老年轻度认知功能障碍的危险因素_West China Medical Journal

Authors：

 周莉 , 吴超然 , 刘俐 ,  姜春玲

四川大学华西医院麻醉科（成都 610041）;

Corresponding author：

姜春玲, Email: 3588962@qq.com

Keywords：

轻度认知功能障碍; 痴呆; 阿尔兹海默病; 危险因素

DOI：

10.7507/1002-0179.201600101

Video：

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Abstract Full text Figures/Tables Video References Cited by

轻度认知功能障碍（MCI）是介于正常老化与老年期痴呆的一种过渡状态，其进展为痴呆的风险较高，而一旦进展为痴呆，其预后极差，将带来一系列的家庭和社会问题。因此，对MCI的早期诊断和干预将减少痴呆的发病率，而提高老年人的生活质量，减轻社会负担。现从MCI的概念、分类、流行病学及其危险因素等方面作一综述，以期能够早期识别相关危险因素，早期防治。

Citation： 周莉, 吴超然, 刘俐, 姜春玲. 老年轻度认知功能障碍的危险因素. West China Medical Journal, 2016, 31(2): 374-378. doi: 10.7507/1002-0179.201600101 Copy

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10.	Ritchie LJ, Tuokko H. Patterns of cognitive decline, conversion rates, and predictive validity for 3 models of MCI[J]. Am J Alzheimers Dis Other Demen, 2010, 25(7):592-603.
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1. Werner P, Korczyn AD. Mild cognitive impairment:conceptual, assessment, ethical, and social issues[J]. Clin Interv Aging, 2008, 3(3):413-420.
2. Petersen RC, Doody R, Kurz A, et al. Current concepts in mild cognitive impairment[J]. Arch Neurol, 2001, 58(12):1985-1992.
3. Petersen RC, Roberts RO, Knopman DS, et al. Mild cognitive impairment:ten years later[J]. Arch Neurol, 2009, 66(12):1447-1455.
4. Winblad B, Palmer K, Kivipelto M, et al. Mild cognitive impairment——beyond controversies, towards a consensus:report of the International Working Group on Mild Cognitive Impairment[J]. J Intern Med, 2004, 256(3):240-246.
5. Alexopoulos P, Grimmer T, Perneczky R, et al. Progression to dementia in clinical subtypes of mild cognitive impairment[J]. Dement Geriatr Cogn Disord, 2006, 22(1):27-34.
6. Ganguli M, Snitz BE, Saxton JA, et al. Outcomes of mild cognitive impairment by definition:a population study[J]. Arch Neurol, 2011, 68(6):761-767.
7. Manly JJ, Tang MX, Schupf N, et al. Frequency and course of mild cognitive impairment in a multiethnic community[J]. Ann Neurol, 2008, 63(4):494-506.
8. Nordlund A, Rolstad S, Klang O, et al. Two-year outcome of MCI subtypes and aetiologies in the Göteborg MCI study[J]. J Neurol Neurosurg Psychiatry, 2010, 81(5):541-546.
9. Rasquin SM, Lodder J, Visser PJ, et al. Predictive accuracy of MCI subtypes for Alzheimer's disease and vascular dementia in subjects with mild cognitive impairment:a 2-year follow-up study[J]. Dement Geriatr Cogn Disord, 2005, 19(2/3):113-119.
10. Ritchie LJ, Tuokko H. Patterns of cognitive decline, conversion rates, and predictive validity for 3 models of MCI[J]. Am J Alzheimers Dis Other Demen, 2010, 25(7):592-603.
11. Diniz BS, Nunes PV, Yassuda MS, et al. Diagnosis of mild cognitive impairment revisited after one year. Preliminary results of a prospective study[J]. Dement Geriatr Cogn Disord, 2009, 27(3):224-231.
12. Petersen RC, Caracciolo B, Brayne C, et al. Mild cognitive impairment:a concept in evolution[J]. J Intern Med, 2014, 275(3):214-228.
13. 徐明颖, 陈爱保, 杨家强, 等. 上海市某社区老年人群生活满意度的初步研究[J]. 中国全科医学, 2002, 5(8):637-638.
14. 于宝成, 王玉敏, 王成章, 等. 部队干休所老年人轻度认知功能损害调查[J]. 中华老年医学杂志, 2003, 22(1):40-42.
15. 翟金国, 赵丽, 于兰. 正常老年人轻度认知功能损害及相关因素研究[J]. 中国神经精神疾病杂志, 2004, 30(3):237-238.
16. Jia J, Zhou A, Wei C, et al. The prevalence of mild cognitive impairment and its etiological subtypes in elderly Chinese[J]. Alzheimers Dement, 2014, 10(4):439-447.
17. Yang ZJ, Liu J, Ge JP, et al. Prevalence of cardiovascular disease risk factor in the Chinese population:the 2007-2008 China National Diabetes and Metabolic Disorders Study[J]. Eur Heart J, 2012, 33(2):213-220.
18. Gauthier S, Reisberg B, Zaudig M, et al. Mild cognitive impairment[J]. Lancet, 2006, 367(9518):1262-1270.
19. Petersen RC, Smith GE, Waring SC, et al. Mild cognitive impairment:clinical characterization and outcome[J]. Arch Neurol, 1999, 56(3):303-308.
20. 梁小妞, 罗剑锋, 郭起浩, 等. 轻度认知功能障碍筛查量表研究进展[J]. 中国临床神经科学, 2014, 22(6):704-710.
21. Seligman SC, Giovannetti T, Sestito J, et al. A new approach to the characterization of subtle errors in everyday action:implications for mild cognitive impairment[J]. Clin Neuropsychol, 2014, 28(1):97-115.
22. Smith EE, Egorova S, Blacker D, et al. Magnetic resonance imaging white matter hyperintensities and brain volume in the prediction of mild cognitive impairment and dementia[J]. Arch Neurol, 2008, 65(1):94-100.
23. Mosconi L, Tsui WH, Herholz K, et al. Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer's disease, and other dementias[J]. J Nucl Med, 2008, 49(3):390-398.
24. Sachdev PS, Lipnicki DM, Crawford J, et al. Risk profiles for mild cognitive impairment vary by age and sex:the Sydney Memory and Ageing study[J]. Am J Geriatr Psychiatry, 2012, 20(10):854-865.
25. Unverzagt FW, Ogunniyi A, Taler V, et al. Incidence and risk factors for cognitive impairment no dementia and mild cognitive impairment in African Americans[J]. Alzheimer Dis Assoc Disord, 2011, 25(1):4-10.
26. 刘楠, 刘薇, 李冰, 等. 老年轻度认知功能障碍患者的相关因素分析[J]. 中国实用神经疾病杂志, 2014, 17(8):38-39.
27. Tervo S, Kivipelto M, Hänninen T, et al. Incidence and risk factors for mild cognitive impairment:a population-based three-year follow-up study of cognitively healthy elderly subjects[J]. Dement Geriatr Cogn Disord, 2004, 17(3):196-203.
28. Roberts RO, Geda YE, Knopman DS, et al. The incidence of MCI differs by subtype and is higher in men:the Mayo Clinic Study of Aging[J]. Neurology, 2012, 78(5):342-351.
29. Brenowitz WD, Kukull WA, Beresford SA, et al. Social relationships and risk of incident mild cognitive impairment in U.S. Alzheimer's disease centers[J]. Alzheimer Dis Assoc Disord, 2014, 28(3):253-260.
30. 冀瑞俊, 贾建平. 糖尿病患者总体认知功能和认知功能域的研究[J]. 中国临床康复, 2004, 8(21):4133-4135.
31. Winkler A, Dlugaj M, Weimar C, et al. Association of diabetes mellitus and mild cognitive impairment in middle-aged men and women[J]. J Alzheimers Dis, 2014, 42(4):1269-1277.
32. 周良佳, 马菲. 老年轻度认知功能障碍影响因素的研究进展[J]. 现代预防医学, 2013, 40(2):306-311.
33. Elias MF, Wolf PA, D'agostino RB, et al. Untreated blood pressure level is inversely related to cognitive functioning:the Framingham Study[J]. Am J Epidemiol, 1993, 138(6):353-364.
34. Knopman D, Boland LL, Mosley T, et al. Cardiovascular risk factors and cognitive decline in middle-aged adults[J]. Neurology, 2001, 56(1):42-48.
35. Decarli C, Miller BL, Swan GE, et al. Cerebrovascular and brain morphologic correlates of mild cognitive impairment in the National Heart, Lung, and Blood Institute Twin Study[J]. Arch Neurol, 2001, 58(4):643-647.
36. Carmelli D, Swan GE, Reed T, et al. Midlife cardiovascular risk factors, ApoE, and cognitive decline in elderly male twins[J]. Neurology, 1998, 50(6):1580-1585.
37. Petrovitch H, White LR, Izmirilian G, et al. Midlife blood pressure and neuritic plaques, neurofibrillary tangles, and brain weight at death:the HAAS. Honolulu-Asia aging Study[J]. Neurobiol Aging, 2000, 21(1):57-62.
38. Kivipelto M, Helkala EL, Hanninen T, et al. Midlife vascular risk factors and late-life mild cognitive impairment:a population-based study[J]. Neurology, 2001, 56(12):1683-1689.
39. Kim J, Park MH, Kim E, et al. Plasma homocysteine is associated with the risk of mild cognitive impairment in an elderly Korean population[J]. J Nutr, 2007, 137(9):2093-2097.
40. Singh B, Mielke MM, Parsaik AK, et al. A prospective study of chronic obstructive pulmonary disease and the risk for mild cognitive impairment[J]. JAMA Neurol, 2014, 71(5):581-588.
41. Singh B, Parsaik AK, Mielke MM, et al. Chronic obstructive pulmonary disease and association with mild cognitive impairment:the Mayo Clinic Study of Aging[J]. Mayo Clin Proc, 2013, 88(11):1222-1230.
42. Villeneuve S, Pepin V, Rahayel S, et al. Mild cognitive impairment in moderate to severe COPD:a preliminary study[J]. Chest, 2012, 142(6):1516-1523.
43. Rusanen M, Ngandu T, Laatikainen T, et al. Chronic obstructive pulmonary disease and asthma and the risk of mild cognitive impairment and dementia:a population based CAIDE study[J]. Curr Alzheimer Res, 2013, 10(5):549-555.
44. Gagnon K, Baril AA, Gagnon JF, et al. Cognitive impairment in obstructive sleep apnea[J]. Pathol Biol (Paris), 2014, 62 (5):233-240.
45. 彭万达, 陈锐, 蒋震, 等. 阻塞性睡眠呼吸暂停低通气综合征患者海马及脑白质病变与认知功能的相关性[J]. 中华医学杂志, 2014, 94(10):724-728.
46. Tan ZS, Beiser A, Vasan RS, et al. Thyroid function and the risk of Alzheimer disease:the Framingham Study[J]. Arch Intern Med, 2008, 168(14):1514-1520.
47. Resta F, Triggiani V, Barile G, et al. Subclinical hypothyroidism and cognitive dysfunction in the elderly[J]. Endocr Metab Immune Disord Drug Targets, 2012, 12(3):260-267.
48. van Boxtel MP, Menheere PP, Bekers O, et al. Thyroid function, depressed mood, and cognitive performance in older individuals:the Maastricht Aging Study[J]. Psychoneuroendocrinology, 2004, 29(7):891-898.
49. Wu T, Flowers JW, Tudiver F, et al. Subclinical thyroid disorders and cognitive performance among adolescents in the United States[J]. BMC Pediatr, 2006, 6:12.
50. de Jongh RT, Lips P, van Schoor NM, et al. Endogenous subclinical thyroid disorders, physical and cognitive function, depression, and mortality in older individuals[J]. Eur J Endocrinol, 2011, 165(4):545-554.
51. Roberts LM, Pattison H, Roalfe A, et al. Is subclinical thyroid dysfunction in the elderly associated with depression or cognitive dysfunction?[J]. Ann Intern Med, 2006, 145(8):573-581.
52. Parsaik AK, Singh B, Roberts RO, et al. Hypothyroidism and risk of mild cognitive impairment in elderly persons:a population-based study[J]. JAMA Neurol, 2014, 71(2):201-207.
53. Engelhart MJ, Geerlings MI, Ruitenberg A, et al. Diet and risk of dementia:Does fat matter?:The Rotterdam Study[J]. Neurology, 2002, 59(12):1915-1921.
54. Engelhart MJ, Geerlings MI, Ruitenberg A, et al. Dietary intake of antioxidants and risk of Alzheimer disease[J]. JAMA, 2002, 287(24):3223-3229.
55. Lourida I, Soni M, Thompson-Coon J, et al. Mediterranean diet, cognitive function, and dementia:a systematic review[J]. Epidemiology, 2013, 24(4):479-489.
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