Clinical Review and Analysis of Sodium Chlorophyllin in the Treatment of Geriatric Oncology-related Anemia_West China Medical Journal

Authors：

 CHENHong ¹ ,  HELang ² , ZENGEn-quan ³

1. Department of Traditional Chinese Medicine, Affiliated Hospital;North Sichuan Medical College, Nanchong, Sichuan 637007, P. R. China;
2. Department of Oncology, the Second Clinical College;North Sichuan Medical College, Nanchong, Sichuan 637007, P. R. China;
3. Department of Forensic Medicine;North Sichuan Medical College, Nanchong, Sichuan 637007, P. R. China;

Corresponding author：

HELang, Email: helang729@163.com

Keywords：

Sodium chlorophyllin; Oncology-related anemia; Elderly

DOI：

10.7507/1002-0179.20140671

Video：

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Objective To analyze the clinical effect of sodium chlorophyllin in the treatment of geriatric oncology-related anemia and its significance. Methods We retrospectively analyzed the clinical data of elderly cancer patients with similar treatment background between December 2011 and February 2013, and the patients were divided into sodium chlorophyllin treatment group and no special treatment group. Then, parallel comparative study was carried out for anemia-related indexes and scores of quality of life. Results Hemoglobin, red blood cells and quality of life of sodium chlorophyllin treatment group were improved after treatment, and these indexes were also better than those in the no special treatment group (P<0.05). Conclusion Sodium chlorophyllin can ameliorate anemia in elderly patients with oncology-related anemia, which is worthy of being popularized.

Citation： CHENHong, HELang, ZENGEn-quan. Clinical Review and Analysis of Sodium Chlorophyllin in the Treatment of Geriatric Oncology-related Anemia. West China Medical Journal, 2014, 29(12): 2220-2222. doi: 10.7507/1002-0179.20140671 Copy

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9.	Streja E, Kovesdy CP, Greenland S, et al. Erythropoietin, iron depletion, and relative thrombocytosis:a possible explanation for hemoglobin-survival paradox in hemodialysis[J]. Am J Kidney Dis, 2008, 52(4):727-736.
10.	Ludwig H, Fritz E, Leitgeb C, et al. Prediction of response to erythropoietin treatment in chronic anemia of cancer[J]. Blood, 1994, 84(4):1056-1063.
11.	Leyland-Jones B, BEST investigators and Study Group. Breast cancer trial with erythro poietin terminated unexpcetedly[J]. Lancet Oncol, 2003, 4(8):459.
12.	Henke M, Laszig R, Rübe C, et al. Erythropoietin to treat head and neek cancer patients with anaemiaun undergoing radiotherapy:randomised, double-blind, placebo-controlled trial[J]. Lancet, 2003, 362(9392):1255-1260.
13.	Leyland-Jones B. Evidence for erythropoietin as a molecular targeting agent[J]. Semin Oncol, 2002, 29(3 Suppl 11):145-154.
14.	Yasuda Y, Fujita Y, Masuda S, et al. Erythropoietin is involved in growth and angiogenesis in malignant tumours of female reproductive organs[J]. Carcinogenesis, 2002, 23(11):1797-1805.
15.	吴一龙. 美国FDA警示:癌症患者需慎用红细胞生成素[J]. 循证医学, 2007, 7(l):202.
16.	陈红, 曾恩泉. 叶绿酸防治肿瘤的作用及其机制研究进展[J]. 中华肿瘤防治杂志, 2010, 17(16):1315-1318.
17.	柯有甫, 魏克民, 郑军献, 等. 生血宁治疗缺铁性贫血的临床研究[J]. 中国中西医结合杂志, 2004, 24(10):893-896.

1. Caro JJ, Salas M, Ward A, et al. Anemia as an independent prognostic factor for survival in patients with cancer:a systemic, qualitative review[J]. Cancer, 2001, 91(12):2214-2221.
2. Ludwig H, Strasser K. Symptomatology of anemia[J]. Semin Oncol, 2001, 28(2 Suppl 8):7-14.
3. Tchekmedyian NS. Anemia in cancer patients:significance, epidemiology, and current therapy[J]. Oncology (Williston Park), 2002, 16(9 Suppl 10):17-24.
4. 周际昌. 实用肿瘤内科治疗[M]. 北京:北京科学技术出版社, 2013:444.
5. 叶任高, 陆再英. 内科学[M]. 6版. 北京:人民卫生出版社, 2004:558.
6. Spivak JL. The anaemia of cancer:death by a thousand cuts[J]. Nat Rev Cancer, 2005, 5(7):543-555.
7. Spivak JL. Iron and the anemia of chronic disease[J]. Oncology (Williston Park), 2002, 16(9 Suppl 10):25-33.
8. Besarab A, Hörl WH, Silverberg D. Iron metabolism, iron deficiency, thrombocytosis, and the cardiorenal anemia syndrome[J]. Oncologist, 2009, 14(Suppl 1):22-33.
9. Streja E, Kovesdy CP, Greenland S, et al. Erythropoietin, iron depletion, and relative thrombocytosis:a possible explanation for hemoglobin-survival paradox in hemodialysis[J]. Am J Kidney Dis, 2008, 52(4):727-736.
10. Ludwig H, Fritz E, Leitgeb C, et al. Prediction of response to erythropoietin treatment in chronic anemia of cancer[J]. Blood, 1994, 84(4):1056-1063.
11. Leyland-Jones B, BEST investigators and Study Group. Breast cancer trial with erythro poietin terminated unexpcetedly[J]. Lancet Oncol, 2003, 4(8):459.
12. Henke M, Laszig R, Rübe C, et al. Erythropoietin to treat head and neek cancer patients with anaemiaun undergoing radiotherapy:randomised, double-blind, placebo-controlled trial[J]. Lancet, 2003, 362(9392):1255-1260.
13. Leyland-Jones B. Evidence for erythropoietin as a molecular targeting agent[J]. Semin Oncol, 2002, 29(3 Suppl 11):145-154.
14. Yasuda Y, Fujita Y, Masuda S, et al. Erythropoietin is involved in growth and angiogenesis in malignant tumours of female reproductive organs[J]. Carcinogenesis, 2002, 23(11):1797-1805.
15. 吴一龙. 美国FDA警示:癌症患者需慎用红细胞生成素[J]. 循证医学, 2007, 7(l):202.
16. 陈红, 曾恩泉. 叶绿酸防治肿瘤的作用及其机制研究进展[J]. 中华肿瘤防治杂志, 2010, 17(16):1315-1318.
17. 柯有甫, 魏克民, 郑军献, 等. 生血宁治疗缺铁性贫血的临床研究[J]. 中国中西医结合杂志, 2004, 24(10):893-896.

West China Medical Journal

Clinical Review and Analysis of Sodium Chlorophyllin in the Treatment of Geriatric Oncology-related Anemia

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