Study on the distribution characteristics of bone metabolic markers in plateau builders and the influencing factors_West China Medical Journal

Authors：

 HE Qinghua , ZHOU Xiaomei , ZHU Ke , TANG Chen , GAO Xueming

Department of Internal Medicine, Sichuan Electric Power Hospital, Chengdu, Sichuan 610021, P. R. China;

Corresponding author：

HE Qinghua, Email: cdhqh@163.com

Keywords：

Bone metabolic markers; Plateau; Altitude; Working intensity

DOI：

10.7507/1002-0179.201507042

Video：

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Objective To study the distribution of bone-specific alkaline phosphatase (BALP), type Ⅰ collagen cross-linked C-telopeptide (CTX) and tartrate-resistant acid phosphatase (TRAP)-5b in plateau area builders, and analyze the influencing factors under plateau environment. Methods Between April and May, 2014, using random stratified cluster sampling, we included in our study 650 blood samples from the power grid construction people in Batang County of Ganzi Autonomous Prefecture of Sichuan Province and Mangkang County of Tibet Autonomous Region with an altitude ranging from 2 600 to 4 450 meters, averaging (3 586.50±610.85) meters. We collected their fasting blood and detected their TRAP-5b, CTX and BALP by enzyme-linked immunosorbent assay method. By using SPSS 13.0, we analyzed the relationship between TRAP-5b, CTX, BALP and the influencing factors such as age, working intensity, residence time in the plateau area and altitude of the plateau. In the end, we tried to find out the main influencing factors of bone metabolic markers in the plateau environment.Results The levels of CTX, BALP and TRAP-5b were the highest before the age of 20, and the average levels of them were respectively (1.04±0.38) ng/mL, (52.09±14.62) μg/L, and (4.22±1.38) U/L. With the increase of age, the levels of CTX, TRAP-5b and BALP showed a downward trend, but CTX and BALP reached the lowest level in the age group of 40 to 49 years old, and the average levels of CTX and BALP were (0.44±0.26) ng/mL and (24.77±9.89) μg/L, respectively. Then they gradually increased after the age of 50. TRAP-5b reached the lowest level in the age group of 30 to 39 years old, and the average level of TRAP-5b was (2.59±0.95) U/L. Then it gradually increased after the age of 40. The activity of CTX and BALP increased obviously with the increase of altitude. With the increase of labor intensity, BALP, TRAP-5b and CTX all increased. However, no matter what labor intensity, the bone formation marker BALP first increased and then decreased with the plateau residence time, while the bone absorption marker TRAP-5b increased after the first reduction.Conclusions Bone metabolic markers are different in different age groups. Altitude, working intensity and plateau working time have significant effects on bone metabolism markers.

Citation： HEQinghua, ZHOUXiaomei, ZHUKe, TANGChen, GAOXueming. Study on the distribution characteristics of bone metabolic markers in plateau builders and the influencing factors. West China Medical Journal, 2017, 32(2): 164-168. doi: 10.7507/1002-0179.201507042 Copy

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4.	Ross PD, Kress BC, Parson RE, et al. Serum bone alkaline phosphatase and calcaneus bone density predict fractures: a prospective study. Osteoporos Int, 2000, 11(1): 76-82.
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9.	Garner P, Derte C, Delmas PD. A model to monitor the efficacy of alendronate treatment in women with osteoporosis using a biochemical marker of bone turnover. Bone, 1999, 24(6): 603-609.
10.	Delmas PD, Hardy P, Garnero P, et al. Monitoring individual response to hormone replacement therapy with bone markers. Bone, 2000, 26(6): 553-560.
11.	张红品, 王维群. 运动对骨代谢调节激素和生化指标的作用. 中国组织工程研究与临床康复, 2007, 11(6): 1106-1108.
12.	Eliakim A, Raisz LG, Brasel JA, et al. Evidence for increased bone formation following a brief endurance-type training intervention in adolescent males. J Bone Miner Res, 1997, 12(10): 1708-1713.
13.	Fujimura R, Ashizawa N, Watanabe M, et al. Effect of resistance exercise training on bone formation and resorption in young male subjects assessed by biomarkers of bone metabolism. J Bone Miner Res, 1997, 12(4): 656-662.
14.	Etherington J, Keeling J, Bramley R, et al. The effects of 10 weeks military training on heel ultrasound and bone turnover. Calcif Tissue Int, 1999, 64(5): 389-393.
15.	付蕾, 柯丹丹, 张玲莉, 等. 运动与骨代谢: 骨密度、骨生物力学及生化指标的评价. 中国组织工程研究, 2014, 18(46): 7487-7491.

1. 张新菊, 李融. 骨代谢标志物相关研究进展. 山东医药, 2014, 54(16): 93-95.
2. Garnero P, Hausherr E, Chapuy MC, et al. Markers of bone resorption predict hip fracture in elderly women: the EPIDOS Prospective Study. J Bone Mineral Res, 1996, 11(10): 1531-1538.
3. Garnero P, Sornay-Rendu E, Claustrat B, et al. Biochemical markers of bone turnover, endogenous hormones and the risk of fractures in postmenopausal women: the OFELY study. J Bone Miner Res, 2000, 15(8): 1526-1536.
4. Ross PD, Kress BC, Parson RE, et al. Serum bone alkaline phosphatase and calcaneus bone density predict fractures: a prospective study. Osteoporos Int, 2000, 11(1): 76-82.
5. 张萌萌, 毛未贤, 马倩倩, 等. 骨代谢标志物在骨质疏松诊疗中的应用指南. 中国骨质疏松杂志, 2013, 19(7): 645-657.
6. 陈德才, 王覃, 廖二元, 等. 骨代谢生化标志物临床应用指南.中华骨质疏松和骨矿盐疾病杂志, 2015, 8(4): 283-293.
7. 杨春云, 邱清芳, 翟学君, 等. 胶东半岛健康成年人群骨代谢生化指标与骨密度相关性研究. 中国骨质疏松杂志, 2011, 17(6): 493-497.
8. Martínez ME, del Campo MT, Medina S, et al. Influence of skeletal site of origin and donor age on osteoblastic cell growth and differentiation. Calcif Tissue Int, 1999, 64(4): 280-286.
9. Garner P, Derte C, Delmas PD. A model to monitor the efficacy of alendronate treatment in women with osteoporosis using a biochemical marker of bone turnover. Bone, 1999, 24(6): 603-609.
10. Delmas PD, Hardy P, Garnero P, et al. Monitoring individual response to hormone replacement therapy with bone markers. Bone, 2000, 26(6): 553-560.
11. 张红品, 王维群. 运动对骨代谢调节激素和生化指标的作用. 中国组织工程研究与临床康复, 2007, 11(6): 1106-1108.
12. Eliakim A, Raisz LG, Brasel JA, et al. Evidence for increased bone formation following a brief endurance-type training intervention in adolescent males. J Bone Miner Res, 1997, 12(10): 1708-1713.
13. Fujimura R, Ashizawa N, Watanabe M, et al. Effect of resistance exercise training on bone formation and resorption in young male subjects assessed by biomarkers of bone metabolism. J Bone Miner Res, 1997, 12(4): 656-662.
14. Etherington J, Keeling J, Bramley R, et al. The effects of 10 weeks military training on heel ultrasound and bone turnover. Calcif Tissue Int, 1999, 64(5): 389-393.
15. 付蕾, 柯丹丹, 张玲莉, 等. 运动与骨代谢: 骨密度、骨生物力学及生化指标的评价. 中国组织工程研究, 2014, 18(46): 7487-7491.

West China Medical Journal

Study on the distribution characteristics of bone metabolic markers in plateau builders and the influencing factors

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