Objective Monitoring of Neonatal Nosocomial Infection and Analysis of Antibiotic Resistance_West China Medical Journal

Authors：

 LIRong ^1,2 , WANGLu ² , ZHANGHai-jin ² ,  YANYong-ping ¹

1. Teaching and Research Section of Epidemiology, the Fourth Military Medical University, Xi'an, Shaanxi 710032, P. R. China;
2. Department of Hospital Infection Control, The Children's Hospital of Xi'an, Xi'an, Shaanxi 710003, P. R. China;

Corresponding author：

YANYong-ping, Email: yanyping@fmmu.edu.cn

Keywords：

Neonates; Nosocomial infections; Risk factors; Resistance

DOI：

10.7507/1002-0179.20140457

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

ObjectiveTo explore the risk factors for neonatal nosocomial infection and the pathogen resistance, in order to provide the basis for hospital infection control. MethodsSurveillance of hospital infection in newborns hospitalized for more than 48 hours were carried out from January to December 2012, and the risk factors for hospital infection were analyzed. ResultsThere were 54 newborn cases with neonatal nosocomial infection, and the infection rate of newborns was 1.25%. The major infection sites were respiratory tract (66.7%), gastrointestinal tract (18.5%), skin and soft tissues (9.2%). Birth weight (χ²_Trend=126.88, P<0.001), hospitalization days (χ²_Trend=106.89, P<0.001), invasive operation (χ²=5.338, P=0.021) were the major risk factors. A total of 54 strains of pathogenic bacteria were isolated from 54 newborn cases with neonatal nosocomial infection. Twenty-three strains of gram-positive bacteria accounted for 42.6%, which were generally resistant to penicillin and large ring lactone class antibiotic drugs. Thirty-one strains of gram-negative bacteria accounted for 57.4%, which were mainly resistant to the three generations of cephalosporins. ConclusionThe hospital infection rate of newborns is low. Birth weight, hospitalization days and invasive operation are the major risk factors for neonatal nosocomial infection.

Citation： LIRong, WANGLu, ZHANGHai-jin, YANYong-ping. Objective Monitoring of Neonatal Nosocomial Infection and Analysis of Antibiotic Resistance. West China Medical Journal, 2014, 29(8): 1491-1493. doi: 10.7507/1002-0179.20140457 Copy

1.	中华人民共和国卫生部. 医院感染诊断标准(试行)[J]. 中华医学杂志, 2001, 81(5):314-320.
2.	曾成惠, 何俊, 李雪梅, 等. 新生儿患者多重耐药菌筛查结果与分析[J]. 华西医学, 2013, 28(8):1149-1151.
3.	徐莲香, 徐康立, 邓军霞. 新生儿医院感染因素分析及控制措施[J]. 中华医院感染学杂志, 2010, 20(7):937-938.
4.	袁晓明, 王杏茶, 赵立双. 母婴同室新生儿医院感染的相关分析与研究[J]. 护士进修杂志, 2011, 26(21):2004-2006.
5.	徐珍, 唐素琴, 曹先伟, 等. 新生儿病房医院感染目标性监测结果分析[J]. 中华医院感染学杂志, 2010, 20(21):3324-3326.
6.	龚秀萍. 新生儿医院感染监测与护理对策[J]. 中国医药导报, 2010, 7(12):141-142.
7.	Oeseburg B, Wynia K, Middel B, et al. Effects of case management for frail older people or those with chronic illness:a systematic review[J]. Nurs Res, 2009, 58(3):201-210.
8.	Sohn AH, Garrett DO, Sinkowitz-Cochran RL, et al. Prevalence of nosocomial infections in neonatal intensive care unit patients:results from the first national point-prevalence survey[J]. J Pediatr, 2001(139):821-827.
9.	吕婕, 陈峰, 是俊凤, 等. 新生儿医院感染病例分析与干预措施[J]. 中华医院感染学杂志, 2010, 20(12):1702-1703.
10.	管利荣, 徐冰, 何晓芸, 等. 新生儿呼吸机相关性肺炎临床分析[J]. 华西医学, 2007, 22(2):353-354.
11.	陈大鹏, 陈娟, 熊英, 等. 新生儿呼吸机相关性肺炎病原学分析[J]. 华西医学, 2005, 20(2):344.
12.	谢坚, 刘蓉, 余静, 等. 新生儿呼吸机相关性肺炎发病情况、病原及耐药菌分析[J]. 华西医学, 2008, 23(3):584-585.
13.	吴安华, 李丹. 重症监护病房临床与环境、手分离耐药革兰阴性杆菌的同源性研究[J]. 中华医院感染学杂志, 2008, 18(7):909-912.

1. 中华人民共和国卫生部. 医院感染诊断标准(试行)[J]. 中华医学杂志, 2001, 81(5):314-320.
2. 曾成惠, 何俊, 李雪梅, 等. 新生儿患者多重耐药菌筛查结果与分析[J]. 华西医学, 2013, 28(8):1149-1151.
3. 徐莲香, 徐康立, 邓军霞. 新生儿医院感染因素分析及控制措施[J]. 中华医院感染学杂志, 2010, 20(7):937-938.
4. 袁晓明, 王杏茶, 赵立双. 母婴同室新生儿医院感染的相关分析与研究[J]. 护士进修杂志, 2011, 26(21):2004-2006.
5. 徐珍, 唐素琴, 曹先伟, 等. 新生儿病房医院感染目标性监测结果分析[J]. 中华医院感染学杂志, 2010, 20(21):3324-3326.
6. 龚秀萍. 新生儿医院感染监测与护理对策[J]. 中国医药导报, 2010, 7(12):141-142.
7. Oeseburg B, Wynia K, Middel B, et al. Effects of case management for frail older people or those with chronic illness:a systematic review[J]. Nurs Res, 2009, 58(3):201-210.
8. Sohn AH, Garrett DO, Sinkowitz-Cochran RL, et al. Prevalence of nosocomial infections in neonatal intensive care unit patients:results from the first national point-prevalence survey[J]. J Pediatr, 2001(139):821-827.
9. 吕婕, 陈峰, 是俊凤, 等. 新生儿医院感染病例分析与干预措施[J]. 中华医院感染学杂志, 2010, 20(12):1702-1703.
10. 管利荣, 徐冰, 何晓芸, 等. 新生儿呼吸机相关性肺炎临床分析[J]. 华西医学, 2007, 22(2):353-354.
11. 陈大鹏, 陈娟, 熊英, 等. 新生儿呼吸机相关性肺炎病原学分析[J]. 华西医学, 2005, 20(2):344.
12. 谢坚, 刘蓉, 余静, 等. 新生儿呼吸机相关性肺炎发病情况、病原及耐药菌分析[J]. 华西医学, 2008, 23(3):584-585.
13. 吴安华, 李丹. 重症监护病房临床与环境、手分离耐药革兰阴性杆菌的同源性研究[J]. 中华医院感染学杂志, 2008, 18(7):909-912.

West China Medical Journal

Objective Monitoring of Neonatal Nosocomial Infection and Analysis of Antibiotic Resistance

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content