系统性红斑狼疮患者骨髓病态造血的临床分析_West China Medical Journal

Authors：

 曹红 , 何秋连 , 马春蓉

南充市中心医院血液内科四川南充 637000;

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Keywords：

系统性红斑狼疮; 血细胞减少; 骨髓病态造血

DOI：

10.7507/1002-0179.20150317

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目的探讨系统性红斑狼疮（SLE）伴发血细胞减少的患者骨髓病态造血的出现概率及其与狼疮病情的关系。方法回顾性分析2010年1月－2013年6月32例伴发血细胞减少的SLE患者资料，分析骨髓病态造血情况及其与临床病情的关系。结果 SLE例患者中15例存在骨髓病态造血。粒、红、巨核系均可出现，其中红系单系病态造血5例，粒系单系病态造血4例，巨核系单系病态造血2例，粒红两系病态造血4例。出现病态造血的患者其疾病活动度[（38.5±10.3）分]较未出现病态造血的患者[（7.6±4.6）分]严重，差异有统计学意义（t’=10.714，P＜0.001）。3例患者狼疮病情好转后复查骨髓涂片，病态造血消失。结论 SLE伴发血细胞下降的患者出现病态造血的发生率不低，其病态造血随病情好转是可逆的。

Citation： 曹红, 何秋连, 马春蓉. 系统性红斑狼疮患者骨髓病态造血的临床分析. West China Medical Journal, 2015, 30(6): 1109-1111. doi: 10.7507/1002-0179.20150317 Copy

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1. 胡喜梅, 樊志荣, 周水阳, 等. 系统性红斑狼疮血液学异常与临床特点[J]. 中国实验血液学杂志, 2004, 12(2):170-173.
2. 王桂菊. 系统性红斑狼疮相关性血液病血液学异常临床特点[J]. 中国实验血液学杂志, 2002, 10(4):359-361.
3. Oka Y, Kameoka J, Hirabayashi Y, et al. Reversible bone marrow dysplasia in patients with systemic lupus erythematosus[J]. Intern Med, 2008, 47(8):737-742.
4. Papadaki HA. Autoreactive T-lymphocytes are implicated in the pathogenesis of bone marrow failure in patients with systemic lupus erythematosus[J]. Leuk Lymphoma, 2003, 44(8):1301-1307.
5. Sun LY, Zhou KX, Feng XB, et al. Abnormal surface markers expression on bone marrow CD34⁺ cells and correlation with disease activity in patients with systemic lupus erythematosus[J]. Clin Rheumatol, 2007, 26(12):2073-2079.
6. 李只福. 系统性红斑狼疮病人的血液系统改变及处理[J]. 中华风湿病学杂志, 2001, 5(3):139-141.
7. Li X, Wu L, Ying S, et al. Clonality investigation of morphologically dysplastic hematopoietic cells in myelodysplastic syndrome marrows[J]. Int J Hematol, 2008, 87(2):176-183.
8. Papo T, Andre MH, Amoura Z, et al. The spectrum of reactive hemophagocytic syndrome in systemic lupus erythematosus[J].J Rheumatol, 1999, 26(4):927-930.
9. Nawata M, Suzuki J, Ikeda K, et al. Haemophagocytic syndrome in a systemic lupus erythematosus patient with antiphospholipid antibodies[J]. Rheumatology, 2001, 40(7):828-829.
10. van Bekkum DW. Autologous stem cell transplantation for treatment of autoimmune diseases[J]. Stem Cells, 1999, 17(3):172-178.
11. 黄林喜, 吴贤仁. 血细胞减少的系统性红斑狼疮45例骨髓细胞学表现及治疗反应[J]. 中华全科医师杂志, 2005, 4(1):44-45.
12. 许杰州, 曾庆馀, 肖征宇, 等. 血细胞减少的系统性红斑狼疮患者骨髓细胞学表现[J]. 中华皮肤科杂志, 2001, 34(5):382.

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系统性红斑狼疮患者骨髓病态造血的临床分析

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