Clinical Analysis on 121 Cases of Hepatic Hydatidosis_West China Medical Journal

Authors：

 YANGPing ^1,2 , LONGHai-yan ¹ , YANGJing-yu ¹ ,  FENGPing ¹ , CHENLi-yu ¹

1. Infectious Disease Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Intensive Care Unit, No.4 West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

FENGPing, Email: fengp-62@163.com

Keywords：

Hepatic hydatidosis; Hepatic dysfunction; Treatment method; Effectiveness

DOI：

10.7507/1002-0179.20150470

Video：

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Objective To describe the current situation of the prevalence of hepatic hydatidosis, analyze the clinical characteristics and treatment method of the disease, in order to provide scientific basis for personal treatment plans of hepatic hydatidosis. Method The clinical data of 121 patients with recurrent hepatic hydatidosis treated between July 2006 and December 2013 were analyzed retrospectively. The general information of hydatid disease of liver, mass of liver, clinical manifestations, laboratory test results, treatment method, effectiveness of the treatment during hospitalization, and follow-up results were collected and analyzed. Results Most of the patients were adults from Sichuan and Tibet, and the majority of them had no clear occupation or clear animal contact history and had not taken raw or fresh meat. Lesions in the right lobe occurred in 87 cases, accounting for 71.90%. Abdominal pain and distension were the main clinical manifestations. Twenty-five (20.66%) of these patients were associated with hepatic dysfunction, among whom 23 patients had mild hepatic dysfunction. Alpha-fetoprotein level was increased in one (0.83%) of these cases. A total of 119 of the 121 patients received surgical treatment (98.35%) and all the surgeries were successful. Follow-up results revealed that three of the patients had recurrence. Conclusions Hepatic hydatidosis is an epidemic mainly in the Tibetan district of the West of China. The disease mainly occurs in the right lobe of the liver, which mainly causes mile liver damage. Hepatocellular carcinoma has not been found in these cases. Surgery treatment is the main therapy for liver hydatidosis and may result in good effectiveness.

Citation： YANGPing, LONGHai-yan, YANGJing-yu, FENGPing, CHENLi-yu. Clinical Analysis on 121 Cases of Hepatic Hydatidosis. West China Medical Journal, 2015, 30(9): 1645-1649. doi: 10.7507/1002-0179.20150470 Copy

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1. Guidelines for treatment of cystic and alveolar echinococcosis in humans. WHO Informal Working Group on Echinococcosis[J]. Bull World Health Organ, 1996, 74(3):231-242.
2. 徐秉银, 赵慰先, 陈佩惠, 等. 人体寄生虫学[M]. 北京:人民卫生出版社, 1994:142.
3. Abboud G, Kaplowitz N. Drug-induced liver injury[J]. Drug Saf, 2007, 30(4):277-294.
4. 中华医学会传染病与寄生虫病学分会, 中华医学会肝病学分会. 病毒性肝炎防治方案[J]. 人民军医, 1989, 19(12):15-21, 80.
5. 李晓东, 李波, 严律南, 等. 肝包虫病的外科治疗和并发症的处理[J]. 华西医学, 2005, 20(2):229-230.
6. Moro P, Schantz PM. Echinococcosis:a review[J]. Int J Infect Dis, 2009, 13(2):125-133.
7. Siqueira NG, Siqueira CM, Rodrigues-Silva R, et al. Polycystic echinococcosis in the state of Acre, Brazil:contribution to patient diagnosis, treatment and prognosis[J]. Mem Inst Oswaldo Cruz, 2013, 108(5):533-540.
8. 彭心宇, 张示杰, 牛建华, 等. 肝包虫病外科治疗术式选择的新观点(附684例报道)[J]. 腹部外科, 2003, 16(1):19-21.
9. 吕海龙, 彭心宇, 张士杰, 等. 不同药物杀灭原头节对小鼠肝细粒棘球蚴感染的影响[J]. 中国人兽共患病学报, 2009, 25(3):295-297.
10. Halezeroglu S, Okur E, Tanyü MO. Surgical management for hydatid disease[J]. Thorac Surg Clin, 2012, 22(3):375-385.
11. Parelkar SV, Gupta RK, Shah H, et al. Experience with video-assisted thoracoscopic removal of pulmonary hydatid cysts in children[J]. J Pediatr Surg, 2009, 44(4):836-841.
12. 陈文庆, 柴福禄, 顾树南. 肝包虫病外科治疗经验[J]. 中华外科杂志, 1994, 32(3):166-168.
13. 黄韬, 刘佳, 罗彪, 等. 肝包虫病的诊治体会[J]. 华西医学, 2014, 29(9):1650-1652.
14. Meyssonnier V, Makovec T, Caumes E. Cystic splenomegaly[J]. J Travel Med, 2011, 18(4):294-295.
15. Pawlowski ZS, Eckert J, Vuitton DA RW, et al. Echinococcosis in humans:clinical aspects, diagnosis and treatment[M]//Eckert J, Gemmell MA, Meslin FX, et al. WHO/OIE manual on echinococcosis in humans and animals:a public health problem of global concern. Paris:Office International des E'pizooties, 2001:20-71.
16. 陈亮, 谢增如. 包虫病放射治疗的研究进展[J]. 新疆医科大学学报, 2014, 36(4):557-559.
17. 鲍佳春, 袁凤来, 陆伟国. 包虫病治疗进展[J]. 中国血吸虫病防治杂志, 2010, 22(2):197-199.

West China Medical Journal

Clinical Analysis on 121 Cases of Hepatic Hydatidosis

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