The Study of Laparoscopic High Ligation for Repairing Inguinal Hernia on Rabbits_West China Medical Journal

Authors：

 YangXiguang ¹ , ChenXiaoxun ¹ ,  XiangGuoan ² , ZhangDa ³ , ZhangZhaoming ¹ , ChenKaiyun ² , WangHanning ²

1. Department of Gastrointestinal Surgery, People's Hospital of Guigang City, Guigang, Guangxi 537100, P. R. China;
2. Department of General Surgery, the Second People's Hospital of Guangdong Province, Guangzhou, Guangdong 510317, P. R. China;
3. Department of General Surgery, the Central Hospital of Xi'an City, Xi'an, Shaanxi 710003, P. R. China;

Corresponding author：

XiangGuoan, Email: guoan_66@163.com

Keywords：

Laparoscope; Animal experiment; Inguinal hernia; Hernia model; High ligation

DOI：

10.7507/1002-0179.20160009

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To survey the feasibility of laparoscopic high ligation for pediatric inguinal hernias by performing the surgery on rabbit models. Methods Laparoscopic high ligation was operated on 32 healthy New-Zealand male rabbits. Eight random rabbits were observed under laparoscope on the 7th, 15th, 30th, and 60th days after operation, and the anti-tension strength at the instant when hernial inner ring cracked was measured. Repair regions were resected. After HE-staining, the syzygial status of the repair regions were checked. Results None of the rabbits died during the research with no such complications as ankylenteron intestinal obstruction or hernia relapses after surgery. The anti-tension strength by the inguinal regions of the experimental rabbits after surgery on the 7th, 15th, 30th, and 60th days was respectively (42.69±6.98), (69.31±6.52), (102.64±7.91), and (106.53±7.54) mm Hg (1 mm Hg=0.133 kPa). As for the pathological section observation, the agglutination of the repair region was consistent with reparative process of chronic nonbacterial inflammation. Conclusion The operation of laparoscopic high ligation for repairing inguinal hernia on rabbits is safe and reliable.

Citation： YangXiguang, ChenXiaoxun, XiangGuoan, ZhangDa, ZhangZhaoming, ChenKaiyun, WangHanning. The Study of Laparoscopic High Ligation for Repairing Inguinal Hernia on Rabbits. West China Medical Journal, 2016, 31(1): 33-36. doi: 10.7507/1002-0179.20160009 Copy

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2.	姚干, 杨庆堂, 张庆峰, 等. 微型腹腔镜治疗小儿腹股沟斜疝6 100例报告[J]. 腹腔镜外科杂志, 2011, 16(1):18-20.
3.	Alzahem A. Laparoscopic versus open inguinal herniotomy in infants and children:a meta-analysis[J]. Pediatr Surg Int, 2011, 27(6):605-612.
4.	Esposito C, St Peter SD, Escolino M, et al. Laparoscopic versus open inguinal hernia repair in pediatric patients:a systematic review[J]. J Laparoendosc Adv Surg Tech A, 2014, 24(11):811-818.
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6.	Zendejas B, Ramirez T, Jones T, et al. Trends in the utilization of inguinal hernia repair techniques:a population-based study[J]. Am J Surg, 2012, 203(3):313-317.
7.	方艳丽, 赖洲惠, 王睿, 等. 小儿日间腹腔镜下腹股沟疝修补术后的近期随访分析[J]. 华西医学, 2013, 28(11):1740-1741.
8.	秦川. 医学实验动物学[M]. 2版. 北京:人民卫生出版社, 2012:38.
9.	Ignat'ev RO, Bataev SM, Bogdanov SE, et al. Laparoscopic herniorrhaphy in children[J]. Khirurgiia (Mosk), 2014(6):30-35.
10.	Marte A, Sabatino MD, Borrelli M, et al. Decreased recurrence rate in the laparoscopic herniorraphy in children:comparison between two techniques[J]. J Laparoendosc Adv Surg Tech A, 2009, 19(2):259-262.
11.	Saha N, Biswas I, Rahman MA, et al. Surgical outcome of laparoscopic and open surgery of pediatric inguinal hernia[J]. Mymensingh Med J, 2013, 22(2):232-236.
12.	张建平, 吴俊民, 杜文安, 等. 经脐双孔法腹腔镜下内环缝合联合高位结扎治疗小儿腹股沟斜疝[J]. 中国普通外科杂志, 2013, 22(7):953-955.
13.	Yang C, Zhang H, Pu J, et al. Laparoscopic vs open herniorrhaphy in the management of pediatric inguinal hernia:a systemic review and meta-analysis[J]. J Pediatr Surg, 2011, 46(9):1824-1834.
14.	何秀娟, 林燕, 吕喆, 等. 朱红膏对脂多糖刺激人单核细胞系THP-1细胞分泌细胞因子和黏附分子的影响[J]. 首都医科大学学报, 2013, 34(4):572-575.
15.	Kroeze KL, Vink L, de Boer EM, et al. Simple woundexudate collection method identifies bioactive cytokines and chemokines in (arterio) venous ulcers[J]. Wound Repair Regen, 2012, 20(3): 294-303.
16.	Pukstad BS, Ryan L, Flo TH, et al. Non-healing is associated with persistent stimulation of the innate immune response in chronic venous leg ulcers[J]. J Dermatol Sci, 2010, 59(2):115-122.
17.	An, Mushin OP, Lazar DA. Wound healing characteristics of ICAM-1 null mice devoid of all isoforms of ICAM-1[J]. J Surg Res, 2011, 171(1):81-87.
18.	Monteiro GA, Delossantos AI, Rodriguez NL, et al. Porcine incisional hernia model:evaluation of biologically derived intact extracellular matrix repairs[J]. J Tissue Eng, 2013, 4(4):2041731413508771.
19.	Liu J, Baird M, Tang Y, et al. Medial umbilic ligament flap reinforcement of the internal ring in children with indirect inguinal hernia[J]. J Laparoendosc Adv Surg Tech A, 2011, 21(6):561-565.

1. Zani A, Eaton S, Hoellwarth M, et al. Management of pediatric inguinal hernias in the era of laparoscopy:results of an international survey[J]. Eur J Pediatr Surg, 2014, 24(1):9-13.
2. 姚干, 杨庆堂, 张庆峰, 等. 微型腹腔镜治疗小儿腹股沟斜疝6 100例报告[J]. 腹腔镜外科杂志, 2011, 16(1):18-20.
3. Alzahem A. Laparoscopic versus open inguinal herniotomy in infants and children:a meta-analysis[J]. Pediatr Surg Int, 2011, 27(6):605-612.
4. Esposito C, St Peter SD, Escolino M, et al. Laparoscopic versus open inguinal hernia repair in pediatric patients:a systematic review[J]. J Laparoendosc Adv Surg Tech A, 2014, 24(11):811-818.
5. 汪雪, 汪树林. 两种自制导线缝扎针在腹腔镜小儿腹股沟疝手术中的应用[J]. 华西医学, 2011, 26(3):378-381.
6. Zendejas B, Ramirez T, Jones T, et al. Trends in the utilization of inguinal hernia repair techniques:a population-based study[J]. Am J Surg, 2012, 203(3):313-317.
7. 方艳丽, 赖洲惠, 王睿, 等. 小儿日间腹腔镜下腹股沟疝修补术后的近期随访分析[J]. 华西医学, 2013, 28(11):1740-1741.
8. 秦川. 医学实验动物学[M]. 2版. 北京:人民卫生出版社, 2012:38.
9. Ignat'ev RO, Bataev SM, Bogdanov SE, et al. Laparoscopic herniorrhaphy in children[J]. Khirurgiia (Mosk), 2014(6):30-35.
10. Marte A, Sabatino MD, Borrelli M, et al. Decreased recurrence rate in the laparoscopic herniorraphy in children:comparison between two techniques[J]. J Laparoendosc Adv Surg Tech A, 2009, 19(2):259-262.
11. Saha N, Biswas I, Rahman MA, et al. Surgical outcome of laparoscopic and open surgery of pediatric inguinal hernia[J]. Mymensingh Med J, 2013, 22(2):232-236.
12. 张建平, 吴俊民, 杜文安, 等. 经脐双孔法腹腔镜下内环缝合联合高位结扎治疗小儿腹股沟斜疝[J]. 中国普通外科杂志, 2013, 22(7):953-955.
13. Yang C, Zhang H, Pu J, et al. Laparoscopic vs open herniorrhaphy in the management of pediatric inguinal hernia:a systemic review and meta-analysis[J]. J Pediatr Surg, 2011, 46(9):1824-1834.
14. 何秀娟, 林燕, 吕喆, 等. 朱红膏对脂多糖刺激人单核细胞系THP-1细胞分泌细胞因子和黏附分子的影响[J]. 首都医科大学学报, 2013, 34(4):572-575.
15. Kroeze KL, Vink L, de Boer EM, et al. Simple woundexudate collection method identifies bioactive cytokines and chemokines in (arterio) venous ulcers[J]. Wound Repair Regen, 2012, 20(3): 294-303.
16. Pukstad BS, Ryan L, Flo TH, et al. Non-healing is associated with persistent stimulation of the innate immune response in chronic venous leg ulcers[J]. J Dermatol Sci, 2010, 59(2):115-122.
17. An, Mushin OP, Lazar DA. Wound healing characteristics of ICAM-1 null mice devoid of all isoforms of ICAM-1[J]. J Surg Res, 2011, 171(1):81-87.
18. Monteiro GA, Delossantos AI, Rodriguez NL, et al. Porcine incisional hernia model:evaluation of biologically derived intact extracellular matrix repairs[J]. J Tissue Eng, 2013, 4(4):2041731413508771.
19. Liu J, Baird M, Tang Y, et al. Medial umbilic ligament flap reinforcement of the internal ring in children with indirect inguinal hernia[J]. J Laparoendosc Adv Surg Tech A, 2011, 21(6):561-565.

West China Medical Journal

The Study of Laparoscopic High Ligation for Repairing Inguinal Hernia on Rabbits

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