Diagnosis Accuracy of Interleukin-12 for Tuberculous Pleurisy: A Meta-analysis_West China Medical Journal

Authors：

 CHENFu-xiang ¹ , GONGYa-nan ² , ZHANGHai-fei ¹

1. Department of Respiratory Medicine;the Traditional Chinese Medicine Hospital of Pengzhou, Pengzhou, Sichuan 611930, P. R. China;
2. Department of Emergency;the Traditional Chinese Medicine Hospital of Pengzhou, Pengzhou, Sichuan 611930, P. R. China;

Corresponding author：

Keywords：

Interleukin-12; Tuberculous pleurisy; Meta-analysis

DOI：

10.7507/1002-0179.20140507

Video：

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Objective To investigate the overall accuracy of interleukin-12 (IL-12) for diagnosis of tuberculous pleurisy. Methods We searched in PubMed, Embase, Web of Science, China National Knowledge Infrastructure databases, WanFang Data, and VIP Information for qualified studies that reported diagnostic accuracy of IL-12 for tuberculous pleurisy up to February 2014. The methodological quality of each study was evaluated by Quality assessment of diagnostic accuracy studies. Statistical analyses were performed by Meta-Disc 1.4 software and the pooled sensitivity, specificity and other diagnostic indexes. Meta-analysis of the reported accuracy of each study and summary receiver operating characteristic (SROC) curve were also performed. Results Eight studies met the inclusion criteria for the analysis. The summary estimates for IL-12 in the diagnosis of tuberculous pleurisy were:sensitivity 0.80 [95% CI (0.76, 0.84)], specificity 0.76 [95% CI (0.71, 0.81)], positive likelihood ratio 3.23 [95% CI (2.26, 4.60)], negative likelihood ratio 0.30 [95% CI (0.20, 0.45)], diagnostic odds ratio 13.57 [95% CI (6.66, 27.64)], and the area under the curve of SROC was 0.86. Conclusion IL-12 plays a valuable role in the diagnosis of tuberculous pleurisy, and IL-12 may be a useful diagnostic marker for tuberculous pleurisy.

Citation： CHENFu-xiang, GONGYa-nan, ZHANGHai-fei. Diagnosis Accuracy of Interleukin-12 for Tuberculous Pleurisy: A Meta-analysis. West China Medical Journal, 2014, 29(9): 1653-1657. doi: 10.7507/1002-0179.20140507 Copy

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10.	Valdés L,San José E,Alvarez Dobaño JM,et al.Diagnostic value of interleukin-12 p40 in tuberculous pleural effusions[J].Eur Respir J,2009,33(4):816-820.
11.	姜振东,王蔚然,刘心.白细胞介素12在结核性胸膜炎诊断中的应用价值[J].中国实用医药,2010,5(1):50-51.
12.	陈利华,蒋捍东,林存智.γ干扰素、白细胞介素18、白细胞介素12及可溶性白细胞介素2受体在结核性和恶性胸腔积液中表达意义分析[J].中华临床医师杂志·电子版,2011,5(12):3602-3604.
13.	Fernández de Larrea C,Duplat A,Giampietro F,et al.Diagnostic accuracy of immunological methods in patients with tuberculous pleural effusion from Venezuela[J].Invest Clin,2011,52(1):23-34.
14.	周世新,谭金,肖学平.腺苷脱氨酶与肿瘤坏死因子-α和白细胞介素-12检测在诊断结核性胸腔积液中临床价值的比较[J].检验医学与临床,2012,9(12):1436-1437.
15.	Bays AM,Pierson DJ.Tuberculous pleural effusion[J].Respir Care,2012,57(10):1682-1684.
16.	刘关键,吴泰相.诊断性试验的Meta分析——SROC曲线法介绍[J].中国循证医学杂志,2003,3(1):41-44.
17.	童峰,陈坤,何寒青.优势比在诊断试验评价中的应用[J].中华流行病学杂志,2005,26(10):813-814.
18.	Hiraki A,Aoe K,Eda R,et al.Comparison of six biological markers for the diagnosis of tuberculous pleuritis[J].Chest,2004,125(3):987-989.

1. Zhou Q,Chen YQ,Qin SM,et al.Diagnostic accuracy of T-cell interferon-gamma release assays in tuberculous pleurisy:a meta-analysis[J].Respirology,2011,16(3):473-480.
2. Pandit S,Chaudhuri AD,Datta SB,et al.Role of pleural biopsy in etiological diagnosis of pleural effusion[J].Lung India,2010,27(4):202-204.
3. 吴桂辉,何畏,马瑶,等.胸膜活检在结核性胸膜炎中的诊断价值[J].华西医学,2010,25(8):1412-1414.
4. Shafiani S,Dinh C,Ertelt JM,et al.Pathogen-specific Treg cells expand early during mycobacterium tuberculosis infection but are later eliminated in response to Interleukin-12[J].Immunity,2013,38(6):1261-1270.
5. Whiting P,Weswood ME,Rutjes AW,等.QUADAS评价:一种用于诊断性研究的质量评价工具(修订版)[J].中国循证医学杂志,2007,7(7):531-536.
6. Devillé WL,Buntinx F,Bouter LM,et al.Conducting systematic reviews of diagnostic studies:didactic guidelines[J].BMC Med Res Methodol,2002,2:9.
7. 顾秀英,李殿云,王淑艳,等.胸液白细胞介素12检测对结核性胸膜炎诊断价值的探讨[J].中国防痨杂志,2002,24(4):240-240.
8. 田瑞雪,高占成.干扰素γ、白细胞介素12及腺苷脱氨酶同工酶对结核性胸腔积液的诊断价值[J].中华结核和呼吸杂志,2004,27(7):435-438.
9. Okamoto M,Kawabe T,Iwasaki Y,et al.Evaluation of interferon-gamma,interferon-gamma-inducing cytokines,and interferon-gamma-inducible chemokines in tuberculous pleural effusions[J].J Lab Clin Med,2005,145(2):88-93.
10. Valdés L,San José E,Alvarez Dobaño JM,et al.Diagnostic value of interleukin-12 p40 in tuberculous pleural effusions[J].Eur Respir J,2009,33(4):816-820.
11. 姜振东,王蔚然,刘心.白细胞介素12在结核性胸膜炎诊断中的应用价值[J].中国实用医药,2010,5(1):50-51.
12. 陈利华,蒋捍东,林存智.γ干扰素、白细胞介素18、白细胞介素12及可溶性白细胞介素2受体在结核性和恶性胸腔积液中表达意义分析[J].中华临床医师杂志·电子版,2011,5(12):3602-3604.
13. Fernández de Larrea C,Duplat A,Giampietro F,et al.Diagnostic accuracy of immunological methods in patients with tuberculous pleural effusion from Venezuela[J].Invest Clin,2011,52(1):23-34.
14. 周世新,谭金,肖学平.腺苷脱氨酶与肿瘤坏死因子-α和白细胞介素-12检测在诊断结核性胸腔积液中临床价值的比较[J].检验医学与临床,2012,9(12):1436-1437.
15. Bays AM,Pierson DJ.Tuberculous pleural effusion[J].Respir Care,2012,57(10):1682-1684.
16. 刘关键,吴泰相.诊断性试验的Meta分析——SROC曲线法介绍[J].中国循证医学杂志,2003,3(1):41-44.
17. 童峰,陈坤,何寒青.优势比在诊断试验评价中的应用[J].中华流行病学杂志,2005,26(10):813-814.
18. Hiraki A,Aoe K,Eda R,et al.Comparison of six biological markers for the diagnosis of tuberculous pleuritis[J].Chest,2004,125(3):987-989.

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West China Medical Journal

Diagnosis Accuracy of Interleukin-12 for Tuberculous Pleurisy: A Meta-analysis

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