白细胞介素-6表达与耳廓假性囊肿发病的关系_West China Medical Journal

Authors：

 戴林桐 ¹ , 徐德 ²

1. ;
2. ;

Corresponding author：

Keywords：

耳廓假性囊肿; 白细胞介素-6; 酶联免疫吸附试验; 免疫组织化学

DOI：

10.7507/1002-0179.20140634

Video：

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目的检测白细胞介素（IL）-6在耳廓假性囊肿（PCA）患者的血清、囊液、囊壁组织及正常耳廓软骨组织中的表达，探讨IL-6与PCA发病的关系。方法对2010年9月－2013年6月68例PCA患者血清及囊液和60例健康对照者血清分别利用酶联免疫吸附试验法测定IL-6水平，并选择10例PCA患者囊壁组织经免疫组织化学二抗-酶标多聚体（Envision）二步法检测囊壁组织中的IL-6。结果患者血清与健康者血清IL-6水平差异无统计学意义（P=0.388），患者囊液与健康者血清IL-6水平差异有统计学意义（P＜0.001），且患者囊液与患者血清IL-6水平差异也有统计学意义（P＜0.001）。免疫组织化学Envision法检测IL-6在正常软骨呈低表达，在PCA患者囊肿囊壁表达则明显增多（P＜0.01）。结论 IL-6高表达与PCA的发病原因具有相关性。

Citation： 戴林桐, 徐德. 白细胞介素-6表达与耳廓假性囊肿发病的关系. West China Medical Journal, 2014, 29(11): 2107-2109. doi: 10.7507/1002-0179.20140634 Copy

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13.	Li LJ, Elenitsas R, Bondi E. Off-center fold:noninflammatory, fluctuant swelling of the ear. Pseudocyst of auricle[J]. Arch Dermatol, 2001, 137(5):657-662.
14.	Miyamoto H, Oida M, Onuma S, et al. Steroid injection therapy for pseudocyst of the auricle[J]. Acta Derm Venereol, 1994, 74(2):140-142.
15.	Kim TY, Kim DH, Yoon MS. Treatment of a recurrent auricular pseudocyst with intralesional steroid injection and clip compression dressing[J]. Dermatol Surg, 2009, 35(2):245-247.
16.	Han A, Li LJ, Mirmirani P. Successful treatment of auricular pseudocyst using a surgical bolster:a case report and review of the literature[J]. Cutis, 2006, 77(2):102-104.
17.	Watanabe T, Hirano T, Suzuki M, et al. Role of interleukin-1 beta in a murine model of otitis media with effusion[J]. Ann Otol Rhinol Laryngol, 2001, 110(6):574-580.
18.	Yamamoto T, Yokoyama A, Umeda T. Cytokine profile of bilateral pseudocyst of the auricle[J]. Acta Derm Venereol, 1996, 76(1):92-93.
19.	Mohtai M, Gupta MK, Donlon B, et al. Expression of interleukin-6 in osteoarthritic chondrocytes and effects of fluid-induced shear on this expression in normal human chondrocytes in vitro[J]. J Orthop Res, 1996, 14(1):67-73.

1. Engel D. Pseudocyst of the auricle in Chinese[J]. Arch Otolaryngol, 1966, 83(3):197-202.
2. Choi S, Lam KH, Chan KW, et al. Endochondral pseudocyst of the auricle in Chinese[J]. Arch Otolaryngol, 1984, 110(12):792-796.
3. Tan BY. Hsu PP. Auricular pseudocyst in the tropics:a multi-racial Singapore experience[J]. J Laryngol Otol, 2004, 118(3):185-188.
4. Ming LC, Hong GY, Shuen CS, et al. Pseudocyst of the auricle:A histologic perspective[J]. Laryngoscope, 2004, 114(7):1281-1284.
5. Lazar RH, Heffner DK, Hughes GB, et al. Pseudocyst of the auricle:a review of 21 cases[J]. Otolaryngol Head Neck Surg, 1986, 94(3):360-361.
6. Cohen PR, Grossman ME. Pseudocyst of the auricle. Case report and world literature review[J]. Arch Otolaryngol Head Neck Surg, 1990, 116(10):1202-1204.
7. Santos VB, Polisar IA, Ruffy ML. Bilateral pseudocysts of the auricle in a female[J]. Ann Otol Rhinol Laryngol, 1974, 83(1):9-11.
8. Heffner DK, Hyam VJ. Cystic chondromalacia (endochondral pseudocyst) of the auricle[J]. Arch Pathol Lab Med, 1986, 110(8):740-743.
9. Mohammed E, Jakubikova J, Plank L, et al. Bilateral pseudocysts of the auricle[J]. Bratisl Lek Listy, 2007, 108(10/11):470-473.
10. Miyamoto H, Okajima M, Takahashi I. Lactate dehydrogenase isozymes in and intralesional steroid injection therapy for pseudocyst of the auricle[J]. Int J Dermatol, 2001, 40(6):380-384.
11. Kopera D, Soyer HP, Smolle J, et al. "Pseudocyst of the auricle", othematoma and otoseroma:three faces of the same coin?[J]. Eur J Dermatol, 2000, 10(6):451-454.
12. 陈乾美, 费樱, 赵田芬, 等. 耳廓假性囊肿与机体免疫功能的关系[J].临床耳鼻咽喉科杂志, 2001, 15(7):304-305.
13. Li LJ, Elenitsas R, Bondi E. Off-center fold:noninflammatory, fluctuant swelling of the ear. Pseudocyst of auricle[J]. Arch Dermatol, 2001, 137(5):657-662.
14. Miyamoto H, Oida M, Onuma S, et al. Steroid injection therapy for pseudocyst of the auricle[J]. Acta Derm Venereol, 1994, 74(2):140-142.
15. Kim TY, Kim DH, Yoon MS. Treatment of a recurrent auricular pseudocyst with intralesional steroid injection and clip compression dressing[J]. Dermatol Surg, 2009, 35(2):245-247.
16. Han A, Li LJ, Mirmirani P. Successful treatment of auricular pseudocyst using a surgical bolster:a case report and review of the literature[J]. Cutis, 2006, 77(2):102-104.
17. Watanabe T, Hirano T, Suzuki M, et al. Role of interleukin-1 beta in a murine model of otitis media with effusion[J]. Ann Otol Rhinol Laryngol, 2001, 110(6):574-580.
18. Yamamoto T, Yokoyama A, Umeda T. Cytokine profile of bilateral pseudocyst of the auricle[J]. Acta Derm Venereol, 1996, 76(1):92-93.
19. Mohtai M, Gupta MK, Donlon B, et al. Expression of interleukin-6 in osteoarthritic chondrocytes and effects of fluid-induced shear on this expression in normal human chondrocytes in vitro[J]. J Orthop Res, 1996, 14(1):67-73.

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白细胞介素-6表达与耳廓假性囊肿发病的关系

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