Systematic Review on Shenfu Injection in Reducing Adverse Toxicity of Chemotherapy_West China Medical Journal

Authors：

 XIAOXiong ¹ , LIShu ² , WUZhen-zhen ² ,  LITing-qian ²

1. Department of Integrated TCM & Western Medicine, the Fifth People's Hospital of Chengdu, Chengdu, Sichuan 611130, P. R. China;
2. Department of Integrated TCM & Western Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

LITing-qian, Email: litingqian@163.com

Keywords：

Shenfu injection; Chemotherapy; Adverse Reaction

DOI：

10.7507/1002-0179.20140509

Video：

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Objective To evaluate the clinical efficacy of shenfu injection in reducing the side effects of chemotherapy in patients with cancer. Methods We searched Medline, PubMed, EMbase, VIP, Chinese science and technology periodical database full text database, China journal full database, Chinese biomedical literature database, and WANFANG database the durationi was from January 1994 to May 2013 for controlled trials about the use of shenfu injection to reduce the side effects of chemotherapy, without any language limitations. The quality of literature was evaluated by Jadad rating scale, and the included trials were analyze for systematic review. Results A total of 30 articles were included, and all of them were from Chinese literature. There were altogether 2039 cases. Compared with single chemotherapy group, the normal rate of white blood cells [RR=1.54, 95%CI (1.28, 1.84), P<0.0000 1], hemoglobin [RR=1.30, 95%CI (1.14, 1.48), P<0.000 1], platelet [RR=1.39, 95%CI (1.19, 1.62), P<0.000 1], and the number of patients without vomiting or sickness [RR=1.54, 95%CI (1.30, 1.81), P<0.0000 1] in the shenfu treatment group were all significantly higher. The life quality of the shenfu treatment group was also obviously better than the single chemotherapy group. Conclusion Compared with single chemotherapy, shenfu injection can reduce the peripheral blood cell reduction, gastrointestinal reaction and improve the patients' quality of life. Because the quality of included studies in this research is generally low, it is necessary to design a more reasonable and strict experiment with a large sample to get an exact conclusion.

Citation： XIAOXiong, LIShu, WUZhen-zhen, LITing-qian. Systematic Review on Shenfu Injection in Reducing Adverse Toxicity of Chemotherapy. West China Medical Journal, 2014, 29(9): 1659-1669. doi: 10.7507/1002-0179.20140509 Copy

1.	夏宝泉,纪钧,陆跃美,等.参附注射液防治恶性肿瘤化疗毒副反应30例临床观察[J].江苏中医,1999,20(12):41-42.
2.	丁松云.参附注射液对晚期肺癌化疗患者免疫功能影响的临床研究[J].实用中医内科杂志,2001,15(4):3-4.
3.	刘展华,陈锐深,曹洋.参附注射液配合化疗对中晚期非小细胞肺癌患者生活质量的影响[J].中国中西医结合杂志,2004,24(9):856-857.
4.	黄金活,嵇玉峰,梁洪江,等.参附注射液治疗恶性肿瘤化疗毒副反应的临床观察[J].现代肿瘤医学,2004,12(3):185-187.
5.	雷静,李琼,田丽华,等.参附注射液减轻肿瘤化疗毒性反应及改善生活质量的作用[J].中国中医急症,2004,13(12):813-814.
6.	卢利员,刘展华,余丽娟.参附注射液对非小细胞肺癌化疗的骨髓保护作用[J].中国中西医结合杂志,2005,25(8):764.
7.	徐文,卢爱萍,卞淑芬.参附注射液降低泰索帝为主的化疗方案毒副反应的临床研究[J].辽宁中医杂志,2005,32(11):1145-1146.
8.	李艺,李晓琳.参附注射液改善化疗引起的骨髓抑制[J].云南中医学院学报,2005,28(4):46-47,53.
9.	金向宇,孔祥鸣.参附注射液治疗化疗毒副作用临床观察[J].浙江中西医结合杂志,2005,15(4):231-232.
10.	杨振淮,袁小东,李关宁.参附注射液联合ELFP方案治疗晚期胃癌40例[J].中医研究,2005,18(7):26-27.
11.	吴万垠,龙顺钦,张海波,等.参附注射液对健择联合顺铂治疗非小细胞肺癌的减毒作用[J].上海中医药大学学报,2005,19(4):21-24.
12.	熊钢,李欣,顾昱,等.参附注射液对减轻中、晚期非小细胞肺癌化疗毒副反应的临床观察[J].中国药房,2006,17(23):1803-1804.
13.	吴万垠,王斌,张海波,等.参附注射液对NP方案治疗非小细胞肺癌减毒作用的临床研究[J].新中医,2006,38(10):20-23.
14.	吴万垠,王斌,张海波,等.参附注射液对TP方案治疗非小细胞肺癌减毒作用的研究[J].广州中医药大学学报,2006,23(5):387-390.
15.	郭中宁,杨宇飞,吴煜.参附注射液对长春瑞宾联合顺铂方案治疗非小细胞肺癌引起血液学毒性反应的影响[J].中国药房,2006,17(24):1888-1890.
16.	张微微,陈越,钱义明.参附注射液对含阿霉素类化疗方案减毒增效作用的临床观察[J].河南中医,2007,27(4):70-71.
17.	龙顺钦,邓宏,吴万垠,等.参附注射液防治GP方案治疗非小细胞肺癌所致骨髓抑制[J].广东医学,2007,28(8):1339-1341.
18.	刘少平,茅卫东,钱文军,等.参附注射液对中、晚期非小细胞肺癌化疗患者骨髓毒性及免疫功能的影响[J].中国中医急症,2008,17(12):1705-1706.
19.	刘秀艳.参附注射液对GP方案治疗非小细胞肺癌减毒作用的临床观察[J].辽宁中医杂志,2008,35(3):415-415.
20.	龚红卫,罗秀丽.参附注射液辅助化疗治疗老年晚期非小细胞肺癌临床观察[J].中国中医急症,2008,17(6):782-783.
21.	张素芳,常万里,张玉芳,等.参附注射液配合化疗治疗老年晚期非小细胞肺癌的临床观察[J].中华实用诊断与治疗杂志,2009,23(5):505-506.
22.	杜以萍,王永顺,周遵伟.参附注射液联合化疗治疗中晚期恶性肿瘤临床观察[J].中国中医急症,2009,18(7):1094-1094,1108.
23.	姚丽鸽,李鹏,马静,等.参附注射液在大肠癌术后化疗中的应用[J].中国中医急症,2009,18(5):739-740.
24.	司淑平,郭继中,占强,等.参附注射液在晚期消化道肿瘤化疗中的应用——附40例临床资料分析[J].中国中医急症,2009,18(3):385-386.
25.	方乃青,肖寒,申小苏.参附注射液联合化疗治疗脾肾两虚型肠癌的疗效与安全性[J].山东医药,2010,50(49):70-71.
26.	谢伟国,江莲,侯昕珩.参附注射液联合NP方案治疗老年非小细胞肺癌临床研究[J].中国中医急症,2010,19(3):422-423.
27.	陆新岸,杨泽江,邓朝明.参附注射液配合化疗对晚期非小细胞肺癌患者免疫功能的影响[J].中医学报,2010,25(6):1049-1051.
28.	刘俊波,黄常江.参附注射液对晚期非小细胞肺癌化疗患者造血功能及生活质量的影响[J].中国医药导报,2011,8(20):119-120.
29.	姜孝新,伍小平,蒋艳.参附注射液对中晚期非小细胞肺癌患者化疗后免疫功能的影响[J].苏州大学学报·医学版,2011,31(5):814-815,830.
30.	邓卓娟,曹海宁,高铁牛.参附注射液联合PCF化疗方案治疗40例晚期胃癌的临床研究[J].当代医学,2011,17(12):116-118.
31.	邱仲川,陈珮.参附注射液辨证治疗肾阳虚型再生障碍性贫血[J].华西药学杂志,1999,14(4):280-282.

1. 夏宝泉,纪钧,陆跃美,等.参附注射液防治恶性肿瘤化疗毒副反应30例临床观察[J].江苏中医,1999,20(12):41-42.
2. 丁松云.参附注射液对晚期肺癌化疗患者免疫功能影响的临床研究[J].实用中医内科杂志,2001,15(4):3-4.
3. 刘展华,陈锐深,曹洋.参附注射液配合化疗对中晚期非小细胞肺癌患者生活质量的影响[J].中国中西医结合杂志,2004,24(9):856-857.
4. 黄金活,嵇玉峰,梁洪江,等.参附注射液治疗恶性肿瘤化疗毒副反应的临床观察[J].现代肿瘤医学,2004,12(3):185-187.
5. 雷静,李琼,田丽华,等.参附注射液减轻肿瘤化疗毒性反应及改善生活质量的作用[J].中国中医急症,2004,13(12):813-814.
6. 卢利员,刘展华,余丽娟.参附注射液对非小细胞肺癌化疗的骨髓保护作用[J].中国中西医结合杂志,2005,25(8):764.
7. 徐文,卢爱萍,卞淑芬.参附注射液降低泰索帝为主的化疗方案毒副反应的临床研究[J].辽宁中医杂志,2005,32(11):1145-1146.
8. 李艺,李晓琳.参附注射液改善化疗引起的骨髓抑制[J].云南中医学院学报,2005,28(4):46-47,53.
9. 金向宇,孔祥鸣.参附注射液治疗化疗毒副作用临床观察[J].浙江中西医结合杂志,2005,15(4):231-232.
10. 杨振淮,袁小东,李关宁.参附注射液联合ELFP方案治疗晚期胃癌40例[J].中医研究,2005,18(7):26-27.
11. 吴万垠,龙顺钦,张海波,等.参附注射液对健择联合顺铂治疗非小细胞肺癌的减毒作用[J].上海中医药大学学报,2005,19(4):21-24.
12. 熊钢,李欣,顾昱,等.参附注射液对减轻中、晚期非小细胞肺癌化疗毒副反应的临床观察[J].中国药房,2006,17(23):1803-1804.
13. 吴万垠,王斌,张海波,等.参附注射液对NP方案治疗非小细胞肺癌减毒作用的临床研究[J].新中医,2006,38(10):20-23.
14. 吴万垠,王斌,张海波,等.参附注射液对TP方案治疗非小细胞肺癌减毒作用的研究[J].广州中医药大学学报,2006,23(5):387-390.
15. 郭中宁,杨宇飞,吴煜.参附注射液对长春瑞宾联合顺铂方案治疗非小细胞肺癌引起血液学毒性反应的影响[J].中国药房,2006,17(24):1888-1890.
16. 张微微,陈越,钱义明.参附注射液对含阿霉素类化疗方案减毒增效作用的临床观察[J].河南中医,2007,27(4):70-71.
17. 龙顺钦,邓宏,吴万垠,等.参附注射液防治GP方案治疗非小细胞肺癌所致骨髓抑制[J].广东医学,2007,28(8):1339-1341.
18. 刘少平,茅卫东,钱文军,等.参附注射液对中、晚期非小细胞肺癌化疗患者骨髓毒性及免疫功能的影响[J].中国中医急症,2008,17(12):1705-1706.
19. 刘秀艳.参附注射液对GP方案治疗非小细胞肺癌减毒作用的临床观察[J].辽宁中医杂志,2008,35(3):415-415.
20. 龚红卫,罗秀丽.参附注射液辅助化疗治疗老年晚期非小细胞肺癌临床观察[J].中国中医急症,2008,17(6):782-783.
21. 张素芳,常万里,张玉芳,等.参附注射液配合化疗治疗老年晚期非小细胞肺癌的临床观察[J].中华实用诊断与治疗杂志,2009,23(5):505-506.
22. 杜以萍,王永顺,周遵伟.参附注射液联合化疗治疗中晚期恶性肿瘤临床观察[J].中国中医急症,2009,18(7):1094-1094,1108.
23. 姚丽鸽,李鹏,马静,等.参附注射液在大肠癌术后化疗中的应用[J].中国中医急症,2009,18(5):739-740.
24. 司淑平,郭继中,占强,等.参附注射液在晚期消化道肿瘤化疗中的应用——附40例临床资料分析[J].中国中医急症,2009,18(3):385-386.
25. 方乃青,肖寒,申小苏.参附注射液联合化疗治疗脾肾两虚型肠癌的疗效与安全性[J].山东医药,2010,50(49):70-71.
26. 谢伟国,江莲,侯昕珩.参附注射液联合NP方案治疗老年非小细胞肺癌临床研究[J].中国中医急症,2010,19(3):422-423.
27. 陆新岸,杨泽江,邓朝明.参附注射液配合化疗对晚期非小细胞肺癌患者免疫功能的影响[J].中医学报,2010,25(6):1049-1051.
28. 刘俊波,黄常江.参附注射液对晚期非小细胞肺癌化疗患者造血功能及生活质量的影响[J].中国医药导报,2011,8(20):119-120.
29. 姜孝新,伍小平,蒋艳.参附注射液对中晚期非小细胞肺癌患者化疗后免疫功能的影响[J].苏州大学学报·医学版,2011,31(5):814-815,830.
30. 邓卓娟,曹海宁,高铁牛.参附注射液联合PCF化疗方案治疗40例晚期胃癌的临床研究[J].当代医学,2011,17(12):116-118.
31. 邱仲川,陈珮.参附注射液辨证治疗肾阳虚型再生障碍性贫血[J].华西药学杂志,1999,14(4):280-282.

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Systematic Review on Shenfu Injection in Reducing Adverse Toxicity of Chemotherapy

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