Clinical Analysis of Plasma Amino Acids and Trace Elements in Breast Cancer Patients_West China Medical Journal

Authors：

 GAOQing-shuang ,  GAOCui-hong , LIUShu-ping

Clinical Laboratory, Tangshan Maternal and Child Health Hospital, Tangshan, Hebei 063000, P. R. China;

Corresponding author：

GAOCui-hong, Email: tsgaocan@163.com

Keywords：

Breast cancer; Trace elements; Amino acids

DOI：

10.7507/1002-0179.20140672

Video：

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Objective To understand the function of trace element and amino acids detection in early diagnosis of breast cancer, and explore the correlation between plasma amino acid and trace element changes. Methods Fifty-five patients with breast cancer and 50 normal controls were included in our study from May 2012 to June 2013. Trace elements were detected by atomic absorption spectrophotometer, and the level of amino acids was detected by Hitachi L-8900 amino acids analyzer. Then, we analyzed the correlation between the two indexes. Results Compared with the normal controls, breast cancer patients had a higher level of Cu and Fe (P<0.05), and a lower level of Zn (P<0.05). Seven kinds of amino acids had significant changes (P<0.05), including three kinds of increased amino acids, and four reduced. Amino acids and trace element correlation analysis showed that Mg was negatively correlated with Leu, Tyr, Lys, and His; and Ca was negatively correlated with Lys and His. Conclusion There are many kinds of changes of plasma amino acids and trace elements in breast cancer patients. Serum trace element and amino acids detection in patients with breast cancer are helpful in the severity judgment and regimen design.

Citation： GAOQing-shuang, GAOCui-hong, LIUShu-ping. Clinical Analysis of Plasma Amino Acids and Trace Elements in Breast Cancer Patients. West China Medical Journal, 2014, 29(12): 2223-2225. doi: 10.7507/1002-0179.20140672 Copy

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12.	Bozzetti F, Gavazzi C, Cozzaglio L, et al. Total parenteral nutrition and tumor growth in malnourished patients with gastric cancer[J]. Tumori, 1999, 85(3):163-166.
13.	Tsukishiro T, Shimizu Y, Higuchi K, et al. Effect of branched-chain amino acids on the composition and cytolytic activity of liver-associated lymphocytes in rats[J]. J Gastroenterol Hepatol, 2000, 15(8):849-859.
14.	欧敬民, 张一楚, 陈大伟, 等. 蛋氨酸对肝癌细胞生长影响的实验研究[J]. 中国临床营养杂志, 2002, 10(3):172-174.
15.	Heys SD, Segar A, Payne S, et al. Dietary supplementation with L-arginine:modulation of tumour-infiltrating lymphocytes in patients with colorectal cancer[J]. Br J Surg, 1997, 84(2):238-241.

1. 曾昭华, 曾雪萍. 中国乳腺癌与土壤环境中化学元素的相关性研究[J]. 江苏环境科技, 1999, 12(3):1-3.
2. 李桂芝, 郭健, 李萍, 等. 恶性肿瘤患者血清微量元素水平的变化[J]. 潍坊医学院学报, 2003, 25(1):66-67.
3. 陆东东. 微量元素与肝癌[J]. 湖北预防医学杂志, 2000, 11(1):11-12.
4. 戴冬梅, 于瑞珍. 乳腺癌患者治疗前后微量元素含量的变化[J]. 临床检验杂志, 2005, 23(6):461.
5. Kuo HW, Chen SF, Wu CC, et al. Serum and tissue trace elements in patients with breast cancer in Taiwan[J]. Biol Trace Elem Res, 2002, 89(1):1-11.
6. 黄家琛. 微量元素铜、锌与肿瘤[J]. 实用癌症杂志, 1992, 7(1):55-57.
7. Wu HD, Chou SY, Chen DR, et al. Differentiation of serum levels of trance elements in normal and malignant breast patients[J].Biol Trance Elem Res, 2006, 113(1):9-18.
8. 武力, 马宇光. 微量元素与乳腺癌的临床研究[J]. 现代肿瘤医学, 2008, 16(5):745-746.
9. 李卫华. 临汾市正常人血清Cu、Fe、Zn含量分析[J]. 预防医学情报杂志, 2000, 16(2):161.
10. 王俊雅, 尹颂超. 原发性肝癌患者血清多种微量元素、铜蓝蛋白、T淋巴细胞测定与分析[J]. 广东微量元素科学, 1994, 1(3):32-37.
11. 杨晶, 陆伟, 邹满意, 等. 荷肝癌小鼠血浆和肿瘤组织游离氨基酸代谢变化及其与肿瘤体积相关性研究[J]. 实用肝脏病杂志, 2006, 9(1):22-24.
12. Bozzetti F, Gavazzi C, Cozzaglio L, et al. Total parenteral nutrition and tumor growth in malnourished patients with gastric cancer[J]. Tumori, 1999, 85(3):163-166.
13. Tsukishiro T, Shimizu Y, Higuchi K, et al. Effect of branched-chain amino acids on the composition and cytolytic activity of liver-associated lymphocytes in rats[J]. J Gastroenterol Hepatol, 2000, 15(8):849-859.
14. 欧敬民, 张一楚, 陈大伟, 等. 蛋氨酸对肝癌细胞生长影响的实验研究[J]. 中国临床营养杂志, 2002, 10(3):172-174.
15. Heys SD, Segar A, Payne S, et al. Dietary supplementation with L-arginine:modulation of tumour-infiltrating lymphocytes in patients with colorectal cancer[J]. Br J Surg, 1997, 84(2):238-241.

West China Medical Journal

Clinical Analysis of Plasma Amino Acids and Trace Elements in Breast Cancer Patients

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