性别及性腺激素对睡眠影响的临床研究进展_West China Medical Journal

Authors：

 付聪 , 谢晨 ,  陈云飞

上海中医药大学附属岳阳中西医结合医院中心实验室（上海 200347）;

Corresponding author：

陈云飞, Email: icyf1968@163.com

Keywords：

性别; 性腺激素; 生理睡眠; 慢性失眠; 临床研究

DOI：

10.7507/1002-0179.20150166

Video：

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睡眠和生理节律的机制已得到广泛研究，其异常存在着性别差异，因此针对不同性别失眠患者的临床研究对提高临床疗效有着重要作用和意义。现综合近5年国内外相关临床文献，从性别和性腺激素角度探讨其对生理睡眠和慢性失眠的影响。

Citation： 付聪, 谢晨, 陈云飞. 性别及性腺激素对睡眠影响的临床研究进展. West China Medical Journal, 2015, 30(3): 577-581. doi: 10.7507/1002-0179.20150166 Copy

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1. Bolge SC, Joish VN, Balkrishnan R, et al. Burden of chronic sleep maintenance insomnia characterized by nighttime awakenings[J]. Popul Health Manag, 2010, 13(1):15-20.
2. 孙卉, 张田. 589名徐州市大学生睡眠质量及其相关因素分析[J]. 中国校医, 2009, 23(2):160-162.
3. 李燕芬, 叶小华, 徐英. 中国大学生睡眠质量性别差异的Meta分析[J]. 中国学校卫生, 2012, 33(1):74-77.
4. 潘敬菊, 谭晓东, 谢朝军. 大学生睡眠质量和相关影响因素调查[J]. 中国热带医学, 2007, 7(5):845-847.
5. 邹枝玲, 黄希庭, 杨勋, 等. 大学生睡眠质量与睡眠卫生意识现状[J]. 西南大学学报:人文社会科学版, 2006, 32(3):7-11.
6. 姜丹宁. 沈阳市大学生睡眠质量及影响因素分析[J]. 中国公共卫生, 2008, 24(9):1130-1131.
7. 王生平. 高原地区大学生睡眠质量调查[J]. 卫生职业教育, 2009, 27(22):106.
8. 章劲松. 在校大学生睡眠质量及其影响因素研究[D]. 武汉:武汉科技大学, 2012:8-10.
9. 戚东桂, 刘荣, 吴晓茜, 等. 大学生睡眠质量及其影响因素调查[J]. 现代预防医学, 2007, 34(5):875-877.
10. 张林, 刁娟. 大学生睡眠质量及其相关影响因素的研究[J]. 中国临床心理学杂志, 2006, 14(5):515-517.
11. 曹炳健, 曹辉, 白吉可. 石河子大学在校大学生睡眠质量与心理健康状况的调查研究[J]. 中国健康心理学杂志, 2009, 17(10):1225-1227.
12. 赵崇莲, 郑涌. 大学生睡眠质量与A型行为模式的相关研究[J]. 西南大学学报:社会科学版, 2008, 34(6):7-10.
13. 邹宗峰, 方小衡, 刘茂玲, 等. 某医药院校大学生睡眠质量与考试焦虑的关系研究[J]. 中国健康心理学杂志, 2010, 18(6):697-700.
14. 尹辉, 王丽娜, 袁岗. 医学院校大学生睡眠质量及影响因素分析[J]. 中国公共卫生, 2008, 24(11):1346.
15. Mccall C, Mccall WV. Objective vs. subjective measurements of sleep in depressed insomniacs:first night effect or reverse first night effect?[J]. J Clin Sleep Med, 2012, 8(1):59-65.
16. Van den Berg JF, Miedema HM, Tulen JH, et al. Sex differences in subjective and actigraphic sleep measures:a population-based study of elderly persons[J]. Sleep, 2009, 32(10):1367-1375.
17. Kuriyama K, Mishima K, Soshi T, et al. Effects of sex differences and regulation of the sleep-wake cycle on aversive memory encoding[J]. Neurosci Res, 2011, 70(1):104-110.
18. 潘集阳, 马文彬, 张继辉, 等. 慢性原发性失眠患者主客观睡眠质量差异及相关因素[J]. 中国神经精神疾病杂志, 2007, 33(2):69-72.
19. Giménez S, Romero S, Gich I, et al. Sex differences in sleep after a single oral morning dose of olanzapine in healthy volunteers[J]. Hum Psychopharmacol, 2011, 26(7):498-507.
20. Dijk DJ, James LM, Peters S, et al. Sex differences and the effect of gaboxadol and zolpidem on EEG power spectra in NREM and REM sleep[J]. J Psychopharmacol, 2010, 24(11):1613-1618.
21. Paul KN, Turek FW, Kryger MH. Influence of sex on sleep regulatory mechanisms[J]. J Womens Health (Larchmt), 2008, 17(7):1201-1208.
22. Duffy JF, Cain SW, Chang AM, et al. Sex difference in the near-24-hour intrinsic period of the human circadian timing system[J]. Proc Natl Acad Sci USA, 2011, 108(Suppl 3):15602-15608.
23. Toh KL, Jones CR, He Y, et al. An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome[J]. Science, 2001, 291(5506):1040-1043.
24. Ebisawa T, Uchiyama M, Kajimura N, et al. Association of structural polymorphisms in the human period 3 gene with delayed sleep phase syndrome[J]. EMBO Rep, 2001, 2(4):342-346.
25. Archer SN, Robillard DL, Skene DJ, et al. A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference[J]. Sleep, 2003, 26(4):413-415.
26. Dijk DJ, Beersma DG, Bloem GM. Sex differences in the sleep EEG of young adults:visual scoring and spectral analysis[J]. Sleep, 1989, 12(6):500-507.
27. Ehlers CL, Kupfer DJ. Slow-wave sleep:do young adult men and women age differently?[J]. J Sleep Res, 1997, 6(3):211-215.
28. Armitage R, Hoffmann RF. Sleep EEG, depression and gender[J]. Sleep Med Rev, 2001, 5(3):237-246.
29. Armitage R, Thompson SC, Thompson S, et al. Sex differences in slow wave activity in response to sleep deprivation[J]. Sleep Res Online, 2001, 4:33-41.
30. Carter JR, Durocher JJ, Larson RA, et al. Sympathetic neural responses to 24-hour sleep deprivation in humans:sex differences[J]. Am J Physiol Heart Circ Physiol, 2012, 302(10):H1991-H1997.
31. Pawlyk AC, Morrison AR, Ross RJ. Stress-induced changes in sleep in rodents:models and mechanisms[J]. Neurosci Biobehav Rev, 2008, 32(1):99-117.
32. Buysse DJ, Germain A, Hall ML, et al. EEG spectral analysis in primary insomnia:NREM period effects and sex differences[J]. Sleep, 2008, 31(12):1673-1682.
33. 姚华, 邹媛. 新疆高校3288名管理干部及高级知识分子健康调查研究[J]. 新疆医科大学学报, 2011, 34(12):1402-1405.
34. Green MJ, Espie CA, Hunt K, et al. The longitudinal course of insomnia symptoms:inequalities by sex and occupational class among two different age cohorts followed for 20 years in the West of Scotland[J]. Sleep, 2012, 35(6):815-823.
35. 梁政亭, 朱奇, 张星平, 等. 失眠症PSG睡眠结构参数男女性别差异比较[J]. 新疆医科大学学报, 2013, 36(6):796-798.
36. Richards A, Metzler TJ, Ruoff LM, et al. Sex differences in objective measures of sleep in post-traumatic stress disorder and healthy control subjects[J]. J Sleep Res, 2013, 22(6):679-687.
37. Kobayashi I, Cowdin N, Mellman T. One's sex, sleep, and post-traumatic stress disorder[J]. Biol Sex Differ, 2012, 3(1):29.
38. Born L, Shea A, Steiner M. The Roots of depression in adolescent girls:is menarche the key?[J]. Curr Psychiatry Rep, 2002, 4(6):449-460.
39. Zhang B, Wing YK. Sex differences in insomnia:a meta-analysis[J]. Sleep, 2006, 29(1):85-93.
40. Thordstein M, Lofgren N, Flisberg AA, et al. Sex differences in electrocortical activity in human neonates[J]. Neuroreport, 2006, 17(11):1165-1168.
41. Menna-Barreto L, Montagner H, Soussignan R, et al. The sleep/wake cycle in 4-to 14-month-old children:general aspects and sex differences[J]. Braz J Med Biol Res, 1989, 22(1):103-106.
42. Nagy E, Loveland KA, Orvos H, et al. Gender-related physiologic differences in human neonates and the greater vulnerability of males to developmental brain disorders[J]. J Gend Specif Med, 2001, 4(1):41-49.
43. Sadeh A, Dark I, Vohr BR. Newborns' sleep-wake patterns:the role of maternal, delivery and infant factors[J]. Early Hum Dev, 1996, 44(2):113-126.
44. Hoppenbrouwers T, Hodgman JE, Rybine D, et al. Sleep architecture in term and preterm infants beyond the neonatal period:the influence of gestational age, steroids, and ventilatory support[J]. Sleep, 2005, 28(11):1428-1436.
45. Campbell IG, Grimm KJ, De Bie E, et al. Sex, puberty, and the timing of sleep EEG measured adolescent brain maturation[J]. Proc Natl Acad Sci USA, 2012, 109(15):5740-5743.
46. Genzel L, Kiefer T, Renner L, et al. Sex and modulatory menstrual cycle effects on sleep related memory consolidation[J]. Psychoneuroendocrinology, 2012, 37(7):987-998.
47. Olds T, Blunden S, Petkov J, et al. The relationships between sex, age, geography and time in bed in adolescents. A meta-analysis of data from 23 countries[J]. Sleep Med Rev, 2010, 14(6):371-378.
48. Tonetti L, Fabbri M, Natale V. Sex difference in sleep-time preference and sleep need:a cross-sectional survey among Italian pre-adolescents, adolescents, and adults[J]. Chronobiol Int, 2008, 25(5):745-759.
49. Johnson EO, Roth T, Schultz L, et al. Epidemiology of DSM-Ⅳinsomnia in adolescence:lifetime prevalence, chronicity, and an emergent gender difference[J]. Pediatrics, 2006, 117(2):E₂47-E₂56.
50. Mong JA, Baker FC, Mahoney MM, et al. Sleep, rhythms, and the endocrine brain:influence of sex and gonadal hormones[J]. J Neurosci, 2011, 31(45):16107-16116.
51. Schiff I, Regestein Q, Tulchinsky D, et al. Effects of estrogens on sleep and psychological state of hypogonadal women[J]. JAMA, 1979, 242(22):2405-2407.
52. Antonijevic IA, Stalla GK, Steiger A. Modulation of the sleep electroencephalogram by estrogen replacement in postmenopausal women[J]. Am J Obstet Gynecol, 2000, 182(2):277-282.
53. Montplaisir J, Lorrain J, Denesle R, et al. Sleep in menopause:differential effects of two forms of hormone replacement therapy[J]. Menopause, 2001, 8(1):10-16.
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