Dynamic Changes and Clinical Significance of Serum Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 in Patients with Cerebral Infarction_West China Medical Journal

Authors：

 LIBing , JIANGXue-song

Department of Neurology, Jiaozhou Central Hospital of Qingdao, Qingdao, Shandong 266300, P. R. China;

Corresponding author：

Keywords：

Acute cerebral infarction; Matrix metalloproteinase-2; Matrix metalloproteinase

DOI：

10.7507/1002-0179.20150574

Video：

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Objective To observe the dynamic changes of the concentrations of serum matrix metalloproteinase (MMP)-2 and MMP-9, and to discuss its clinical significance. Methods From January to May 2014, 50 cases of clinically diagnosed cerebral infarction patients were included in the study as the cerebral infarction group, and we randomly selected 30 healthy volunteers at the same time in the same age group as the control group. The serum MMP-2 and MMP-9 of patients with acute cerebral infarction were detected in the onset of 24 hours, 7th day and 14th day respectively, which were compared with the control group accordingly. The patients with cerebral infarction were divided into small infarction group (1.5-3.0 cm), middle infarction group (3.1-5.0 cm) and large infarction group (>5.0 cm) according to the infraction volume. According to neurological functional deficit score they were divided into mild (0-15 points), moderate (16-30 points) and severe group (31-45 points). Changes of the level of MMP-9 and MMP-2 were compared in patients with different cerebral infarction volume and different impairment degree. Results For the cerebral infarction group, the serum MMP-2 and MMP-9 levels were significantly higher in the onset of 24 hours, 7th day and 14th day[MMP-2:(2.36±0.76), (2.86±0.87), and (2.20±0.79) ng/mL; MMP-9:(238.8±99.6), (360.4±141.8), and (152.2±80.4) ng/mL] than the control group[MMP-2:(1.20±0.27) ng/mL; MMP-9:(124.8±28.2) ng/mL] (P<0.05). The larger the infarction volume was in the patients with acute ischemic stroke, the higher the levels of serum MMP-9 and MMP-2. The severer the neurologic impairment degree was in the patients with acute ischemic stroke, the higher the levels of serum MMP-9 and MMP-2 were. Conclusion For patients with acute cerebral infarction, the levels of serum MMP-2 and MMP-9 are closely related to time of onset, infarct volume and neurological deficits, which can be used as an important basis to estimate the condition and assess the prognosis.

Citation： LIBing, JIANGXue-song. Dynamic Changes and Clinical Significance of Serum Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 in Patients with Cerebral Infarction. West China Medical Journal, 2015, 30(11): 2009-2012. doi: 10.7507/1002-0179.20150574 Copy

1.	Visse R, Nagase H. Matrix metalloproteinases and tissue inhibitors of metalloproteinases:structure, function, and biochemistry[J]. Circ Res, 2003, 92(8):827-839.
2.	Galis ZS, Khatri JJ. Matrix metalloproteinases in vascular remodeling and atherogenesis:the good, the bad, and the ugly[J]. Circ Res, 2002, 90(3):251-262.
3.	Jacob-Ferreira AL, Schulz R. Activation of intracellular matrix metalloproteinase-2 by reactive oxygen-nitrogen species:consequences and therapeutic strategies in the heart[J]. Arch Biochem Biophys, 2013, 540(1/2):82-93.
4.	Horstmann S, Kalb P, Koziol J, et al. Profiles of matrix metalloproteinases, their inhibitors, and laminin in stroke patients:influence of different therapies[J]. Stroke, 2003, 34(9):2165-2170.
5.	Montaner J, Molina CA, Monasterio J, et al. Matrix metalloproteinase-9 pretreatment level predicts intracranial hemorrhagic complications after thrombolysis in human stroke[J]. Circulation, 2003, 107(4):598-603.
6.	全国第四届脑血管病学术会议. 脑卒中患者临床神经功能损伤程度评分标准及临床疗效评定标准[J]. 中华神经科杂志, 1996, 29(6):381-383.
7.	王新, 黄如训, 曾进胜. 脑梗死急性期血清MMP-9的动态变化及其与脑梗死分型关系的研究[J]. 中国神经精神疾病杂志, 2005, 31(1):20-23.
8.	周进. MMP-2及MMP-9在缺血再灌注大鼠脑中的表达及意义[J]. 辽宁医学杂志, 2005, 19(4):175-176.
9.	Akamatsu Y, Saito A, Fujimura M, et al. Stachybotrys microspora triprenyl phenol-7, a novel fibrinolytic agent, suppresses superoxide production, matrix metalloproteinase-9 expression, and thereby attenuates ischemia/reperfusion injury in rat brain[J]. Neurosci Lett, 2011, 503(2):110-114.
10.	Brouns R, Wauters A, De Surgeloose D, et al. Biochemical markers for blood-brain barrier dysfunction in acute ischemic stroke correlate with evolution and outcome[J]. Eur Neurol, 2011, 65(1):23-31.
11.	陈红兵, 郭云良, 孙圣刚, 等. 大鼠脑缺血再灌流后基质金属蛋白酶2和9的表达[J]. 解剖学杂志, 2005, 28(3):304-307.
12.	Chang DI, Hosomi N, Lucero J, et al. Activation systems for latent matrix metalloproteinase-2 are upregulated immediately after focal cerebral ischemia[J]. J Cereb Blood Flow Metab, 2003, 23(12):1408-1419.
13.	Magnoni S, Baker A, George SJ, et al. Differential alterations in the expression and activity of matrix metalloproteinases 2 and 9 after transient cerebral ischemia in mice[J]. Neurobiol Dis, 2004, 17(2):188-197.
14.	Guo M, Cox B, Mahale S, et al. Pre-ischemic exercise reduces matrix metalloproteinase-9 expression and ameliorates blood-brain barrier dysfunction in stroke[J]. Neuroscience, 2008, 151(2):340-351.
15.	Brouns R, Wauters A, De Surgeloose D, et al. Biochemical markers for blood-brain barrier dysfunction in acute ischemic stroke correlate with evolution and outcome[J]. Eur Neurol, 2011, 65(1):23-31.
16.	张建平, 孟凡超, 代吉文, 等. 局部亚低温干预对实验大鼠脑出血后MMP-2/9表达及脑水肿的影响[J]. 中华物理医学与康复杂志, 2007, 29(10):649-652.
17.	陶定波, 姜秀丽, 雷阳, 等. 急性期脑梗死患者血清MMP-9水平动态变化意义及与预后的关系[J]. 中风与神经疾病杂志, 2009, 26(2):176-179.
18.	陶晶, 李志, 刘卉萍. 急性脑梗死患者血清基质金属蛋白酶-9检测的临床意义[J]. 实用医技杂志, 2011, 18(12):1243-1245.

1. Visse R, Nagase H. Matrix metalloproteinases and tissue inhibitors of metalloproteinases:structure, function, and biochemistry[J]. Circ Res, 2003, 92(8):827-839.
2. Galis ZS, Khatri JJ. Matrix metalloproteinases in vascular remodeling and atherogenesis:the good, the bad, and the ugly[J]. Circ Res, 2002, 90(3):251-262.
3. Jacob-Ferreira AL, Schulz R. Activation of intracellular matrix metalloproteinase-2 by reactive oxygen-nitrogen species:consequences and therapeutic strategies in the heart[J]. Arch Biochem Biophys, 2013, 540(1/2):82-93.
4. Horstmann S, Kalb P, Koziol J, et al. Profiles of matrix metalloproteinases, their inhibitors, and laminin in stroke patients:influence of different therapies[J]. Stroke, 2003, 34(9):2165-2170.
5. Montaner J, Molina CA, Monasterio J, et al. Matrix metalloproteinase-9 pretreatment level predicts intracranial hemorrhagic complications after thrombolysis in human stroke[J]. Circulation, 2003, 107(4):598-603.
6. 全国第四届脑血管病学术会议. 脑卒中患者临床神经功能损伤程度评分标准及临床疗效评定标准[J]. 中华神经科杂志, 1996, 29(6):381-383.
7. 王新, 黄如训, 曾进胜. 脑梗死急性期血清MMP-9的动态变化及其与脑梗死分型关系的研究[J]. 中国神经精神疾病杂志, 2005, 31(1):20-23.
8. 周进. MMP-2及MMP-9在缺血再灌注大鼠脑中的表达及意义[J]. 辽宁医学杂志, 2005, 19(4):175-176.
9. Akamatsu Y, Saito A, Fujimura M, et al. Stachybotrys microspora triprenyl phenol-7, a novel fibrinolytic agent, suppresses superoxide production, matrix metalloproteinase-9 expression, and thereby attenuates ischemia/reperfusion injury in rat brain[J]. Neurosci Lett, 2011, 503(2):110-114.
10. Brouns R, Wauters A, De Surgeloose D, et al. Biochemical markers for blood-brain barrier dysfunction in acute ischemic stroke correlate with evolution and outcome[J]. Eur Neurol, 2011, 65(1):23-31.
11. 陈红兵, 郭云良, 孙圣刚, 等. 大鼠脑缺血再灌流后基质金属蛋白酶2和9的表达[J]. 解剖学杂志, 2005, 28(3):304-307.
12. Chang DI, Hosomi N, Lucero J, et al. Activation systems for latent matrix metalloproteinase-2 are upregulated immediately after focal cerebral ischemia[J]. J Cereb Blood Flow Metab, 2003, 23(12):1408-1419.
13. Magnoni S, Baker A, George SJ, et al. Differential alterations in the expression and activity of matrix metalloproteinases 2 and 9 after transient cerebral ischemia in mice[J]. Neurobiol Dis, 2004, 17(2):188-197.
14. Guo M, Cox B, Mahale S, et al. Pre-ischemic exercise reduces matrix metalloproteinase-9 expression and ameliorates blood-brain barrier dysfunction in stroke[J]. Neuroscience, 2008, 151(2):340-351.
15. Brouns R, Wauters A, De Surgeloose D, et al. Biochemical markers for blood-brain barrier dysfunction in acute ischemic stroke correlate with evolution and outcome[J]. Eur Neurol, 2011, 65(1):23-31.
16. 张建平, 孟凡超, 代吉文, 等. 局部亚低温干预对实验大鼠脑出血后MMP-2/9表达及脑水肿的影响[J]. 中华物理医学与康复杂志, 2007, 29(10):649-652.
17. 陶定波, 姜秀丽, 雷阳, 等. 急性期脑梗死患者血清MMP-9水平动态变化意义及与预后的关系[J]. 中风与神经疾病杂志, 2009, 26(2):176-179.
18. 陶晶, 李志, 刘卉萍. 急性脑梗死患者血清基质金属蛋白酶-9检测的临床意义[J]. 实用医技杂志, 2011, 18(12):1243-1245.

West China Medical Journal

Dynamic Changes and Clinical Significance of Serum Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 in Patients with Cerebral Infarction

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