Effect of early antiretroviral therapy on acquired immune deficiency syndrome in Butuo County, Liangshan Autonomous Prefecture_West China Medical Journal

Authors：

YANG Chengbin ¹ ,  YANG Wen ² , ZENG Yali ² , GU Xiande ¹ , BIAN Shichao ³ , WU Min ¹ , ZHU Zhengde ¹ , LUO Xuewen ¹

1. Department of Medicine, People’s Hospital of Butuo County, Butuo, Sichuan 616350, P. R. China;
2. Sichuan Provincial Center for AIDS/STD Control and Prevention, Chengdu, Sichuan 610041, P. R. China;
3. Clinical Laboratory, Center for Disease Control and Prevention of Liangshan Autonomous Prefecture, Xichang, Sichuan 615000, P. R. China;

Corresponding author：

YANG Wen, Email: yangwenn@yeah.net

Keywords：

Acquired immune deficiency syndrome; Early antiretroviral treatment; Therapeutic effect

DOI：

10.7507/1002-0179.201511052

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Objective To assess the effect of early antiretroviral therapy on acquired immune deficiency syndrome in Butuo County, Liangshan Autonomous Prefecture. Methods A total of 1 037 patients who underwent antiretroviral therapy between January 1st 2012 and December 31st 2013 in Butuo Coungty were divided into 2 groups. The early treatment group (with CD4⁺ lymphocyte count >350 /mm³) was group A (n=459) and delayed treatment group (with CD4⁺ lymphocyte count≤350 /mm³) was group B. After 18-month treatment, the treatment retention rate, clinical effect and the side effects of medication in two groups were observed and analyzed. Results After 18 months, there were 297 (64.7%) and 320 (55.4%) patients who were persisting in treatment in group A and B, respectively; while the mortality was 6.1% (28/459) and 14.4% (83/578), respectively in group A and B. The differences were significant (P<0.001). The rate of virological suppression in group A and B was 64.0% (190/297) and 63.8% (204/320) respectively without any significant difference (P>0.05). Compared with baseline CD4⁺ T lymphocyte counts, the growth rate of CD4⁺ T lymphocyte count in group A and B was 5.7% and 37.5%, respectively; the difference was significant (P<0.001) Conclusions Early treatment for acquired immune deficiency syndrome in Butuo County, Liangshan Autonomous Prefecture is effective, however, its growth rate of CD4⁺ T lymphocyte count is lower than that of delayed treatment. Early treatment doesn’t cause the increasement of the risk of common adverse reactions of medication, and it can reduce the mortality.

Citation： YANG Chengbin, YANG Wen, ZENG Yali, GU Xiande, BIAN Shichao, WU Min, ZHU Zhengde, LUO Xuewen. Effect of early antiretroviral therapy on acquired immune deficiency syndrome in Butuo County, Liangshan Autonomous Prefecture. West China Medical Journal, 2017, 32(6): 867-870. doi: 10.7507/1002-0179.201511052 Copy

1.	李东升, 刘佳, 王哲. 抗病毒治疗作为预防控制 HIV 传播的新策略研究进展. 中国艾滋病性病, 2016, 22(9): 133-137.
2.	国家卫生计生委办公厅. 国家卫生计生委办公厅关于修订艾滋病患者免费抗病毒治疗标准的通(2014-04-18)[2015-01-01]. http://www.nhfpc.gov.cn/yzygj/s3593/201405/95edf9ac8abb4e1a9f3482501b0ae4be.shtml.
3.	李兰娟, 李德新, 吴尊友. 重大传染病社区综合防治实施方案和操作规程(试行版). 北京: 科学出版社, 2012.
4.	卫生部艾滋病临床专家工作组. 国家免费艾滋病抗病毒治疗手册. 3 版. 北京: 人民卫生出版社, 2012: 25-133.
5.	卫生部艾滋病临床专家工作组. 国家免费艾滋病抗病毒治疗手册. 4 版. 北京: 人民卫生出版社, 2016: 47-52.
6.	Dabis F, Newell ML, Hirschel B. HIV drugs for treatment, and for prevention. Lancet, 2010, 375(9731): 2056-2057.
7.	中华医学会感染病学分会艾滋病学组. 艾滋病诊疗指南 (2011 版) 中华临床感染病杂志, 2011, 4(6): 321-330.
8.	赵燕, 张福杰, 刘中夫, 等. 人类免疫缺陷病毒感染者/艾滋病患者抗病毒治疗的公共卫生意义及策略进展. 中华传染病杂志, 2011, 29(7): 442-446.
9.	Cohen MS, Chen YQ, Mccauley M, et al. Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med, 2011, 365(6): 493-505.
10.	杨绍基, 李兰娟, 任红, 等. 传染病学. 8 版. 北京: 人民卫生出版社, 2013: 108-118.
11.	杨文杰, 安伟锋, 马彦民, 等. 早期抗病毒治疗对艾滋病患者生存状况的影响. 中华流行病学杂志, 2014, 35(9): 1065-1068.
12.	陈仕晓, 毛碧容, 朱帆, 等. 51 例艾滋病抗病毒治疗的疗效分析. 华西医学, 2009, 19(3): 661-663.
13.	楼金成, 李惠琴, 劳云飞, 等. 云南省成人 AIDS 病人抗病毒治疗的疗效分析. 中国艾滋病性病, 2013, 19(8): 557-559.
14.	Lichtenstein KA, Armon C, Buchacz K, et al. Initiation of antiretroviral therapy at CD4 cell counts≥350 cells/mm³ does not increase incidence or risk of peripheral neuropathy, anemia, or renal insufficiency. J Acquir Immune Defic Syndr, 2008, 47(1): 27-35.
15.	李侠, 楼金城, 劳云飞, 等. 云龙省 HIV/AIDS 病人早期抗病毒治疗的有效性和安全性分析. 中国艾滋病性病, 2014, 20(3): 165-168.

1. 李东升, 刘佳, 王哲. 抗病毒治疗作为预防控制 HIV 传播的新策略研究进展. 中国艾滋病性病, 2016, 22(9): 133-137.
2. 国家卫生计生委办公厅. 国家卫生计生委办公厅关于修订艾滋病患者免费抗病毒治疗标准的通(2014-04-18)[2015-01-01]. http://www.nhfpc.gov.cn/yzygj/s3593/201405/95edf9ac8abb4e1a9f3482501b0ae4be.shtml.
3. 李兰娟, 李德新, 吴尊友. 重大传染病社区综合防治实施方案和操作规程(试行版). 北京: 科学出版社, 2012.
4. 卫生部艾滋病临床专家工作组. 国家免费艾滋病抗病毒治疗手册. 3 版. 北京: 人民卫生出版社, 2012: 25-133.
5. 卫生部艾滋病临床专家工作组. 国家免费艾滋病抗病毒治疗手册. 4 版. 北京: 人民卫生出版社, 2016: 47-52.
6. Dabis F, Newell ML, Hirschel B. HIV drugs for treatment, and for prevention. Lancet, 2010, 375(9731): 2056-2057.
7. 中华医学会感染病学分会艾滋病学组. 艾滋病诊疗指南 (2011 版) 中华临床感染病杂志, 2011, 4(6): 321-330.
8. 赵燕, 张福杰, 刘中夫, 等. 人类免疫缺陷病毒感染者/艾滋病患者抗病毒治疗的公共卫生意义及策略进展. 中华传染病杂志, 2011, 29(7): 442-446.
9. Cohen MS, Chen YQ, Mccauley M, et al. Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med, 2011, 365(6): 493-505.
10. 杨绍基, 李兰娟, 任红, 等. 传染病学. 8 版. 北京: 人民卫生出版社, 2013: 108-118.
11. 杨文杰, 安伟锋, 马彦民, 等. 早期抗病毒治疗对艾滋病患者生存状况的影响. 中华流行病学杂志, 2014, 35(9): 1065-1068.
12. 陈仕晓, 毛碧容, 朱帆, 等. 51 例艾滋病抗病毒治疗的疗效分析. 华西医学, 2009, 19(3): 661-663.
13. 楼金成, 李惠琴, 劳云飞, 等. 云南省成人 AIDS 病人抗病毒治疗的疗效分析. 中国艾滋病性病, 2013, 19(8): 557-559.
14. Lichtenstein KA, Armon C, Buchacz K, et al. Initiation of antiretroviral therapy at CD4 cell counts≥350 cells/mm³ does not increase incidence or risk of peripheral neuropathy, anemia, or renal insufficiency. J Acquir Immune Defic Syndr, 2008, 47(1): 27-35.
15. 李侠, 楼金城, 劳云飞, 等. 云龙省 HIV/AIDS 病人早期抗病毒治疗的有效性和安全性分析. 中国艾滋病性病, 2014, 20(3): 165-168.

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Effect of early antiretroviral therapy on acquired immune deficiency syndrome in Butuo County, Liangshan Autonomous Prefecture

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