氨甲环酸在髋关节置换术中应用的研究进展_West China Medical Journal

Authors：

 刘莉 , 曾利辉 ,  李鹏程 , 宁宁

四川大学华西医院骨科（成都 610041）;

Corresponding author：

李鹏程, Email: 16699411@qq.com

Keywords：

氨甲环酸; 髋关节置换术; 失血

DOI：

10.7507/1002-0179.20150279

Video：

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Abstract Full text Figures/Tables Video References Cited by

全髋关节置换术于髋关节多种疾病中应用广泛，由于其手术中出血量往往较大，因此如何减少手术引起的出血已成为越来越关注且急需解决的问题。近年来，氨甲环酸在髋关节置换术中应用价值得到肯定，但目前国内外文献对于髋关节置换术后氨甲环酸使用时间、给药方式和剂量上存在争议，甚至对于氨甲环酸是否能够减少髋关节置换术后的隐形失血也存在分歧。而目前文献的研究方法单一，研究的例数不足，标准不统一，现在综述上述文献，并对目前的研究现状进行分析报道。

Citation： 刘莉, 曾利辉, 李鹏程, 宁宁. 氨甲环酸在髋关节置换术中应用的研究进展. West China Medical Journal, 2015, 30(5): 980-982. doi: 10.7507/1002-0179.20150279 Copy

1.	Lemaire R. Strategies for blood management in orthopaedic and trauma surgery[J]. J Bone Joint Surg Br, 2008, 90(9):1128-1136.
2.	Sukeik M, Alshryda S, Haddad FS, et al. Systematic review and meta-analysis of the use of tranexamic acid in total hip replacement[J]. J Bone Joint Surg Br, 2011, 93(1):39-46.
3.	Hiippala ST, Strid LJ, Wennerstrand MI, et al. Tranexamic acid radically decreases blood loss and transfusions associated with total knee arthroplasty[J]. Anesth Analg, 1997, 84(4):839-844.
4.	Jansen AJ, Andreica S, Claeys M, et al. Use of tranexamic acid for an effective blood conservation strategy after total knee arthroplasty[J]. Br J Anaesth, 1999, 83(4):596-601.
5.	Claeys MA, Vermeersch N, Haentjens P. Reduction of blood loss with tranexamic acid in primary total hip replacement surgery[J]. Acta Chir Belg, 2007, 107(4):397-401.
6.	Ido K, Neo M, Asada Y, et al. Reduction of blood loss using tranexamic acid intotal knee and hip arthroplasties[J]. Arch Orthop Trauma Surg, 2000, 120(9):518-520.
7.	Niskanen RO, Korkala OL. Tranexamic acid reduces blood loss in cemented hip arthroplasty-a randomized, double-blind study of 39 patients with osteoarthritis[J]. Acta Orthop, 2005, 76(6):829-832.
8.	Garneti N, Field J. Bone bleeding during total hip arthroplasty after administration of tranexamic acid[J]. J Arthroplasty, 2004, 19(4):488-492.
9.	Benoni G, Lethagen S, Nilsson P, et al. Tranexamic acid, given at the end of the operation, does not reduce postoperative blood loss in hip arthroplasty[J]. Acta Orthop Scand, 2000, 71(3):250-254.
10.	Benoni G, Fredin H, Knebel R, et al. Blood conservation with tranexamic acid in total hip arthroplasty-a randomized, double-blind study in 40 primary operations[J]. Acta Orthop Scand, 2001, 72(5):442-448.
11.	Ekbäck G, Axelsson K, Ryttberg L, et al. Tranexamic acid reduces blood loss in total hip replacement surgery[J]. Anesth Analg, 2000, 91(5):1124-1130.
12.	Husted H, Blønd L, Sonne-Holm S, et al. Tranexamic acid reduces blood loss an blood transfusions in primary total hip arthroplasty:a prospective randomized double-blind study in 40 patients[J]. Acta Orthop Scand, 2003, 74(6):665-669.
13.	Johansson T, Pettersson LG, Lisander B. Tranexamic acid in total hip arthroplast saves blood and money:a randomized, double-blind study in 100 patients[J]. Act Orthop, 2005, 76(3):314-319.
14.	Lemay E, Guay J, Côté C, et al. Tranexamic acid reduces the need for allogenic red blood cell transfusions in patients undergoing total hip replacement[J]. Can J Anaest, 2004, 51(1):31-37.
15.	Yamasaki S, Masuhara K, Fuji T. Tranexamic acid reduces blood loss after cementless total hip arthroplasty-prospective randomized study in 40 cases[J]. Int Orthop, 2004, 28(2):69-73.
16.	Gill JB, Rosenstein A. The use of antifibrinolytic agents in total hip arthroplasty:meta-analysis[J]. J Arthroplasty, 2006, 21(6):869-873.
17.	Andersson L, Eriksson O, Hedlund PO, et al. Special considerations with regard to dosage of tranexamic acid in patients with chronic renal diseases[J]. Urol Res, 1978, 6(2):83-88.
18.	Eriksson O, Kjellman H, Pilbrant A, et al. Pharmacokinetics of tranexamic acid after intravenous administration to normal volunteers[J]. Eur J Clin Pharmacol, 1974, 7(5):375-380.
19.	Nilsson IM. Clinical pharmacology of aminocaproic and tranexamic acids[J]. J Clin Pathol(R Coll Pathol), 1980, 14:41-47.
20.	Sano K, Hakumizu H, Kojima T, et al. Absorption and excretion of tranexamic acid in human[J]. Clin Pharmacol Ther, 1976(7):375-382.

1. Lemaire R. Strategies for blood management in orthopaedic and trauma surgery[J]. J Bone Joint Surg Br, 2008, 90(9):1128-1136.
2. Sukeik M, Alshryda S, Haddad FS, et al. Systematic review and meta-analysis of the use of tranexamic acid in total hip replacement[J]. J Bone Joint Surg Br, 2011, 93(1):39-46.
3. Hiippala ST, Strid LJ, Wennerstrand MI, et al. Tranexamic acid radically decreases blood loss and transfusions associated with total knee arthroplasty[J]. Anesth Analg, 1997, 84(4):839-844.
4. Jansen AJ, Andreica S, Claeys M, et al. Use of tranexamic acid for an effective blood conservation strategy after total knee arthroplasty[J]. Br J Anaesth, 1999, 83(4):596-601.
5. Claeys MA, Vermeersch N, Haentjens P. Reduction of blood loss with tranexamic acid in primary total hip replacement surgery[J]. Acta Chir Belg, 2007, 107(4):397-401.
6. Ido K, Neo M, Asada Y, et al. Reduction of blood loss using tranexamic acid intotal knee and hip arthroplasties[J]. Arch Orthop Trauma Surg, 2000, 120(9):518-520.
7. Niskanen RO, Korkala OL. Tranexamic acid reduces blood loss in cemented hip arthroplasty-a randomized, double-blind study of 39 patients with osteoarthritis[J]. Acta Orthop, 2005, 76(6):829-832.
8. Garneti N, Field J. Bone bleeding during total hip arthroplasty after administration of tranexamic acid[J]. J Arthroplasty, 2004, 19(4):488-492.
9. Benoni G, Lethagen S, Nilsson P, et al. Tranexamic acid, given at the end of the operation, does not reduce postoperative blood loss in hip arthroplasty[J]. Acta Orthop Scand, 2000, 71(3):250-254.
10. Benoni G, Fredin H, Knebel R, et al. Blood conservation with tranexamic acid in total hip arthroplasty-a randomized, double-blind study in 40 primary operations[J]. Acta Orthop Scand, 2001, 72(5):442-448.
11. Ekbäck G, Axelsson K, Ryttberg L, et al. Tranexamic acid reduces blood loss in total hip replacement surgery[J]. Anesth Analg, 2000, 91(5):1124-1130.
12. Husted H, Blønd L, Sonne-Holm S, et al. Tranexamic acid reduces blood loss an blood transfusions in primary total hip arthroplasty:a prospective randomized double-blind study in 40 patients[J]. Acta Orthop Scand, 2003, 74(6):665-669.
13. Johansson T, Pettersson LG, Lisander B. Tranexamic acid in total hip arthroplast saves blood and money:a randomized, double-blind study in 100 patients[J]. Act Orthop, 2005, 76(3):314-319.
14. Lemay E, Guay J, Côté C, et al. Tranexamic acid reduces the need for allogenic red blood cell transfusions in patients undergoing total hip replacement[J]. Can J Anaest, 2004, 51(1):31-37.
15. Yamasaki S, Masuhara K, Fuji T. Tranexamic acid reduces blood loss after cementless total hip arthroplasty-prospective randomized study in 40 cases[J]. Int Orthop, 2004, 28(2):69-73.
16. Gill JB, Rosenstein A. The use of antifibrinolytic agents in total hip arthroplasty:meta-analysis[J]. J Arthroplasty, 2006, 21(6):869-873.
17. Andersson L, Eriksson O, Hedlund PO, et al. Special considerations with regard to dosage of tranexamic acid in patients with chronic renal diseases[J]. Urol Res, 1978, 6(2):83-88.
18. Eriksson O, Kjellman H, Pilbrant A, et al. Pharmacokinetics of tranexamic acid after intravenous administration to normal volunteers[J]. Eur J Clin Pharmacol, 1974, 7(5):375-380.
19. Nilsson IM. Clinical pharmacology of aminocaproic and tranexamic acids[J]. J Clin Pathol(R Coll Pathol), 1980, 14:41-47.
20. Sano K, Hakumizu H, Kojima T, et al. Absorption and excretion of tranexamic acid in human[J]. Clin Pharmacol Ther, 1976(7):375-382.

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氨甲环酸在髋关节置换术中应用的研究进展

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