Objective To explore the influence of treatment against syphilis on pregnancy outcome and neonatal prognosis. Methods The data of 5224 cases of pregnant women from January to December 2013 were analyzed. All the pregnant women were screened by toluidine red unheated serum test (TRUST) method. Then, T.pallidum passive partideag glutining assay (TPPA) was used to confirm those positive cases from TRUST. At last, 128 cases of syphilis in those pregnant women were confirmed. According to whether the pregnant women accepted antenatal examination and treatment, they were divided into treatment group and non-treatment group. The pregnancy outcome and neonatal prognosis of these two groups of women were then compared and analyzed. Results The pregnancy outcome of these two groups had comparatively big difference, but without significant difference (χ²=3.34, P>0.05). The neonatal prognosis of the two groups was significantly different (χ²=9.14, P<0.05). Moreover, TPPA showed positive in all newborn infants, and TURST showed 85 positive cases. Conclusion Early finding and treatment of pregnant women with syphilis by screening before pregnancy or during the early period of pregnancy can reduce abortion, stillbirth, fetal abnormalities, and the incidence of neonatal congenital syphilis.

Citation： LINKeng. Influence of Anti-syphilis Treatment on Pregnancy Outcome and Neonatal Prognosis. West China Medical Journal, 2014, 29(7): 1267-1270. doi: 10.7507/1002-0179.20140388 Copy