细胞凋亡在哮喘伴抑郁发病中作用的探讨_West China Medical Journal

Authors：

 杨茵茵 , 朱敏 ,  姬郁林

四川大学华西医院呼吸内科（成都 610041）;

Corresponding author：

姬郁林, Email: 790754788@qq.com

Keywords：

哮喘; 抑郁; 细胞凋亡; 病因学

DOI：

10.7507/1002-0179.20150272

Video：

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支气管哮喘常伴发抑郁，二者可能存在重叠的发病机制。免疫炎症功能紊乱是学者倾向的一种机制，此紊乱为相应效应细胞生理学发生改变所致。其中，凋亡作为细胞重要的生理过程，其异常表现在疾病发生发展中可能发挥重要作用。现就细胞凋亡在哮喘伴抑郁发病机制中的作用进行综述。

Citation： 杨茵茵, 朱敏, 姬郁林. 细胞凋亡在哮喘伴抑郁发病中作用的探讨. West China Medical Journal, 2015, 30(5): 950-953. doi: 10.7507/1002-0179.20150272 Copy

1.	Fava M, Kendler KS. Major depressive disorder[J]. Neuron, 2000, 28(2):335-341.
2.	Loerbroks A, Herr RM, Subramanian SV, et al. The association of asthma and wheezing with major depressive episodes:an analysis of 245727 women and men from 57 countries[J]. Int J Epidemiol, 2012, 41(5):1436-1444.
3.	Van Lieshout RJ, Bienenstock J, Macqueen GM. A review of candidate pathways underlying the association between asthma and major depressive disorder[J]. Psychosom Med, 2009, 71(2):187-195.
4.	Kerr JF, Wyllie AH, Currie AR. Apoptosis:a basic biological phenomenon with wide-ranging implications in tissue kinetics[J]. Br J Cancer, 1972, 26(4):239-257.
5.	Bratton SB, Macfarlane M, Cain K, et al. Protein complexes activate distinct caspase cascades in death receptor and stress-induced apoptosis[J]. Exp Cell Res, 2000, 256(1):27-33.
6.	Korsmeyer SJ. Regulators of cell death[J]. Trends Genet, 1995, 11(3):101-105.
7.	Ashkenazi A, Dixit VM. Death receptors:signaling and modulation[J]. Science, 1998, 281(5381):1305-1308.
8.	Green DR, Reed JC. Mitochondria and apoptosis[J]. Science, 1998, 281(5381):1309-1312.
9.	Wang YM, Liu XD, Zhang DF, et al. The effects of apoptosis vulnerability markers on the myocardium in depression after myocardial infarction[J]. BMC Med, 2013, 11:32.
10.	Shi YF, Sahai BM, Green DR. Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes[J]. Nature, 1989, 339(6226):625-626.
11.	Krammer PH. CD95's deadly mission in the immune system[J]. Nature, 2000, 407(685):789-795.
12.	Spinozzi F, Fizzotti M, Agea E, et al. Defective expression of Fas messenger RNA and Fas receptor on pulmonary T cells from patients with asthma[J]. Ann Intern Med, 1998, 128(5):363-369.
13.	Algeciras-Schimnich A, Griffith TS, Lynch DH, et al. Cell cycle-dependent regulation of FLIP levels and susceptibility to Fas-mediated apoptosis[J]. J Immunol, 1999, 162(9):5205-5211.
14.	Jiang TW, Sheng JH, Qin YM, et al. Enhanced proliferation and defective activation-induced cell death of CD4⁺ T cells in chilldhood asthma[J]. Asian Pac J Allergy Immunol, 2014, 32(1):75-83.
15.	Müller M, Grunewald J, Olgart Höglund C, et al. Altered apoptosis in bronchoalveolar lavage lymphocytes after allergen exposure of atopic asthmatic subjects[J]. Eur Respir J, 2006, 28(3):513-522.
16.	Vercelli D. Immunoglobulin E and its regulators[J]. Curr Opin Allergy Clin Immunol, 2001, 1(1):61-65.
17.	Laoukili J, Perret E, Willems T, et al. IL-13 alters mucociliary differentiation and ciliary beating of human respiratory epithelial cells[J]. J Clin Invest, 2001, 108(12):1817-1824.
18.	Trautmann A, Schmid-Grendelmeier P, Krüger K, et al. T cells and eosinophils cooperate in the induction of bronchial epithelial cell apoptosis in asthma[J]. J Allergy Clin Immunol, 2002, 109(2):329-337.
19.	Roscioli E, Hamon R, Ruffin RE, et al. Cellular inhibitor of apoptosis-2 is a critical regulator of apoptosis in airway epithelial cells treated with asthma-related inflammatory cytokines[J]. Physiol Rep, 2013, 1(5):e00123.
20.	Amsterdam A, Sasson R. The anti-inflammatory action of glucocorticoids is mediated by cell type specific regulation of apoptosis[J]. Mol Cell Endocrinol, 2002, 189(1/2):1-9.
21.	Irwin MR, Miller AH. Depressive disorders and immunity:20 years of progress and discovery[J]. Brain Behav Immun, 2007, 21(4):374-383.
22.	Blume J, Douglas SD, Evans DL. Immune suppression and immune activation in depression[J]. Brain Behav Immun, 2011, 25(2):221-229.
23.	Dowlati Y, Herrmann N, Swardfager W, et al. A meta-analysis of cytokines in major depression[J]. Biol Psychiatry, 2010, 67(5):446-457.
24.	Biesmans S, Meert TF, Bouwknecht JA, et al. Systemic immune activation leads to neuroinflammation and sickness behavior in mice[J]. Mediators Inflamm, 2013, 2013:271359.
25.	Pan W, Banks WA, Kastin AJ. Permeability of the blood-brain and blood-spinal cord barriers to interferons[J]. J Neuroimmunol, 1997, 76(1/2):105-111.
26.	Kim SJ, Lee H, Lee G, et al. CD4+CD25+ regulatory T cell depletion modulates anxiety and depression-like behaviors in mice[J]. PLoS One, 2012, 7(7):e42054.
27.	Ivanova SA, Semke VY, Vetlugina TP, et al. Signs of apoptosis of immunocompetent cells in patients with depression[J]. Neurosci Behav Physiol, 2007, 37(5):527-530.
28.	Eilat E, Mendlovic S, Doron A, et al. Increased apoptosis in patients with major depression:a preliminary study[J]. J Immunol, 1999, 163(1):533-534.
29.	Szuster-Ciesielska A, Slotwinska M, Stachura A, et al. Accelerated apoptosis of blood leukocytes and oxidative stress in blood of patients with major depression[J]. Prog Neuropsychopharmacol Biol Psychiatry, 2008, 32(3):686-694.
30.	Sommershof A, Aichinger H, Engler HA, et al. Substantial reduction of naive and regulatory T cells following traumatic stress[J]. Brain Behav Immun, 2009, 23(8):1117-1124.
31.	Workman CJ, Szymczak WL, Collison LW, et al. The development and function of regulatory T cells[J]. Cell Mol Life Sci, 2009, 66(16):2603-2622.
32.	Du YJ, Li B, Zhang HY, et al., Airway inflammation and hypothalamic-pituitary-adrenal axis activity in asthmatic adults with depression[J]. J Asthma, 2013, 50(3):274-281.
33.	Raison CL, Capuron L, Miller AH. Cytokines sing the blues:inflammation and the pathogenesis of depression[J]. Trends Immunol, 2006, 27(1):24-31.
34.	Lloyd, C.M. and S. Saglani, T cells in asthma:influences of genetics, environment, and T-cell plasticity[J]. J Allergy Clin Immunol, 2013, 131(5):1267-1274.
35.	Van Lieshout RJ, Macqueen G. Psychological factors in asthma[J]. Allergy Asthma Clin Immunol, 2008, 4(1):12-28.
36.	Oh J, Malter JS. Pin1-FADD interactions regulate Fas-Mediated apoptosis in activated eosinophils[J]. J Immunol, 2013, 190(10):4937-4945.
37.	Wegmann M. Targeting eosinophil biology in asthma therapy[J]. Am J Respir Cell Mol Biol, 2011, 45(4):667-674.
38.	Walsh GM. Eosinophil apoptosis:mechanisms and clinical relevance in asthmatic and allergic inflammation[J]. Br J Haematol, 2000, 111(1):61-67.
39.	Vignola AM, Chanez P, Chiappara G, et al. Evaluation of apoptosis of eosinophils, macrophages, and T lymphocytes in mucosal biopsy specimens of patients with asthma and chronic bronchitis[J]. J Allergy Clin Immunol, 1999, 103(4):563-573.
40.	Jang AS, Choi IS, Lee S, et al. Bcl-2 expression in sputum eosinophils in patients with acute asthma[J]. Thorax, 2000, 55(5):370-374.
41.	Druilhe A, Wallaert B, Tsicopoulos A, et al. Apoptosis, proliferation, and expression of Bcl-2, Fas, and Fas ligand in bronchial biopsies from asthmatics[J]. Am J Respir Cell Mol Biol, 1998, 19(5):747-757.
42.	Kankaanranta H, Lindsay MA, Giembycz MA, et al. Delayed eosinophil apoptosis in asthma[J]. J Allergy Clin Immunol, 2000, 106(1 Pt 1):77-83.
43.	Simon HU, Yousefi S, Schranz C, et al. Direct demonstration of delayed eosinophil apoptosis as a mechanism causing tissue eosinophilia[J]. J Immunol, 1997, 158(8):3902-3908.
44.	Robinson D, Hamid Q, Bentley A, et al. Activation of CD4⁺ T cells, increased TH2-type cytokine mRNA expression, and eosinophil recruitment in bronchoalveolar lavage after allergen inhalation challenge in patients with atopic asthma[J]. J Allergy Clin Immunol, 1993, 92(2):313-324.
45.	Druilhe A, Létuvé S, Pretolani M. Glucocorticoid-induced apoptosis in human eosinophils:mechanisms of action[J]. Apoptosis, 2003, 8(5):481-495.
46.	Campbell S, Marriott M, Nahmias C, et al. Lower hippocampal volume in patients suffering from depression:a meta-analysis[J]. Am J Psychiatry, 2004, 161(4):598-607.
47.	Lucassen PJ, Muller MB, Holsboer F, et al. Hippocampal apoptosis in major depression is a minor event and absent from subareas at risk for glucocorticoid overexposure[J]. Am J Pathol, 2001, 158(2):453-468.
48.	Kajiyama Y, Iijima Y, Chiba S, et al. Prednisolone causes anxiety- and depression-like behaviors and altered expression of apoptotic genes in mice hippocampus[J]. Prog Neuropsychopharmacol Biol Psychiatry, 2010, 34(1):159-165.
49.	Harlan J, Chen Y, Gubbins E, et al. Variants in Apaf-1 segregating with major depression promote apoptosome function[J]. Mol Psychiatry, 2006, 11(1):76-85.
50.	Uchoa ET, Aguilera G, Herman JP, et al. Novel aspects of glucocorticoid actions[J]. J Neuroendocrinol, 2014, 26(9):557-572.

1. Fava M, Kendler KS. Major depressive disorder[J]. Neuron, 2000, 28(2):335-341.
2. Loerbroks A, Herr RM, Subramanian SV, et al. The association of asthma and wheezing with major depressive episodes:an analysis of 245727 women and men from 57 countries[J]. Int J Epidemiol, 2012, 41(5):1436-1444.
3. Van Lieshout RJ, Bienenstock J, Macqueen GM. A review of candidate pathways underlying the association between asthma and major depressive disorder[J]. Psychosom Med, 2009, 71(2):187-195.
4. Kerr JF, Wyllie AH, Currie AR. Apoptosis:a basic biological phenomenon with wide-ranging implications in tissue kinetics[J]. Br J Cancer, 1972, 26(4):239-257.
5. Bratton SB, Macfarlane M, Cain K, et al. Protein complexes activate distinct caspase cascades in death receptor and stress-induced apoptosis[J]. Exp Cell Res, 2000, 256(1):27-33.
6. Korsmeyer SJ. Regulators of cell death[J]. Trends Genet, 1995, 11(3):101-105.
7. Ashkenazi A, Dixit VM. Death receptors:signaling and modulation[J]. Science, 1998, 281(5381):1305-1308.
8. Green DR, Reed JC. Mitochondria and apoptosis[J]. Science, 1998, 281(5381):1309-1312.
9. Wang YM, Liu XD, Zhang DF, et al. The effects of apoptosis vulnerability markers on the myocardium in depression after myocardial infarction[J]. BMC Med, 2013, 11:32.
10. Shi YF, Sahai BM, Green DR. Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes[J]. Nature, 1989, 339(6226):625-626.
11. Krammer PH. CD95's deadly mission in the immune system[J]. Nature, 2000, 407(685):789-795.
12. Spinozzi F, Fizzotti M, Agea E, et al. Defective expression of Fas messenger RNA and Fas receptor on pulmonary T cells from patients with asthma[J]. Ann Intern Med, 1998, 128(5):363-369.
13. Algeciras-Schimnich A, Griffith TS, Lynch DH, et al. Cell cycle-dependent regulation of FLIP levels and susceptibility to Fas-mediated apoptosis[J]. J Immunol, 1999, 162(9):5205-5211.
14. Jiang TW, Sheng JH, Qin YM, et al. Enhanced proliferation and defective activation-induced cell death of CD4⁺ T cells in chilldhood asthma[J]. Asian Pac J Allergy Immunol, 2014, 32(1):75-83.
15. Müller M, Grunewald J, Olgart Höglund C, et al. Altered apoptosis in bronchoalveolar lavage lymphocytes after allergen exposure of atopic asthmatic subjects[J]. Eur Respir J, 2006, 28(3):513-522.
16. Vercelli D. Immunoglobulin E and its regulators[J]. Curr Opin Allergy Clin Immunol, 2001, 1(1):61-65.
17. Laoukili J, Perret E, Willems T, et al. IL-13 alters mucociliary differentiation and ciliary beating of human respiratory epithelial cells[J]. J Clin Invest, 2001, 108(12):1817-1824.
18. Trautmann A, Schmid-Grendelmeier P, Krüger K, et al. T cells and eosinophils cooperate in the induction of bronchial epithelial cell apoptosis in asthma[J]. J Allergy Clin Immunol, 2002, 109(2):329-337.
19. Roscioli E, Hamon R, Ruffin RE, et al. Cellular inhibitor of apoptosis-2 is a critical regulator of apoptosis in airway epithelial cells treated with asthma-related inflammatory cytokines[J]. Physiol Rep, 2013, 1(5):e00123.
20. Amsterdam A, Sasson R. The anti-inflammatory action of glucocorticoids is mediated by cell type specific regulation of apoptosis[J]. Mol Cell Endocrinol, 2002, 189(1/2):1-9.
21. Irwin MR, Miller AH. Depressive disorders and immunity:20 years of progress and discovery[J]. Brain Behav Immun, 2007, 21(4):374-383.
22. Blume J, Douglas SD, Evans DL. Immune suppression and immune activation in depression[J]. Brain Behav Immun, 2011, 25(2):221-229.
23. Dowlati Y, Herrmann N, Swardfager W, et al. A meta-analysis of cytokines in major depression[J]. Biol Psychiatry, 2010, 67(5):446-457.
24. Biesmans S, Meert TF, Bouwknecht JA, et al. Systemic immune activation leads to neuroinflammation and sickness behavior in mice[J]. Mediators Inflamm, 2013, 2013:271359.
25. Pan W, Banks WA, Kastin AJ. Permeability of the blood-brain and blood-spinal cord barriers to interferons[J]. J Neuroimmunol, 1997, 76(1/2):105-111.
26. Kim SJ, Lee H, Lee G, et al. CD4+CD25+ regulatory T cell depletion modulates anxiety and depression-like behaviors in mice[J]. PLoS One, 2012, 7(7):e42054.
27. Ivanova SA, Semke VY, Vetlugina TP, et al. Signs of apoptosis of immunocompetent cells in patients with depression[J]. Neurosci Behav Physiol, 2007, 37(5):527-530.
28. Eilat E, Mendlovic S, Doron A, et al. Increased apoptosis in patients with major depression:a preliminary study[J]. J Immunol, 1999, 163(1):533-534.
29. Szuster-Ciesielska A, Slotwinska M, Stachura A, et al. Accelerated apoptosis of blood leukocytes and oxidative stress in blood of patients with major depression[J]. Prog Neuropsychopharmacol Biol Psychiatry, 2008, 32(3):686-694.
30. Sommershof A, Aichinger H, Engler HA, et al. Substantial reduction of naive and regulatory T cells following traumatic stress[J]. Brain Behav Immun, 2009, 23(8):1117-1124.
31. Workman CJ, Szymczak WL, Collison LW, et al. The development and function of regulatory T cells[J]. Cell Mol Life Sci, 2009, 66(16):2603-2622.
32. Du YJ, Li B, Zhang HY, et al., Airway inflammation and hypothalamic-pituitary-adrenal axis activity in asthmatic adults with depression[J]. J Asthma, 2013, 50(3):274-281.
33. Raison CL, Capuron L, Miller AH. Cytokines sing the blues:inflammation and the pathogenesis of depression[J]. Trends Immunol, 2006, 27(1):24-31.
34. Lloyd, C.M. and S. Saglani, T cells in asthma:influences of genetics, environment, and T-cell plasticity[J]. J Allergy Clin Immunol, 2013, 131(5):1267-1274.
35. Van Lieshout RJ, Macqueen G. Psychological factors in asthma[J]. Allergy Asthma Clin Immunol, 2008, 4(1):12-28.
36. Oh J, Malter JS. Pin1-FADD interactions regulate Fas-Mediated apoptosis in activated eosinophils[J]. J Immunol, 2013, 190(10):4937-4945.
37. Wegmann M. Targeting eosinophil biology in asthma therapy[J]. Am J Respir Cell Mol Biol, 2011, 45(4):667-674.
38. Walsh GM. Eosinophil apoptosis:mechanisms and clinical relevance in asthmatic and allergic inflammation[J]. Br J Haematol, 2000, 111(1):61-67.
39. Vignola AM, Chanez P, Chiappara G, et al. Evaluation of apoptosis of eosinophils, macrophages, and T lymphocytes in mucosal biopsy specimens of patients with asthma and chronic bronchitis[J]. J Allergy Clin Immunol, 1999, 103(4):563-573.
40. Jang AS, Choi IS, Lee S, et al. Bcl-2 expression in sputum eosinophils in patients with acute asthma[J]. Thorax, 2000, 55(5):370-374.
41. Druilhe A, Wallaert B, Tsicopoulos A, et al. Apoptosis, proliferation, and expression of Bcl-2, Fas, and Fas ligand in bronchial biopsies from asthmatics[J]. Am J Respir Cell Mol Biol, 1998, 19(5):747-757.
42. Kankaanranta H, Lindsay MA, Giembycz MA, et al. Delayed eosinophil apoptosis in asthma[J]. J Allergy Clin Immunol, 2000, 106(1 Pt 1):77-83.
43. Simon HU, Yousefi S, Schranz C, et al. Direct demonstration of delayed eosinophil apoptosis as a mechanism causing tissue eosinophilia[J]. J Immunol, 1997, 158(8):3902-3908.
44. Robinson D, Hamid Q, Bentley A, et al. Activation of CD4⁺ T cells, increased TH2-type cytokine mRNA expression, and eosinophil recruitment in bronchoalveolar lavage after allergen inhalation challenge in patients with atopic asthma[J]. J Allergy Clin Immunol, 1993, 92(2):313-324.
45. Druilhe A, Létuvé S, Pretolani M. Glucocorticoid-induced apoptosis in human eosinophils:mechanisms of action[J]. Apoptosis, 2003, 8(5):481-495.
46. Campbell S, Marriott M, Nahmias C, et al. Lower hippocampal volume in patients suffering from depression:a meta-analysis[J]. Am J Psychiatry, 2004, 161(4):598-607.
47. Lucassen PJ, Muller MB, Holsboer F, et al. Hippocampal apoptosis in major depression is a minor event and absent from subareas at risk for glucocorticoid overexposure[J]. Am J Pathol, 2001, 158(2):453-468.
48. Kajiyama Y, Iijima Y, Chiba S, et al. Prednisolone causes anxiety- and depression-like behaviors and altered expression of apoptotic genes in mice hippocampus[J]. Prog Neuropsychopharmacol Biol Psychiatry, 2010, 34(1):159-165.
49. Harlan J, Chen Y, Gubbins E, et al. Variants in Apaf-1 segregating with major depression promote apoptosome function[J]. Mol Psychiatry, 2006, 11(1):76-85.
50. Uchoa ET, Aguilera G, Herman JP, et al. Novel aspects of glucocorticoid actions[J]. J Neuroendocrinol, 2014, 26(9):557-572.

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细胞凋亡在哮喘伴抑郁发病中作用的探讨

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