Clinical Observation of Sitagliptin plus Glargine Insulin versus Repaglinide plus Glargine Insulin in the Treatment of Type-2 Diabetes_West China Medical Journal

Authors：

 HUAYan , WUJin-wen , JIANGCheng-xia , LIMei , LIUXin

Department of Endocrinology, the Second People's Hospital of Yibin City, Yibin, Sichuan 644000, P. R. China;

Corresponding author：

Keywords：

Sitagliptin; Repaglinide; Glargine insulin; Type-2 diabetes mellitus

DOI：

10.7507/1002-0179.20140440

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Objective To compare the efficacy of sitagliptin plus glargine insulin versus repaglinide plus glargine insulin in the treatment of Type-2 diabetes mellitus (T₂DM). Methods A total of 140 T₂DM patients who were inadequately controlled by oral anti-diabetic agents from January 2011 to December 2012 were divided into sitagliptin plus glargine insulin group (observation group) or repaglinide plus glargine insulin group (control group). The duration of treatment was 12 weeks. Fasting blood glucose (FBG), 2h plasma glucose (2hPG), glycated haemoglobin (HbA1c), body max index (BMI) and dose of insulin as well as hypoglycemia events were recorded and analyzed. Results After treatment, FBG, 2hPG, and HbA1c were significantly decreased in both groups (P<0.05). HbA1c targeting rate was 88.3% in the observation group and 87.8% in the control group. Compared with the control group, the observation group used 12.1% less dosage of insulin, and had decreased BMI and low incidence of hypoglycemia. Conclusion Sitagliptin plus glargine insulin can effectively control blood glucose and body weight with low incidence of hypoglycemia and much less insulin dosage under the same HbA1c targeting rate. Sitagliptin plus glargine insulin is a good combination therapy for the treatment of T₂DM.

Citation： HUAYan, WUJin-wen, JIANGCheng-xia, LIMei, LIUXin. Clinical Observation of Sitagliptin plus Glargine Insulin versus Repaglinide plus Glargine Insulin in the Treatment of Type-2 Diabetes. West China Medical Journal, 2014, 29(8): 1429-1431. doi: 10.7507/1002-0179.20140440 Copy

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4.	周映红, 黄文龙, 张惠斌, 等. GLP-1受体激动剂及DPP-4抑制剂的研究进展[J]. 中国药科大学学报, 2008, 39(5):385-391.
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6.	Basu AK, Bandyopadhyay D, Bandyopahyay R. Insulin in type 2 diabetes:promises to keep[J]. J Indian Med Assoc, 2004, 102(1):438-442.
7.	Dailey G. New strategies for basal insulin treatment in type 2 diabetes mellitus[J]. Clin Ther, 2004, 263(11):889-901.
8.	Gerich J, Becker RH, Zhu R, et al. Fluctuation of serum basal insulin levels following single and multiple dosing of insulin glarging[J]. Diabetes Technol Ther, 2006, 8(2):237-243.
9.	潘宇平, 郑启东, 陈婉, 等. 西格列汀联合二甲双胍治疗2型糖尿病临床观察[J]. 中国乡村医学, 2013, 6(1):21-22.
10.	Nonaka K, kakikawa T, Sato A, et al. Efficacy and safety of sitaglipt in monotherapy in Japanese patients with type 2 diabetes[J]. Diabetes Res Clin Pract, 2008, 79(4):291-298.
11.	Fonseca V, Schweizer A, Albrecht D, et al. Addition of vildagliptin to insulin improves glycaemic control in type 2 diabetes[J]. Diabetologia, 2007, 50(3):1148-1155.
12.	陈卓, 张庆文. DPP-4抑制剂研究进展[J]. 上海医药, 2013, 7(1):50-54.
13.	曾丽丽, 丁英杰, 宋宏锐, 等. 二肽基肽酶-Ⅳ抑制剂的最新研究进展[J].中国药物化学杂志, 2009, 19(1):65-70.
14.	Herman G, Hanefeld M, Wu M, et al. Effect of MK-0431, a dipeptidyl peptidase Ⅳ(DPPⅣ) inhibitor on glycaemic control after 12 weeks in patients with type 2 diabetes[J]. Diabetes, 2005, 54(Suppl 1):A134, 541.
15.	Hansen AM, Hansen JB, Car RD, et al. Kir62 dependent high-affinity repaglinide binding to betacell K (ATP) channels[J]. Br J Pharmacol, 2005, 144(4):551-557.
16.	廖二元, 莫朝晖. 内分泌学[M]. 北京:人民卫生出版社, 2007:1395.

1. Yang WY, Lu JM, Weng JP, et al. Prevalence of diabetes among men and woman in China[J]. N Engl J Med, 2012, 362(2):1090-1101.
2. 马学毅, 杨明功, 邓大同, 等. 现代糖尿病诊断治疗学[M]. 北京:人民军医出版社, 2007:68-197.
3. 马艳芬, 刘薇, 袁明霞, 等. 胰岛素与口服降糖药对新诊断2型糖尿病患者β细胞功能的影响[J]. 中国糖尿病杂志, 2009, 17(5):349.
4. 周映红, 黄文龙, 张惠斌, 等. GLP-1受体激动剂及DPP-4抑制剂的研究进展[J]. 中国药科大学学报, 2008, 39(5):385-391.
5. Bergman AJ, Cote J, Mase A, et al. Sitagliptin (MK-0431), a selective dipeptidyl-peptidase (DPP-4) inhibitor dose not affect the pharmacokinetics of simvastatin in humans[J]. Clin Pharmaol Ther, 2005, 79(2):48.
6. Basu AK, Bandyopadhyay D, Bandyopahyay R. Insulin in type 2 diabetes:promises to keep[J]. J Indian Med Assoc, 2004, 102(1):438-442.
7. Dailey G. New strategies for basal insulin treatment in type 2 diabetes mellitus[J]. Clin Ther, 2004, 263(11):889-901.
8. Gerich J, Becker RH, Zhu R, et al. Fluctuation of serum basal insulin levels following single and multiple dosing of insulin glarging[J]. Diabetes Technol Ther, 2006, 8(2):237-243.
9. 潘宇平, 郑启东, 陈婉, 等. 西格列汀联合二甲双胍治疗2型糖尿病临床观察[J]. 中国乡村医学, 2013, 6(1):21-22.
10. Nonaka K, kakikawa T, Sato A, et al. Efficacy and safety of sitaglipt in monotherapy in Japanese patients with type 2 diabetes[J]. Diabetes Res Clin Pract, 2008, 79(4):291-298.
11. Fonseca V, Schweizer A, Albrecht D, et al. Addition of vildagliptin to insulin improves glycaemic control in type 2 diabetes[J]. Diabetologia, 2007, 50(3):1148-1155.
12. 陈卓, 张庆文. DPP-4抑制剂研究进展[J]. 上海医药, 2013, 7(1):50-54.
13. 曾丽丽, 丁英杰, 宋宏锐, 等. 二肽基肽酶-Ⅳ抑制剂的最新研究进展[J].中国药物化学杂志, 2009, 19(1):65-70.
14. Herman G, Hanefeld M, Wu M, et al. Effect of MK-0431, a dipeptidyl peptidase Ⅳ(DPPⅣ) inhibitor on glycaemic control after 12 weeks in patients with type 2 diabetes[J]. Diabetes, 2005, 54(Suppl 1):A134, 541.
15. Hansen AM, Hansen JB, Car RD, et al. Kir62 dependent high-affinity repaglinide binding to betacell K (ATP) channels[J]. Br J Pharmacol, 2005, 144(4):551-557.
16. 廖二元, 莫朝晖. 内分泌学[M]. 北京:人民卫生出版社, 2007:1395.

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West China Medical Journal

Clinical Observation of Sitagliptin plus Glargine Insulin versus Repaglinide plus Glargine Insulin in the Treatment of Type-2 Diabetes

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