The Effect of Bacillus Calmette-guerin Polysaccharides Nucleic Acid on Humoral Immunity, Interleukin-8 and Tumor Necrosis Factor-αin Patients with Chronic Obstructive Pulmonary Disease_West China Medical Journal

Authors：

 XULin , ZHANGCheng , YEXian-wei , LIUWei-jia , YUHong ,  ZHANGXiang-yan

Department of Respiratory and Critical Care Medicine, Guizhou Provincial People's Hospital, Guiyang, Guizhou 550002, P. R. China;

Corresponding author：

ZHANGXiang-yan, Email: zxy35762@126.com

Keywords：

Chronic obstructive pulmonary disease; Bacillus calmette-guerin polysaccharides nucleic acid; Humoral immunity; Tumor necrosis factor-α; Interleukin

DOI：

10.7507/1002-0179.20150001

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To study the effect of bacillus calmette-guerin(BCG) polysaccharides nucleic acid on humoral immunity, interleukin(IL)-8 and tumor necrosis factor(TNF)-αin patients with chronic obstructive pulmonary disease (COPD), and to provide theoretical basis for evaluation of its clinical effectiveness. Methods Thirty hospitalized elderly patients with AECOPD treated from March 2012 to February 2013 and 60 patients with stable COPD treated at the same time were randomly selected as the study subjects. At the same time, 60 healthy people from our physical examination center were also enrolled and divided into two groups:the elderly healthy group (n=30) and nonelderly healthy group (n=30). IL-8, TNF-α, IgA, IgG and IgM levels were determined. The stable COPD group was randomly divided into two groups:group A (n=30) and group B (n=30). Group A received only routine therapy; group B received both routine therapy and intramuscular injection of BCG polysaccharide nucleic acid (0.35 mg/day, three times a week). IL-8, TNF-α, IgA, IgG and IgM levels in peripheral blood were investigated before treatment and one month later. Results There were no statistically significant differences in IL-8 and TNF-αlevels in peripheral blood between elderly healthy group and nonelderly healthy group (P > 0.05), but the IgA, IgG and IgM levels were lower in the nonelderly healthy group than in the elderly healthy group (P < 0.05). Compared with the elderly healthy grouping, IgG and IgM levels were significantly lower in AECOPD group and stable COPD group (P < 0.05), but IL-8 and TNF-αlevels were significantly higher (P > 0.05). There were statistically significant differences in TNF-α, IgA, IgG and IgM levels between group B before and after treatment (P > 0.05). Conclusions Human's humoral immunity decreases with age. Elderly COPD patients are at high risks of abnormal immunologic function, particularly in the acute exacerbation period. The BCG polysaccharides nucleic acid can strength patients' humoral immunity. The levels of inflammatory cytokines can be reduced using BCG polysaccharides nucleic acid.

Citation： XULin, ZHANGCheng, YEXian-wei, LIUWei-jia, YUHong, ZHANGXiang-yan. The Effect of Bacillus Calmette-guerin Polysaccharides Nucleic Acid on Humoral Immunity, Interleukin-8 and Tumor Necrosis Factor-αin Patients with Chronic Obstructive Pulmonary Disease. West China Medical Journal, 2015, 30(1): 1-5. doi: 10.7507/1002-0179.20150001 Copy

1.	冉丕鑫.从我国《慢性阻塞性肺疾病诊治规范》的修订看COPD的定义及诊断研究进展[J].实用医学杂志, 2002, 18(7):682-683.
2.	中华医学会重症医学分会.慢性阻塞性肺疾病急性加重患者的治疗指南(2007)[J].中国危重病急救医学, 2007, 19(9):513-518.
3.	胡瑞成, 戴爱国.慢性阻塞性肺疾病急性加重期的治疗[J].内科急危重症杂志, 2006, 12(2):88-91.
4.	中华医学会呼吸病学分会慢性阻塞性肺疾病学组.第二届全国慢性阻塞性肺疾病与第八届全国肺心病学术会议纪要[J].中华结核与呼吸杂志, 2002, 25(8):504-506.
5.	朱渊红, 王新华, 王真, 等. 60例慢性阻塞性肺疾病细胞免疫功能的临床观察[J].浙江实用医学, 2005, 10(5):321-322.
6.	刘玉春, 王静波, 林士军, 等.慢性阻塞性肺疾病患者IL-2、slL-2R表达的研究[J].中国基层医药, 2007, 14(1):25-30.
7.	Cosio MG, Majo J, Cosio MG, et al. Inflammation of the airways and lung parenchy ma in COPD:role of T cells[J]. Chest, 2010, 121(Suppl 5):160S-165S.
8.	黄奕江, 冯夏, 郑万川.慢性阻塞性肺病患者免疫功能的研究[J].临床内科杂志, 1997, 14(1):30-31.
9.	中华人民共和国卫生部.慢性阻塞性肺疾病(COPD)诊治规范(草案)[J].中国实用内科杂志, 1998, 20(5):53-57.
10.	张湘燕, 张程, 王娜, 等.卡介菌多糖核酸对慢性阻塞性肺疾病患者免疫功能的影响[J].中国药房, 2011, 36(36):3394-3395.
11.	Majo J, Ghezzo H, Cosio MG, et al. Lymphocyte population and apoptosis in the lungs of smokers and their relation to emphysema[J]. Eur Respir, 2010, 37(9):946-950.
12.	时宏珍.支气管哮喘患儿细胞因子的变化[J].中国儿科杂志, 1997, 35(2):84-86.
13.	龚非力.医学免疫学[M].北京:科学出版社, 2000:126-128.
14.	余传霖.现代医学免疫学[M].上海:上海医科大学出版社, 1998:1112-1124.
15.	Shaughnessy TC, Ansari TW, Bames NG, et al. Inflammation in bronchial biopsies of subjects with chronic bronchitis inverse relationship of CD8+T lymphocytes with FEV1[J]. Am J Respir Crit Care Med, 1997, 155(3):852-853.
16.	中华医学会呼吸病学分会慢性阻塞性肺疾病学组.全国慢性阻塞性肺疾病与第九届全国肺心病学术会议纪要[J].中华结核与呼吸杂志, 2004, 5(4):504-510.
17.	吴达会, 丁毅鹏, 林莉, 等.慢性肺心病T淋巴细胞亚群、NK细胞活性及红细胞免疫功能的初步观察[J].海南医学, 2000, 11(2):34.
18.	Priecto A, Reyes E, Bernstein ED, et al. Defective killer and phagocytic activities in chronic obstructive pulmonary disease are restored by glycophosphopeptical (inmunoferÓn)[J]. Am J Respir Crit Care Med, 2001, 163(7):1578-1583.
19.	Hogg JC, Chu F, Utokaparch S, et al. The Nature of small-airway obstruction in chronic obstructive pulmonary disease[J]. N Engl J Med, 2004, 350(26):2645-2653.
20.	Van DB, Postma DS, Brandsma CA, et al. Cigarette smoke-induced emphysema:a role for the B cell[J]. Am J Respir Crit Care Med, 2006, 173(7):751-758.
21.	Feghali-Bostwick CA, Gadgil AS, Otterbein LE, et al. Autoantibodies in patients with chronic obstructive pulmonary disease[J]. Am J Respir Crit Care Med, 2008, 177(2):156-163.
22.	于云芝, 漆自立, 刘跃建, 等.卡介菌多糖核酸对慢性阻塞性肺病免疫调节及临床疗效的观察[J].四川医学, 2001, 22(6):529-530.
23.	林恩尧, 王世珍, 刘冰洁, 等.卡介菌提取物调节慢性支气管炎免疫功能效果的观察[J].中华结核和呼吸杂志, 1987, 10(1):41-43.

1. 冉丕鑫.从我国《慢性阻塞性肺疾病诊治规范》的修订看COPD的定义及诊断研究进展[J].实用医学杂志, 2002, 18(7):682-683.
2. 中华医学会重症医学分会.慢性阻塞性肺疾病急性加重患者的治疗指南(2007)[J].中国危重病急救医学, 2007, 19(9):513-518.
3. 胡瑞成, 戴爱国.慢性阻塞性肺疾病急性加重期的治疗[J].内科急危重症杂志, 2006, 12(2):88-91.
4. 中华医学会呼吸病学分会慢性阻塞性肺疾病学组.第二届全国慢性阻塞性肺疾病与第八届全国肺心病学术会议纪要[J].中华结核与呼吸杂志, 2002, 25(8):504-506.
5. 朱渊红, 王新华, 王真, 等. 60例慢性阻塞性肺疾病细胞免疫功能的临床观察[J].浙江实用医学, 2005, 10(5):321-322.
6. 刘玉春, 王静波, 林士军, 等.慢性阻塞性肺疾病患者IL-2、slL-2R表达的研究[J].中国基层医药, 2007, 14(1):25-30.
7. Cosio MG, Majo J, Cosio MG, et al. Inflammation of the airways and lung parenchy ma in COPD:role of T cells[J]. Chest, 2010, 121(Suppl 5):160S-165S.
8. 黄奕江, 冯夏, 郑万川.慢性阻塞性肺病患者免疫功能的研究[J].临床内科杂志, 1997, 14(1):30-31.
9. 中华人民共和国卫生部.慢性阻塞性肺疾病(COPD)诊治规范(草案)[J].中国实用内科杂志, 1998, 20(5):53-57.
10. 张湘燕, 张程, 王娜, 等.卡介菌多糖核酸对慢性阻塞性肺疾病患者免疫功能的影响[J].中国药房, 2011, 36(36):3394-3395.
11. Majo J, Ghezzo H, Cosio MG, et al. Lymphocyte population and apoptosis in the lungs of smokers and their relation to emphysema[J]. Eur Respir, 2010, 37(9):946-950.
12. 时宏珍.支气管哮喘患儿细胞因子的变化[J].中国儿科杂志, 1997, 35(2):84-86.
13. 龚非力.医学免疫学[M].北京:科学出版社, 2000:126-128.
14. 余传霖.现代医学免疫学[M].上海:上海医科大学出版社, 1998:1112-1124.
15. Shaughnessy TC, Ansari TW, Bames NG, et al. Inflammation in bronchial biopsies of subjects with chronic bronchitis inverse relationship of CD8+T lymphocytes with FEV1[J]. Am J Respir Crit Care Med, 1997, 155(3):852-853.
16. 中华医学会呼吸病学分会慢性阻塞性肺疾病学组.全国慢性阻塞性肺疾病与第九届全国肺心病学术会议纪要[J].中华结核与呼吸杂志, 2004, 5(4):504-510.
17. 吴达会, 丁毅鹏, 林莉, 等.慢性肺心病T淋巴细胞亚群、NK细胞活性及红细胞免疫功能的初步观察[J].海南医学, 2000, 11(2):34.
18. Priecto A, Reyes E, Bernstein ED, et al. Defective killer and phagocytic activities in chronic obstructive pulmonary disease are restored by glycophosphopeptical (inmunoferÓn)[J]. Am J Respir Crit Care Med, 2001, 163(7):1578-1583.
19. Hogg JC, Chu F, Utokaparch S, et al. The Nature of small-airway obstruction in chronic obstructive pulmonary disease[J]. N Engl J Med, 2004, 350(26):2645-2653.
20. Van DB, Postma DS, Brandsma CA, et al. Cigarette smoke-induced emphysema:a role for the B cell[J]. Am J Respir Crit Care Med, 2006, 173(7):751-758.
21. Feghali-Bostwick CA, Gadgil AS, Otterbein LE, et al. Autoantibodies in patients with chronic obstructive pulmonary disease[J]. Am J Respir Crit Care Med, 2008, 177(2):156-163.
22. 于云芝, 漆自立, 刘跃建, 等.卡介菌多糖核酸对慢性阻塞性肺病免疫调节及临床疗效的观察[J].四川医学, 2001, 22(6):529-530.
23. 林恩尧, 王世珍, 刘冰洁, 等.卡介菌提取物调节慢性支气管炎免疫功能效果的观察[J].中华结核和呼吸杂志, 1987, 10(1):41-43.

Next Article
腮腺肿瘤术中保留耳大神经分支的临床分析

West China Medical Journal

The Effect of Bacillus Calmette-guerin Polysaccharides Nucleic Acid on Humoral Immunity, Interleukin-8 and Tumor Necrosis Factor-αin Patients with Chronic Obstructive Pulmonary Disease

Abstract Full text Figures/Tables Video References Cited by

Next Article

Format

Content