钇铝石榴石晶体激光联合光动力治疗顽固性跖疣临床观察_West China Medical Journal

Authors：

 易勤 , 刘珈言 ,  梅蓉 , 李二龙

四川大学华西医院皮肤性病科（成都 610041）;

Corresponding author：

易勤, Email: creat7701204@163.com; 梅蓉, Email: 1308535206@qq.com

Keywords：

钇铝石榴石晶体激光; 光动力治疗; 顽固性跖疣; 临床观察

DOI：

10.7507/1002-0179.20150653

Video：

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目的探讨钇铝石榴石晶体（Nd:YAG）激光联合光动力治疗（PDT）对顽固性跖疣的疗效及安全性。方法选取2012年5月-2015年5月就诊的38例顽固性跖疣患者予Nd:YAG激光联合PDT，随访3个月后评价疗效。结果 38例患者经过2~6次治疗后痊愈，平均治疗2.8次，其中2次治疗后治愈15例，3次治疗后治愈19例，3次PDT治愈率达89.5%。随访3个月均未见复发及严重不良反应。结论 Nd:YAG激光联合PDT治疗顽固性跖疣疗效好，安全可靠。

Citation： 易勤, 刘珈言, 梅蓉, 李二龙. 钇铝石榴石晶体激光联合光动力治疗顽固性跖疣临床观察. West China Medical Journal, 2015, 30(12): 2282-2283. doi: 10.7507/1002-0179.20150653 Copy

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1. 赵辨. 中国临床皮肤病学[M]. 南京:江苏科学技术出版社, 2009:413-418.
2. Kwok CS, Holland R, Gibbs S. Efficacy of topical treatments for cutaneous warts:a meta-analysis and pooled analysis of randomized controlled trials[J]. Br J Dermatol, 2011, 165(2):233-246.
3. Kimura U, Takeuchi K, Kinoshita A, et al. Long-pulsed 1064-nm neodymium:yttrium-aluminum-garnet laser treatment for refractory warts on hands and feet[J]. J Dermatol, 2014, 41(3):252-257.
4. El-Mohamady Ael-S, Mearag I, El-Khalawany M, et al. Pulsed dye laser versus Nd:YAG laser in the treatment of plantar warts:a comparative study[J]. Lasers Med Sci, 2014, 29(3):1111-1116.
5. Fehr MK, Chapman CF, Krasieva T, et al. Selective photosensitizer distribution in vulvar condyloma acuminatum after topical application of 5-aminolevulinic acid[J]. Am J Obstet Gynecol, 1996, 174(3):951-957.
6. Stender IM, Na R, Fogh H, et al. Photodynamic therapy with 5-aminolaevulinic acid or placebo for recalcitrant foot and hand warts:randomised double-blind trial[J]. Lancet, 2000, 355(928):963-966.
7. Wang YS, Tay YK, Kwok C, et al. Photodynamic therapy with 20% aminolevulinic acid for the treatment of recalcitrant viral warts in an Asian population[J]. Int J Dermatol, 2007, 46(11):1180-1184.
8. Ziolkowski P, Osiecka BJ, Siewinski M, et al. Pretreatment of plantar warts with azone enhances the effect of 5-aminolevulinic acid photodynamic therapy[J]. J Environ Pathol Toxicol Oncol, 2006, 25(1/2):403-409.
9. Fernández-Guarino M, Harto A, Jaén P. Treatment of recalcitrant viral warts with pulsed dye laser MAL-PDT[J]. J Dermatolog Treat, 2011, 22(4):226-228.
10. Yoo KH, Kim BJ, Kim MN. Enhanced efficacy of photodynamic therapy with methyl 5-aminolevulinic acid in recalcitrant periungual warts after ablative carbon dioxide fractional laser:a pilot study[J]. Dermatol Surg, 2009, 35(12):1927-1932.
11. Diniz IM, Horta ID, Azevedo CS, et al. Antimicrobial photodynamic therapy:a promise candidate for caries lesions treatment[J]. Photodiagnosis Photodyn Ther, 2015, 12(3):511-518.
12. 曹嘉力, 何焱玲, 张秀英. 尖锐湿疣患者HPV感染与细胞免疫功能的相关性[J]. 中国皮肤性病学杂志, 2012, 26(5):383-385.

West China Medical Journal

钇铝石榴石晶体激光联合光动力治疗顽固性跖疣临床观察

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