Correlation between Intima-media Thickness of Carotid Artery in Color Ultrasonography and Heart Rate Variability_West China Medical Journal

Authors：

 LIYan-fang ¹ , MAChun-lan ² ,  LUOFeng-ming ¹

1. Department of General Practice Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Department of Respiratory Medicine, the First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610500, P. R. China;

Corresponding author：

LUOFeng-ming, Email: luofengming@hotmail.com

Keywords：

Carotid color ultrasonography; Intima-media thickness; Dynamic electrocardiogram; Heart rate variability

DOI：

10.7507/1002-0179.20140554

Video：

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Objective To investigate the correlation between intima-media thickness (IMT) of carotid artery in color ultrasonography and the heart rate variability. Methods A retrospective analysis was performed in 64 patients from West China Hospital of Sichuan University between March and May 2013. Carotid intima-media thickness was measured with color ultrasonography and dynamic electrocardiogram, and the heart rate variability was assayed at the same time. Results IMT in the cardiovascular disease group, combination group, coronary heart disease group and hypertension group was significantly thicker than the control group (P<0.05). The differences of SDNN and SDANN were statistically significant (P<0.05) between the combination group and the control group. There were 23 cases with IMT ≥ 1.0 mm in the cardiovascular disease group including 8 cases in the combination group, 10 cases in the coronary heart disease group and 5 cases in the hypertension group. IMT in those groups were all significantly higher than that in the control group with only 2 cases having IMT ≥ 1.0 mm (P<0.05). There were 18 cases with SDNN<100 ms in the cardiovascular disease group including 7 cases in the combination group, 6 cases in the coronary heart disease group and 5 cases in the hypertension group, but there was no statistically significant difference compared with that in the control group with only 11 cases (P>0.05). Negative correlation was found between IMT and SDNN, SDANN in the cardiovascular diseases group (r=-0.574, -0.544; P<0.01) and negative correlation was found between IMT and SDANN in the control group (r=-0.392, P<0.05). Conclusion The carotid artery lesions and autonomic nerve especially sympathetic nerve dysfunction are obvious in patients with cardiovascular diseases and there is a negative correlation between them.

Citation： LIYan-fang, MAChun-lan, LUOFeng-ming. Correlation between Intima-media Thickness of Carotid Artery in Color Ultrasonography and Heart Rate Variability. West China Medical Journal, 2014, 29(10): 1819-1822. doi: 10.7507/1002-0179.20140554 Copy

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12.	Mizuguchi Y, Oishi Y, Tanaka H, et al. Arterial stiffness is associated with left ventricular diastolic function in patients with cardiovascular risk factors:Early detection with the use of cardio-ankle vascular index and ultrasonic strain imaging[J]. J Card Fail, 2007, 13(9):744-751.
13.	Task Force of the European Society of Cardiology, the North America Society of Pacing, Electrophysiology. Heart rate variability:standards of measurement, physiological interpretation and clinical use[J]. Circulation, 1996, 93(5):1043-1065.
14.	Sullivan Jib, Conroy RM, MacDonald K, et al. Silent ischemia indiabetic men with autonomic neuropathy[J]. Br Heart J, 1999, 66:313-315.
15.	Tsuchiya T, Okumura K, Yasue H, et al. Heart period variability in patients with variant angina[J]. Am J Cardi01, 1996, 77(11):932-936.
16.	陈平安, 刘震, 李韶南. 冠状动脉病变情况与心率变异性的关系[J]. 实用医学杂志, 2010, 26(12):2151-2152.
17.	席海林. 55例心功能不全患者心率变异性分析的临床价值[J]. 四川医学, 2011, 32(5):715-716.
18.	刘丹, 陈丽江, 陈汉华, 等. 心率变异评价高血压性心脏病的价值分析[J]. 牡丹江医学院学报, 2013, 34(4):41-43.
19.	Femia R, Kozakova M, Nannipieri MA, et al. Carotid intima-media thickness in confirmed prehypertensive subjects; predictors and progression[J]. Arterioscler Thromb Vasc Biol, 2007, 27(10):2244-2249.
20.	全国心率变异性分析多中心研究协作组, 尹彦琳, 吴宁, 等. 心率变异性正常值及其重复性的多中心研究[J]. 中华心律失常学杂志, 2000, 4(3):6-11.

1. 中国医师协会超声医师分会. 血管超声检查指南[J]. 中华超声影像学杂志, 2009, 18(10):911-920.
2. 杨东伟, 刘新叶, 许富英, 等. 颈动脉内-中膜厚度与冠状动脉病变严重程度相关性研究[J]. 临床和实验医学杂志, 2013, 12(10):745-746, 749.
3. Ray A, Tamsma JT, Hovens M, et al. Accuracy of carotid plaque detection and intima-media thickness measurement with ultrasonography in routine clinical practice[J]. Eur J Intern Med, 2010, 21(1):35-39.
4. 茹秀颖. 高血压病程与颈动脉硬化的关系研究[J]. 现代中西医结合杂志, 2012, 21(19):2088-2089.
5. 中华医学会心电生理和起搏分会心电图学学组. 动态心电图工作指南[J]. 临床心电学杂志, 1999, 8(2):125-129.
6. Wahab A, Zaheer MS, Rabbani M, et al. A study of heart rate variability and QT dispersion in patients of acute ST elevation myocardial infarction[J]. Indian Heart J, 2009, 61(3):261-264.
7. 李智, 卢喜烈, 汪剑锋, 等. 高龄老年住院患者不同性别心率变异性对比分析[J]. 广东医学, 2010, 31(2):194-195.
8. 孙顺洋, 时阳成, 吕正涛, 等. 颈动脉超声检查在高血压病诊治中的意义[J]. 现代中西医结合杂志, 2012, 21(6):627-628.
9. Zanchetti A, Crepaldi G, Bond MG, et al. Systolic and pulse blood pressures (but not diastolic blood pressure and serum cholesterol)are associated with alterations in carotid intima-media thickness in the moderately hypercholesterolaemic hypertensive patients of the Plaque Hypertension Lipid Lowering Italian Study. PHYLLIS study group[J]. J Hypertens, 2001, 19(1):79-88.
10. Magyar MT, Paragh G, Katona E, et al. Serum cholesterols have a more important role than triglycerides in determining intima-media thickness of the common carotid artery in subjects younger than 55 years of age[J]. Ultrasound Med, 2004, 23(9):1161.
11. Ohara K, Tabara Y, Tachibana R, et al. Micro albuminuria and arterial stiffness in a general population:the Shimanami Health Promoting Program(J-SHIPP)study[J]. J Hypertens Bes, 2004, 27(7):471.
12. Mizuguchi Y, Oishi Y, Tanaka H, et al. Arterial stiffness is associated with left ventricular diastolic function in patients with cardiovascular risk factors:Early detection with the use of cardio-ankle vascular index and ultrasonic strain imaging[J]. J Card Fail, 2007, 13(9):744-751.
13. Task Force of the European Society of Cardiology, the North America Society of Pacing, Electrophysiology. Heart rate variability:standards of measurement, physiological interpretation and clinical use[J]. Circulation, 1996, 93(5):1043-1065.
14. Sullivan Jib, Conroy RM, MacDonald K, et al. Silent ischemia indiabetic men with autonomic neuropathy[J]. Br Heart J, 1999, 66:313-315.
15. Tsuchiya T, Okumura K, Yasue H, et al. Heart period variability in patients with variant angina[J]. Am J Cardi01, 1996, 77(11):932-936.
16. 陈平安, 刘震, 李韶南. 冠状动脉病变情况与心率变异性的关系[J]. 实用医学杂志, 2010, 26(12):2151-2152.
17. 席海林. 55例心功能不全患者心率变异性分析的临床价值[J]. 四川医学, 2011, 32(5):715-716.
18. 刘丹, 陈丽江, 陈汉华, 等. 心率变异评价高血压性心脏病的价值分析[J]. 牡丹江医学院学报, 2013, 34(4):41-43.
19. Femia R, Kozakova M, Nannipieri MA, et al. Carotid intima-media thickness in confirmed prehypertensive subjects; predictors and progression[J]. Arterioscler Thromb Vasc Biol, 2007, 27(10):2244-2249.
20. 全国心率变异性分析多中心研究协作组, 尹彦琳, 吴宁, 等. 心率变异性正常值及其重复性的多中心研究[J]. 中华心律失常学杂志, 2000, 4(3):6-11.

West China Medical Journal

Correlation between Intima-media Thickness of Carotid Artery in Color Ultrasonography and Heart Rate Variability

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