• 1. Department of Combination of Traditional Chinese Medicine and Western Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
  • 2. Department of Respiratory Diseases, Tianjin Medical University General Hospital, Tianjin 300052, P. R. China;
  • 3. Department of Respiratory Diseases, the Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, Jilin 130021, P. R. China;
  • 4. Department of Respiratory Diseases, the Integrated Medicine Hospital of Jilin Province, Changchun, Jilin 130021, P. R. China;
  • 5. Department of Respiratory Diseases, the Second Affiliated Hospital to Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning 110034, P. R. China;
  • 6. Department of Respiratory Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, P. R. China;
  • 7. Department of Respiratory Diseases, the Affiliated Hospital to Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi 330006, P. R. China;
  • 8. Department of Respiratory Diseases, Fujian Institute of Traditional Chinese Medicine, Fuzhou, Fujian 350003, P. R. China;
MAOBing, Email: maobing@medmail.com.cn
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Objective To evaluate the safety and efficacy of Chaihu drop-pill in the treatment of common cold (wind-heat syndrome). Methods A multi-center, double blind, double dummy, randomized controlled trial was conducted. A total of 479 patients with common cold (wind-heat syndrome) diagnosed between February and August, 2011, were randomly divided into two groups:the trial group (n=359) and the control group (n=120). The trial group received Chaihu drop-pill and Yinchai granule analogue three times a day, while the control group received Yinchai granule and Chaihu drop-pill analogue. The therapeutic courses of both groups were 3 days. Clinical symptoms, syndromes, and adverse effects were observed before and after the treatment. Furthermore, blood, urine and stool test, hepatorenal function test and electrocardiogram were also carried out before and after treatment. Results After treatment, the healing rates of the trial group and the control group were 32.4%, 20.2% (for full analysis set) and 32.6%, 20.5% (for per protocol set), and the overall response rates were 96.3%, 87.4% (for full analysis set) and 96.5%, 87.2% (for per protocol set). There were significant differences between the two groups (P<0.01). No adverse effects were found in the trial. Conclusion Chaihu drop-pill is effective and safe in the treatment of common cold (wind-heat syndrome).

Citation: CHANGJing, TANGFang, YANFeng-jie, CAIHong-yan, QIAOShi-ju, XIONGXu-dong, XUEHan-rong, CHENZhi-bin, MAOBing. Chaihu Drop-pill in Treatment of Common Cold: A Multi-center and Randomized Controlled Trial. West China Medical Journal, 2015, 30(4): 635-639. doi: 10.7507/1002-0179.20150185 Copy

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