The Distribution of Mite Allergens in Chronic Obstructive Pulmonary Disease Patients and the Role of Allergen in Acute Exacerbation of Chronic Obstructive Pulmonary Disease in Hainan Province_West China Medical Journal

Authors：

 XIETian , HUANGYi-jiang , GAOFang-die

Department of Respiratory Medicine, Hainan Provincial People's Hospital, Haikou, Hainan 570311, P. R. China;

Corresponding author：

Keywords：

Chronic obstructive pulmonary disease; Skin prick test; Blomia Tropicalis

DOI：

10.7507/1002-0179.20140611

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Objective To explore the distribution of mite allergens in chronic obstructive pulmonary disease (COPD) patients and the role of allergen in acute exacerbation of COPD (AECOPD) in Hainan Province. Methods We selected 65 COPD patients, 58 other patients without allergic disease and 34 healthy subjects as the control group from January to June in 2009. All subjects underwent skin prick test (SPT) to make statistical analysis. We observed the COPD patients for 3 years to analyze the correlation between SPT positive incidence and frequency of acute exacerbation. Results The SPT positive incidence was higher in the COPD group (P<0.05). The most frequent allergen in COPD group was Blomia Tropicalis. But the SPT positive incidence and frequency of acute exacerbation was not obvious correlated (P>0.05). Conclusion The exogenous allergens may participate in the pathogenesis of COPD. Blomia Tropicalis may be an important allergen of COPD patients in Hainan Province other than Dermatophagoides Pteronyssinus and Dermatophagoides Farinae. But allergy does not play a role in acute exacerbation of COPD.

Citation： XIETian, HUANGYi-jiang, GAOFang-die. The Distribution of Mite Allergens in Chronic Obstructive Pulmonary Disease Patients and the Role of Allergen in Acute Exacerbation of Chronic Obstructive Pulmonary Disease in Hainan Province. West China Medical Journal, 2014, 29(11): 2016-2018. doi: 10.7507/1002-0179.20140611 Copy

1.	辛晓峰, 施毅. 支气管哮喘和慢性阻塞性肺疾病的相似关系[J]. 中华结核和呼吸杂志, 2006, 29(6):428-430.
2.	Orie NGM, Sluiter HJ, de Vries K, et al. The host factor in bronchitis[M]//Orie NGM, Sluiter HJ. Bronchitis:an international symposium[M]. Assen:Royal van Gorcum, 1961:43-59.
3.	秦兴国, 周瑛, 肖平, 等. 尘螨过敏在慢性阻塞性肺病急性加重中的作用[J]. 河南诊断与治疗杂志, 1999, 13(1):11, 13.
4.	中华医学会呼吸病学分会慢性阻塞性肺疾病学组. 慢性阻塞性肺疾病诊治指南(2013年修订版)[J]. 中华结核和呼吸杂志, 2013, 36(4):1-10.
5.	张晓军, 何韶衡, 谢华, 等. 慢性阻塞性肺疾病患者痰中肥大细胞和嗜酸粒细胞因子变化及其相关性研究[J]. 中华结核和呼吸杂志, 2004, 27(10):649-653.
6.	Pesci A, Rossi GA, Bertorelli G, et al. Mast cells in the airway lumen and bronchial mucosa of patients with chronic bronchitis[J]. Am J Respir Crit Care Med, 1994, 149(5):1311-1316.
7.	刘云霞, 黄家淼, 宗晓福, 等. COPD与哮喘体外过敏原血清特异性IgE检测的结果分析[J]. 东南国防医药, 2007, 9(2):84-85, 104.
8.	Liao EC, Ho CM, Tsai JJ. Prevalence of Tyrophagus putrescentiae hypersensitivity in subjects over 70 years of age in a veterans' nursing home in Taiwan[J]. Int Arch Allergy Immunol, 2010, 152(4):368-377.
9.	Li J, Sun B, Huang Y, et al. A multicenter study assessing the prevalence of sensitizations in patients with asthma and/or rhinitis in China[J]. Allergy, 2009, 64(7):1083-1092.
10.	崔玉宝. 尘螨的生物学、生态学与流行概况[J]. 国外医学·寄生虫病分册, 2004, 31(6):277-281.
11.	谢甜, 黄奕江. 热带螨与支气管哮喘[J]. 国际呼吸杂志, 2010, 30(11):693-696.
12.	朱洪, 崔玉宝, 饶朗毓. 哮喘患者居室内尘螨孳生种类、密度及其与抗原浓度的相关性研究[J]. 中国媒介生物学及控制杂志, 2007, 18(5):381-383.
13.	陈实, 郑轶武, 王灵, 等. 海南变态反应性疾病患儿对屋尘螨/粉尘螨和仓储螨的特异性IgE[J]. 中华临床免疫和变态反应杂志, 2010, 4(3):191-195.
14.	喻海琼, 刘志刚, 于琨瑛, 等. 重组屋尘螨2类变应原疫苗免疫治疗小鼠过敏性气道炎症的研究[J]. 中国寄生虫学与寄生虫病杂志, 2006, 24(6):414-419.
15.	国华, 朱清仙, 刘志刚, 等. 粉尘螨-壳聚糖疫苗经鼻免疫治疗小鼠过敏性哮喘的实验研究[J]. 现代免疫学, 2008, 28(1):21-25.
16.	Sato MN, Oliveira CR, Futata EA, et al. Oral tolerance induction to Dermatophagoides pteronyssinus and Blomia tropicalis in sensitized mice:occurrence of natural autoantibodies to immunoglobulin E[J]. Clin Exp Allergy, 2002, 32(11):1667-1674.

1. 辛晓峰, 施毅. 支气管哮喘和慢性阻塞性肺疾病的相似关系[J]. 中华结核和呼吸杂志, 2006, 29(6):428-430.
2. Orie NGM, Sluiter HJ, de Vries K, et al. The host factor in bronchitis[M]//Orie NGM, Sluiter HJ. Bronchitis:an international symposium[M]. Assen:Royal van Gorcum, 1961:43-59.
3. 秦兴国, 周瑛, 肖平, 等. 尘螨过敏在慢性阻塞性肺病急性加重中的作用[J]. 河南诊断与治疗杂志, 1999, 13(1):11, 13.
4. 中华医学会呼吸病学分会慢性阻塞性肺疾病学组. 慢性阻塞性肺疾病诊治指南(2013年修订版)[J]. 中华结核和呼吸杂志, 2013, 36(4):1-10.
5. 张晓军, 何韶衡, 谢华, 等. 慢性阻塞性肺疾病患者痰中肥大细胞和嗜酸粒细胞因子变化及其相关性研究[J]. 中华结核和呼吸杂志, 2004, 27(10):649-653.
6. Pesci A, Rossi GA, Bertorelli G, et al. Mast cells in the airway lumen and bronchial mucosa of patients with chronic bronchitis[J]. Am J Respir Crit Care Med, 1994, 149(5):1311-1316.
7. 刘云霞, 黄家淼, 宗晓福, 等. COPD与哮喘体外过敏原血清特异性IgE检测的结果分析[J]. 东南国防医药, 2007, 9(2):84-85, 104.
8. Liao EC, Ho CM, Tsai JJ. Prevalence of Tyrophagus putrescentiae hypersensitivity in subjects over 70 years of age in a veterans' nursing home in Taiwan[J]. Int Arch Allergy Immunol, 2010, 152(4):368-377.
9. Li J, Sun B, Huang Y, et al. A multicenter study assessing the prevalence of sensitizations in patients with asthma and/or rhinitis in China[J]. Allergy, 2009, 64(7):1083-1092.
10. 崔玉宝. 尘螨的生物学、生态学与流行概况[J]. 国外医学·寄生虫病分册, 2004, 31(6):277-281.
11. 谢甜, 黄奕江. 热带螨与支气管哮喘[J]. 国际呼吸杂志, 2010, 30(11):693-696.
12. 朱洪, 崔玉宝, 饶朗毓. 哮喘患者居室内尘螨孳生种类、密度及其与抗原浓度的相关性研究[J]. 中国媒介生物学及控制杂志, 2007, 18(5):381-383.
13. 陈实, 郑轶武, 王灵, 等. 海南变态反应性疾病患儿对屋尘螨/粉尘螨和仓储螨的特异性IgE[J]. 中华临床免疫和变态反应杂志, 2010, 4(3):191-195.
14. 喻海琼, 刘志刚, 于琨瑛, 等. 重组屋尘螨2类变应原疫苗免疫治疗小鼠过敏性气道炎症的研究[J]. 中国寄生虫学与寄生虫病杂志, 2006, 24(6):414-419.
15. 国华, 朱清仙, 刘志刚, 等. 粉尘螨-壳聚糖疫苗经鼻免疫治疗小鼠过敏性哮喘的实验研究[J]. 现代免疫学, 2008, 28(1):21-25.
16. Sato MN, Oliveira CR, Futata EA, et al. Oral tolerance induction to Dermatophagoides pteronyssinus and Blomia tropicalis in sensitized mice:occurrence of natural autoantibodies to immunoglobulin E[J]. Clin Exp Allergy, 2002, 32(11):1667-1674.

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West China Medical Journal

The Distribution of Mite Allergens in Chronic Obstructive Pulmonary Disease Patients and the Role of Allergen in Acute Exacerbation of Chronic Obstructive Pulmonary Disease in Hainan Province

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