Incidence of Congenital Heart Disease in Neonates and Its Risk Factors in Mianyang after“ 5·12” Earthquake_West China Medical Journal

Authors：

 GUANLi-rong ¹ ,  HUYu ¹ , YUJing ¹ , LIZhuo-ya ² , WUXiao-ji ³ , LIJian-jun ⁴ , CHENJia ¹ , ZHENGXiao-lan ¹ , WUXiao-fang ¹ , WANGXiao-shuang ¹

1. Department of Pediatrics, Mianyang Central Hospital, Mianyang, Sichuan 621000, P. R. China;
2. Department of Pediatrics, Mianyang People's Hospital, Mianyang, Sichuan 621000, P. R. China;
3. Department of Pediatrics, Mianyang Fulin Hospital, Mianyang, Sichuan 621000, P. R. China;
4. Department of Pediatrics, the Third People's Hospital of Mianyang, Mianyang, Sichuan 621000, P. R. China;

Corresponding author：

HUYu, Email: huyu02001a@163.com

Keywords：

Earthquake; Congenital heart disease; Incidence; Risk factors

DOI：

10.7507/1002-0179.20140389

Video：

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Objective To comprehend the incidence of and to search for the possible risk factors for neonatal congenital heart disease (CHD) in Mianyang after "5·12" Earthquake. Methods CHD screening was performed on 5536 neonates born between December 2011 and December 2012 by cardiac auscultation, respiration evaluation, blood oxygen saturation determination and color doppler flow imaging. Case control study was applied to study the diagnosed cases of CHD. Results Sixty-five cases of CHD were found during the screening, and the incidence was 11.74‰. The most common CHD was ventricular septal defect, followed by atrial septum defect and patent ductusarteriosus. Possible risk factors were listed in order of their risks were as follows:family history of CHD, infection history in the early period of pregnancy, drug and alcohol history during pregnancy, and aged pregnancy and smoking history of the parents. However, earthquake experience history of parents was not correlated with CHD incidence. Conclusion Earthquake experience of parents is not correlated with CHD incidence. Enforcing health education for women before gestation, and avoiding or decreasing risk factors exposure can reduce the risk of CHD. CHD screening for neonates can detect CHD as early as possible, which is helpful for intervention during the follow-up, reduction of fatality, and improvement of neonates' quality of life.

Citation： GUANLi-rong, HUYu, YUJing, LIZhuo-ya, WUXiao-ji, LIJian-jun, CHENJia, ZHENGXiao-lan, WUXiao-fang, WANGXiao-shuang. Incidence of Congenital Heart Disease in Neonates and Its Risk Factors in Mianyang after“ 5·12” Earthquake. West China Medical Journal, 2014, 29(7): 1271-1274. doi: 10.7507/1002-0179.20140389 Copy

1.	胡煜, 刘斌. 结缔组织生长因子对血管平滑肌细胞增殖、迁移和细胞外基质沉积影响的研究进展[J]. 国际儿科学杂志, 2010, 37(2):152-154.
2.	高燕、黄国英. 先天性心脏病病因及流行病学研究进展[J]. 中国循证儿科杂志,2008, 3(3):213-222.
3.	高秉仁、岳风珍. 甘肃等六地市先天性心脏病流行病学调查研究[J]. 中国循环杂志,2000, 15(5):298-299.
4.	王慧珊,袁雪,奚一生. 19432名婴幼儿先天性心脏病患病率的调查研究[J]. 中国儿童保健杂志, 2001, 9(4):236-238.
5.	闰宗荣,吴明昌,郑秀华,等. 随访后校正的新生儿先天性心脏病发病率研究[J]. 中华围产医学杂志, 2009, 12(1):32-35.
6.	崔爱平, 刘伯宁. 胎儿先天性心脏病的孕期筛查[J]. 中国实用妇科与产科杂志, 2002, 18(9):520-522.
7.	Simpson LL. Indications for fetal eehocardiography from a tertiarycare obstetricsonography practice[J]. J Clin Ultrasuond, 2004, 32(3):123-128.
8.	任秀珍, 张晓新, 姜红红,等. CDFI在新生儿先天性心脏病筛查中的应用[J]. 中国循证心血管医学杂志, 2011, 8(3):220-221.
9.	Wurst KE, Ephross SA, Loehr J, et al. Evaluation of the Gengeal Practice Reseaech Datdbase congenital heart defects prevalence:comparison to United Kingdom national systems[J]. Brith Defects Res A Clin Mol Teratol, 2007, 79(4):309-316.
10.	DeGroff CG, BhatikarS, Hertzberg J, et al. Artificial neural network-based method of screening heart murmurs in children[J]. Circulation, 2001, 103(22):2711-2716.
11.	D'Alto M, Mahadevan VS. Pulmonary arterial hypertension associated with congenital heart disease[J]. Eur Respir Rev, 2012, 21(126):328-337.
12.	Apostolopoulou SC, Manginas A, Cokkinos DV, et al. Effect of the oral endothelin antagonist bosentan on the clinical, exercise, and haemodynamic status of patients with pulmonary arterial hypertension related to congenital heart disease[J]. Heart, 2005, 91(11):1447-1452.
13.	Mahle WT, Martin GR, Beekman RH, et al. Endorsement of health and human services recommendation for pulse oximetry screening for critical congenital heart disease[J]. Pediatrics, 2012, 129(1):190-192.
14.	Mahle WT, Newburger JW, Matherne GP, et al. Role of pulse oximetry in examining newborns for congenital heart disease:a scientific statement from the American Heart Association and American Academy of Pediatrics[J]. Circulation, 2009, 120(5):447-458.
15.	Okubo A, Miyoshi O, Baba K, et al. A novel GATA4 mutation completely segregated with atrial septal defect in a large Japanese family[J]. J Med Genet, 2004, 41(7):e97.
16.	王连生, 黄峻, 曹克将, 等. 家族性房间隔缺损调查及遗传特点分析[J]. 临床心血管病杂志, 2002, 18(12):654-655.
17.	Duppenthaler A, Ammann RA, Gorgievski-Hrisoho M, et al. Low incidence of respiratory syncytial virus hospitalisations in haemodynamically significant congenital heart disease[J]. Arch Dis Child, 2004, 89(10):961-965.
18.	Goyal P, Kiran U, Chauhan S, et al. Efficacy of nitroglycerin inhalation in reducing pulmonary arterial hypertension in children with congenital heart disease[J]. Br J Anaesth, 2006, 97(2):208-214.
19.	Baardman ME, Kerstjens-Frederikse WS, Corpeleijn E, et al. Combined adverse effects of maternal smoking and high body mass index on heart development in offspring:evidence for interaction?[J]. Heart, 2012, 98(6):474-479.
20.	Khairy P, Ouyang DW, Fernandes SM, et al. Pregnancy outcomes in women with congenital heart disease[J]. Circulation, 2006, 113(4):517-524.
21.	Marelli AJ, Mackie AS, Ionescu-Ittu R, et al. Congenital heart disease in the general population:changing prevalence and age distribution[J]. Circulation, 2007, 115(2):163-172.
22.	Olsen M, Videbæk J, Johnsen SP, et al. The Danish register of congenital heart disease[J]. Scand J Public Health, 2011, 39(7):50-53.
23.	刘世炜, 季加芬. 孕早期精神刺激与先天性心脏病关系探索[J]. 现代预防医学, 2005, 32(3):260-261.
24.	陈芳, 赵铀, 胡宗琼, 等. 5·12汶川地震期间绵阳市妇女生殖道感染率的变化[J]. 中国计划生育和妇产科, 2010, 1(2):47-49.
25.	李小红, 李尚为, 秦朗, 等. 地震丧子对再生育妇女月经和心理的影响[J]. 实用妇产科杂志, 2011, 1(27):69-72.
26.	杨帆, 白祥军, 刘开俊, 等. 60例汶川地震经历者创伤后应激障碍分析[J]. 重庆医学, 2009, 23(38):2987-2990.

1. 胡煜, 刘斌. 结缔组织生长因子对血管平滑肌细胞增殖、迁移和细胞外基质沉积影响的研究进展[J]. 国际儿科学杂志, 2010, 37(2):152-154.
2. 高燕、黄国英. 先天性心脏病病因及流行病学研究进展[J]. 中国循证儿科杂志,2008, 3(3):213-222.
3. 高秉仁、岳风珍. 甘肃等六地市先天性心脏病流行病学调查研究[J]. 中国循环杂志,2000, 15(5):298-299.
4. 王慧珊,袁雪,奚一生. 19432名婴幼儿先天性心脏病患病率的调查研究[J]. 中国儿童保健杂志, 2001, 9(4):236-238.
5. 闰宗荣,吴明昌,郑秀华,等. 随访后校正的新生儿先天性心脏病发病率研究[J]. 中华围产医学杂志, 2009, 12(1):32-35.
6. 崔爱平, 刘伯宁. 胎儿先天性心脏病的孕期筛查[J]. 中国实用妇科与产科杂志, 2002, 18(9):520-522.
7. Simpson LL. Indications for fetal eehocardiography from a tertiarycare obstetricsonography practice[J]. J Clin Ultrasuond, 2004, 32(3):123-128.
8. 任秀珍, 张晓新, 姜红红,等. CDFI在新生儿先天性心脏病筛查中的应用[J]. 中国循证心血管医学杂志, 2011, 8(3):220-221.
9. Wurst KE, Ephross SA, Loehr J, et al. Evaluation of the Gengeal Practice Reseaech Datdbase congenital heart defects prevalence:comparison to United Kingdom national systems[J]. Brith Defects Res A Clin Mol Teratol, 2007, 79(4):309-316.
10. DeGroff CG, BhatikarS, Hertzberg J, et al. Artificial neural network-based method of screening heart murmurs in children[J]. Circulation, 2001, 103(22):2711-2716.
11. D'Alto M, Mahadevan VS. Pulmonary arterial hypertension associated with congenital heart disease[J]. Eur Respir Rev, 2012, 21(126):328-337.
12. Apostolopoulou SC, Manginas A, Cokkinos DV, et al. Effect of the oral endothelin antagonist bosentan on the clinical, exercise, and haemodynamic status of patients with pulmonary arterial hypertension related to congenital heart disease[J]. Heart, 2005, 91(11):1447-1452.
13. Mahle WT, Martin GR, Beekman RH, et al. Endorsement of health and human services recommendation for pulse oximetry screening for critical congenital heart disease[J]. Pediatrics, 2012, 129(1):190-192.
14. Mahle WT, Newburger JW, Matherne GP, et al. Role of pulse oximetry in examining newborns for congenital heart disease:a scientific statement from the American Heart Association and American Academy of Pediatrics[J]. Circulation, 2009, 120(5):447-458.
15. Okubo A, Miyoshi O, Baba K, et al. A novel GATA4 mutation completely segregated with atrial septal defect in a large Japanese family[J]. J Med Genet, 2004, 41(7):e97.
16. 王连生, 黄峻, 曹克将, 等. 家族性房间隔缺损调查及遗传特点分析[J]. 临床心血管病杂志, 2002, 18(12):654-655.
17. Duppenthaler A, Ammann RA, Gorgievski-Hrisoho M, et al. Low incidence of respiratory syncytial virus hospitalisations in haemodynamically significant congenital heart disease[J]. Arch Dis Child, 2004, 89(10):961-965.
18. Goyal P, Kiran U, Chauhan S, et al. Efficacy of nitroglycerin inhalation in reducing pulmonary arterial hypertension in children with congenital heart disease[J]. Br J Anaesth, 2006, 97(2):208-214.
19. Baardman ME, Kerstjens-Frederikse WS, Corpeleijn E, et al. Combined adverse effects of maternal smoking and high body mass index on heart development in offspring:evidence for interaction?[J]. Heart, 2012, 98(6):474-479.
20. Khairy P, Ouyang DW, Fernandes SM, et al. Pregnancy outcomes in women with congenital heart disease[J]. Circulation, 2006, 113(4):517-524.
21. Marelli AJ, Mackie AS, Ionescu-Ittu R, et al. Congenital heart disease in the general population:changing prevalence and age distribution[J]. Circulation, 2007, 115(2):163-172.
22. Olsen M, Videbæk J, Johnsen SP, et al. The Danish register of congenital heart disease[J]. Scand J Public Health, 2011, 39(7):50-53.
23. 刘世炜, 季加芬. 孕早期精神刺激与先天性心脏病关系探索[J]. 现代预防医学, 2005, 32(3):260-261.
24. 陈芳, 赵铀, 胡宗琼, 等. 5·12汶川地震期间绵阳市妇女生殖道感染率的变化[J]. 中国计划生育和妇产科, 2010, 1(2):47-49.
25. 李小红, 李尚为, 秦朗, 等. 地震丧子对再生育妇女月经和心理的影响[J]. 实用妇产科杂志, 2011, 1(27):69-72.
26. 杨帆, 白祥军, 刘开俊, 等. 60例汶川地震经历者创伤后应激障碍分析[J]. 重庆医学, 2009, 23(38):2987-2990.

West China Medical Journal

Incidence of Congenital Heart Disease in Neonates and Its Risk Factors in Mianyang after“ 5·12” Earthquake

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