• 1. Evidence-based Medicine Center, Chouzhou Hospital of Yiwu City, Yiwu, Zhejiang 322000, P. R. China;
  • 2. Surgical Center, Chouzhou Hospital of Yiwu City, Yiwu, Zhejiang 322000, P. R. China;
  • 3. Department of Surgery, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P. R. China;
SHIXiao-ke, Email: sxk158258@163.com
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Objective To systematically evaluate the correlation between type-2 diabetes mellitus (T2DM) and T/C polymorphism in 190 locus ofβ3-adrenergic receptor (β3-AR) gene in Chinese population. Methods The following databases such as CNKI, VIP, CBM, PubMed, EMbase, the Cochrane Library (Issue 8, 2012) and WanFang Data were searched to collect case-control studies on the correlation between T2DM and T/C polymorphism in 190 locus of β3-AR gene. The retrieval time was from October 1980 to October 2013. Two reviewers independently screened the literature according to the inclusion and exclusion criteria, extracted the data and assessed the quality. Then the meta-analysis was conducted by using RevMan 5.0 and Stata 12.0 software, and the publication bias was analyzed by means of Egger's linear regression. Results A total of 11 studies involving 1 602 T2DM patients and 1 773 healthy volunteers were included. The results of meta-analyses showed that, for Chinese population, TC genotype in case group was more than that in control group[OR=1.19, 95%CI (1.01, 1.40), P=0.04]. CC+TC genotype in case group was more than that in control group[OR=1.23, 95%CI (1.05, 1.45), P=0.01]. Allele C in case group was more than that in control group[OR=1.24, 95%CI (1.08, 1.43), P=0.003]. Conclusions The allele C in 190 locus of β3-AR gene in Chinese population is significantly associated with T2DM. For the quantity and quality limitation of the included studies, this conclusion has to be further proved by more studies.

Citation: YOUHang, ZHANGBen-long, SUNYun-peng, SHIXiao-ke. Correlation between T/C Polymorphism in 190 Locus ofβ3-adrenergic Receptor Gene and Type-2 Diabetes Mellitus in Chinese Population: A Meta-analysis. West China Medical Journal, 2015, 30(1): 12-11. doi: 10.7507/1002-0179.20150003 Copy

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