The Influence of Psychological Intervention on Immune Function and Psychological State in Patients Undergoing Chemotherapy after Radical Operation of Colorectal Cancer_West China Medical Journal

Authors：

 WANMin , WANGXiu-yun

Department of Abdominal Oncology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

Keywords：

Psychological intervention; Cancer chemotherapy; Immune function; Psychological state

DOI：

10.7507/1002-0179.20150658

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Objective To study the influence of psychological intervention on the immune function and psychological state in patients undergoing chemotherapy after radical operation of colorectal cancer. Method Sixty-four patients who underwent chemotherapy after eradicative resection of rectal cancer between August 2008 and August 2013 were randomly divided into control group and intervention group. Both the two groups of patients accepted conventional chemotherapy and nursing, while patients in the intervention group were also given psychological intervention. At the beginning of and 8 weeks after the therapy, self-evaluation of anxiety scale and depression self-rating scale were used to determine the psychological state (anxiety and depression) of patients in the two groups, and we evaluated the effect of psychological intervention. At the same time, the immune index and inflammatory cytokines were determined and compared between the two groups. Results Before treatment, patients in both the two groups were accompanied by mild anxiety and depression. After psychological intervention, compared with the control group, anxiety and depression of patients in the intervention group were significantly alleviated (P<0.05). Before chemotherapy, patients in the two groups were not statistically different in the immune factor index (P>0.05). After chemotherapy, compared with the control group, natural killer cells, CD3⁺, CD4⁺, CD4⁺/CD8⁺, C-reactive protein, immunoglobulin (Ig) G, interleukin (IL)-10 level of the intervention group significantly increased (P<0.05), and IL-6 and tumor necrosis factor alpha expression decreased (P<0.05). CD8⁺, IgA and IgM were not significantly changed (P>0.05). Conclusions Psychological intervention can alleviate anxiety and depression and improve the immune function in patients who undergo chemotherapy after radical operation of colorectal cancer, which is an effective auxiliary treatment.

Citation： WANMin, WANGXiu-yun. The Influence of Psychological Intervention on Immune Function and Psychological State in Patients Undergoing Chemotherapy after Radical Operation of Colorectal Cancer. West China Medical Journal, 2015, 30(12): 2299-2302. doi: 10.7507/1002-0179.20150658 Copy

1.	黄英. 心理干预对肿瘤患者化疗后免疫功能的影响[J]. 现代中西医结合杂志, 2011, 20(35):4553-4554.
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8.	邵枫, 林文娟. 情绪应激体液免疫调节作用的影响因素[J]. 心理学报, 2001, 33(6):543-547.
9.	李建中, 吴爱勤, 吴彩云, 等. 肿瘤患者的心理社会因素与免疫功能的测定[J]. 中国心理卫生杂志, 2002, 16(6):386-389.
10.	杨秀木, 马语莲, 陈永侠, 等. 综合心理干预显著改善围术期老年乳腺癌患者的情绪和免疫功能[J]. 中国老年学杂志, 2013, 33(18):4399-4401.
11.	Bödvarsdóttir I, Elklit A. Psychological reactions in Icelandic earthquake survivors[J]. Scand J Psychol, 2004, 45(1):3-13.
12.	Maria K, Jane LH, Richard A. The relationship between acute stress disorder and posttraumatic stress disorder following cancer[J]. J Consult Clin Psychol, 2005, 73(2):360-364.
13.	Palesh O, Butler LD, Koopman C, et al. Stress history and breast cancer recurrence[J]. J Psychosom Res, 2007, 63(2):233-239.
14.	Duck HK, Traci M, Michael T, et al. Dose effects of relaxation practice on immune responses in women newly diagnosed with breast cancer:an exploratory study[J]. Oncol Nurs Forum, 2011, 38(3):240-253.

1. 黄英. 心理干预对肿瘤患者化疗后免疫功能的影响[J]. 现代中西医结合杂志, 2011, 20(35):4553-4554.
2. 赵蓓蓓, 周郁秋, 王玉玲, 等. 早期心理干预对车祸伤者负性情绪及免疫功能的影响[J]. 中华护理杂志, 2013, 48(10):920-923.
3. 焦安秀, 高伟, 杨敏, 等. 心理干预对肿瘤放疗患者情绪及免疫功能的影响[J]. 齐鲁护理杂志, 2009, 15(11):4-6.
4. 郑华彬, 刘正湘. 心理干预对老年高血压患者心理状况与免疫功能的影响[J]. 高血压杂志, 2003, 11(4):349-351.
5. 刘艳, 林文娟, 刘新帆, 等. 心理行为干预对乳腺癌患者情绪反应及免疫功能的影响[J]. 心理学报, 2001, 33(5):437-441.
6. 肖灿华, 王惠珍. 心理干预对乳腺癌患者情绪及免疫功能影响的研究进展(综述)[J]. 中国心理卫生杂志, 2005, 19(10):691-693.
7. 林文娟, 王玮雯, 邵枫, 等. 慢性情绪应激对大鼠行为、神经内分泌和免疫反应的影响:一个新的情绪应激模型[J]. 科学报, 2003, 48(9):926-929.
8. 邵枫, 林文娟. 情绪应激体液免疫调节作用的影响因素[J]. 心理学报, 2001, 33(6):543-547.
9. 李建中, 吴爱勤, 吴彩云, 等. 肿瘤患者的心理社会因素与免疫功能的测定[J]. 中国心理卫生杂志, 2002, 16(6):386-389.
10. 杨秀木, 马语莲, 陈永侠, 等. 综合心理干预显著改善围术期老年乳腺癌患者的情绪和免疫功能[J]. 中国老年学杂志, 2013, 33(18):4399-4401.
11. Bödvarsdóttir I, Elklit A. Psychological reactions in Icelandic earthquake survivors[J]. Scand J Psychol, 2004, 45(1):3-13.
12. Maria K, Jane LH, Richard A. The relationship between acute stress disorder and posttraumatic stress disorder following cancer[J]. J Consult Clin Psychol, 2005, 73(2):360-364.
13. Palesh O, Butler LD, Koopman C, et al. Stress history and breast cancer recurrence[J]. J Psychosom Res, 2007, 63(2):233-239.
14. Duck HK, Traci M, Michael T, et al. Dose effects of relaxation practice on immune responses in women newly diagnosed with breast cancer:an exploratory study[J]. Oncol Nurs Forum, 2011, 38(3):240-253.

West China Medical Journal

The Influence of Psychological Intervention on Immune Function and Psychological State in Patients Undergoing Chemotherapy after Radical Operation of Colorectal Cancer

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