Testing and Analysis of Antigen and Antibody for Children's Immunization Program Targeted Diseases_West China Medical Journal

Authors：

 HEWei-feng , LIQiu-lian , LUOYue-juan

Yongning District Center for Disease Control and Prevention, Nanning, Guangxi 530200, P. R. China;

Corresponding author：

Keywords：

Children; Immune planning for the disease; Antigen; Antibody; Testing

DOI：

10.7507/1002-0179.20140629

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Objective To summarize the results of testing and analysis of antigen and antibody for diseases under the frame of children's immunization program, in order to know the effects of prevention and control of such diseases in this area. Methods A total of 150 children from each of the 5 communities or administrative villages in Yongning District of Nanning City were selected for our survey between January and December 2012. The 150 children were composed of 30 children (residents, 1-6 years old, 5 children from each different age group) randomly selected from each of the four directions (east, south, west and north) and the mid-area of each community or village. The serum samples were collected to analyze the existence of poliomyelitis antibody, measles antibody, hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (HBsAb), and diphtheria antibody. Results Among the 150 school-age children, antibody immune qualified rate was high for hepatitis B (HBV) antigen, in which the HBsAg immune qualified rate was 99.3%, and HBsAb immune qualified rate was 88.0%, showing no significant difference between boys and girls (P>0.05). All poliomyelitis Ⅰ, Ⅱ, and Ⅲ antibody positive rates reached 100.0%. Measles antibody test results were also satisfying for each age group, among whom the 2 and 3 year-olds reached a positive rate of the highest, 100%, and the 1, 4, 5, and 6 year-old children had a measles antibody positive rate of 96.0%, 84.0%, 88.0%, and 96.0%, respectively. The positive rate for diphtheria antibody was 100%. Conclusion The antibody and antigen detection and analysis results for the children's immune program targeted diseases are generally satisfying in this area. Especially, the prevention of poliomyelitis and diphtheria is the best. However, prevention of HBV and measles is not as good. Therefore, tracking immunization coverage, promoting public awareness on immune planning, actively participating in the vaccination of children should be enhanced for further disease prevention.

Citation： HEWei-feng, LIQiu-lian, LUOYue-juan. Testing and Analysis of Antigen and Antibody for Children's Immunization Program Targeted Diseases. West China Medical Journal, 2014, 29(11): 2092-2095. doi: 10.7507/1002-0179.20140629 Copy

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2.	申剑波, 张建中, 宋承声, 等. 西双版纳州1~15岁儿童脊灰、百日咳、白喉、破伤风、麻疹和乙肝抗体水平监测结果[J]. 职业与健康, 2012, 28(1):68-70.
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6.	侯新月, 李培勇. 玛纳斯县学龄前儿童乙肝表面抗体水平及表面抗原携带状况调查分析[J]. 中国卫生检验杂志, 2012, 22(9):2179-2180.
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9.	郑红茹, 刘青恋, 漆琪, 等. 2009-2011年四川省儿童免疫规划接种率抽样调查[J]. 预防医学情报杂志, 2014, 30(1):35-39.
10.	刘明禹, 杨霞, 周雅媗, 等. 2011年大连市高新区免疫规划疫苗接种率调查[J]. 预防医学情报杂志, 2012, 28(4):309-311.
11.	张胜利, 刘志霞, 曹胜文, 等. 兰州市红古区健康人群麻疹、脊髓灰质炎、风疹抗体水平监测分析[J]. 疾病预防控制通报, 2013, 28(2):64-65.
12.	蔡广俊, 韦阳, 李传道, 等. 临泉县2009年脊髓灰质炎和麻疹抗体水平调查分析[J]. 安徽预防医学杂志, 2011, 17(6):413-415.
13.	张俊杰. 共和县2010年-2012年儿童免疫规划4种疫苗免疫效果监测分析[J]. 青海医药杂志, 2014, 44(1):49-50.
14.	祁庆贺, 哈杰, 范学彬. 2012年蛟河市14周岁以下人群麻疹、脊髓灰质炎抗体水平的监测[J]. 中国生物制品学杂志, 2013, 26(12):1812-1813.
15.	张俊杰, 杨恒丹, 崔振铎, 等. 平顶山市2010年麻疹疫苗强化免疫活动的分析[J]. 中国生物制品学杂志, 2012, 25(12):1676-1679.
16.	曾鸿, 黄志雄, 张桂玲, 等. 佛山市南海区免疫规划儿童免疫水平的监测与分析[J]. 中国生物制品学杂志, 2012, 25(3):349-352.
17.	曾昭长, 曾雪霞, 莫少雄, 等. 海南省2010年儿童白喉疫苗免疫效果分析[J]. 中国公共卫生, 2012, 28(6):851.
18.	林宝妮, 方琼, 曹丽, 等. 2009-2011年福田区儿童免疫接种率调查[J]. 实用预防医学, 2012, 19(3):385-386.

1. 蔡琳, 方琼, 王永刚, 等. 2010年深圳市福田区儿童免疫接种率调查[J]. 职业与健康, 2012, 28(14):1761-1762, 1765.
2. 申剑波, 张建中, 宋承声, 等. 西双版纳州1~15岁儿童脊灰、百日咳、白喉、破伤风、麻疹和乙肝抗体水平监测结果[J]. 职业与健康, 2012, 28(1):68-70.
3. 窦俊娟. 天津市汉沽区儿童卡介苗免疫接种效果分析[J]. 职业与健康, 2011, 27(17):1987-1988.
4. 李凤英, 徐艺, 刘军礼, 等. 2009-2010年咸阳市健康儿童乙型肝炎抗体水平监测结果[J]. 职业与健康, 2012, 28(14):1742-1743.
5. 陈晓微, 胡斌. 永嘉县2006-2010年儿童免疫规划接种率调查[J]. 浙江预防医学, 2012, 24(4):30-31.
6. 侯新月, 李培勇. 玛纳斯县学龄前儿童乙肝表面抗体水平及表面抗原携带状况调查分析[J]. 中国卫生检验杂志, 2012, 22(9):2179-2180.
7. Murhekar MV, Bitragunta S, Hutin Y, et al. Immunization coverage and immunity to diphtheria and tetanus among children in Hyderabad, India[J]. J Infect, 2009, 58(3):191-196.
8. 吕惠荣, 郭金香. 2009-2011年信阳市麻疹实验室监测结果分析[J]. 职业与健康, 2012, 28(19):2383-2385.
9. 郑红茹, 刘青恋, 漆琪, 等. 2009-2011年四川省儿童免疫规划接种率抽样调查[J]. 预防医学情报杂志, 2014, 30(1):35-39.
10. 刘明禹, 杨霞, 周雅媗, 等. 2011年大连市高新区免疫规划疫苗接种率调查[J]. 预防医学情报杂志, 2012, 28(4):309-311.
11. 张胜利, 刘志霞, 曹胜文, 等. 兰州市红古区健康人群麻疹、脊髓灰质炎、风疹抗体水平监测分析[J]. 疾病预防控制通报, 2013, 28(2):64-65.
12. 蔡广俊, 韦阳, 李传道, 等. 临泉县2009年脊髓灰质炎和麻疹抗体水平调查分析[J]. 安徽预防医学杂志, 2011, 17(6):413-415.
13. 张俊杰. 共和县2010年-2012年儿童免疫规划4种疫苗免疫效果监测分析[J]. 青海医药杂志, 2014, 44(1):49-50.
14. 祁庆贺, 哈杰, 范学彬. 2012年蛟河市14周岁以下人群麻疹、脊髓灰质炎抗体水平的监测[J]. 中国生物制品学杂志, 2013, 26(12):1812-1813.
15. 张俊杰, 杨恒丹, 崔振铎, 等. 平顶山市2010年麻疹疫苗强化免疫活动的分析[J]. 中国生物制品学杂志, 2012, 25(12):1676-1679.
16. 曾鸿, 黄志雄, 张桂玲, 等. 佛山市南海区免疫规划儿童免疫水平的监测与分析[J]. 中国生物制品学杂志, 2012, 25(3):349-352.
17. 曾昭长, 曾雪霞, 莫少雄, 等. 海南省2010年儿童白喉疫苗免疫效果分析[J]. 中国公共卫生, 2012, 28(6):851.
18. 林宝妮, 方琼, 曹丽, 等. 2009-2011年福田区儿童免疫接种率调查[J]. 实用预防医学, 2012, 19(3):385-386.

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