Objective To investigate the correlation of synovial fluid uric acid, the serum and synovial fluid interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α with knee osteoarthritis (KOA).
Methods The clinical data of 130 patients with KOA treated between January and December 2013 and 30 patients with gouty arthritis (GA) treated at the same period were collected. The clinical symptoms, Western Ontario and McMaster Universities Osteoarthritis Index score, the serum and synovial fluid IL-1β, IL-6, and TNF-α, uric acid levels, radiographic joint stenosis score, and bone hyperplasia score of the patients were compared using t-test analysis and Spearman correlation analysis.
Results In the KOA group, the synovial fluid uric acid and joint stenosis score (r=0.31, P=0.037), bone hyperplasia score (r=0.38, P=0.027) were positively correlated; serum and synovial fluid uric acid gradient and hypnalgia were positively correlated (r=0.34, P=0.031); the synovial fluid IL-6 and joint stenosis score (r=0.33, P=0.029), bone hyperplasia score (r=0.37, P=0.032) were positively correlated; the synovial fluid IL-1β and joint stenosis score (r=0.39, P=0.023), bone hyperplasia score (r=0.34, P=0.034) were positively correlated; and the synovial fluid uric acid and IL-1β (r=0.26, P=0.003), IL-6 (r=0.21, P=0.016) were positively correlated.
Conclusion Synovial uric acid, IL-1β and IL-6 play a role in the inflammatory progress of knee osteoarthritis.
Citation：
WUXiao-hui, TANGLiu-gang, WANGBiao, LIUTai, ZHAOChen, YUWen-jing, LIMin. Study on the Correlation of Synovial Fluid Uric Acid, Interleukin-1β, Interleukin-6 and Tumor Necrosis Factor-α with Knee Osteoarthritis. West China Medical Journal, 2015, 30(10): 1862-1865. doi: 10.7507/1002-0179.20150535
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Copyright © the editorial department of West China Medical Journal of West China Medical Publisher. All rights reserved
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- 1. 中华医学会风湿病学分会. 骨关节炎诊断及治疗指南[J]. 中华风湿病学杂志, 2010, 14(6):416-419.
- 2. 沈海丽, 夏亚一, 王翠芳, 等. 骨关节炎的疼痛机制研究进展[J]. 中华风湿病学杂志, 2011, 14(11):769-771.
- 3. 李敏, 梁翼, 吴晓惠, 等. 伴骨髓水肿的膝骨关节炎患者白细胞介素-1β、IL-6、TNF-α的相关性研究[J]. 中华风湿病学杂志, 2012, 16(2):107-111.
- 4. Denoble AE, Huffman KM, Stabler TV, et al. Uric acid is a danger signal of increasing risk for osteoarthritis through inflammasome activation[J]. Proc Natl Acad Sci USA, 2011, 108(5):2088-2093.
- 5. 伍沪生. 痛风研究正逢其时[J]. 中华风湿病学杂志, 2012, 16(4): 217-219.
- 6. 吴华香. 美国风湿病学会痛风治疗指南解读[J]. 浙江医学, 2014, 25(2):92-93.
- 7. 李敏, 梁翼, 余文景, 等. 盐酸氨基葡萄糖联合双醋瑞因在伴骨髓水肿的膝骨关节炎的疗效评估[J]. 华西医学, 2012, 27(12):1764-1767.
- 8. 王洪, 张青松, 杨述华, 等. IL-1RⅠ、IL-1RⅡ、IL-1RAcP在骨关节炎滑膜中的表达及其生物学意义[J]. 中华风湿病学杂志, 2006, 10(8):470-473, 513.
- 9. 青玉凤, 周京国. 痛风发病机制及药物治疗研究现状及展望[J]. 中华临床医师杂志:电子版, 2012, 6(10):2719-2723.
- 10. Lorenz H, Richter W. Osteoarthritis:cellular and molecular changes in degenerating cartilage[J]. Prog Histochem Cytochem, 2006, 40(3): 135-163.
- 11. 丁国良. IL-1和IL-6在绝经后骨关节炎患者滑膜上的表达及临床分析[J]. 内蒙古医学杂志, 2014, 46(4):399-402, 512.
- 12. 帅明, 林荔军, 林昭伟, 等. IL-1β、HIF-1α和VEGF在兔膝关节骨性关节炎模型滑膜中的表达[J]. 中国老年学杂志, 2013, 33(10): 2311-2313.
- 13. 杨雪晴, 徐建华, 丁长海, 等. 膝骨关节炎患者髌上囊渗液量与疼痛及血清白细胞介素-6、-17、-23相关性研究[J]. 中华风湿病学杂志, 2015, 19(4):219-223.
- 14. 张薇, 刘昌莲, 刘小玲, 等. 滑液尿酸与骨关节炎患者病情严重程度相关性研究[J]. 陕西医学杂志, 2014, 43(11):1474-1475.
- 15. Jin C, Frayssinet P, Pelker R, et al. NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy[J]. Proc Natl Acad Sci USA, 2011, 108(36):14867-14872.
