颅内原发性绒毛膜癌的诊治进展_West China Medical Journal

Authors：

 刘志勇 ¹ , 郄远巍 ² ,  徐建国 ¹

1. ;
2. ;

Corresponding author：

徐建国, Email: jianguo_1229@sina.com

Keywords：

颅内原发性绒毛膜癌; 影像学表现; 人绒毛膜促性腺激素; 联合治疗

DOI：

10.7507/1002-0179.20150111

Video：

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颅内原发性绒毛膜癌是一种恶性程度极高的非生殖细胞性生殖细胞瘤，其临床罕见，以易发生致命性出血和颅内外播散为主要临床特征。目前国内外对其治疗方法不一，且认识不足，常出现误诊及延误治疗，预后极差。为提高对该病的认识，避免延误诊治，改善预后，现就国内外对于颅内原发性绒毛膜癌的诊治进展作一综述。

Citation： 刘志勇, 郄远巍, 徐建国. 颅内原发性绒毛膜癌的诊治进展. West China Medical Journal, 2015, 30(2): 373-376. doi: 10.7507/1002-0179.20150111 Copy

1.	Askanazy M. Das teratom und chorioepitheliom der zwirbel[J]. Verh Dtsch Ges Pathol, 1906, 10(1):58-76.
2.	Matsutani M, Sano K, Takakura K, et al. Primary intracranial germ cell tumors:a clinical analysis of 153 histologically verified cases[J]. J Neurosurg, 1997, 86(3):446-455.
3.	Jennings MT, Gelman R, Hochberg F. Intracranial germ-cell tumors:natural history and pathogenesis[J]. J Neurosurg, 1985, 63(2):155-167.
4.	The Committee of the Brain Tumor Registry of Japan. Report of the brain tumor registry of Japan (1969-1993) 10th edn[J]. Neurol Med Chir, 2000, 40(Suppl):1-106.
5.	Junko H, Yoichi N. Pathology of pineal region tumors[J]. J Neuro-Oncol, 2001, 54(3):239-249.
6.	Kazuhiro N. Epidemiology of germ cell tumors in Asia of pineal region tumor[J]. J Neuro-Oncol, 2001, 54(3):211-217.
7.	Koyama S, Tsubokawa T, Katayama Y, et al. Choriocarcinoma of the septum pellucidum:case report[J]. Surg Neurol, 1991, 35(6):478-482.
8.	Shinoda J, Sakai N, Yano H, et al. Prognostic factors and therapeutic problems of primary intracranial choriocarcinoma/germ-cell tumors with high levels of HCG[J]. J Neuro-Oncol, 2004, 66(1/2):225-240.
9.	Page R, Doshi B, Sharr MM. Primary intracranial choriocarcinoma[J]. J Neurol Neurosurg Psychiatry, 1986, 49(1):93-95.
10.	孙学进, 沈进, 戴建平, 等. 颅内原发绒毛膜上皮癌影像学诊断分析[J]. 中国现代影像学杂志, 2006, 3(12):1065-1068.
11.	Teruyoshi K, Shinji N, Kazuhito M et al. Successful neoadjuvant synchronous chemo- and radiotherapy for disseminated primary intracranial choriocarcinoma:case report[J]. J Neurooncol, 2007, 83(2):199-204.
12.	Nomura K. Special report of brain tumor registry of Japan (1969-1990):Part Ⅱ Results of treatment[J]. Neuro Med Chir, 1999, 39(1):76-106.
13.	Sesterhenn LA,Davis CJ.Pathology of germ cell tumors of the testis[J]. Cancer Control, 2004, 11(6):374-387.
14.	Fine G, Smith RW, Pachter MR. Primary extragenital chiriocarcinoma in the male subject:case report and review of the literature[J]. Am J Med, 1962, 32:776-794.
15.	Ikura Y, Inoue T, Tsukuda H, et al. Primary choriocarcinoma and human chorionic gonadotrophin-producing giant cell carcinoma of the lung:are they independent entities?[J]. Histopathology, 2000, 36(1):17-25.
16.	于向荣, 张威江, 李薇. 成年男性鞍区原发性绒毛膜上皮癌一例[J]. 临床放射学杂志, 2012, 31(10):1485-1486.
17.	陈路佳, 蔡军, 陈左权, 等. 原发性颅内绒毛膜癌1例[J]. 实用医学杂志, 2012, 28(15):2051.
18.	Kazuhiko S, Kazunori A, Atsushi T. Morphologic features of human chorionic gonadotropin- or alpha-fetoprotein-producing germ cell tumors of the central nervous system:histological heterogeneity and surgical meaning[J]. Brain Tumor Pathol, 2001, 18(2):115-122.
19.	张喜安, 漆松涛, 方陆雄, 等. 原发性松果体区绒毛膜癌的综合治疗(附 2 例报告)[J]. 南方医科大学学报, 2007, 27(8):1193-1195.
20.	李欣欣,汪秀玲. 鞍区绒毛膜癌一例[J]. 临床放射学杂志, 2011, 30(12):1875.
21.	邱炳辉, 肖罡, 莫益萍, 等. 松果体区肿瘤的MRI表现与其病理学对照研究[J]. 中国临床神经外科杂志, 2011, 16(8):456-459.
22.	Kohyama S, Uematsu M, Ishihara S, et al. An experience of stereotactic radiation therapy for primary intracranial choriocarcinoma[J]. Tumori, 2001, 87(3):162-165.
23.	Lv XF, Qiu WY, Zhang XL. Primary intracranial choriocarcinoma:MR imaging findings[J]. AJNR Am J Neuroradiol, 2010, 31(10):1994-1998.
24.	徐嬿, 陈燕萍, 王琦, 等. 颅内绒毛膜上皮癌的影像学表现[J]. 临床放射学杂, 2012, 31(5):746-749.
25.	刘红艳, 张雪林, 李绍林. 原发性颅内绒毛膜癌的MRI表现[J]. 中华放射学杂志, 2008, 42(10):1108-1109.
26.	Athanassios P, Kyritsis. Management of primary intracranial germ cell tumors[J]. J Neurooncol, 2010, 96(2):143-149.
27.	Shin KH, Kim IH, Choe G. Impacts of elevated level of hCG in serum on clinical course and radiotherapy results in the histology conformed intracranial germinomas[J]. Acta Oncologica, 2001, 40(1):98-101.
28.	Ogawa K, Toita T, Nakamura K, et al. Treatment and prognosis of patients with intracranial nongerminomatous malignant germ cell tumors:a multiinstitutional retrospective analysis of 41 patients[J].Cancer, 2003, 98(2):369-376.
29.	Tomohiro K, Toshihiro K, Masayuki K. Logarithmic decrease of serum alpha-fetoprotein or human chorionic gonadotropin in response to chemotherapy can distinguish a subgroup with better prognosis among highly malignant intracranial non-germinomatous germ cell tumors[J]. J Neurooncol, 2011, 104(3):779-787.
30.	Utsuki S, Oka H, Tanaka y, et al. Long-term outcome of Intracranial germinoma with hCG elevation in cerebrospinal fluid but not in Serum[J]. Acta Neurochir, 2002, 144(11):1151-1154.
31.	Michel L, Gustavo T, Sabine C. Are stereotactic sample biopsies still of value in the modern management of pineal region tumours? Lessons from a single-department, retrospective series[J]. Acta Neurochir, 2011, 153(5):1111-1122.
32.	柴成奎周俊林. 颅内生殖细胞肿瘤研究进展[J]. 中国CT和MRI杂志, 2012, 10(5):101-105.
33.	Matsutani M, Ushio Y, Abe H, et al. Combined chemotherapy and radiation therapy for central nervous system germ cell tumors:preliminary results of a phase Ⅱ study of the Japanese Pediatric Brain Tumor Study Group(C). Neurosurg Focus, 1998, 5(1):1-7.
34.	Kyritsis AP. Management of primary intracranial germ cell tumors[J]. J Neurooncol, 2010, 96(2):143-149.
35.	Kanamori M, Kumabe T, Saito R, et al. Optimal treatment strategy for intracranial germ cell tumors:a single institution analysis[J]. J Neurosurg Pediatr, 2009, 4(6):506-514.
36.	Antonio S, Marica E, Andrea S, et al. Combined chemotherapy and radiotherapy for intracranial germinomas in adult patients: a single-institution study[J]. J Neuro-Oncol, 2005, 71(3):271-276.
37.	Kimura H, Miyashita Y, Inoue K, et al. A case report of successfully treated HCG-secreting primary intracranial choriocarcinoma by high-dose chemotherapy with autologous marrow transplantation[J]. Nippon Naika Gakkai Zasshi, 1995, 84(2):132-134.
38.	Tsuyoshi T, Takeomi T, Fumi N, et al. Treatment of intracranial nongerminomatous germ-cell tumor by high-dose chemotherapy and autologous stem-cell rescue[J]. J Neuro-Oncol, 1999, 44(1):71-76.

1. Askanazy M. Das teratom und chorioepitheliom der zwirbel[J]. Verh Dtsch Ges Pathol, 1906, 10(1):58-76.
2. Matsutani M, Sano K, Takakura K, et al. Primary intracranial germ cell tumors:a clinical analysis of 153 histologically verified cases[J]. J Neurosurg, 1997, 86(3):446-455.
3. Jennings MT, Gelman R, Hochberg F. Intracranial germ-cell tumors:natural history and pathogenesis[J]. J Neurosurg, 1985, 63(2):155-167.
4. The Committee of the Brain Tumor Registry of Japan. Report of the brain tumor registry of Japan (1969-1993) 10th edn[J]. Neurol Med Chir, 2000, 40(Suppl):1-106.
5. Junko H, Yoichi N. Pathology of pineal region tumors[J]. J Neuro-Oncol, 2001, 54(3):239-249.
6. Kazuhiro N. Epidemiology of germ cell tumors in Asia of pineal region tumor[J]. J Neuro-Oncol, 2001, 54(3):211-217.
7. Koyama S, Tsubokawa T, Katayama Y, et al. Choriocarcinoma of the septum pellucidum:case report[J]. Surg Neurol, 1991, 35(6):478-482.
8. Shinoda J, Sakai N, Yano H, et al. Prognostic factors and therapeutic problems of primary intracranial choriocarcinoma/germ-cell tumors with high levels of HCG[J]. J Neuro-Oncol, 2004, 66(1/2):225-240.
9. Page R, Doshi B, Sharr MM. Primary intracranial choriocarcinoma[J]. J Neurol Neurosurg Psychiatry, 1986, 49(1):93-95.
10. 孙学进, 沈进, 戴建平, 等. 颅内原发绒毛膜上皮癌影像学诊断分析[J]. 中国现代影像学杂志, 2006, 3(12):1065-1068.
11. Teruyoshi K, Shinji N, Kazuhito M et al. Successful neoadjuvant synchronous chemo- and radiotherapy for disseminated primary intracranial choriocarcinoma:case report[J]. J Neurooncol, 2007, 83(2):199-204.
12. Nomura K. Special report of brain tumor registry of Japan (1969-1990):Part Ⅱ Results of treatment[J]. Neuro Med Chir, 1999, 39(1):76-106.
13. Sesterhenn LA,Davis CJ.Pathology of germ cell tumors of the testis[J]. Cancer Control, 2004, 11(6):374-387.
14. Fine G, Smith RW, Pachter MR. Primary extragenital chiriocarcinoma in the male subject:case report and review of the literature[J]. Am J Med, 1962, 32:776-794.
15. Ikura Y, Inoue T, Tsukuda H, et al. Primary choriocarcinoma and human chorionic gonadotrophin-producing giant cell carcinoma of the lung:are they independent entities?[J]. Histopathology, 2000, 36(1):17-25.
16. 于向荣, 张威江, 李薇. 成年男性鞍区原发性绒毛膜上皮癌一例[J]. 临床放射学杂志, 2012, 31(10):1485-1486.
17. 陈路佳, 蔡军, 陈左权, 等. 原发性颅内绒毛膜癌1例[J]. 实用医学杂志, 2012, 28(15):2051.
18. Kazuhiko S, Kazunori A, Atsushi T. Morphologic features of human chorionic gonadotropin- or alpha-fetoprotein-producing germ cell tumors of the central nervous system:histological heterogeneity and surgical meaning[J]. Brain Tumor Pathol, 2001, 18(2):115-122.
19. 张喜安, 漆松涛, 方陆雄, 等. 原发性松果体区绒毛膜癌的综合治疗(附 2 例报告)[J]. 南方医科大学学报, 2007, 27(8):1193-1195.
20. 李欣欣,汪秀玲. 鞍区绒毛膜癌一例[J]. 临床放射学杂志, 2011, 30(12):1875.
21. 邱炳辉, 肖罡, 莫益萍, 等. 松果体区肿瘤的MRI表现与其病理学对照研究[J]. 中国临床神经外科杂志, 2011, 16(8):456-459.
22. Kohyama S, Uematsu M, Ishihara S, et al. An experience of stereotactic radiation therapy for primary intracranial choriocarcinoma[J]. Tumori, 2001, 87(3):162-165.
23. Lv XF, Qiu WY, Zhang XL. Primary intracranial choriocarcinoma:MR imaging findings[J]. AJNR Am J Neuroradiol, 2010, 31(10):1994-1998.
24. 徐嬿, 陈燕萍, 王琦, 等. 颅内绒毛膜上皮癌的影像学表现[J]. 临床放射学杂, 2012, 31(5):746-749.
25. 刘红艳, 张雪林, 李绍林. 原发性颅内绒毛膜癌的MRI表现[J]. 中华放射学杂志, 2008, 42(10):1108-1109.
26. Athanassios P, Kyritsis. Management of primary intracranial germ cell tumors[J]. J Neurooncol, 2010, 96(2):143-149.
27. Shin KH, Kim IH, Choe G. Impacts of elevated level of hCG in serum on clinical course and radiotherapy results in the histology conformed intracranial germinomas[J]. Acta Oncologica, 2001, 40(1):98-101.
28. Ogawa K, Toita T, Nakamura K, et al. Treatment and prognosis of patients with intracranial nongerminomatous malignant germ cell tumors:a multiinstitutional retrospective analysis of 41 patients[J].Cancer, 2003, 98(2):369-376.
29. Tomohiro K, Toshihiro K, Masayuki K. Logarithmic decrease of serum alpha-fetoprotein or human chorionic gonadotropin in response to chemotherapy can distinguish a subgroup with better prognosis among highly malignant intracranial non-germinomatous germ cell tumors[J]. J Neurooncol, 2011, 104(3):779-787.
30. Utsuki S, Oka H, Tanaka y, et al. Long-term outcome of Intracranial germinoma with hCG elevation in cerebrospinal fluid but not in Serum[J]. Acta Neurochir, 2002, 144(11):1151-1154.
31. Michel L, Gustavo T, Sabine C. Are stereotactic sample biopsies still of value in the modern management of pineal region tumours? Lessons from a single-department, retrospective series[J]. Acta Neurochir, 2011, 153(5):1111-1122.
32. 柴成奎周俊林. 颅内生殖细胞肿瘤研究进展[J]. 中国CT和MRI杂志, 2012, 10(5):101-105.
33. Matsutani M, Ushio Y, Abe H, et al. Combined chemotherapy and radiation therapy for central nervous system germ cell tumors:preliminary results of a phase Ⅱ study of the Japanese Pediatric Brain Tumor Study Group(C). Neurosurg Focus, 1998, 5(1):1-7.
34. Kyritsis AP. Management of primary intracranial germ cell tumors[J]. J Neurooncol, 2010, 96(2):143-149.
35. Kanamori M, Kumabe T, Saito R, et al. Optimal treatment strategy for intracranial germ cell tumors:a single institution analysis[J]. J Neurosurg Pediatr, 2009, 4(6):506-514.
36. Antonio S, Marica E, Andrea S, et al. Combined chemotherapy and radiotherapy for intracranial germinomas in adult patients: a single-institution study[J]. J Neuro-Oncol, 2005, 71(3):271-276.
37. Kimura H, Miyashita Y, Inoue K, et al. A case report of successfully treated HCG-secreting primary intracranial choriocarcinoma by high-dose chemotherapy with autologous marrow transplantation[J]. Nippon Naika Gakkai Zasshi, 1995, 84(2):132-134.
38. Tsuyoshi T, Takeomi T, Fumi N, et al. Treatment of intracranial nongerminomatous germ-cell tumor by high-dose chemotherapy and autologous stem-cell rescue[J]. J Neuro-Oncol, 1999, 44(1):71-76.

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颅内原发性绒毛膜癌的诊治进展

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