Analysis on the Sensitivity of 496 Clinical Isolated Strains of Bloodborne Infectious Staphylococci to Antibacterial Drugs_West China Medical Journal

Authors：

 ZhaoRuiting ^1,2 ,  FengPing ¹ , ZongZhiyong ¹ , ChenLiyu ¹

1. Infectious Disease Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Department of Gastroenterology, PLA 452 Hospital, Chengdu, Sichuan 610065, P. R. China;

Corresponding author：

FengPing, Email: fengp_62@163.com

Keywords：

Staphylococcus; Septicemia; Drug-resistance

DOI：

10.7507/1002-0179.201600187

Video：

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Objective To survey and analyze the drug resistance of clinical isolated strains of bloodborne infectious staphylococci, in order to provide references for clinical diagnosis of aureus septicemia and rational use of antimicrobial agents. Methods We retrospectively studied the clinical data of 496 patients with staphylococcal septicemia confirmed by blood culture between June 2008 and May 2015 in West China Hospital of Sichuan University. The microbiological characteristics of the disease were analyzed. Results In the included 496 cases, there were 216 (43.55%) cases of coagulase-positive Staphylococcus (CPS) septicemia and 280 (56.45%) of coagulase-negative Staphylococcus (CNS) septicemia; 85 (17.14%) cases were caused by community infection, while the other 411 (82.86%) resulted from hospital infection. The drug resistance rate of CPS and CNS toward oxacillin was respectively 27.78% (60/216) and 87.50% (245/280), with a significant difference (P < 0.05). In al l the clinical isolated strains of CPS, the drug resistance rate of community infected strains and hospital infected strains toward oxacillin was respectively 9.67% (6/62) and 35.06% (54/154), with a significant difference (P < 0.05). For the clinical isolated strains of CNS, the drug resistance rate of community infected strains and hospital infected strains toward oxacillin was respectively 69.57% (16/23) and 89.11% (229/257), also with a significant difference (P < 0.05). Conclusions The drug resistance of hospital infected staphylococcal strains is stronger than community infected strains. The CNS strains are more drug-resistant than CPS strains.

Citation： ZhaoRuiting, FengPing, ZongZhiyong, ChenLiyu. Analysis on the Sensitivity of 496 Clinical Isolated Strains of Bloodborne Infectious Staphylococci to Antibacterial Drugs. West China Medical Journal, 2016, 31(4): 683-687. doi: 10.7507/1002-0179.201600187 Copy

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1. Gould SW, Cuschieri P, Rollason J, et al. The need for continued monitoring of antibiotic resistance patterns in clinical isolates of Staphylococcus aureus from London and Malta[J]. Ann Clin Microbiol Antinicrob, 2010, 21(9): 20.
2. Stefani S. Evolution in the antibiotic susceptibity and resistance[J].Infez Med, 2009, 17(2): 5-12.
3. Wang L, Barrett JF. Control and prevention of MRSA infections[J].Methods Mol Biol, 2007, 391(4): 209-225.
4. 马筱玲, 王敬华, 李华, 等. 异质性万古霉素耐药葡萄球菌分离及生物学特性观察[J]. 中华微生物学和免疫学杂志, 2004, 24(7): 583-586.
5. 余方友, 李美兰, 林晓梅, 等. 万古霉素对金黄色葡萄球菌体外抗菌活性研究[J]. 中国微生态学杂志, 2006, 18(3): 240-242.
6. 廖康, 陈冬梅, 曾燕, 等. 异质性万古霉素中介金黄色葡萄球菌的检测与分析[J]. 中国临床实用医学, 2008, 2(12): 4-5.
7. 中华人民共和国卫生部. 医院感染诊断标准(试行)[J]. 现代实用医学, 2003, 81(7): 460-465.
8. 马序竹, 李湘燕, 侯芳, 等.成人败血症249例回顾性临床分析[J]. 中华医院感染学杂志, 2010, 20(5): 648-650.
9. 江应安, 胡亚华, 杨丽华, 等. 55例葡萄球菌败血症临床生物学分型及耐药性分析[J]. 中国实用内科杂志, 2002, 22(4): 233-234.
10. 李石好, 唐正运. 45例葡萄球菌败血症临床生物学分型及药敏分析[J]. 广东医学, 2007, 28(9): 1501-1502.
11. 饶希, 吕晓菊, 刘焱斌, 等. 金黄色葡萄球菌败血症55例临床分析[J]. 四川大学学报: 医学版, 2009, 40(2): 347-349, 360.
12. 梁冰, 王军, 姜美娟, 等. 凝固酶阴性葡萄球菌生物膜标志物3种检测方法比较[J]. 临床检验杂志, 2010, 28(6): 410-412.
13. Rogers KL, Ruoo ME, Fey PD. The presence of ica ADBC is detrimental to the colonization of human skin by Staphylococcus epidermidis[J]. Appl Environ Microbiol, 2008, 74(19): 6155-6157.
14. Torma MA, Marti M, Valle J, et al. sar A is an essential positive regulator of Staphylococcus epidermidis biofilm development[J]. J Bacterial, 2005, 187(7): 2348-2356.
15. Rachid S, Cho S, Ohlesn K, et al. Induction of Staphylococcus epidermidis biofilm formation by environmental factors: the possible involvement of the alternative transcription factor sig B[J].Adv Exp Med Biol, 2000, 485(2): 159-166.
16. Gu J, Li H, Li M, et al. Bacterial insertion sequence IS256 as a protention molecular maker to discriminate invasive strains from commensal strains of Straphylococcus epidermids[J]. J Hosp Infect, 2005, 61(4): 342-348.
17. Novotna G, Adamkova V, Janata J, et al. Prevalence of resistance mechanisms against macrolides and linsosamids in the Czech Repulic and occurrence of an undefined mechanism of resistance to lincosamides[J]. Antimicrob Agents Chemother, 2005, 49(8): 3586-3589.
18. Correa JE, De Paulis A, Predari S, et al. First report of qac G, qac H and qac J genes in Staphylococcus haemolyticus human clinical isolates[J]. J Antimicrob Chemother, 2008, 62(5): 956-960.

West China Medical Journal

Analysis on the Sensitivity of 496 Clinical Isolated Strains of Bloodborne Infectious Staphylococci to Antibacterial Drugs

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