Assessment of Liver Perfusion in Hepatitis Pregnant Women by Three-dimensinal-sonography Power Doppler Vascular Indexes_West China Medical Journal

Authors：

 DANMin ¹ , HANZhen ² , WANGJuan ¹ ,  AIHong ¹

1. Department of Ultrasound;the First Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P. R. China;
2. Department of Gynecology & Obstetrics;the First Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P. R. China;

Corresponding author：

AIHong, Email: Hong-ai@163.com

Keywords：

Hepatitis; Pregnant woman; Vascular index; Three-dimensional power Doppler; Three-dimensional color power angiography

DOI：

10.7507/1002-0179.20140684

Video：

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Objective To evaluate liver perfusion in pregnant women with hepatitis between 13 and 41 weeks of gestation by three-dimensional color power Doppler angiography (3D-CPA) vascular indexes. Methods This study involved 73 pregnant women with hepatitis and 44 healthy pregnant women who had the pregnancy examination between February 2012 and June 2013. We sampled in the area which was near the right lobe of the pregnant women liver's portal vein branch, and obtained the vascularization index (VI), flow index (FI) and vascularization flow index (VFI) via the virtual organ computer-aided analysis (VOCAL) method. Then, we compared the liver perfusion differences between the pregnant women with hepatitis and healthy pregnant women. Results The hepatic flow indexes obtained by 3D-CPA were significantly different between the HBV-DNA viral load and the control groups. The cutoff values of the three vascular indexes of patients with hepatitis with HBV-DNA viral load and the healthy pregnant women were respectively VI=8.760 (P<3×10^-4); FI=22.180 (P<6×10^-7); and VFI=1.575 (P<3×10^-5). Conclusion Application of the 3D-CPA on liver perfusion may differentiate pregnant women with hepatitis B from normal ones, thus offer a support for clinical prevention and treatment for pregnant women with hepatitis B.

Citation： DANMin, HANZhen, WANGJuan, AIHong. Assessment of Liver Perfusion in Hepatitis Pregnant Women by Three-dimensinal-sonography Power Doppler Vascular Indexes. West China Medical Journal, 2014, 29(12): 2263-2266. doi: 10.7507/1002-0179.20140684 Copy

1.	Rubin JM, Bude RO, Carson PL, et al. Power Doppler US:a potentially useful alternative to mean frequency-based color Doppler US[J]. Radiology, 1994, 190(3):853-856.
2.	Pairleitner H, Steiner H, Hasenoehrl G, et al. Three-dimensional power Doppler sonography:imaging and quantifying blood flow and vascularization[J]. Ultrasound Obstet Gynecol, 1999, 14(2):139-143.
3.	Merce LT, Barco MJ, Bau S, et al. Assessment of placental vascularization by three-dimensional power Doppler "vascular biopsy" in normal pregnancies[J]. Croat Med J, 2005, 46(5):765-771.
4.	Lavanchy D. Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures[J]. J Viral Hepat, 2004, 11(2):97-107.
5.	Ni YH, Chang MH, Huang LM, et al. Hepatitis B virus infection in children and adolescents in a hyperendemic area:15 years after mass hepatitis B vaccination[J]. Ann Intern Med, 2001, 135(9):796-800.
6.	Iwamoto K. Estimation of gestational age with ultrasonographic measurement of the fetus in each trimester[J]. Nihon Sanka Fujinka Gakkai Zasshi, 1983, 35(12):2330-2338.
7.	Kim SU, Lee JH, Kim DY, et al. Prediction of liver-related events using fibroscan in chronic hepatitis B patients showing advanced liver fibrosis[J]. PLoS One, 2012, 7(5):e36676.
8.	Apgar V. A proposal for a new method of evaluation of the newborn infant[J]. Curr Res Anesth Analg, 1953, 32(4):260-267.
9.	Van Heijst ML, Van Roosmalen G, Keirse MJ. Classifying meconium-stained liquor:is it feasible?[J]. Birth, 1995, 22(4):191-195.
10.	Degertekin B, Lok AS. When to start and stop hepatitis B treatment:can one set of criteria apply to all patients regardless of age at infection?[J]. Ann Intern Med, 2007, 147(1):62-64.
11.	Nakai A, Sekiya I, Oya A, et al. Assessment of the hepatic arterial and portal venous blood flows during pregnancy with Doppler ultrasonography[J]. Arch Gynecol Obstet, 2002, 266(1):25-29.
12.	Raine-Fenning NJ, Nordin NM, Ramnarine KV, et al. Determining the relationship between three-dimensional power Doppler data and true blood flow characteristics:an in-vitro flow phantom experiment[J]. Ultrasound Obstet Gynecol, 2008, 32(4):540-550.
13.	Han GR, Xu CL, Zhao W, et al. Management of chronic hepatitis B in pregnancy[J]. World J Gastroenterol, 2012, 18(33):4517-4521.
14.	Su ZZ, Shan H, Ke WM, et al. Portalsystemic hemodynamic changes in chronic severe hepatitis B:an ultrasonographic study[J]. World J Gastroenterol, 2008, 14(5):795-799.
15.	Ter Borg MJ, Leemans WF, De Man RA, et al. Exacerbation of chronic hepatitis B infection after delivery[J]. J Viral Hepat, 2008, 15(1):37-41.

1. Rubin JM, Bude RO, Carson PL, et al. Power Doppler US:a potentially useful alternative to mean frequency-based color Doppler US[J]. Radiology, 1994, 190(3):853-856.
2. Pairleitner H, Steiner H, Hasenoehrl G, et al. Three-dimensional power Doppler sonography:imaging and quantifying blood flow and vascularization[J]. Ultrasound Obstet Gynecol, 1999, 14(2):139-143.
3. Merce LT, Barco MJ, Bau S, et al. Assessment of placental vascularization by three-dimensional power Doppler "vascular biopsy" in normal pregnancies[J]. Croat Med J, 2005, 46(5):765-771.
4. Lavanchy D. Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures[J]. J Viral Hepat, 2004, 11(2):97-107.
5. Ni YH, Chang MH, Huang LM, et al. Hepatitis B virus infection in children and adolescents in a hyperendemic area:15 years after mass hepatitis B vaccination[J]. Ann Intern Med, 2001, 135(9):796-800.
6. Iwamoto K. Estimation of gestational age with ultrasonographic measurement of the fetus in each trimester[J]. Nihon Sanka Fujinka Gakkai Zasshi, 1983, 35(12):2330-2338.
7. Kim SU, Lee JH, Kim DY, et al. Prediction of liver-related events using fibroscan in chronic hepatitis B patients showing advanced liver fibrosis[J]. PLoS One, 2012, 7(5):e36676.
8. Apgar V. A proposal for a new method of evaluation of the newborn infant[J]. Curr Res Anesth Analg, 1953, 32(4):260-267.
9. Van Heijst ML, Van Roosmalen G, Keirse MJ. Classifying meconium-stained liquor:is it feasible?[J]. Birth, 1995, 22(4):191-195.
10. Degertekin B, Lok AS. When to start and stop hepatitis B treatment:can one set of criteria apply to all patients regardless of age at infection?[J]. Ann Intern Med, 2007, 147(1):62-64.
11. Nakai A, Sekiya I, Oya A, et al. Assessment of the hepatic arterial and portal venous blood flows during pregnancy with Doppler ultrasonography[J]. Arch Gynecol Obstet, 2002, 266(1):25-29.
12. Raine-Fenning NJ, Nordin NM, Ramnarine KV, et al. Determining the relationship between three-dimensional power Doppler data and true blood flow characteristics:an in-vitro flow phantom experiment[J]. Ultrasound Obstet Gynecol, 2008, 32(4):540-550.
13. Han GR, Xu CL, Zhao W, et al. Management of chronic hepatitis B in pregnancy[J]. World J Gastroenterol, 2012, 18(33):4517-4521.
14. Su ZZ, Shan H, Ke WM, et al. Portalsystemic hemodynamic changes in chronic severe hepatitis B:an ultrasonographic study[J]. World J Gastroenterol, 2008, 14(5):795-799.
15. Ter Borg MJ, Leemans WF, De Man RA, et al. Exacerbation of chronic hepatitis B infection after delivery[J]. J Viral Hepat, 2008, 15(1):37-41.

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Assessment of Liver Perfusion in Hepatitis Pregnant Women by Three-dimensinal-sonography Power Doppler Vascular Indexes

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