瞬时感受器电位C亚族蛋白6通道与肿瘤发生的研究进展_West China Medical Journal

Authors：

 白莉平 , 郭清民 , 王慧 ,  郑艾

四川大学华西第二医院妇产科（成都 610041）;

Corresponding author：

郑艾, Email: 894591422@qq.com

Keywords：

瞬时感受器电位C亚族蛋白6; 钙离子; 离子通道; 肿瘤

DOI：

10.7507/1002-0179.20150053

Video：

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Abstract Full text Figures/Tables Video References Cited by

细胞内游离钙离子（Ca²⁺）与肿瘤关系密切, 直接参与调控肿瘤的生长、侵袭、转移和分化。瞬时感受器电位(TRP)是细胞膜上的一种非选择性阳离子通道，且被认为是最可能的钙库操纵性钙通道和受体操纵性钙通道的分子基础。TRP通道C亚族蛋白（TRPC）在多种细胞中表达。近年研究多发现调控Ca²⁺进入细胞的TRPC6通道与多种癌症的发生和浸润转移有关。如果能阻遏此过程，可能对肿瘤的治疗提供一个新的思路。现对近年来TRPC6通道与肿瘤的关系的相关研究作一综述。

Citation： 白莉平, 郭清民, 王慧, 郑艾. 瞬时感受器电位C亚族蛋白6通道与肿瘤发生的研究进展. West China Medical Journal, 2015, 30(1): 175-178. doi: 10.7507/1002-0179.20150053 Copy

1.	Nomura M, Ueno A, Saga K, et al. Accumulation of cytosolic calcium induces necroptotic cell death in human neuroblastoma[J]. Cancer Res, 2014, 74(4):1056-1066.
2.	Demaurex N, Distelhorst C. Apoptosis:the calcium connection[J]. Science, 2003, 300(5616):65-67.
3.	Cook SJ, Lockyer PJ. Recent advances in Ca²⁺-dependent Ras regulation and cell proliferation[J]. Cell Calcium, 2006, 39(2):101-112.
4.	Whitfield JF. Calcium signals and cancer[J]. Crit Rev Oncog, 1991, 3(1/2):55-90.
5.	Monteith GR, Mcandrew D, Faddy HM. Calcium and cancer:targeting Ca²⁺ transport[J]. Nat Rev Cancer, 2007, 7(7):519-530.
6.	Bading H. Nuclear calcium signalling in the regulation of brain function[J]. Nat Rev Neurosci, 2013, 14(9):593-608.
7.	Pimentel AA, Benaim G. Ca²⁺ and sphingolipids as modulators for apoptosis and cancer[J]. Invest Clín, 2012, 53(1):84-110.
8.	Rafiei S, Komarova SV. Molecular signaling pathways mediating osteoclastogenesis induced by prostate cancer cells[J]. BMC Cancer, 2013, 13(1):605.
9.	Marchi S, Pinton P. Mitochondrial calcium uniporter, MiRNA and cancer:live and let die[J]. Commun Integr Biol, 2013, 6(3):e23818.
10.	Parekh AB, Putney JW. Store-operated calcium channels[J]. Physiol Rev, 2005, 85(2):757-810.
11.	Putney JW. A model for receptor-regulated calcium entry[J]. Cell Calcium, 1986, 7(1):1-12.
12.	Dolmetsch RE, Xu K, Lewis RS. Calcium oscillations increse the efficiency and specificity of gene expression[J]. Nature, 1998, 392(6679):933-936.
13.	Rao W, Zhang L, Su N, et al. Blockade of SOCE protects HT22 cells from hydrogen peroxide-induced apoptosis[J]. Biochem Biophys Res Commun, 2013, 441(2):351-356.
14.	Li X, Chen W, Zhang L, et al. Inhibition of store-operated calcium entry attenuates MPP(+)-induced oxidative stress via preservation of mitochondrial function in PC12 cells:involvement of Homer1a[J]. PLoS One, 2013, 8(12):e83638.
15.	Jara E, Hidalgo MA, Hancke JL, et al. Delphinidin activates NFAT and induces IL-2 production through SOCE in T cells[J]. Cell Biochem Biophys, 2014, 68(3):497-509.
16.	Ambudkar IS, Brazer SC, Liu X, et al. Plasma membrane localization of TRPC channels:role of caveolar lipid rafts[J]. Novartis Found Symp, 2004, 258:63-70.
17.	Bréchard S, Melchior C, Plançon S, et al. Store-operated Ca(2+)channels formed by TRPC1, TRPC6 and Orai1 and non-store-operated channels formed by TRPC3 are involved in the regulation of NADPH oxidase in HL-60 granulocytes[J]. Cell Calcium, 2008, 44(5):492-506.
18.	Soboloff J, Spassova M, Xu W, et al. Role of endogenous TRPC6 channels in Ca²⁺ signal Generation in A7r5 smooth muscle cells[J]. J Biol Chem, 2005, 280(48):39786-39794.
19.	Xie J, Cha SK, An SW, et al. Cardioprotection by klotho through downregulation of TRPC6 channels in the mouse heart[J]. Nat Commun, 2012(3):1238.
20.	Dietrich A, Kalwa H, Fuchs B, et al. In vivo TRPC functions in the cardiopulmonary vasculature[J]. Cell Calcium, 2007, 42(2):233-244.
21.	Tauseef M, Knezevic N, Chava KR, et al. TLR4 activation of TRPC6-dependent calcium signaling mediates endotoxin-induced lung vascular permeability and inflammation[J]. J Exp Med, 2012, 209(11):1953-1968.
22.	Xia Y, Yang XR, Fu Z, et al. Classical transient receptor potential 1 and 6 contribute to hypoxic pulmonary hypertension through differential regulation of pulmonary vascular functions[J]. Hypertension, 2014, 63(1):173-180.
23.	Li H, Huang J, Du W, et al. TRPC6 inhibited NMDA receptor activities and protected neurons from ischemic excitotoxicity[J]. J Neurochem, 2012, 123(6):1010-1018.
24.	Heiser JH, Schuwald AM, Sillani G, et al. TRPC6 channel-mediated neurite outgrowth in PC12 cells and hippocampal neurons involves activation of RAS/MEK/ERK, PI3K, and CAMKIV signaling[J]. J Neurochem, 2013, 127(3):303-313.
25.	Dionisio N, Redondo PC, Jardin I, et al. Transient receptor potential channels in human platelets:expression and functional role[J]. Curr Mol Med, 2012, 12(10):1319-1328.
26.	Davis J, Burr AR, Davis GF, et al. A TRPC6-Dependent pathway for myofibroblast transdifferentiation and wound healing in vivo[J]. Dev Cell, 2012, 23(4):705-715.
27.	Chen W, Oberwinkler H, Werner F, et al. Atrial natriuretic peptide-mediated inhibition of microcirculatory endothelial Ca²⁺ and permeability response to histamine involves cGMP-dependent protein kinase I and TRPC6 channels[J]. Arterioscler Thromb Vasc Biol, 2013, 33(9):2121-2129.
28.	Dalal MD, Morgans CW, Duvoisin RM, et al. Diagnosis of occult melanoma using transient receptor potential melastatin 1 (TRPM1) autoantibody testing:a novel approach[J]. Ophthalmology, 2013, 120(12):2560-2564.
29.	Erickson LA, Letts GA, Shah SM, et al. TRPM1 (melastatin-1/MLSN1) mRNA expression in spitz nevi and nodular melanomas[J]. Mod Pathol, 2009, 22(7):969-976.
30.	Lu S, Slominski A, Yang SE, et al. The correlation of TRPM1 (Melastatin) mRNA expression with microphthalmia-associated transcription factor (MITF) and other melanogenesis-related proteins in normal and pathological skin, hair follicles and melanocytic nevi[J]. J Cutan Pathol, 2010, 37(Suppl 1):26-40.
31.	Lehen'kyi V, Prevarskaya N. Oncogenic TRP Channels[J]. Adv Exp Med Biol, 2011, 704:929-945.
32.	Zhu GB, Wang XH, Yang ZH, et al. Effects of TRPM8 on the proliferation and angiogenesis of prostate cancer PC-3 cells in vivo[J]. Oncol Lett, 2011, 2(6):1213-1217.
33.	Yang ZH, Wang XH, Wang HP, et al. Effects of TRPM8 on the proliferation and motility of prostate cancer PC-3 cells[J]. Asian J Androl, 2009, 11(2):157-165.
34.	Fixemer T, Wissenbach U, Flockerzi V, et al. Expression of the Ca²⁺-selective cation Channel TRPV6 in human prostate cancer:a novel prognostic marker for tumor progression[J]. Oncogene, 2003, 22(49):7858-7861.
35.	赵晓智, 郭宏骞, 刘光香, 等.靶向TRPV6的siRNA对前列腺癌LNCaP细胞抑制作用的体外研究[J].中国男科学杂志, 2010, 16(5):423-427.
36.	Lehen'kyi V, Raphaël M, Oulidi A, et al. TRPV6 determines the effect of vitamin D3 on prostate cancer cell growth[J]. PLoS One, 2011, 6(2):e16856.
37.	Cai R, Ding X, Zhou KC, et al. Blockade of TRPC6 channels induced G2/M phase arrest and suppressed growth in human gastric cancer cells[J]. Int J Cancer, 2009, 125(10):2281-2287.
38.	Shi Y, Ding X, He ZH, et al. Critical role of TRPC6 channels in G2 phase transition and the development of human oesophageal cancer[J]. Gut, 2009, 58(11):1443-1450.
39.	Ding X, He Z, Shi Y, et al. Targeting TRPC6 channels in oesophageal carcinoma growth[J]. Expert Opin Ther Targets, 2010, 14(5):513-527.
40.	Zhang SS, Wen J, Yang F, et al. High expression of transient potential receptor C6 correlated with poor prognosis in patients with esophagealsquamous cell carcinoma[J]. Med Oncol, 2013, 30(3):607.
41.	Yue D, Wang Y, Xiao JY, et al. Expression of TRPC6 in benign and malignant human prostate tissues[J]. Asian J Androl, 2009, 11(5):541-547.
42.	Thebault S, Flourakis M, Vanoverberghe K, et al. Differential role of transient receptor potential channels in Ca²⁺ entry and proliferation of prostate cancer epithelial cells[J]. Cancer Res, 2006, 66(4):2038-2047.
43.	Jiang HN, Zeng B, Zhang Y, et al. Involvement of TRPC channels in lung cancer cell differentiation and the correlation analysis in human non-small cell lung cancer[J]. PLoS One, 2013, 8(6):e67637.
44.	Song J, Wang Y, Li X, et al. Critical role of TRPC6 channels in the development of human renal cell carcinoma[J]. Mol Biol Rep, 2013, 40(8):5115-5122.
45.	Bernaldo De Quirós S, Merlo A. Identification of TRPC6 as a possible candidate target gene within an amplicon at 11q21-q22.2 for migratorycapacity in head and neck squamous cell carcinomas[J]. BMC Cancer, 2013, 13(1):1-11.
46.	Chigurupati S, Venkataraman R, Barrera D, et al. Receptor Channel TRPC6 is a key mediator of Notch-driven glioblastoma growth and invasiveness[J]. Cancer Res, 2010, 70(1):418-427.
47.	Ding X, He ZH, Zhou KC, et al. Essential role of TRPC6 channels in G2/M phase transition and development of human glioma[J]. J Natl Cancer Inst, 2010, 102(14):1052-1068.
48.	Zeng B, Yuan C, Yang X, et al. TRPC channels and their splice variants are essential for promoting human ovarian cancer cell proliferation and tumorigenesis[J]. Curr Cancer Drug Targets, 2013, 13(1):103-116.
49.	Guilbert A, Dhennin-Duthille I, Hiani YE. Expression of TRPC6 channels in human epithelial breast cancer cells[J]. BMC Cancer, 2008, 8(1):125.
50.	Dhennin-Duthille I, Gautier M, Faouzi M. High expression of transient receptor potential channels in human breast cancer epithelial cells and tissues:correlation with pathological parameters[J]. Cell Physiol Biochem, 2011, 28(5):813-822.
51.	El Boustany C, Bidaux G, Enfissi A, et al. Capacitative calcium entry and transient receptor potential canonical 6 expression control human hepatoma cell proliferation[J]. Hepatology, 2008, 47(6):2068-2077.
52.	Wan Q, Zheng A, Liu X, et al. Expression of transient receptor potential Channel 6 in cervical cancer[J]. Onco Targets Ther, 2012, 5(5):171-176.
53.	万琪, 褚艳侠, 郑艾, 等.维拉帕米对宫颈癌HeLa细胞株增殖和迁移的影响[J].四川大学学报:医学版, 2011, 42(1):78-81.
54.	Murdoch C, Muthana M, Coffelt SB, et al. The role of myeloid cells in the promotion of tumour angiogenesis[J]. Nat Rev Cancer, 2008, 8(8):618-631.
55.	El BC, Bidaux G, Enfissi A, et al. Capacitative calcium entry and transient receptor potential canonical 6 expression control human hepatoma cell proliferation[J]. Hepatology, 2008, 47(6):2068-2077.
56.	Ge RL, Tai YL, Sun YY, et al. Critical role of TRPC6 channels in VEGF-mediated angiogenesis[J]. Cancer Lett, 2009, 283(1):43-51.
57.	Thilo F, Liu Y, Loddenkemper C, et al. VEGF regulates TRPC6 channels in podocytes[J]. Nephrol Dial Transplant, 2012, 27(3):921-929.
58.	Jung S, Strotmann R, Schultz G, et al. TRPC6 is a candidate Channel involved in receptor-stimulated cation currents in A7r5 smooth muscle cells[J]. Am J Physiol Cell Physiol, 2002, 282(2):C347-C359.
59.	Madan E, Gogna R, Keppler B, et al. p53 increases intra-cellular calcium release by transcriptional regulation of calcium Channel TRPC6 in GaQ3-treated cancer cells[J]. PLoS One, 2013, 8(8):e71016.
60.	Kim JM, Heo K, Choi J, et al. The histone variant MacroH2A regulates Ca(2+) influx through TRPC3 and TRPC6 channels[J]. Oncogenesis, 2013(2):e77.

1. Nomura M, Ueno A, Saga K, et al. Accumulation of cytosolic calcium induces necroptotic cell death in human neuroblastoma[J]. Cancer Res, 2014, 74(4):1056-1066.
2. Demaurex N, Distelhorst C. Apoptosis:the calcium connection[J]. Science, 2003, 300(5616):65-67.
3. Cook SJ, Lockyer PJ. Recent advances in Ca²⁺-dependent Ras regulation and cell proliferation[J]. Cell Calcium, 2006, 39(2):101-112.
4. Whitfield JF. Calcium signals and cancer[J]. Crit Rev Oncog, 1991, 3(1/2):55-90.
5. Monteith GR, Mcandrew D, Faddy HM. Calcium and cancer:targeting Ca²⁺ transport[J]. Nat Rev Cancer, 2007, 7(7):519-530.
6. Bading H. Nuclear calcium signalling in the regulation of brain function[J]. Nat Rev Neurosci, 2013, 14(9):593-608.
7. Pimentel AA, Benaim G. Ca²⁺ and sphingolipids as modulators for apoptosis and cancer[J]. Invest Clín, 2012, 53(1):84-110.
8. Rafiei S, Komarova SV. Molecular signaling pathways mediating osteoclastogenesis induced by prostate cancer cells[J]. BMC Cancer, 2013, 13(1):605.
9. Marchi S, Pinton P. Mitochondrial calcium uniporter, MiRNA and cancer:live and let die[J]. Commun Integr Biol, 2013, 6(3):e23818.
10. Parekh AB, Putney JW. Store-operated calcium channels[J]. Physiol Rev, 2005, 85(2):757-810.
11. Putney JW. A model for receptor-regulated calcium entry[J]. Cell Calcium, 1986, 7(1):1-12.
12. Dolmetsch RE, Xu K, Lewis RS. Calcium oscillations increse the efficiency and specificity of gene expression[J]. Nature, 1998, 392(6679):933-936.
13. Rao W, Zhang L, Su N, et al. Blockade of SOCE protects HT22 cells from hydrogen peroxide-induced apoptosis[J]. Biochem Biophys Res Commun, 2013, 441(2):351-356.
14. Li X, Chen W, Zhang L, et al. Inhibition of store-operated calcium entry attenuates MPP(+)-induced oxidative stress via preservation of mitochondrial function in PC12 cells:involvement of Homer1a[J]. PLoS One, 2013, 8(12):e83638.
15. Jara E, Hidalgo MA, Hancke JL, et al. Delphinidin activates NFAT and induces IL-2 production through SOCE in T cells[J]. Cell Biochem Biophys, 2014, 68(3):497-509.
16. Ambudkar IS, Brazer SC, Liu X, et al. Plasma membrane localization of TRPC channels:role of caveolar lipid rafts[J]. Novartis Found Symp, 2004, 258:63-70.
17. Bréchard S, Melchior C, Plançon S, et al. Store-operated Ca(2+)channels formed by TRPC1, TRPC6 and Orai1 and non-store-operated channels formed by TRPC3 are involved in the regulation of NADPH oxidase in HL-60 granulocytes[J]. Cell Calcium, 2008, 44(5):492-506.
18. Soboloff J, Spassova M, Xu W, et al. Role of endogenous TRPC6 channels in Ca²⁺ signal Generation in A7r5 smooth muscle cells[J]. J Biol Chem, 2005, 280(48):39786-39794.
19. Xie J, Cha SK, An SW, et al. Cardioprotection by klotho through downregulation of TRPC6 channels in the mouse heart[J]. Nat Commun, 2012(3):1238.
20. Dietrich A, Kalwa H, Fuchs B, et al. In vivo TRPC functions in the cardiopulmonary vasculature[J]. Cell Calcium, 2007, 42(2):233-244.
21. Tauseef M, Knezevic N, Chava KR, et al. TLR4 activation of TRPC6-dependent calcium signaling mediates endotoxin-induced lung vascular permeability and inflammation[J]. J Exp Med, 2012, 209(11):1953-1968.
22. Xia Y, Yang XR, Fu Z, et al. Classical transient receptor potential 1 and 6 contribute to hypoxic pulmonary hypertension through differential regulation of pulmonary vascular functions[J]. Hypertension, 2014, 63(1):173-180.
23. Li H, Huang J, Du W, et al. TRPC6 inhibited NMDA receptor activities and protected neurons from ischemic excitotoxicity[J]. J Neurochem, 2012, 123(6):1010-1018.
24. Heiser JH, Schuwald AM, Sillani G, et al. TRPC6 channel-mediated neurite outgrowth in PC12 cells and hippocampal neurons involves activation of RAS/MEK/ERK, PI3K, and CAMKIV signaling[J]. J Neurochem, 2013, 127(3):303-313.
25. Dionisio N, Redondo PC, Jardin I, et al. Transient receptor potential channels in human platelets:expression and functional role[J]. Curr Mol Med, 2012, 12(10):1319-1328.
26. Davis J, Burr AR, Davis GF, et al. A TRPC6-Dependent pathway for myofibroblast transdifferentiation and wound healing in vivo[J]. Dev Cell, 2012, 23(4):705-715.
27. Chen W, Oberwinkler H, Werner F, et al. Atrial natriuretic peptide-mediated inhibition of microcirculatory endothelial Ca²⁺ and permeability response to histamine involves cGMP-dependent protein kinase I and TRPC6 channels[J]. Arterioscler Thromb Vasc Biol, 2013, 33(9):2121-2129.
28. Dalal MD, Morgans CW, Duvoisin RM, et al. Diagnosis of occult melanoma using transient receptor potential melastatin 1 (TRPM1) autoantibody testing:a novel approach[J]. Ophthalmology, 2013, 120(12):2560-2564.
29. Erickson LA, Letts GA, Shah SM, et al. TRPM1 (melastatin-1/MLSN1) mRNA expression in spitz nevi and nodular melanomas[J]. Mod Pathol, 2009, 22(7):969-976.
30. Lu S, Slominski A, Yang SE, et al. The correlation of TRPM1 (Melastatin) mRNA expression with microphthalmia-associated transcription factor (MITF) and other melanogenesis-related proteins in normal and pathological skin, hair follicles and melanocytic nevi[J]. J Cutan Pathol, 2010, 37(Suppl 1):26-40.
31. Lehen'kyi V, Prevarskaya N. Oncogenic TRP Channels[J]. Adv Exp Med Biol, 2011, 704:929-945.
32. Zhu GB, Wang XH, Yang ZH, et al. Effects of TRPM8 on the proliferation and angiogenesis of prostate cancer PC-3 cells in vivo[J]. Oncol Lett, 2011, 2(6):1213-1217.
33. Yang ZH, Wang XH, Wang HP, et al. Effects of TRPM8 on the proliferation and motility of prostate cancer PC-3 cells[J]. Asian J Androl, 2009, 11(2):157-165.
34. Fixemer T, Wissenbach U, Flockerzi V, et al. Expression of the Ca²⁺-selective cation Channel TRPV6 in human prostate cancer:a novel prognostic marker for tumor progression[J]. Oncogene, 2003, 22(49):7858-7861.
35. 赵晓智, 郭宏骞, 刘光香, 等.靶向TRPV6的siRNA对前列腺癌LNCaP细胞抑制作用的体外研究[J].中国男科学杂志, 2010, 16(5):423-427.
36. Lehen'kyi V, Raphaël M, Oulidi A, et al. TRPV6 determines the effect of vitamin D3 on prostate cancer cell growth[J]. PLoS One, 2011, 6(2):e16856.
37. Cai R, Ding X, Zhou KC, et al. Blockade of TRPC6 channels induced G2/M phase arrest and suppressed growth in human gastric cancer cells[J]. Int J Cancer, 2009, 125(10):2281-2287.
38. Shi Y, Ding X, He ZH, et al. Critical role of TRPC6 channels in G2 phase transition and the development of human oesophageal cancer[J]. Gut, 2009, 58(11):1443-1450.
39. Ding X, He Z, Shi Y, et al. Targeting TRPC6 channels in oesophageal carcinoma growth[J]. Expert Opin Ther Targets, 2010, 14(5):513-527.
40. Zhang SS, Wen J, Yang F, et al. High expression of transient potential receptor C6 correlated with poor prognosis in patients with esophagealsquamous cell carcinoma[J]. Med Oncol, 2013, 30(3):607.
41. Yue D, Wang Y, Xiao JY, et al. Expression of TRPC6 in benign and malignant human prostate tissues[J]. Asian J Androl, 2009, 11(5):541-547.
42. Thebault S, Flourakis M, Vanoverberghe K, et al. Differential role of transient receptor potential channels in Ca²⁺ entry and proliferation of prostate cancer epithelial cells[J]. Cancer Res, 2006, 66(4):2038-2047.
43. Jiang HN, Zeng B, Zhang Y, et al. Involvement of TRPC channels in lung cancer cell differentiation and the correlation analysis in human non-small cell lung cancer[J]. PLoS One, 2013, 8(6):e67637.
44. Song J, Wang Y, Li X, et al. Critical role of TRPC6 channels in the development of human renal cell carcinoma[J]. Mol Biol Rep, 2013, 40(8):5115-5122.
45. Bernaldo De Quirós S, Merlo A. Identification of TRPC6 as a possible candidate target gene within an amplicon at 11q21-q22.2 for migratorycapacity in head and neck squamous cell carcinomas[J]. BMC Cancer, 2013, 13(1):1-11.
46. Chigurupati S, Venkataraman R, Barrera D, et al. Receptor Channel TRPC6 is a key mediator of Notch-driven glioblastoma growth and invasiveness[J]. Cancer Res, 2010, 70(1):418-427.
47. Ding X, He ZH, Zhou KC, et al. Essential role of TRPC6 channels in G2/M phase transition and development of human glioma[J]. J Natl Cancer Inst, 2010, 102(14):1052-1068.
48. Zeng B, Yuan C, Yang X, et al. TRPC channels and their splice variants are essential for promoting human ovarian cancer cell proliferation and tumorigenesis[J]. Curr Cancer Drug Targets, 2013, 13(1):103-116.
49. Guilbert A, Dhennin-Duthille I, Hiani YE. Expression of TRPC6 channels in human epithelial breast cancer cells[J]. BMC Cancer, 2008, 8(1):125.
50. Dhennin-Duthille I, Gautier M, Faouzi M. High expression of transient receptor potential channels in human breast cancer epithelial cells and tissues:correlation with pathological parameters[J]. Cell Physiol Biochem, 2011, 28(5):813-822.
51. El Boustany C, Bidaux G, Enfissi A, et al. Capacitative calcium entry and transient receptor potential canonical 6 expression control human hepatoma cell proliferation[J]. Hepatology, 2008, 47(6):2068-2077.
52. Wan Q, Zheng A, Liu X, et al. Expression of transient receptor potential Channel 6 in cervical cancer[J]. Onco Targets Ther, 2012, 5(5):171-176.
53. 万琪, 褚艳侠, 郑艾, 等.维拉帕米对宫颈癌HeLa细胞株增殖和迁移的影响[J].四川大学学报:医学版, 2011, 42(1):78-81.
54. Murdoch C, Muthana M, Coffelt SB, et al. The role of myeloid cells in the promotion of tumour angiogenesis[J]. Nat Rev Cancer, 2008, 8(8):618-631.
55. El BC, Bidaux G, Enfissi A, et al. Capacitative calcium entry and transient receptor potential canonical 6 expression control human hepatoma cell proliferation[J]. Hepatology, 2008, 47(6):2068-2077.
56. Ge RL, Tai YL, Sun YY, et al. Critical role of TRPC6 channels in VEGF-mediated angiogenesis[J]. Cancer Lett, 2009, 283(1):43-51.
57. Thilo F, Liu Y, Loddenkemper C, et al. VEGF regulates TRPC6 channels in podocytes[J]. Nephrol Dial Transplant, 2012, 27(3):921-929.
58. Jung S, Strotmann R, Schultz G, et al. TRPC6 is a candidate Channel involved in receptor-stimulated cation currents in A7r5 smooth muscle cells[J]. Am J Physiol Cell Physiol, 2002, 282(2):C347-C359.
59. Madan E, Gogna R, Keppler B, et al. p53 increases intra-cellular calcium release by transcriptional regulation of calcium Channel TRPC6 in GaQ3-treated cancer cells[J]. PLoS One, 2013, 8(8):e71016.
60. Kim JM, Heo K, Choi J, et al. The histone variant MacroH2A regulates Ca(2+) influx through TRPC3 and TRPC6 channels[J]. Oncogenesis, 2013(2):e77.

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瞬时感受器电位C亚族蛋白6通道与肿瘤发生的研究进展

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