Research on the Effect of Prevention and Control Intervention on Multidrug-resistant Organism in A Comprehensive Hospital of the First Grade_West China Medical Journal

Authors：

 LeiXibing ,  ChenLiping , XiaoYaxiong , TangYan , TanMuyang , SunRui

Nosocomial Infection Management Office, the First People's Hospital of Yibin City, Yibin, Sichuan 644000, P. R. China;

Corresponding author：

ChenLiping, Email: 1837639492@qq.com

Keywords：

Multi-drug resistance; Prevention and control interventions; Evaluation

DOI：

10.7507/1002-0179.201600112

Video：

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Objective To learn the status quo and characteristics of multi-drug resistant organism (MDRO) infection in a comprehensive hospital of the first grade in Sichuan Province, analyze the effect of prevention and control intervention, in order to provide a scientific basis for clinical MDRO prevention and control. Methods We collected MDRO data from January to June 2014 and from January to June 2015 through multi-drug resistance reporting software, and analyzed and compared the infection of MDRO during those two time periods. Then, we evaluated the prevention and control effect of MDRO infection. Results The number of inpatients from January to June 2014 was 24709, among which 813 were detected with MDRO infection. Of those infected patients, 196 had nosocomial infection of MDRO and the other 617 had community infection/colonization. The proportion of nosocomial MDRO infection was 24.10%. The MDRO nosocomial infection case rate was 0.79%. The proportion of community MDRO infection/colonization was 75.90%. The number of inpatients from January to June 2015 was 25329, and 739 of them were found with MDRO infection, of whom 132 had nosocomial infection and 607 community infection/colonization. The proportion of nosocomial MDRO infection was 17.86%. The MDRO nosocomial infection case rate was 0.52%. The proportion of community infection/colonization was 80.14%. Compared with the first half of 2014, the proportion of nosocomial MDRO infection was lower with a statistically significant difference (χ²=9.062, P<0.001), and MDRO nosocomial infection case rate was also significantly lowered (χ²=14.220, P<0.001). There were significant differences between the first half of 2015 and the same period of 2014 in hospital department distribution of MDRO infection, patient infection site distribution and pathogen detection. Conclusion The nosocomial MDRO infection control situation of our hospital is improved after the comprehensive prevention and control interventions, and we should focus on the prevention and control of key departments, important infection sites and major resistant bacteria in the future MDRO hospital infection control work.

Citation： LeiXibing, ChenLiping, XiaoYaxiong, TangYan, TanMuyang, SunRui. Research on the Effect of Prevention and Control Intervention on Multidrug-resistant Organism in A Comprehensive Hospital of the First Grade. West China Medical Journal, 2016, 31(3): 409-413. doi: 10.7507/1002-0179.201600112 Copy

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1. 孙风琳, 田龙飞, 李莺, 等. 多重耐药菌主动监测及防控干预的效果研究[J]. 宁夏医学. 杂志, 2013, 35(11):1102-1103.
2. 高莲英, 尹绕竹, 李云华. 多重耐药菌监测分析及控制对策[J]. 医药与保健, 2014, 22(10):83-83.
3. 中华人民共和国卫生部. 卫生部办公厅关于加强多重耐药菌医院感染控制工作的通知[EB/OL]. (2008-07-15)[2014-01-01]. http://www.moh.gov.cn/pygj/s3593/200807/7858200369d349b38961902ad5b37778.shtml.
4. 中华人民共和国卫生部卫生部办公厅关于印发《多重耐药菌医院感染预防与控制技术指南(试行)》的通知[EB/OL]. (2011-01-06)[2014-01-01]. http://www.nhfpc.gov.cn/mohyzs/s3594/201101/50487.shtml.
5. 顾忠民, 吴荣华, 中国医药科学. PCT在ICU多重耐药菌MDR的定植与感染鉴别中的应用[J]. 中国医药科学, 2012, 11(2):90-91.
6. Schuetz P, Albrich WC, Mueller B. Procalcitonin for diagnosis of infection and guide to antibiotic decisions:past, present and future[J]. BMC Med, 2011, 9(1):107.
7. 中华人民共和国卫生部. WS/T 313-2009 医务人员手卫生规范[S]. 2009.
8. 中华人民共和国卫生部. 抗菌药物临床应用管理办法[EB/OL]. (2012-08-01)[2012-02-13]. http://www.moh.gov.cn/mohyzs/s3584/201205/54645.shtml.
9. 中华人民共和国卫生部, 国家中医药管理局, 总后卫生部. 抗菌药物临床应用指导原则[EB/OL]. (2014-08-19)[2015-01-01]. http://www.sfda.gov.cn/wyf04285/2004285.zip.
10. 李辉, 孙晓辉, 欧柳红. 综合ICU多重耐药菌感染的监测及综合干预研究[J]. 中国感染控制杂志, 2013, 12(3):196-198.
11. 舒菊香. 浅谈医院感染管理防控方面存在的问题和对策[J]. 中国中医药咨讯, 2010, 2(18):77-78.
12. 周健, 孟军, 江淑芳. 综合ICU多重耐药菌感染的分析与护理干预[J]. 护士进修杂志, 2012, 27(19):1743-1744.
13. 赵红霞. 某综合医院多重耐药菌感染类型调查[J]. 中国消毒学杂志, 2015, 32(2):181-182.
14. 刘彩红, 李福琴, 刘盛楠, 等. 综合干预措施可降低重症监护病房多重耐药菌医院感染发病率[J]. 中国感染控制杂志, 2015, 8(8):553-556.
15. 李霞, 邢志广, 王明永. 尿路感染大肠埃希菌的分离鉴定及抗菌药物选择[J]. 现代预防医学, 2011, 38(8):1518-1519.
16. 陈晓娟, 黄建琼. 烧伤层流病房多重耐药菌感染的相关因素分析及干预措施[J]. 华西医学, 2013, 28(10):1486-1488.
17. 陈美恋, 贾会学, 李六亿. 多重耐药菌感染监测及防控现状综述[J]. 中国感染控制杂志, 2015, 14(8):571-576.
18. 任丽, 雷霞, 张馨. 某基层医院泛耐药鲍曼不动杆菌感染暴发的调查与控制[J]. 中国感染控制杂志, 2015, 14(6):370-373.

West China Medical Journal

Research on the Effect of Prevention and Control Intervention on Multidrug-resistant Organism in A Comprehensive Hospital of the First Grade

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