Study on the Curative Effect of Interventional Chemotherapy for Advanced Gastric Cancer_West China Medical Journal

Authors：

 LIUJia-yun , JIANGChao , XUZhe , CHENChe , YAOXue-quan ,  LIWei-su , LIUFu-kun

Department of Digestive Tumor Surgery, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing 210029, P. R. China;

Corresponding author：

LIWei-su, Email: scidoc@aliyun.com

Keywords：

Advanced gastric cancer; Interventional chemotherapy; Curative effect

DOI：

10.7507/1002-0179.20150024

Video：

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Objective To observe the clinical curative effect of interventional chemotherapy in the treatment of advanced gastric cancer. Methods Thirty advanced gastric cancer patients underwent arterial infusion chemotherapy and embolization treatment between January and December 30, 2013. The treatment was carried out every three weeks. We evaluated the clinical results after the third treatment. The clinical improvement was assessed based on alleviation of such symptoms as epigastric pain, poor appetite, nausea, vomiting and fecal occult blood. The tumor size was evaluated through abdominal CT examination. Results Abdominal pain relieved in 19 out of 28 patients (67.9%); appetite improved in 18 out of 24 patients (75.0%); vomiting relieved in 15 out of 16 cases (93.8%); and fecal 9 out of 12 patients with positive occult blood turned to negative (75.0%). The total effective rate was 83.3%, and 8 patients accepted interventional therapy after operation. The survival rates during the 6, 12 and 24-month follow-up were respectively 85.0%, 65.0%, and 25.0%. Conclusions Interventional chemotherapy and embolization treatment are effective for advanced gastric cancer, which can relieve symptoms and lower tumor stage. Some patients have a second chance of operation, which can be an effective method in the treatment of advanced gastric cancer.

Citation： LIUJia-yun, JIANGChao, XUZhe, CHENChe, YAOXue-quan, LIWei-su, LIUFu-kun. Study on the Curative Effect of Interventional Chemotherapy for Advanced Gastric Cancer. West China Medical Journal, 2015, 30(1): 89-92. doi: 10.7507/1002-0179.20150024 Copy

1.	Krejs GJ. Gastric cancer:epidemiology and risk factors[J]. Dig Dis, 2010, 28(4/5):600-603.
2.	Yang D, Hendifar A, Lenz C, et al. Survival of metastatic gastric cancer:significance of age, sex and race/ethnicity[J]. J Gastrointest Oncol, 2011, 2(2):77-84.
3.	Jiang Y, Montero AJ, Staveley-O'Carroll KF. Adjuvant and preoperative therapy for localized gastric cancer[J]. Gastrointest Cancer Res, 2007, 1(4):139-145.
4.	彭淑牖.晚期胃癌不要轻易放弃手术切除的机会[J].中国实用外科杂志, 2001, 21(7):400-401.
5.	Koizumi W, Narahara H, Hara T, et al. S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial):a phaseⅢtrial[J]. Lancet Oncol, 2008, 9(3):215-221.
6.	Miller AB, Hoogstraten B, Staquet M, et al. Reporting results of cancer treatment[J]. Cancer, 1981, 47(1):207-214.
7.	金晟娴.肿瘤化疗药物新的不良反应评价系统-CTCAE v3.0[J].儿科药学杂志, 2011, 17(3):53-55.
8.	周际昌.实用肿瘤内科学[M].北京:人民卫生出版社, 1998:47-48.
9.	韩宇.内镜下介入治疗进展期胃癌的疗效观察[J].中国肿瘤临床与康复, 2007, 14(3):263.
10.	金巨光, 赵忠春, 徐克, 等.进行期胃癌术前经动脉化疗栓塞的临床及病理学研究[J].临床医学影像杂志, 1996(2):86-88.
11.	路平, 王舒宝, 袁媛, 等.胃癌术前动脉栓塞化疗的临床及病理学研究[J].中华医学杂志, 1996(2):67-68.
12.	刘福坤, 李国立, 陈忠豪, 等.胃癌术前介入治疗的临床和病理观察(附250例报告)[J].南京大学学报:自然科学版, 1998, 34(2):45-49.
13.	刘福坤, 陈忠豪, 李国立, 等.胃癌术前介入治疗后血管变化与癌组织坏死的关系[J].华人消化杂志, 1998, 6(8):686-688.
14.	帅磊渊, 王子卫.介入化疗在进展期胃癌新辅助化疗中的应用现状[J].医学综述, 2007, 13(13):993-996.
15.	潘彦康.胃癌介入化疗与全身化疗的疗效比较[J].吉林医学, 2009, 30(15):1561-1562.
16.	刘福坤.介入治疗在胃肠道肿瘤中的应用[J].腹部外科, 2004, 17(5):267-269.
17.	吴鹏, 朱正纲, 叶正宝, 等. 5-氟尿嘧啶-2'-脱氧核苷经胃左动脉介入灌注后的药代动力学实验研究[J].外科理论与实践, 2004, 9(2):135-139.
18.	詹文华.胃癌联合脏器切除术的合理选择及应用——胰十二指肠切除术在进展期胃癌中的应用[J].中国实用外科杂志, 2001, 21(7):398-400.

1. Krejs GJ. Gastric cancer:epidemiology and risk factors[J]. Dig Dis, 2010, 28(4/5):600-603.
2. Yang D, Hendifar A, Lenz C, et al. Survival of metastatic gastric cancer:significance of age, sex and race/ethnicity[J]. J Gastrointest Oncol, 2011, 2(2):77-84.
3. Jiang Y, Montero AJ, Staveley-O'Carroll KF. Adjuvant and preoperative therapy for localized gastric cancer[J]. Gastrointest Cancer Res, 2007, 1(4):139-145.
4. 彭淑牖.晚期胃癌不要轻易放弃手术切除的机会[J].中国实用外科杂志, 2001, 21(7):400-401.
5. Koizumi W, Narahara H, Hara T, et al. S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial):a phaseⅢtrial[J]. Lancet Oncol, 2008, 9(3):215-221.
6. Miller AB, Hoogstraten B, Staquet M, et al. Reporting results of cancer treatment[J]. Cancer, 1981, 47(1):207-214.
7. 金晟娴.肿瘤化疗药物新的不良反应评价系统-CTCAE v3.0[J].儿科药学杂志, 2011, 17(3):53-55.
8. 周际昌.实用肿瘤内科学[M].北京:人民卫生出版社, 1998:47-48.
9. 韩宇.内镜下介入治疗进展期胃癌的疗效观察[J].中国肿瘤临床与康复, 2007, 14(3):263.
10. 金巨光, 赵忠春, 徐克, 等.进行期胃癌术前经动脉化疗栓塞的临床及病理学研究[J].临床医学影像杂志, 1996(2):86-88.
11. 路平, 王舒宝, 袁媛, 等.胃癌术前动脉栓塞化疗的临床及病理学研究[J].中华医学杂志, 1996(2):67-68.
12. 刘福坤, 李国立, 陈忠豪, 等.胃癌术前介入治疗的临床和病理观察(附250例报告)[J].南京大学学报:自然科学版, 1998, 34(2):45-49.
13. 刘福坤, 陈忠豪, 李国立, 等.胃癌术前介入治疗后血管变化与癌组织坏死的关系[J].华人消化杂志, 1998, 6(8):686-688.
14. 帅磊渊, 王子卫.介入化疗在进展期胃癌新辅助化疗中的应用现状[J].医学综述, 2007, 13(13):993-996.
15. 潘彦康.胃癌介入化疗与全身化疗的疗效比较[J].吉林医学, 2009, 30(15):1561-1562.
16. 刘福坤.介入治疗在胃肠道肿瘤中的应用[J].腹部外科, 2004, 17(5):267-269.
17. 吴鹏, 朱正纲, 叶正宝, 等. 5-氟尿嘧啶-2'-脱氧核苷经胃左动脉介入灌注后的药代动力学实验研究[J].外科理论与实践, 2004, 9(2):135-139.
18. 詹文华.胃癌联合脏器切除术的合理选择及应用——胰十二指肠切除术在进展期胃癌中的应用[J].中国实用外科杂志, 2001, 21(7):398-400.

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