广泛性焦虑障碍静息态功能磁共振研究进展_West China Medical Journal

Authors：

 邱昌建 , 穆超 , 沈聃琳 , 叶应华 , 孟雅婧 ,  杨彦春

四川大学华西医院心理卫生中心（成都 610041）;

Corresponding author：

杨彦春, Email: yanchun_yang@hotmail.com

Keywords：

广泛性焦虑障碍; 功能磁共振; 静息态

DOI：

10.7507/1002-0179.20150278

Video：

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任务态功能磁共振成像研究很大程度上受制于任务本身的设计与性质，随着静息态功能磁共振成像技术的发展，静息态功能磁共振成像已成为研究神经、精神疾病的热点。现就广泛性焦虑障碍静息态功能磁共振研究进展进行综述。

Citation： 邱昌建, 穆超, 沈聃琳, 叶应华, 孟雅婧, 杨彦春. 广泛性焦虑障碍静息态功能磁共振研究进展. West China Medical Journal, 2015, 30(5): 976-979. doi: 10.7507/1002-0179.20150278 Copy

1.	Raichle ME, Mintun MA. Brain work and brain imaging[J]. Annu Rev Neurosci, 2006, 29:449-476.
2.	Biswal B, Yetkin FZ, Haughton VM, et al. Functional connectivity in the motor cortex of resting human brain using echo-planar MRI[J]. Magn Reson Med, 1995, 34(4):537-541.
3.	Cordes D, Haughton VM, Arfanakis K, et al. Frequencies contributing to functional connectivity in the cerebral cortex in "resting-state" data[J]. AJNR Am J Neuroradiol, 2001, 22(7):1326-1333.
4.	Birn RM, Diamond JB, Smith MA, et al. Separating respiratory-variation-related fluctuations from neuronal-activity-related fluctuations in fMRI[J]. Neuroimage, 2006, 31(4):1536-1548.
5.	Beall EB, Lowe MJ. Isolating physiologic noise sources with independently determined spatial measures[J]. Neuroimage, 2007, 37(4):1286-1300.
6.	Arfanakis K, Cordes D, Haughton VM, et al. Combining Independent component analysis and correlation analysis to probe interregional connectivity in fMRI task activation datasets[J]. Magn Reson Imaging, 2000, 18(8):921-930.
7.	Fox MD, Corbetta M, Snyder AZ, et al. Spontaneous neuronal activity distinguishes human dorsal and ventral attention systems[J]. Proc Natl Acad Sci USA, 2006, 103(26):10046-10051.
8.	Fox MD, Snyder AZ, Vincent JL, et al. The human brain is intrinsically organized into dynamic, anticorrelated functional networks[J]. Proc Natl Acad Sci USA, 2005, 102(27):9673-9678.
9.	Fransson P. How default is the default mode of brain function? Further evidence from intrinsic BOLD signal fluctuations[J]. Neuropsychologia, 2006, 44(14):2836-2845.
10.	Greicius MD, Menon V. Default-mode activity during a passive sensory task:uncoupled from deactivation but impacting activation[J]. J Cogn Neurosci, 2004, 16(9):1484-1492.
11.	Fukunaga M, Horovitz SG, Van Gelderen P, et al. Large-amplitude, spatially correlated fluctuations in BOLD fMRI signals during extended rest and early sleep stages[J]. Magn Reson Imaging, 2006, 24(8):979-992.
12.	Horovitz SG, Fukunaga M, De Zwart JA, et al. Low frequency BOLD fluctuations during resting wakefulness and light sleep:a simultaneous EEG-fMRI study[J]. Hum Brain Mapp, 2008, 29(6):671-682.
13.	Vincent JL, Patel GH, Fox MD, et al. Intrinsic functional architecture in the anaesthetized monkey brain[J]. Nature, 2007, 447(7140):83-86.
14.	Kim MJ, Loucks RA, Palmer AL, et al. The structural and functional connectivity of the amygdala:from normal emotion to pathological anxiety[J]. Behav Brain Res, 2011, 223(2):403-410.
15.	杨丽琴, 林富春, 雷皓. 静息状态下脑功能连接的磁共振成像研究[J]. 波谱学杂志, 2010, 27(3):326-340.
16.	Nitschke JB, Sarinopoulos I, Oathes DJ, et al. Anticipatory activation in the amygdala and anterior cingulate in generalized anxiety disorder and prediction of treatment response[J]. Am J Psychiatry, 2009, 166(3):302-310.
17.	Etkin A, Prater KE, Hoeft F, et al. Failure of anterior cingulate activation and connectivity with the amygdala during implicit regulation of emotional processing in generalized anxiety disorder[J]. Am J Psychiatry, 2010, 167(5):545-554.
18.	Thomas KM, Drevets WC, Dahl RE, et al. Amygdala response to fearful faces in anxious and depressed children[J]. Arch Gen Psychiatry, 2001, 58(11):1057-1063.
19.	Mcclure EB, Monk CS, Nelson EE, et al. Abnormal attention modulation of fear circuit function in pediatric generalized anxiety disorder[J]. Arch Gen Psychiatry, 2007, 64(1):97-106.
20.	Monk CS, Telzer EH, Mogg K, et al. Amygdala and ventrolateral prefrontal cortex activation to masked angry faces in children and adolescents with generalized anxiety disorder[J]. Arch Gen Psychiatry, 2008, 65(5):568-576.
21.	Monk CS, Nelson EE, Mcclure EB, et al. Ventrolateral prefrontal cortex activation and attentional bias in response to angry faces in adolescents with generalized anxiety disorder[J]. Am J Psychiatry, 2006, 163(6):1091-1097.
22.	Blair K, Shaywitz J, Smith BW, et al. Response to emotional expressions in generalized social phobia and generalized anxiety disorder:evidence for separate disorders[J]. Am J Psychiatry, 2008, 165(9):1193-1202.
23.	Whalen PJ, Johnstone T, Somerville LH, et al. A functional magnetic resonance imaging predictor of treatment response to venlafaxine in generalized anxiety disorder[J]. Biol Psychiatry, 2008, 63(9):858-863.
24.	Zang Y, Jiang T, Lu Y, et al. Regional homogeneity approach to fMRI data analysis[J]. Neuroimage, 2004, 22(1):394-400.
25.	尤美娜, 程文红, 门卫伟, 等. 青少年广泛性焦虑障碍患者静息态功能磁共振成像研究[J]. 临床精神医学杂志, 2012, 22(5):306-309.
26.	Schienle A, Ebner F, Schäfer A. Localized gray matter volume abnormalities in generalized anxiety disorder[J]. Eur Arch Psychiatry Clin Neurosci, 2011, 261(4):303-307.
27.	Friston KJ, Frith CD, Liddle PF, et al. Functional connectivity:the principal-component analysis of large (PET) data sets[J]. J Cereb Blood Flow Metab, 1993, 13(1):5-14.
28.	Roy AK, Fudge JL, Kelly C, et al. Intrinsic functional connectivity of amygdala-based networks in adolescent generalized anxiety disorder[J]. J Am Acad Child Adolesc Psychiatry, 2013, 52(3):290-299.e2.
29.	Etkin A, Prater KE, Schatzberg AF, et al. Disrupted amygdalar subregion functional connectivity and evidence of a compensatory network in generalized anxiety disorder[J]. Arch Gen Psychiatry, 2009, 66(12):1361-1372.
30.	Beekman AT, Bremmer MA, Deeg DJ, et al. Anxiety disorders in later life:a report from the Longitudinal Aging Study Amsterdam[J]. Int J Geriatr Psychiatry, 1998, 13(10):717-726.
31.	Lenze EJ, Rollman BL, Shear MK, et al. Escitalopram for older adults with generalized anxiety disorder:a randomized controlled trial[J]. JAMA, 2009, 301(3):295-303.
32.	Andreescu C, Gross JJ, Lenze E, et al. Altered cerebral blood flow patterns associated with pathologic worry in the elderly[J]. Depress Anxiety, 2011, 28(3):202-209.
33.	Andreescu C, Sheu LK, Tudorascu D, et al. The ages of anxiety:differences across the lifespan in the default mode network functional connectivity in generalized anxiety disorder[J]. Int J Geriatr Psychiatry, 2014, 29(7):704-712.
34.	Chen AC, Etkin A. Hippocampal network connectivity and activation differentiates post-traumatic stress disorder from generalized anxiety disorder[J]. Neuropsychopharmacology, 2013, 38(10):1889-1898.

1. Raichle ME, Mintun MA. Brain work and brain imaging[J]. Annu Rev Neurosci, 2006, 29:449-476.
2. Biswal B, Yetkin FZ, Haughton VM, et al. Functional connectivity in the motor cortex of resting human brain using echo-planar MRI[J]. Magn Reson Med, 1995, 34(4):537-541.
3. Cordes D, Haughton VM, Arfanakis K, et al. Frequencies contributing to functional connectivity in the cerebral cortex in "resting-state" data[J]. AJNR Am J Neuroradiol, 2001, 22(7):1326-1333.
4. Birn RM, Diamond JB, Smith MA, et al. Separating respiratory-variation-related fluctuations from neuronal-activity-related fluctuations in fMRI[J]. Neuroimage, 2006, 31(4):1536-1548.
5. Beall EB, Lowe MJ. Isolating physiologic noise sources with independently determined spatial measures[J]. Neuroimage, 2007, 37(4):1286-1300.
6. Arfanakis K, Cordes D, Haughton VM, et al. Combining Independent component analysis and correlation analysis to probe interregional connectivity in fMRI task activation datasets[J]. Magn Reson Imaging, 2000, 18(8):921-930.
7. Fox MD, Corbetta M, Snyder AZ, et al. Spontaneous neuronal activity distinguishes human dorsal and ventral attention systems[J]. Proc Natl Acad Sci USA, 2006, 103(26):10046-10051.
8. Fox MD, Snyder AZ, Vincent JL, et al. The human brain is intrinsically organized into dynamic, anticorrelated functional networks[J]. Proc Natl Acad Sci USA, 2005, 102(27):9673-9678.
9. Fransson P. How default is the default mode of brain function? Further evidence from intrinsic BOLD signal fluctuations[J]. Neuropsychologia, 2006, 44(14):2836-2845.
10. Greicius MD, Menon V. Default-mode activity during a passive sensory task:uncoupled from deactivation but impacting activation[J]. J Cogn Neurosci, 2004, 16(9):1484-1492.
11. Fukunaga M, Horovitz SG, Van Gelderen P, et al. Large-amplitude, spatially correlated fluctuations in BOLD fMRI signals during extended rest and early sleep stages[J]. Magn Reson Imaging, 2006, 24(8):979-992.
12. Horovitz SG, Fukunaga M, De Zwart JA, et al. Low frequency BOLD fluctuations during resting wakefulness and light sleep:a simultaneous EEG-fMRI study[J]. Hum Brain Mapp, 2008, 29(6):671-682.
13. Vincent JL, Patel GH, Fox MD, et al. Intrinsic functional architecture in the anaesthetized monkey brain[J]. Nature, 2007, 447(7140):83-86.
14. Kim MJ, Loucks RA, Palmer AL, et al. The structural and functional connectivity of the amygdala:from normal emotion to pathological anxiety[J]. Behav Brain Res, 2011, 223(2):403-410.
15. 杨丽琴, 林富春, 雷皓. 静息状态下脑功能连接的磁共振成像研究[J]. 波谱学杂志, 2010, 27(3):326-340.
16. Nitschke JB, Sarinopoulos I, Oathes DJ, et al. Anticipatory activation in the amygdala and anterior cingulate in generalized anxiety disorder and prediction of treatment response[J]. Am J Psychiatry, 2009, 166(3):302-310.
17. Etkin A, Prater KE, Hoeft F, et al. Failure of anterior cingulate activation and connectivity with the amygdala during implicit regulation of emotional processing in generalized anxiety disorder[J]. Am J Psychiatry, 2010, 167(5):545-554.
18. Thomas KM, Drevets WC, Dahl RE, et al. Amygdala response to fearful faces in anxious and depressed children[J]. Arch Gen Psychiatry, 2001, 58(11):1057-1063.
19. Mcclure EB, Monk CS, Nelson EE, et al. Abnormal attention modulation of fear circuit function in pediatric generalized anxiety disorder[J]. Arch Gen Psychiatry, 2007, 64(1):97-106.
20. Monk CS, Telzer EH, Mogg K, et al. Amygdala and ventrolateral prefrontal cortex activation to masked angry faces in children and adolescents with generalized anxiety disorder[J]. Arch Gen Psychiatry, 2008, 65(5):568-576.
21. Monk CS, Nelson EE, Mcclure EB, et al. Ventrolateral prefrontal cortex activation and attentional bias in response to angry faces in adolescents with generalized anxiety disorder[J]. Am J Psychiatry, 2006, 163(6):1091-1097.
22. Blair K, Shaywitz J, Smith BW, et al. Response to emotional expressions in generalized social phobia and generalized anxiety disorder:evidence for separate disorders[J]. Am J Psychiatry, 2008, 165(9):1193-1202.
23. Whalen PJ, Johnstone T, Somerville LH, et al. A functional magnetic resonance imaging predictor of treatment response to venlafaxine in generalized anxiety disorder[J]. Biol Psychiatry, 2008, 63(9):858-863.
24. Zang Y, Jiang T, Lu Y, et al. Regional homogeneity approach to fMRI data analysis[J]. Neuroimage, 2004, 22(1):394-400.
25. 尤美娜, 程文红, 门卫伟, 等. 青少年广泛性焦虑障碍患者静息态功能磁共振成像研究[J]. 临床精神医学杂志, 2012, 22(5):306-309.
26. Schienle A, Ebner F, Schäfer A. Localized gray matter volume abnormalities in generalized anxiety disorder[J]. Eur Arch Psychiatry Clin Neurosci, 2011, 261(4):303-307.
27. Friston KJ, Frith CD, Liddle PF, et al. Functional connectivity:the principal-component analysis of large (PET) data sets[J]. J Cereb Blood Flow Metab, 1993, 13(1):5-14.
28. Roy AK, Fudge JL, Kelly C, et al. Intrinsic functional connectivity of amygdala-based networks in adolescent generalized anxiety disorder[J]. J Am Acad Child Adolesc Psychiatry, 2013, 52(3):290-299.e2.
29. Etkin A, Prater KE, Schatzberg AF, et al. Disrupted amygdalar subregion functional connectivity and evidence of a compensatory network in generalized anxiety disorder[J]. Arch Gen Psychiatry, 2009, 66(12):1361-1372.
30. Beekman AT, Bremmer MA, Deeg DJ, et al. Anxiety disorders in later life:a report from the Longitudinal Aging Study Amsterdam[J]. Int J Geriatr Psychiatry, 1998, 13(10):717-726.
31. Lenze EJ, Rollman BL, Shear MK, et al. Escitalopram for older adults with generalized anxiety disorder:a randomized controlled trial[J]. JAMA, 2009, 301(3):295-303.
32. Andreescu C, Gross JJ, Lenze E, et al. Altered cerebral blood flow patterns associated with pathologic worry in the elderly[J]. Depress Anxiety, 2011, 28(3):202-209.
33. Andreescu C, Sheu LK, Tudorascu D, et al. The ages of anxiety:differences across the lifespan in the default mode network functional connectivity in generalized anxiety disorder[J]. Int J Geriatr Psychiatry, 2014, 29(7):704-712.
34. Chen AC, Etkin A. Hippocampal network connectivity and activation differentiates post-traumatic stress disorder from generalized anxiety disorder[J]. Neuropsychopharmacology, 2013, 38(10):1889-1898.

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