Expression of Tumor Necrosis Factor-α in Prostate Cancer and Its Clinical Significance_West China Medical Journal

Authors：

 XURui ¹ , CHENXu ² , WANGLi ¹ , LIUKai-ge ¹ , CHENGBi-ping ³

1. Research Department;Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi 710077, P. R. China;
Nursing Department;Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi 710077, P. R. China;
3. Department of Key Laboratory;Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi 710077, P. R. China;

Corresponding author：

Keywords：

Prostate cancer; Tumor necrosis factor-α; Microvessel density

DOI：

10.7507/1002-0179.20150121

Video：

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Objective To investigate the expression of tumor necrosis factor-α (TNF-α) in prostate cancer tissue and explore its relations with tumor angiogenesis. Methods The expression of TNF-α and CD105 were detected with two-step immunohistochemical staining technique in 20 cases of benign prostatic hyperplasia and 50 cases of prostate cancer between January 2010 and January 2012, and microvessel density (MVD) marked with CD105 was also measured. Results The expressions of TNF-α and CD105 were higher in prostate cancer (41.72±8.67, 20.15±2.67) than those in benign prostatic hyperplasia (21.01±3.85, 4.34±1.67) (t'=13.990, P<0.001; t'=29.771, P<0.001). TNF-α and MVD were not correlated with age and size of tumor, but were positively correlated with tumor differentiation degree (r_s=0.847, P<0.001; r_s=0.776, P<0.001) and negatively correlated with clinical grades (r_s=-0.769, P<0.001; r_s=-0.842, P<0.001). Conclusion The result indicates that over expression of TNF-α exists in prostate cancer. It may play an important role in the anginogenesis and carcinogenesis of prostate cancer.

Citation： XURui, CHENXu, WANGLi, LIUKai-ge, CHENGBi-ping. Expression of Tumor Necrosis Factor-α in Prostate Cancer and Its Clinical Significance. West China Medical Journal, 2015, 30(3): 407-410. doi: 10.7507/1002-0179.20150121 Copy

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15.	白莉, 毛高平, 曹传平, 等. 肝癌切除术后转移过程中炎性递质的作用[J]. 世界华人消化杂志, 2005, 13(13):1507-1509.
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19.	张少华, 刘凯歌, 郑建云, 等. 上皮性卵巢癌中癌胚抗原相关细胞黏附分子1和CD105的表达[J]. 新乡医学院学报, 2012, 29(11):834-836.

1. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013[J]. CA Cancer J Clin, 2013, 63(1):11-30.
2. 王晋龙, 白铁男, 胡海龙, 等. HIF-1α和VEGF-C在前列腺癌中的表达及意义[J]. 天津医药, 2012, 40(1):4-6, 98.
3. Prévost-Blondel A, Roth E, Rosenthal FM, et al. Crucial role of TNF-alpha in CD8 T cell-mediated elimination of 3LL-A9 Lewis lung carcinoma cells in vivo[J]. J Immmunol, 2000, 164(7):3645-3651.
4. Baxevanis CN, Voutsas IF, Tsitsilonis OE, et al. Compromised anti-tumor responses in tumor necrosis factor-alpha knockout mice[J]. Eur J Immunol, 2000, 30(7):1957-1966.
5. 王弱, 刘爱东, 庞久玲, 等. CD105在结直肠腺癌组织中的表达及意义[J]. 山东医药, 2007, 47(20):27.
6. Egevad L, Granfors T, Karlberg L, et al. Prognostic value of the Gleason score in prostate cancer[J]. BJU Int, 2002, 89(6):538-542.
7. Whitmore WF Jr. Natural history and staging of prostate cancer[J]. Urol Clin North Am, 1984, 11(2):205-210.
8. Weidner N, Folkman J, Pozza F, et al. Tumor angiogenesis:a new significant and independent prognostic indicator in early-stage breast carcinoma[J]. J Natl Cancer Inst, 1992, 84(17):1875-1887.
9. 崔力方, 郭晓静, 付丽. TNF-α与肿瘤发生发展关系的研究进展[J]. 中华乳腺病杂志:电子版, 2007, 1(6):236-240.
10. 杨路亭, 邹玉安, 吴晓萱, 等. TNFα在进展期胃癌局部组织中的分布及意义[J]. 世界华人消化杂志, 2000, 8(增刊1):84.
11. 信涛, 徐玉清, 姜秋颖, 等. TNFα和Bcl-2在大肠癌中的表达及意义[J]. 中国现代医学杂志, 2003(13):87-89.
12. Karayiannakis AJ, Syrigos KN, Polychronidis A, et al. Serum levels of tumor necrosis factor-alpha and nutritional status in pancreatic cancer patients[J]. Anticancer Res, 2001, 21(2B):1355-1358.
13. Yoshida N, Ikemoto S, Narita K, et al. Interleukin-6, tumour necrosis factor alpha and interleukin-1 beta in patients with renal cell carcinoma[J]. Br J Cancer, 2002, 86(9):1396-1400.
14. 赵文鹏, 苗战会, 路平, 等. TNF-α基因多态性与食管癌相关性的研究[J]. 中国医疗前沿, 2010, 5(7):6-8.
15. 白莉, 毛高平, 曹传平, 等. 肝癌切除术后转移过程中炎性递质的作用[J]. 世界华人消化杂志, 2005, 13(13):1507-1509.
16. Durkan GC, Nutt JE, Marsh C, et al. Alteration in urinary matrix metalloproteinase-9 to tissue inhibitor of metalloproteinase-1 ratio predicts recurrence in nonmuscle-invasive bladder cancer[J]. Clin Cancer Res, 2003, 9(7):2576-2582.
17. Sier CF, Casetta G, Veheijen JH, et al. Enhanced urinary gelatinase activities (matrix metalloproteinases 2 and 9) are associated with early-stage bladder carcinoma:a comparison with clinically used tumor markers[J]. Clin Cancer Res, 2000, 6(6):2333-2340.
18. 王艳芬, 丁永玲, 李家驭, 等. Ang-2、CD105和CD34在脑胶质瘤中的表达及生物学意义[J]. 现代肿瘤医学, 2008, 16(1):23-26.
19. 张少华, 刘凯歌, 郑建云, 等. 上皮性卵巢癌中癌胚抗原相关细胞黏附分子1和CD105的表达[J]. 新乡医学院学报, 2012, 29(11):834-836.

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Expression of Tumor Necrosis Factor-α in Prostate Cancer and Its Clinical Significance

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