Relationship between Clinicopathological Characteristics and Invasion Depth of Early Gastric Cancer_West China Medical Journal

Authors：

 JIANGZhi-ling , DENGGui-ying

Department of Gastroenterology, the Sixth People's Hospital of Chengdu City, Chengdu, Sichuan 610051, P. R. China;

Corresponding author：

Keywords：

Early gastric cancer; Clinicopathological; Gastroscopy; Lymph node metastasis

DOI：

10.7507/1002-0179.20140619

Video：

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Objective To investigate the relationship between clinicopathological characteristics and invasion depth of early gastric cancer (EGC), in order to put forward suitable regimens for EGC with different clinicopathological characteristics. Methods The clinicopathological data of 18 patients with EGC diagnosed from January 2008 to January 2013 were retrospectively analyzed. Clinicopathologic variables such as age, gender, tumor size and location, Helicobacter pylori infection, melaena, macroscopic type, and histopathological type were investigated by using chi-square test for their possible relationship with the depth of invasion. Results Lymph node metastasis was more common in patients with submucous cancer (3/9, 33.3%) than in those with mucous cancer (0/9, 0%). Submucosal invasion was found in 77.8% (7/9) of undifferentiated adenocarcinoma cases, whereas only 22.2% (2/9) of differentiated adenocarcinoma had submucosal invasion. TypeⅢ EGC had a significant association with submucosal invasion (P<0.05). Conclusion Endoscopic treatment is unsuitable for patients with Type Ⅲ EGC.

Citation： JIANGZhi-ling, DENGGui-ying. Relationship between Clinicopathological Characteristics and Invasion Depth of Early Gastric Cancer. West China Medical Journal, 2014, 29(11): 2050-2054. doi: 10.7507/1002-0179.20140619 Copy

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2.	Triantafillidis JK, Cheracakis P. Diagnostic evaluation of patients with early gastric cancer:a literature review[J]. Hepatogastroenterology, 2004, 51(56):618-624.
3.	Maehara Y, Kakeji Y, Oda S, et al. Tumor growth patterns and biological characteristics of early gastric carcinoma[J]. Oncology, 2001, 61(2):102-112.
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5.	施新岗, 李兆申. 内镜黏膜下剥离术治疗早期胃癌进展[J]. 中华消化内镜杂志, 2008, 25(1):52-54.
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7.	日本胃癌学会. 胃癌治疗指南[M]. 2版. 东京:金原出版社, 2004:6-9.
8.	Japanese Gastric Cancer Association. Japanese classification of gastric carcinoma-2nd English edition[J]. Gastric Cancer, 1998, 1(1):10-24.
9.	The Paris endoscopic classification of superficial neoplastic lesions:esophagus, stomach, and colon:November 30 to December 1, 2002[J]. Gastrointest Endosc, 2003, 58(Suppl 6):S3-S43.
10.	夏玉亭, 吴云林, 房殿春. 胃病诊治进展[M]. 上海:上海科技教育出版社, 2005:123.
11.	Hamanaka H, Gotoda T. Endoscopic resection for early gastric cancer and future expectations[J]. Dig Endosc, 2005(17):275-285.
12.	潘文胜, 曹敏. 伴淋巴结转移的早期胃癌病理组织形态学研究[J]. 中华消化杂志, 2006, 26(2):104-107.
13.	Adachi Y, Shiraishi N, Kitano S. Modern treatment of early gastric cancer:review of the Japanese experience[J]. Dig Surg, 2002, 19(5):333-339.
14.	Nasu J, Nishina T, Hirasaki S, et al. Predictive factors of lymph node metastasis in patients with undifferentiated early gastric cancers[J]. J Clin Gastroenterol, 2006, 40(5):412-415.
15.	李小毅, 王常珺, 钟定荣, 等. 166例早期胃癌的诊治分析[J]. 中国医学科学院学报, 2011, 33(3):325-329.
16.	Shinohara T, Ohyama S, Yamaguchi T, et al. Clinical value of multidetector row computed tomography in detecting lymph node metastasis of early gastric cancer[J]. Eur J Surg Oncol, 2005, 31(7):743-748.
17.	Kwee RM, Kwee TC. Imaging in assessing lymph node status in gastric cancer[J]. Gastric Cancer, 2009, 12(1):6-22.
18.	Tseng LJ, Mo LR, Tio TL, et al. Video-endoscopic ultrasonography in staging gastric carcinoma[J]. Hepatogastroenterology, 2000, 47(33):897-900.
19.	吴道宏, 吴本俨, 王孟薇, 等. 早期胃癌淋巴结转移多因素分析[J]. 解放军医学杂志, 2006, 31(10):941-943.
20.	Kim DY, Joo JK, Ryu SY, et al. Factors related to lymph node metastasis and surgical strategy used to treat early gastric carcinoma[J]. World J Gastroenterol, 2004, 10(5):737-740.
21.	王戈, 张玉华, 吕谦, 等. 早期胃癌临床病理特征与淋巴结转移范围的关系[J]. 山东医药, 2008, 48(45):60-61.
22.	Ohashi S, Segawa K, Okamura S, et al. The utility of endoscopic ultrasonography and endoscopy in the endoscopic mucosal resection of early gastric cancer[J]. Gut, 1999, 45(4):599-604.
23.	Kwee RM, Kwee TC. The accuracy of endoscopic ultrasonography in differentiating mucosal from deeper gastric cancer[J]. Am J Gastroenterol, 2008, 103(7):1801-1809.
24.	Yamamoto S, Nishida T, Kato M, et al. Evaluation of endoscopic ultrasound image quality is necessary in endosonographic assessment of early gastric cancer invasion depth[J]. Gastroenterol Res Pract, 2012:194530.
25.	张桂英, 王娟, 张晓梅, 等. 55例早期胃癌的临床与病理分析[J]. 中国内镜杂志, 2005, 11(12):1269-1272, 1276.
26.	Gotoda T, Yanagisawa A, Sasako M, et al. Incidence of lymph node metastasis from early gastric cancer:estimation with a large number of cases at two large centers[J]. Gastric Cancer, 2000, 3(4):219-225.
27.	朱敏, 李明阳, 吴本俨. 早期胃癌内镜下切除术后复发的相关因素分析[J]. 中华内科杂志, 2011, 50(5):366-369.
28.	Breslin NP, Thomson AB, Bailey RJ, et al. Gastric cancer and other endoscopic diagnoses in patients with benign dyspepsia[J]. Gut, 2000, 46(1):93-97.
29.	萧树东. 上海仁济医院消化内科专题讲座[M]. 郑州:郑州大学出版社, 2005:71-77.
30.	王一平. 早期胃癌的内镜治疗[J]. 实用肿瘤杂志, 2008, 23(2):104-106.

1. Carter KJ, Schaffer HA, Ritchie WP Jr. Early gastric cancer[J]. Ann Surg, 1984, 199(5):604-609.
2. Triantafillidis JK, Cheracakis P. Diagnostic evaluation of patients with early gastric cancer:a literature review[J]. Hepatogastroenterology, 2004, 51(56):618-624.
3. Maehara Y, Kakeji Y, Oda S, et al. Tumor growth patterns and biological characteristics of early gastric carcinoma[J]. Oncology, 2001, 61(2):102-112.
4. Everett SM, Axon AT. Early gastric cancer in Europe[J]. Gut, 1997, 41(2):142-150.
5. 施新岗, 李兆申. 内镜黏膜下剥离术治疗早期胃癌进展[J]. 中华消化内镜杂志, 2008, 25(1):52-54.
6. 于皆平, 沈志祥, 罗和生. 实用消化病学[M]. 2版. 北京:科学出版社, 2008:317-354.
7. 日本胃癌学会. 胃癌治疗指南[M]. 2版. 东京:金原出版社, 2004:6-9.
8. Japanese Gastric Cancer Association. Japanese classification of gastric carcinoma-2nd English edition[J]. Gastric Cancer, 1998, 1(1):10-24.
9. The Paris endoscopic classification of superficial neoplastic lesions:esophagus, stomach, and colon:November 30 to December 1, 2002[J]. Gastrointest Endosc, 2003, 58(Suppl 6):S3-S43.
10. 夏玉亭, 吴云林, 房殿春. 胃病诊治进展[M]. 上海:上海科技教育出版社, 2005:123.
11. Hamanaka H, Gotoda T. Endoscopic resection for early gastric cancer and future expectations[J]. Dig Endosc, 2005(17):275-285.
12. 潘文胜, 曹敏. 伴淋巴结转移的早期胃癌病理组织形态学研究[J]. 中华消化杂志, 2006, 26(2):104-107.
13. Adachi Y, Shiraishi N, Kitano S. Modern treatment of early gastric cancer:review of the Japanese experience[J]. Dig Surg, 2002, 19(5):333-339.
14. Nasu J, Nishina T, Hirasaki S, et al. Predictive factors of lymph node metastasis in patients with undifferentiated early gastric cancers[J]. J Clin Gastroenterol, 2006, 40(5):412-415.
15. 李小毅, 王常珺, 钟定荣, 等. 166例早期胃癌的诊治分析[J]. 中国医学科学院学报, 2011, 33(3):325-329.
16. Shinohara T, Ohyama S, Yamaguchi T, et al. Clinical value of multidetector row computed tomography in detecting lymph node metastasis of early gastric cancer[J]. Eur J Surg Oncol, 2005, 31(7):743-748.
17. Kwee RM, Kwee TC. Imaging in assessing lymph node status in gastric cancer[J]. Gastric Cancer, 2009, 12(1):6-22.
18. Tseng LJ, Mo LR, Tio TL, et al. Video-endoscopic ultrasonography in staging gastric carcinoma[J]. Hepatogastroenterology, 2000, 47(33):897-900.
19. 吴道宏, 吴本俨, 王孟薇, 等. 早期胃癌淋巴结转移多因素分析[J]. 解放军医学杂志, 2006, 31(10):941-943.
20. Kim DY, Joo JK, Ryu SY, et al. Factors related to lymph node metastasis and surgical strategy used to treat early gastric carcinoma[J]. World J Gastroenterol, 2004, 10(5):737-740.
21. 王戈, 张玉华, 吕谦, 等. 早期胃癌临床病理特征与淋巴结转移范围的关系[J]. 山东医药, 2008, 48(45):60-61.
22. Ohashi S, Segawa K, Okamura S, et al. The utility of endoscopic ultrasonography and endoscopy in the endoscopic mucosal resection of early gastric cancer[J]. Gut, 1999, 45(4):599-604.
23. Kwee RM, Kwee TC. The accuracy of endoscopic ultrasonography in differentiating mucosal from deeper gastric cancer[J]. Am J Gastroenterol, 2008, 103(7):1801-1809.
24. Yamamoto S, Nishida T, Kato M, et al. Evaluation of endoscopic ultrasound image quality is necessary in endosonographic assessment of early gastric cancer invasion depth[J]. Gastroenterol Res Pract, 2012:194530.
25. 张桂英, 王娟, 张晓梅, 等. 55例早期胃癌的临床与病理分析[J]. 中国内镜杂志, 2005, 11(12):1269-1272, 1276.
26. Gotoda T, Yanagisawa A, Sasako M, et al. Incidence of lymph node metastasis from early gastric cancer:estimation with a large number of cases at two large centers[J]. Gastric Cancer, 2000, 3(4):219-225.
27. 朱敏, 李明阳, 吴本俨. 早期胃癌内镜下切除术后复发的相关因素分析[J]. 中华内科杂志, 2011, 50(5):366-369.
28. Breslin NP, Thomson AB, Bailey RJ, et al. Gastric cancer and other endoscopic diagnoses in patients with benign dyspepsia[J]. Gut, 2000, 46(1):93-97.
29. 萧树东. 上海仁济医院消化内科专题讲座[M]. 郑州:郑州大学出版社, 2005:71-77.
30. 王一平. 早期胃癌的内镜治疗[J]. 实用肿瘤杂志, 2008, 23(2):104-106.

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Relationship between Clinicopathological Characteristics and Invasion Depth of Early Gastric Cancer

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