An Investigation of Cardiovascular Risk Factors in Pre-diabetes Patients in Rural Areas of Chengdu City_West China Medical Journal

Authors：

 LIAOXiao-yang ¹ , WANGWei-wen ² , WUJia ¹ , ZHOUXin-ping ¹ , WANGNa ¹ , ZHAOQian ¹ ,  LIShuang-qing

1. Department of General Practice, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Department of Neurology, Chengdu Military General Hospital, Chengdu, Sichuan 610083, P. R. China;

Corresponding author：

LIShuang-qing, Email: 1259594471@qq.com

Keywords：

Pre-diabetes; Cardiovascular risk factors; Rural area; Glucose tolerance test

DOI：

10.7507/1002-0179.20150079

Video：

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Objective To investigate the prevalence of impaired glucose regulation (IGR) and IGR combined with cardiovascular risk factors in rural areas of Chengdu City. Methods From February to October 2010, we randomly sampled 1 016 patients in a rural community 100 kilometers away from the city center as the study subjects. The investigation was carried out by using questionnaire survey, physical examination and laboratory tests. The standard 75 g oral glucose tolerance test was used. Results A total of 1 016 subjects were investigated, among whom there were 431 males and 585 females with an average age of 56 years old. Of these subjects, 333 were diagnosed to have IGR with a rate of 32.77% (333/1 016). The age-adjusted standardized prevalence of pre-diabetes in rural areas in Chengdu was 32.52% (336/1 016), and the male and female prevalence were respectively 30.63% (132/431) and 34.36% (201/585) without significant difference (χ²=1.569，P=0.210). Impaired glucose tolerance (IGT) was the most common type of glycometabolism abnormality. Women had a significantly higher prevalence of IGT than men. In IGR population, major cardiovascular risk factors were overweight and obesity (40.8%), high low density lipoprotein cholesterol (38.4%), high triglyceride (30.3%), hypertension (23.7%), smoking (24.3%), and drinking alcohol (23.7%). The stratified analysis showed that the prevalence of overweight, obesity and low high density lipoprotein cholesterol in female was significantly higher than that in males, while the prevalence of smoking and drinking alcohol was significantly higher in males. Conclusion In rural areas, the prevalence of pre-diabetes is high and complicated with multiple cardiovascular risk factors.

Citation： LIAOXiao-yang, WANGWei-wen, WUJia, ZHOUXin-ping, WANGNa, ZHAOQian, LIShuang-qing. An Investigation of Cardiovascular Risk Factors in Pre-diabetes Patients in Rural Areas of Chengdu City. West China Medical Journal, 2015, 30(2): 250-253. doi: 10.7507/1002-0179.20150079 Copy

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22.	徐涛, 李卫, 胡泊, 等. 中国11省市成年人吸烟和被动吸烟情况调查[J]. 中国慢性病预防与控制, 2010, 18(3):229-230.

1. 朱海清, 杨文英. 亚洲人群糖尿病患病情况:现状和未来[J]. 中华流行病学杂志, 2011, 32(11):1065-1067.
2. 中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2010年版)[J]. 中国糖尿病杂志, 2012, 20(1):81-117.
3. 胡大一. 糖尿病患者多重心血管危险因素综合管理中国专家共识[J]. 心脑血管病防治, 2012, 12(4):261-266.
4. World Health Organization. Package of essential noncommunicable (PEN) disease interventions for primary health care in low-resource settings[M]. Geneva:World Health Organization, 2010.
5. 中国高血压防治指南修订委员会. 中国高血压防治指南[J]. 高血压杂志, 2000, 39(2):7-16.
6. 中国成人血脂异常防治指南制订联合委员会. 中国成人血脂异常防治指南[J]. 中华心血管病杂志, 2007, 35(5):390-419.
7. 中国肥胖问题工作组数据汇总分析协作组. 我国成人体重指数和腰围对相关疾病危险因素异常的预测价值:适宜体重指数和腰围切点的研究[J]. 中华流行病学杂志, 2002, 23(1):10-15.
8. 李栩, 冯波, 倪亚芳, 等. 不同诊断标准对上海市浦东新区40岁以上社区人群糖代谢类型分布的影响[J]. 上海医学, 2006, 29(5):283-285.
9. 冀黎明, 张春槐, 柴军土, 等. 浙江省慈溪市部分城乡40岁以上人群糖尿病的患病率调查[J]. 江西医药, 2007, 42(5):402-404.
10. 邹欣, 张娅东, 朱风元, 等. 福建省三明社区糖尿病及糖调节受损患病率现况调查[J]. 中国医学文摘:老年医学分册, 2009, 2(1):32-34.
11. 吕春雷. 杭州城区居民糖代谢异常的流行病学调查[J]. 中国现代医生, 2012, 50(24):10-11, 14.
12. 王帅, 岳仁宋, 龚光明, 等. 农村中老年居民2型糖尿病影响因素分析[J]. 中国公共卫生, 2011, 27(7):819-820.
13. 武阳丰, 马冠生, 胡永华, 等. 中国居民的超重和肥胖流行现状[J]. 中华预防医学杂志, 2005, 39(5):316-320.
14. 李强. 肥胖促进2型糖尿病发生的研究进展[J]. 临床内科杂志, 2012, 29(3):152-154.
15. 姚冬娥, 吴慧芳, 储德节. 农村地区糖尿病患者体质指数与血脂、血糖及血压间的关系[J]. 中华全科医学, 2012, 10(9):1434-1435.
16. 张闻宇, 张素华, 任伟, 等. 重庆地区NGT、IGR、糖尿病血脂异常的特征[J]. 重庆医科大学学报, 2005, 30(5):704-706.
17. DeFronzo RA. Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis:the missing links. The Claude Bernard Lecture 2009[J]. Diabetologia, 2010, 53(7):1270-1287.
18. 陈宇红, 张翼飞, 詹维伟, 等. 早期动脉硬化与不同糖耐量状态的相关性[J]. 中华内分泌代谢杂志, 2005, 21(4):353-356.
19. Ginsberg HN, Elam MB, Lovato LC, et al. Effects of combination lipid therapy in type 2 diabetes mellitus[J]. N Engl J Med, 2010, 362(17):1563-1574.
20. Li G, Zhang P, Wang J, et al. The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study:a 20-year follow-up study[J]. Lancet, 2008, 371(9626):1783-1789.
21. 战义强, 余金明, 胡大一, 等. 北京居民糖尿病患病率及相关知识行为调查[J]. 中国公共卫生, 2012, 28(1):19-21.
22. 徐涛, 李卫, 胡泊, 等. 中国11省市成年人吸烟和被动吸烟情况调查[J]. 中国慢性病预防与控制, 2010, 18(3):229-230.

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