Objective To evaluate the efficacy and safety of traditinal Chinese Medicine (TCM) syndrome classification and intervention for the prophylaxis of menstrual migraine. Methods Patients consistent with the inclusion criteria from January 2013 to June 2014 were included in the trial. Patients were randomized by their visiting order into two groups:the experimental group was treated with Chinese traditional medicine compound decoctions (two doses for three days), and the control group was treated with vitamin B2 (400 mg once daily). The patients were treated for thirty days consecutively. Efficacy was assessed using the records of the frequency, duration, and severity of migraine attacks. Laboratory tests, vital signs, and adverse events were monitored. Results Both treatments led to a significant reduction in the frequency, duration, and severity of migraine attacks (P<0.05). TCM therapy was significantly better than vitamin B₂ for reducing the frequency and the duration of migraine (P<0.05). No serious adverse drug reaction was found in both groups. Conclusion TCM syndrome classification and intervention is effective and relatively safe in the prophylaxis of menstrual migraine attacks.

Citation： ZHOUCong-rong, SUNHong-hui. Controlled Clinical Trials of Traditional Chinese Medicine Syndrome Classification and Intervention in the Prophylaxis of Menstrual Migraine. West China Medical Journal, 2015, 30(4): 618-621. doi: 10.7507/1002-0179.20150180 Copy