Association between Caveolin-1 protein expression and gastric cancer as well as its clinical pathologic features: a Meta-analysis_West China Medical Journal

Authors：

ZHANG Yuling , WANG Jiru ,  CHEN Pei , XU Guoying

Department of Pharmaceutical Inspection, Jiangsu Vocational College of Nursing, Huaian, Jiangsu 223300, P. R. China;

Corresponding author：

CHEN Pei, Email: xiaolajiao1983@126.com

Keywords：

Gastric cancer; Caveolin-1; Clinical pathologic features; Meta-analysis

DOI：

10.7507/1002-0179.201512187

Video：

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Objective To systematically evaluate the association between Caveolin-1 and gastric cancer, as well as its clinical pathologic features. Methods Databases including Wanfang, VIP, CNKI and PubMed were searched to identify case-control studies involving the association between Caveolin-1 and gastric cancer as well as its clinical pathologic features from January 2000 to May 2017. The literatures were screened and the methodological quality was assessed, then RevMan 5.3 software was used to conduct Meta-analysis. Results A total of 12 case-control studies were collected after screening, including 1 380 cases of gastric cancer, with Caveolin-1 expressed positive in 286 cases; 295 cases of non-carcinoma control, with Caveolin-1 expressed positive in 264 cases; 238 cases of precancerous lesions of gastric cancer, with Caveolin-1 expressed positive in 180 cases. Results of Meta-analysis indicated that: as for Caveolin-1 expression, significant differences were found in non-carcinoma vs. gastric cancer [odds ratio (OR)=23.74, 95% confidence interval (CI) (15.19, 37.11), P<0.000 01], precancerous lesions of gastric cancer vs. gastric cancer [OR=6.58, 95%CI (4.52, 9.58), P<0.000 01], and non-carcinoma control vs. precancerous lesions of gastric cancer [OR=2.88, 95%CI (1.58, 5.25), P=0.000 6]. Significant differences were also found between Caveolin-1 expression and gastric cancer clinical pathologic features in undifferentiated vs. differentiated tissue [OR=0.48, 95%CI (0.33, 0.70), P=0.000 1], and without vs. with lymph node metastasis [OR=3.19, 95%CI (1.77, 5.74), P=0.000 1]. Conclusions Caveolin-1 expression is lesser in most gastric cancer patients than in the controls, and is closely associated with its clinical pathologic features. Due to limited quantity and quality of included studies, more high quality studies are needed to verify the conclusion of Caveolin-1 as a tumor marker in gastric cancer.

Citation： ZHANG Yuling, WANG Jiru, CHEN Pei, XU Guoying. Association between Caveolin-1 protein expression and gastric cancer as well as its clinical pathologic features: a Meta-analysis. West China Medical Journal, 2017, 32(8): 1187-1194. doi: 10.7507/1002-0179.201512187 Copy

1.	Salem AF, Bonuccelli G, Bevilacqua GA, et al. Caveolin-1 promotes pancreatic cancer cell differentiation and restores membranous E-cadherin via suppression of the epithelial-mesenchymal transition. Cell Cycle, 2011, 10(21): 3692-3700.
2.	Tse EY, Ko FC, Tung EK, et al. Caveolin-1 overexpression is associated with hepatocellular carcinoma tumourigenesis and metastasis. J Pathol, 2012, 226(4): 645-653.
3.	Higgins PT, Green S. Cochrane handbook for systematic reviews of interventions (5.0.2). London, UK: The Cochrane Collaboration, 2009.
4.	罗红梅, 张蒙夏, 唐圣松, 等. Caveolin-1 表达及其与胃癌生物学行为关系的研究. 肿瘤防治杂志, 2004, 11(4): 341-343, 369.
5.	高雪, 孙媛, 黄磊, 等. Caveolin-1 在胃癌组织中的表达及临床生物学意义. 癌症, 2005, 24(3): 311-316.
6.	刘斌, 杨育生, 邢传平, 等. Caveolin-1 基因 mRNA 和蛋白在胃癌组织的表达. 第四军医大学学报, 2007, 28(20): 1868-1871.
7.	刘茗露, 刘斌, 陈一伟, 等. KAI1 及 Caveolin-1 在胃癌组织中的表达及其意义. 中国肿瘤临床与康复, 2010, 17(4): 323-326.
8.	杨聪颖, 张志梅, 王巧, 等. 胃癌组织中 Caveolin-1、 Paxillin 的表达及其临床生物学意义. 现代肿瘤医学, 2010, 18(11): 2211-2214.
9.	邢敬, 刘朋伟, 彭延申, 等. 胃腺癌微环境 caveolin-1 的表达及其临床意义. 胃肠病学, 2011, 16(8): 454-458.
10.	李远航, 张建国. 窖蛋白-1 与基质金属蛋白酶 2 在胃癌组织中的表达及临床生物学意义. 中华临床医师杂志: 电子版, 2011, 5(19): 5764-5767.
11.	Sun GY, Wu JX, Wu JS, et al. Caveolin-1, E-cadherin and β-catenin in gastric carcinoma, precancerous tissues and chronic non-atrophic gastritis. Chin J Cancer Res, 2012, 24(1): 23-28.
12.	Barresi V, Giuffre’ G, Vitarelli E, et al. Caveolin-1 immuno-expression in human gastric cancer: histopathogenetic hypotheses. Virchows Arch, 2008, 453(6): 571-578.
13.	Zhao X, He Y, Gao J, et al. Caveolin-1 expression level in cancer associated fibroblasts predicts outcome in gastric cancer. PLoS One, 2013, 8(3): e59102.
14.	Nam KH, Lee BL, Park JH, et al. Caveolin 1 expression correlates with poor prognosis and focal adhesion kinase expression in gastric cancer. Pathobiology, 2013, 80(2): 87-94.
15.	He Y, Zhao X, Gao J, et al. Quantum dots-based immunofluorescent imaging of stromal fibroblasts Caveolin-1 and light chain 3B expression and identification of their clinical significance in human gastric cancer. Int J Mol Sci, 2012, 13(11): 13764-13780.
16.	Williams TM, Lisanti MP. Caveolin-1 in oncogenic transformation, cancer, and metastasis. Am J Physiol Cell Physiol, 2005, 288(3): C494-C506.
17.	Torres VA, Tapia JC, Rodriguez DA, et al. Caveolin-1 controls cell proliferation and cell death by suppressing expression of the inhibitor of apoptosis protein survivin. J Cell Sci, 2006, 119(9): 1812-1823.
18.	Cohen AW, Hnasko R, Schubert W, et al. Role of caveolae and caveolins in health and disease. Physiol Rev, 2004, 84(4): 1341-1379.
19.	Burgermeister E, Xing XB, Roecken CA, et al. Differential expression and function of caveolin-1 in human gastric cancer progression. Cancer Res, 2007, 67(18): 8519-8526.
20.	Ye Y, Miao SH, Lu RZ, et al. Prognostic value of caveolin-1 expression in gastric cancer: a meta-analysis. Asian Pac J Cancer Prev, 2014, 15(19): 8367-8370.

1. Salem AF, Bonuccelli G, Bevilacqua GA, et al. Caveolin-1 promotes pancreatic cancer cell differentiation and restores membranous E-cadherin via suppression of the epithelial-mesenchymal transition. Cell Cycle, 2011, 10(21): 3692-3700.
2. Tse EY, Ko FC, Tung EK, et al. Caveolin-1 overexpression is associated with hepatocellular carcinoma tumourigenesis and metastasis. J Pathol, 2012, 226(4): 645-653.
3. Higgins PT, Green S. Cochrane handbook for systematic reviews of interventions (5.0.2). London, UK: The Cochrane Collaboration, 2009.
4. 罗红梅, 张蒙夏, 唐圣松, 等. Caveolin-1 表达及其与胃癌生物学行为关系的研究. 肿瘤防治杂志, 2004, 11(4): 341-343, 369.
5. 高雪, 孙媛, 黄磊, 等. Caveolin-1 在胃癌组织中的表达及临床生物学意义. 癌症, 2005, 24(3): 311-316.
6. 刘斌, 杨育生, 邢传平, 等. Caveolin-1 基因 mRNA 和蛋白在胃癌组织的表达. 第四军医大学学报, 2007, 28(20): 1868-1871.
7. 刘茗露, 刘斌, 陈一伟, 等. KAI1 及 Caveolin-1 在胃癌组织中的表达及其意义. 中国肿瘤临床与康复, 2010, 17(4): 323-326.
8. 杨聪颖, 张志梅, 王巧, 等. 胃癌组织中 Caveolin-1、 Paxillin 的表达及其临床生物学意义. 现代肿瘤医学, 2010, 18(11): 2211-2214.
9. 邢敬, 刘朋伟, 彭延申, 等. 胃腺癌微环境 caveolin-1 的表达及其临床意义. 胃肠病学, 2011, 16(8): 454-458.
10. 李远航, 张建国. 窖蛋白-1 与基质金属蛋白酶 2 在胃癌组织中的表达及临床生物学意义. 中华临床医师杂志: 电子版, 2011, 5(19): 5764-5767.
11. Sun GY, Wu JX, Wu JS, et al. Caveolin-1, E-cadherin and β-catenin in gastric carcinoma, precancerous tissues and chronic non-atrophic gastritis. Chin J Cancer Res, 2012, 24(1): 23-28.
12. Barresi V, Giuffre’ G, Vitarelli E, et al. Caveolin-1 immuno-expression in human gastric cancer: histopathogenetic hypotheses. Virchows Arch, 2008, 453(6): 571-578.
13. Zhao X, He Y, Gao J, et al. Caveolin-1 expression level in cancer associated fibroblasts predicts outcome in gastric cancer. PLoS One, 2013, 8(3): e59102.
14. Nam KH, Lee BL, Park JH, et al. Caveolin 1 expression correlates with poor prognosis and focal adhesion kinase expression in gastric cancer. Pathobiology, 2013, 80(2): 87-94.
15. He Y, Zhao X, Gao J, et al. Quantum dots-based immunofluorescent imaging of stromal fibroblasts Caveolin-1 and light chain 3B expression and identification of their clinical significance in human gastric cancer. Int J Mol Sci, 2012, 13(11): 13764-13780.
16. Williams TM, Lisanti MP. Caveolin-1 in oncogenic transformation, cancer, and metastasis. Am J Physiol Cell Physiol, 2005, 288(3): C494-C506.
17. Torres VA, Tapia JC, Rodriguez DA, et al. Caveolin-1 controls cell proliferation and cell death by suppressing expression of the inhibitor of apoptosis protein survivin. J Cell Sci, 2006, 119(9): 1812-1823.
18. Cohen AW, Hnasko R, Schubert W, et al. Role of caveolae and caveolins in health and disease. Physiol Rev, 2004, 84(4): 1341-1379.
19. Burgermeister E, Xing XB, Roecken CA, et al. Differential expression and function of caveolin-1 in human gastric cancer progression. Cancer Res, 2007, 67(18): 8519-8526.
20. Ye Y, Miao SH, Lu RZ, et al. Prognostic value of caveolin-1 expression in gastric cancer: a meta-analysis. Asian Pac J Cancer Prev, 2014, 15(19): 8367-8370.

West China Medical Journal

Association between Caveolin-1 protein expression and gastric cancer as well as its clinical pathologic features: a Meta-analysis

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