Study on the Relationship between the Levels of Serum Transferrin, Prealbumin and Total Bile Acids and the Hepatic Reserve Function in Primary Liver Cancer Patients_West China Medical Journal

Authors：

 LIUQing-rong ¹ ,  XIAQing-jie ²

1. Clinical Laboratory, Chengdu Central Hospital of Women and Children, Chengdu, Sichuan 610091, P. R. China;
2. State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

XIAQing-jie, Email: xiaqj2005@126.com

Keywords：

Primary hepatic carcinoma; Transferrin; Prealbumin; Total bile acid; Hepatic reserve function

DOI：

10.7507/1002-0179.20140569

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Objective To explore the relationship between the levels of transferrin (TRF), prealbumin (PAB) and total bile acids (TBA) in serum and the loss of the hepatic reserve function in primary liver cancer (PHC) patients and the importance of the former factors for diagnosis of PHC. Methods A total of 154 patients with PHC collected between March 2010 and February 2013 were included in our study. Based on the information of hepatic reserve function and the Child-Pugh classification standard, the patients were divided into Child-Pugh-A, B, and C groups with 67, 55 and 42 patients respectively. Another 58 healthy subjects were selected as the control group. Serum TRF, PAB and TBA levels were measured by automated chemiluminescence immunoassay, immune turbidimetric assay and enzymatic cycling respectively, and they were compared among the groups. Results TRF level of patients in the control group and Child-Pugh-A, B, and C groups was respectively (2.574±0.214), (1.618±0.135), (0.988±0.121), and (0.314±0.107) g/L, with significant differences among the groups (P<0.05). PAB level of patients in four groups was respectively (269.32±37.29), (165.22±21.01), (123.24±31.15), and (83.66±19.74) mg/L, with significant differences among the groups (P<0.05). TBA level in the above four groups was respectively (9.16±2.48), (65.13±4.25), (133.62±8.44), and (250.73±21.59) μmol/L, and there was also significant differences among the groups. A positive correlation between serum TRF and PAB was found (r=0.927, P<0.001), and negative correlations between serum TBA level and serum TRF and between TBA and PAB were found (r=-0.454, P<0.001; r=-0.432, P<0.001, respectively). Conclusion Serum TRF, PAB and TBA levels are closely related to the hepatic reserve function in PHC patients, and they can be used as an important indicator for PHC diagnosis.

Citation： LIUQing-rong, XIAQing-jie. Study on the Relationship between the Levels of Serum Transferrin, Prealbumin and Total Bile Acids and the Hepatic Reserve Function in Primary Liver Cancer Patients. West China Medical Journal, 2014, 29(10): 1883-1886. doi: 10.7507/1002-0179.20140569 Copy

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11.	吴俊琪, 范顺富, 何航兵. 血清PAB、AAG、AAT的检测在肝脏疾病中的意义[J]. 江西医学检验, 2000, 18(2):79-80, 86.
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14.	程峰涛, 李铎, 蔡敏. 乙型肝炎后肝硬化患者血清总胆汁酸测定的意义[J]. 中华消化杂志, 1998, 18(2):92.
15.	Ikeda S, Mitaka T, Harada K, et al. Tumor necrosis factor-alpha and interleukin-6 reduce bile canalicular contractions of rat hepatocytes[J]. Surgery, 2003, 133(1):101-109.
16.	Pazzi P, Morsiani E, Vilei MT, et al. Serum bile acids in patients with liver failure supported with a bioartificial liver[J]. Aliment Pharmacol Ther, 2002, 16(8):1547-1554.

1. Galiegos-Orozco JF, Vargas HE. Liver transplantation:from Child to MELD[J]. Med Clin North Am, 2009, 93(4):931-950.
2. 张阳东, 楚瑞雪. 血清甲胎蛋白与血清铁蛋白检测及其在原发性肝癌中的诊断意义[J]. 标记免疫分析与临床, 2008, 15(1):26-27.
3. 章谷生. 发光分析和发光免疫技术[M]. 上海:上海医科大学出版社, 1999:716.
4. 刘华平, 董荩, 蔡天沛. 血清转铁蛋白测定临床意义的初步观察[J]. 安徽医学院学报, 1983, 18(3):34-35, 91-92.
5. Evans RW, Crawley JB, Garratt RC, et al. Characterization and structural analysis of a functional human serum transferrin variant and implications for receptor recognition[J]. Biochemistry, 1994, 33(41):12512-12520.
6. 张春慧, 崔法新. 血清转铁蛋白测定在小儿感染性疾病中的意义[J]. 临床荟萃, 2002, 17(21):1285-1286.
7. 石胜, 卢岑. 原发性肝癌病人血清总胆汁酸和转铁蛋白水平与Child分级的关系[J]. 中国基层医药, 2004, 11(5):600-601.
8. Sobhonslidsuk A, Roongpisuthipong C, Nantiruj K, et al. Impact of liver cirrhosis on nutritional and immunological status[J]. J Med Assoc Thai, 2001, 84(7):982-988.
9. Guerra LT, Rosa AR, Romani RF, et al. Serum transferrin and serum prealbumin as markers of response to nutritional support in patients with esophageal cancer[J]. Nutr Hosp, 2009, 24(2):241-242.
10. Yasmin MY, Aziz B, Nazim M, et al. Prealbumni rather than albumin is a more sensitive indicator of acute liver disease[J]. Malays J Pathol, 1993, 15(2):147-150.
11. 吴俊琪, 范顺富, 何航兵. 血清PAB、AAG、AAT的检测在肝脏疾病中的意义[J]. 江西医学检验, 2000, 18(2):79-80, 86.
12. 梁影, 雷婷, 石秀芳, 等. 血清前白蛋白、总胆汁酸和胆碱酯酶联合检测在乙型肝炎进展中的临床价值[J]. 淮海医药, 2013, 31(5):386-387.
13. 杨旭, 雷建华, 张永红, 等. 血清总胆汁酸测定的意义及其局限性[J]. 中华内科杂志, 2001, 40(1):16-17.
14. 程峰涛, 李铎, 蔡敏. 乙型肝炎后肝硬化患者血清总胆汁酸测定的意义[J]. 中华消化杂志, 1998, 18(2):92.
15. Ikeda S, Mitaka T, Harada K, et al. Tumor necrosis factor-alpha and interleukin-6 reduce bile canalicular contractions of rat hepatocytes[J]. Surgery, 2003, 133(1):101-109.
16. Pazzi P, Morsiani E, Vilei MT, et al. Serum bile acids in patients with liver failure supported with a bioartificial liver[J]. Aliment Pharmacol Ther, 2002, 16(8):1547-1554.

West China Medical Journal

Study on the Relationship between the Levels of Serum Transferrin, Prealbumin and Total Bile Acids and the Hepatic Reserve Function in Primary Liver Cancer Patients

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