20140380

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Objective To observe the changing patterns of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and serum amyloid A protein (SAA) levels before and after hip replacement surgery, and explore their clinical significances. Methods Ninety-seven consecutive patients enrolled in clinical pathway in our hospital for hip replacement from April 2011 to May 2013 were included in the present study. ESR, CRP and SAA levels were investigated preoperatively and post-operatively at day 1, 3, 5, 7, 14, Month 1 and 3. All the cases were followed up, among which there were 14 cases of total hip replacement, 56 cases of cementless hemianthroplasty, and 27 cases of biotype hemianthroplasty. Results All three of ESR, CRP and SAA levels were elevated post-operatively. Levels of CRP and SAA peaked at day 3 after surgery, and then subsided gradually to pre-operative levels after 1 month. ESR level peaked at day 7 postoperatively, and then subsided gradually to pre-operative levels after 3 months. There was a significant correlation between levels of CRP and levels of SAA. Conclusion Compared with ESR and SAA, CRP appears to be a faster and more sensitive parameter. Cementless hemianthroplasty is associated with changes of SAA levels but not with CRP levels. Close monitoring of evolutionary changes in ESR, SAA and CRP levels may help to diagnose and treat early infection after hip replacement surgery.

Citation： HUANGRui-liang, LINWei-wen, RUANYi, XIONGHao, LIUWei, XIAXiong-chao, LINGHua-jun. Changes of Erythrocyte Sedimentation Rates, C-reactive Protein, and Serum Amyloid A Proteins after Different Types of Hip Replacement and Their Clinical Significances. West China Medical Journal, 2014, 29(7): 1234-1237. doi: 10.7507/1002-0179.20140380 Copy

1.	张炅, 冯建民, 王毅, 等. 三相同位素骨扫描诊断髋关节置换后感染的临床意义[J]. 中国组织工程研究与临床康复, 2010, 25(4):3041-3045.
2.	MeIler J, Sahlmann CO, Scheel AK. ¹⁸F-FDG PET and PET/CT in fever of unknown origin[J]. J Nucl Med, 2007, 48(1):35-45.
3.	付娜, 巩路. ¹⁸F-FDG PET/CT对不明原因发热的诊断价值分析[J]. 临床荟萃, 2013, 28(5):519-521.
4.	耿红莲, 仲人前. 血清淀粉样物质A研究进展[J]. 现代检验医学杂志, 2010, 25(4):10-12.
5.	储诚兵, 王继芳, 王岩, 等. 生化检查对人工髋关节感染的诊断价值[J]. 中华医院感染学杂志, 2006, 16(4):403-405.
6.	陈展宇, 梁晓春, 万智慧. 人工髋关节置换术前后CRP与ESR水平变化研究[J]. 中国医疗前沿, 2010, 5(6):11-12.
7.	陈家富, 孔荣. CRP ESR和WBC计数在髋关节置换手术前后的变化及临床意义[J]. 安徽医学, 2012, 33(2):162-164.
8.	宋炎成, 张慧慧, 卢华定, 等. CRP、ESR在关节置换手术前后变化及其临床意义[J]. 中国矫形外科杂志, 2008, 16(11):823-825.
9.	Shen H, Zhang N, Zhang X, et al. C-reactive protein levels after 4 types of arthroplasty[J]. Acta Orthop, 2009, 80(3):330-333.
10.	White J, Kelly M, Dunsmuir R. C-reactive protein level after total hip and total knee replacement[J]. J Bone Joint Surg Br, 1998, 80(5):909-911.
11.	储怡星, 张锦锋, 范基农, 等. C反应蛋白水平对判断炎症和创伤转归的价值[J]. 上海医学检验杂志, 2000, 15(3):155-156.
12.	林永恩, 胡静云, 陈栋, 等. 全程CRP、WBC、ANC联合检测在血液细菌感染中的应用[J]. 海南医学, 2011, 22(9):104-105.
13.	Lannergård A, Larsson A, Kragsbjerg P, et al. Correlations between serum amyloid A protein and C-reactive protein in infectious diseases[J]. Scand J Clin Lab Invest, 2003, 63(4):267-272.
14.	Hartmann A, Eide TC, Fauchald P, et al. Serum amyloid A protein is a clinically useful indicator of acute renal allograft rejection[J]. Nephrol Dial Transplant, 1997, 12(1):161-166.
15.	Urieli-Shoval S, Linke RP, Matzner Y. Expression and function of serum amyloid A, a major acute-phase protein, in normal and disease states[J]. Curr Opin Hematol, 2000, 7(1):64-69.
16.	盛秀芝, 蔡溢, 周杰. 血清淀粉样蛋白A在肾移植术后排斥反应诊断中的价值[J]. 中国实验诊断学, 2010, 14(2):242.
17.	陈玉玲, 孙莉, 郑春京. 术后镇痛对C-反应蛋白和血清淀粉样A蛋白的影响[J]. 中国临床医生, 2006, 34(3):39-40.

1. 张炅, 冯建民, 王毅, 等. 三相同位素骨扫描诊断髋关节置换后感染的临床意义[J]. 中国组织工程研究与临床康复, 2010, 25(4):3041-3045.
2. MeIler J, Sahlmann CO, Scheel AK. ¹⁸F-FDG PET and PET/CT in fever of unknown origin[J]. J Nucl Med, 2007, 48(1):35-45.
3. 付娜, 巩路. ¹⁸F-FDG PET/CT对不明原因发热的诊断价值分析[J]. 临床荟萃, 2013, 28(5):519-521.
4. 耿红莲, 仲人前. 血清淀粉样物质A研究进展[J]. 现代检验医学杂志, 2010, 25(4):10-12.
5. 储诚兵, 王继芳, 王岩, 等. 生化检查对人工髋关节感染的诊断价值[J]. 中华医院感染学杂志, 2006, 16(4):403-405.
6. 陈展宇, 梁晓春, 万智慧. 人工髋关节置换术前后CRP与ESR水平变化研究[J]. 中国医疗前沿, 2010, 5(6):11-12.
7. 陈家富, 孔荣. CRP ESR和WBC计数在髋关节置换手术前后的变化及临床意义[J]. 安徽医学, 2012, 33(2):162-164.
8. 宋炎成, 张慧慧, 卢华定, 等. CRP、ESR在关节置换手术前后变化及其临床意义[J]. 中国矫形外科杂志, 2008, 16(11):823-825.
9. Shen H, Zhang N, Zhang X, et al. C-reactive protein levels after 4 types of arthroplasty[J]. Acta Orthop, 2009, 80(3):330-333.
10. White J, Kelly M, Dunsmuir R. C-reactive protein level after total hip and total knee replacement[J]. J Bone Joint Surg Br, 1998, 80(5):909-911.
11. 储怡星, 张锦锋, 范基农, 等. C反应蛋白水平对判断炎症和创伤转归的价值[J]. 上海医学检验杂志, 2000, 15(3):155-156.
12. 林永恩, 胡静云, 陈栋, 等. 全程CRP、WBC、ANC联合检测在血液细菌感染中的应用[J]. 海南医学, 2011, 22(9):104-105.
13. Lannergård A, Larsson A, Kragsbjerg P, et al. Correlations between serum amyloid A protein and C-reactive protein in infectious diseases[J]. Scand J Clin Lab Invest, 2003, 63(4):267-272.
14. Hartmann A, Eide TC, Fauchald P, et al. Serum amyloid A protein is a clinically useful indicator of acute renal allograft rejection[J]. Nephrol Dial Transplant, 1997, 12(1):161-166.
15. Urieli-Shoval S, Linke RP, Matzner Y. Expression and function of serum amyloid A, a major acute-phase protein, in normal and disease states[J]. Curr Opin Hematol, 2000, 7(1):64-69.
16. 盛秀芝, 蔡溢, 周杰. 血清淀粉样蛋白A在肾移植术后排斥反应诊断中的价值[J]. 中国实验诊断学, 2010, 14(2):242.
17. 陈玉玲, 孙莉, 郑春京. 术后镇痛对C-反应蛋白和血清淀粉样A蛋白的影响[J]. 中国临床医生, 2006, 34(3):39-40.

West China Medical Journal

Changes of Erythrocyte Sedimentation Rates, C-reactive Protein, and Serum Amyloid A Proteins after Different Types of Hip Replacement and Their Clinical Significances

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