Correlation between serum level of 25(OH)D<sub>3</sub> and peripheral neuropathy in patients with impaired glucose tolerance_West China Medical Journal

Authors：

 GUO Baoqiang , XU Xiuli , HAO Cuicui , HE Donghua

Department of Endocrinology, the Second People’s Hospital of Liaocheng City, Liaocheng, Shandong 252601, P. R. China;

Corresponding author：

GUO Baoqiang, Email: baoqiangg@aliyun.com

Keywords：

Vitamin D; Impaired glucose tolerance; Peripheral neuropathy

DOI：

10.7507/1002-0179.201509033

Video：

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Objective To investigate the correlation between serum level of 25(OH)D₃ and peripheral neuropathy in patients with impaired glucose tolerance. Methods A total of 108 patients with impaired glucose tolerance treated or examined between January 2012 and July 2014 were recruited in this study. According to whether peripheral neuropathy was combined, the patients were divided into neuropathy group (n=50) and non-neuropathy group (n=58). The level of 25(OH)D₃ was measured and compared between the two groups, and the correlation of 25(OH)D₃ with the clinical indexes of impaired glucose tolerance was analyzed. Results The level of 25(OH)D₃ in the neuropathy group and non-neuropathy group was respectively (16.1±4.2) and (19.6±4.7) ng/mL with a significant difference (P<0.05). The 25(OH)D₃ deficiency rate of the above two groups was respectively 80.0% and 41.38%, also with a significant difference (P<0.05). The 25(OH)D₃ level had a negative correlation with body mass index (BMI) and glycosylated hemoglobin (P<0.05). Conclusions There is a significant relationship between impaired glucose tolerance and 25(OH)D₃ level. The 25(OH)D₃ level has a negative correlation with BMI and glycosylated hemoglobin.

Citation： GuoBaoqiang, XuXiuli, HaoCuicui, HeDonghua. Correlation between serum level of 25(OH)D₃ and peripheral neuropathy in patients with impaired glucose tolerance. West China Medical Journal, 2017, 32(2): 161-163. doi: 10.7507/1002-0179.201509033 Copy

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7.	Boulton AJ, Malik RA. Neuropathy of impaired glucose tolerance and its measurement. Diabetes Care, 2010, 33(1): 207-209.
8.	中华医学会糖尿病学分会. 中国 2 型糖尿病防治指南. 中华糖尿病杂志, 2014, 6(7): 447-498.
9.	Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline. J Clin Endocrinol Metab, 2011, 96(7): 1911-1930.
10.	Kamen DL, Tangpricha V. Vitamin D and molecular actions on the immune system: modulation of innate and autoimmunity. J Mol Med (Berl), 2010, 88(5): 441-450.
11.	Zhao GX, Ford ES, Li CY. Associations of serum concentrations of 25-Hydroxyvitamin D and parathyroid hormone with surrogate markers of insulin resistance among US adults without Physician-Diagnosed diabetes: NHANES, 2003-2006. Diabetes Care, 2010, 33(2): 344-347.
12.	邵雪景, 缪珩. 维生素 D 和肥胖. 国际内分泌代谢杂志, 2010, 30(3): 168-170.
13.	Asemi Z, Samimi M, Tabassi Z, et al. Vitamin D supplementation affects serum high-sensitivity C-reactive protein, insulin resistance, and biomarkers of oxidative stress in pregnant women. J Nutr, 2013, 143(9): 1432-1438.
14.	Shehab D, Al-Jarallah K, Mojiminiyi OA, et al. Does vitamin D deficiency play a role in peripheral neuropathy in type 2 diabetes?. Diabet Med, 2012, 29(1): 43-49.
15.	李菲, 胡波, 刘静芳, 等. 维生素 D 补充对 2 型糖尿病患者血糖控制、胰岛素抵抗及胰岛 β 细胞功能的 Meta 分析. 中国循证医学杂志, 2016, 16(9): 1080-1089.

1. Chan C, Zhang Y, Ning G. Diabetes in China: a societal solution for a personal challenge. Lancet Diabetes Endocrinol, 2014, 2(12): 969-979.
2. Bouhassira D, Letanoux M, Hartemann A. Chronic pain with neuropathic characteristics in diabetic patients: a french cross-sectional study. PLoS One, 2013, 8(9): e74195.
3. Garcion E, Wion-Barbot N, Montero-Menei CN, et al. New clues about vitamin D functions in the nervous system. Trends Endocrinol Metab, 2002, 13(3): 100-105.
4. 赵静, 张倩, 张环美, 等. 北京市怀柔区儿童维生素 D 营养状况及其与体成分的关系. 中华流行病学杂志, 2010, 31(1): 34-38.
5. 朱汉民, 程群, 甘洁民, 等. 上海地区人群维生素 D 状态研究. 中华骨质疏松和骨矿盐疾病杂志, 2010, 3(3): 157-163.
6. Holick MF, Chen TC, Lu Z, et al. Vitamin D and skin physiology: a D-lightful story. J Bone Miner Res, 2007, 22 (Suppl 2): V28-V33.
7. Boulton AJ, Malik RA. Neuropathy of impaired glucose tolerance and its measurement. Diabetes Care, 2010, 33(1): 207-209.
8. 中华医学会糖尿病学分会. 中国 2 型糖尿病防治指南. 中华糖尿病杂志, 2014, 6(7): 447-498.
9. Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline. J Clin Endocrinol Metab, 2011, 96(7): 1911-1930.
10. Kamen DL, Tangpricha V. Vitamin D and molecular actions on the immune system: modulation of innate and autoimmunity. J Mol Med (Berl), 2010, 88(5): 441-450.
11. Zhao GX, Ford ES, Li CY. Associations of serum concentrations of 25-Hydroxyvitamin D and parathyroid hormone with surrogate markers of insulin resistance among US adults without Physician-Diagnosed diabetes: NHANES, 2003-2006. Diabetes Care, 2010, 33(2): 344-347.
12. 邵雪景, 缪珩. 维生素 D 和肥胖. 国际内分泌代谢杂志, 2010, 30(3): 168-170.
13. Asemi Z, Samimi M, Tabassi Z, et al. Vitamin D supplementation affects serum high-sensitivity C-reactive protein, insulin resistance, and biomarkers of oxidative stress in pregnant women. J Nutr, 2013, 143(9): 1432-1438.
14. Shehab D, Al-Jarallah K, Mojiminiyi OA, et al. Does vitamin D deficiency play a role in peripheral neuropathy in type 2 diabetes?. Diabet Med, 2012, 29(1): 43-49.
15. 李菲, 胡波, 刘静芳, 等. 维生素 D 补充对 2 型糖尿病患者血糖控制、胰岛素抵抗及胰岛 β 细胞功能的 Meta 分析. 中国循证医学杂志, 2016, 16(9): 1080-1089.

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Correlation between serum level of 25(OH)D₃ and peripheral neuropathy in patients with impaired glucose tolerance

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West China Medical Journal

Correlation between serum level of 25(OH)D3 and peripheral neuropathy in patients with impaired glucose tolerance

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Correlation between serum level of 25(OH)D₃ and peripheral neuropathy in patients with impaired glucose tolerance